Tag: M.W=100-150

Wood, Murray R. published the artcileInvestigation of the Experimental Factors Affecting the Trithiocarbonate-Mediated RAFT Polymerization of Methyl Acrylate, Safety of Ethyl 2-mercaptopropanoate, the publication is Australian Journal of Chemistry (2007), 60(10), 772-778, database is CAplus.

The reversible addition-fragmentation chain transfer polymerization of acrylates, using Me acrylate (MA) as a monomer model, mediated by a trithiocarbonate was tested under several conditions where the exptl. parameters were systematically altered. The most significant parameter in controlling the rate and control of the polymerization was found to be the ratio of chain transfer agent (CTA) to initiator. Decreasing this ratio increased the rate of polymerization and had little noticeable effect on the control over mol. weight distribution. A ratio of CTA to initiator of unity was shown to give the best compromise between rate and control of the polymerization Targeted d.p. (equivalent to ratios of monomer to CTA) had negligible effect on the rate of polymerization and polydispersity index (PDI). Performing the polymerization in the presence of solvent (up to 41.2% (weight/weight) in toluene) had no neg. effect on the rate of polymerization Indeed, marginally higher conversions and lower PDIs than for bulk polymerization were achieved for similar reaction times. A higher amount of toluene (66.6% (weight/weight)) induced a lower rate of polymerization, but the evolution of mol. weight and PDI were unaffected. Polymerizations performed in the presence of toluene, N,N-dimethylformamide, and Me Et ketone showed that solvent polarity and aromaticity had no observable effect on the rate of polymerization and over the control of mol. weight distribution. The optimum conditions for the polymerization of MA, mediated by 2-ethylthiocarbonylsulfanyl-propionic acid Et ester at 50°C were found to be [CTA]/[AIBN] = 1/1 and ∼ 40% solvent (weight/weight).

Australian Journal of Chemistry published new progress about 19788-49-9. 19788-49-9 belongs to esters-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Ester, name is Ethyl 2-mercaptopropanoate, and the molecular formula is C12H25Br, Safety of Ethyl 2-mercaptopropanoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Wood, Murray R. published the artcileSelective one-pot synthesis of trithiocarbonates, xanthates, and dithiocarbamates for use in RAFT/MADIX living radical polymerizations, Application of Ethyl 2-mercaptopropanoate, the publication is Organic Letters (2006), 8(4), 553-556, database is CAplus and MEDLINE.

A facile route is developed for the production of chain transfer agents for reversible addition fragmentation chain transfer (RAFT) and macromol. design via the interchange of xanthates (MADIX) polymerizations, via a one-pot reaction. 1,1′-Thiocarbonyl diimidazole (TCDI) undergoes controlled monosubstitution when reacted with secondary thiols or alcs. The intermediate S/O-esters of imidazole-N-thionocarboxylic acid react efficiently with a range of primary thiols, alcs., and amines to form asym. dithiocarbonates, trithiocarbonates, and dithiocarbamates, resp. The synthesis provides a facile approach to the controlled radical polymerization of vinyl monomers through the reversible addition-fragmentation chain transfer (RAFT) mechanism.

Organic Letters published new progress about 19788-49-9. 19788-49-9 belongs to esters-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Ester, name is Ethyl 2-mercaptopropanoate, and the molecular formula is C18H21BO4, Application of Ethyl 2-mercaptopropanoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Wood, Murray R. published the artcileNovel one-pot synthesis of chain transfer agents for RAFT/MADIX polymerizations; trithiocarbonates, xanthates and dithiocarbamates, COA of Formula: C5H10O2S, the publication is Polymer Preprints (American Chemical Society, Division of Polymer Chemistry) (2005), 46(2), 320-321, database is CAplus.

Starting from 1,1′-thiocarbonyldiimidazole and primary, secondary, or tertiary thiols, benzyl alc., or benzylamine, the title di- and trithiocarbonate and dithiocarbamate chain-transfer agents were prepared without the need for CS₂.

Polymer Preprints (American Chemical Society, Division of Polymer Chemistry) published new progress about 19788-49-9. 19788-49-9 belongs to esters-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Ester, name is Ethyl 2-mercaptopropanoate, and the molecular formula is C18H21BO4, COA of Formula: C5H10O2S.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Serushkina, O. V. published the artcileRegioselective replacement of nitro groups in 2,4,6-trinitrotoluene under the action of alkanethiols. Synthesis of ortho-(alkylthio)-substituted nitrotoluenes and their oxidation to sulfoxides and sulfones, Formula: C5H10O2S, the publication is Russian Chemical Bulletin (Translation of Izvestiya Akademii Nauk, Seriya Khimicheskaya) (2001), 50(2), 261-264, database is CAplus.

The reactions of 2,4,6-trinitrotoluene with alkanethiols in the presence of K₂CO₃ (the molar ratio of the reactants is 1: 1: 1) in dipolar aprotic solvents result in selective replacement of the ortho-nitro group to form 2-alkylthio-4,6-dinitrotoluenes, which can be oxidized to the corresponding sulfoxides of sulfones. The 2nd ortho-nitro group can be replaced under the action of one more equivalent of alkanethiol on sulfides as exemplified in PhCH₂SH.

Russian Chemical Bulletin (Translation of Izvestiya Akademii Nauk, Seriya Khimicheskaya) published new progress about 19788-49-9. 19788-49-9 belongs to esters-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Ester, name is Ethyl 2-mercaptopropanoate, and the molecular formula is C10H18O, Formula: C5H10O2S.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Valenca, Helber da Maia published the artcileBeneficial effects of Ilex paraguariensis in the prevention of obesity-associated metabolic disorders in mice, Formula: C6H8O4, the publication is Phytotherapy Research (2022), 36(2), 1032-1042, database is CAplus and MEDLINE.

Obesity is a chronic condition involving inflammation and oxidative stress that commonly predisposes affected individuals to develop metabolic disorders. We hypothesize that Ilex paraguariensis (IP) can modulate oxidative stress and inflammation underpinning metabolic disorders caused by obesity. C57BL/6 mice were fed a high-fat diet (HFD group) for 12 wk. Concomitantly, some mice were treated with roasted IP (15 mg/mL – HFD + IP) or di-Me fumarate (DMF) as a pos. control (2 mg/mL – HFD + DMF). The control group received standard chow and water ad libitum. Histol. analyses of fat tissue and liver, and quantification of mediators related to oxidative stress (Kelch-like ECH-associated protein 1/NF-E2-related factor 2, NADP(H) quinone oxidoreductase-1 [NQO1], heme oxygenase 1 [HO1], and superoxide dismutase) as well as metabolic profile blood biomarkers (glucose, leptin, resistin, high-d. lipoproteins [HDLs], and triglycerides) were performed. Metabolic disorders were prevented in mice treated with IP, as evidenced by the observation that glucose, HDL, and resistin levels were similar to those assessed in the control group. Morphol. analyses showed that both IP and DMF treatments prevented hepatic steatosis and adipocyte hypertrophy in visceral adipose tissue. Finally, although the antioxidant response stimulated by IP was quite limited, significant effects were found on NQO1 and HO1 expression. In conclusion, IP has promising preventative effects on the development of metabolic disorders caused by obesity.

Phytotherapy Research published new progress about 624-49-7. 624-49-7 belongs to esters-buliding-blocks, auxiliary class Inhibitor,Natural product, name is Dimethyl fumarate, and the molecular formula is C3H6O2, Formula: C6H8O4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Vainio, S. K. published the artcileDimethyl fumarate decreases short-term but not long-term inflammation in a focal EAE model of neuroinflammation, Name: Dimethyl fumarate, the publication is EJNMMI Research (2022), 12(1), 6, database is CAplus and MEDLINE.

Abstract: Background: Di-Me fumarate (DMF) is an oral immunomodulatory drug used in the treatment of autoimmune diseases. Here, we sought to study whether the effect of DMF can be detected using positron emission tomog. (PET) targeting the 18-kDa translocator protein (TSPO) in the focal delayed-type hypersensitivity rat model of multiple sclerosis (fDTH-EAE). The rats were treated orally twice daily from lesion activation (day 0) with either vehicle (tap water with 0.08% Methocel, 200μL; control group n = 4 (3 after week four)) or 15 mg/kg DMF (n = 4) in 0.08% aqueous Methocel (200μL) for 8 wk. The animals were imaged by PET using the TSPO tracer [¹⁸F]GE-180 in weeks 0, 1, 2, 4, 8, and 18 following lesion activation, and the non-displaceable binding potential (BP_ND) was calculated Immunohistochem. staining for Iba1, CD4, and CD8 was performed in week 18, and in sep. cohorts of animals, following 2 or 4 wk of treatment. Results: Using the fDTH-EAE model, DMF reduced the [¹⁸F]GE-180 BP_ND in the DMF-treated animals compared to control animals after 1 wk of treatment (two-tailed unpaired t test, p = 0.031), but not in weeks 2, 4, 8, or 18 when imaged in vivo by PET. Immunostaining for Iba1 showed that DMF had no effect on the perilesional volume or the core lesion volume after 2 or 4 wk of treatment, or at 18 wk. However, the optical d. (OD) measurements of CD4⁺ staining showed reduced OD in the lesions of the treated rats. Conclusions: DMF reduced the microglial activation in the fDTH-EAE model after 1 wk of treatment, as detected by PET imaging of the TSPO ligand [¹⁸F]GE-180. However, over an extended time course, reduced microglial activation was not observed using [¹⁸F]GE-180 or by immunohistochem. for Iba1⁺ microglia/macrophages. Addnl., DMF did affect the infiltration of CD4⁺ and CD8⁺ T-lymphocytes at the fDTH-EAE lesion.

EJNMMI Research published new progress about 624-49-7. 624-49-7 belongs to esters-buliding-blocks, auxiliary class Inhibitor,Natural product, name is Dimethyl fumarate, and the molecular formula is C18H16N2O6, Name: Dimethyl fumarate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Li, Jiajia published the artcileVisible Light-Induced Living Radical Polymerization of Butyl Acrylate: Photocatalyst-Free, Ultrafast, and Oxygen Tolerance, SDS of cas: 19788-49-9, the publication is Macromolecular Rapid Communications (2017), 38(13), n/a, database is CAplus and MEDLINE.

Bu acrylate is polymerized in the living way under the irradiation of purple light-emitting diode (LED) or sunlight without photocatalyst at ambient temperature 2-((Phenoxycarbonothioyl)thio) Et propanoate is exclusively added and acted as an initiator and a chain transfer agent simultaneously in the current system. Poly(Bu acrylate) with well-regulated mol. weight and relatively narrow mol. weight distribution (ETH < 1.30) is synthesized. High conversion (>95%) can be achieved within several minutes. Polymerization shows oxygen tolerance. Near quant. end-group fidelity of polymer is demonstrated by ¹H NMR and matrix-assisted laser desorption/ionization time-of-flight mass spectra.

Macromolecular Rapid Communications published new progress about 19788-49-9. 19788-49-9 belongs to esters-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Ester, name is Ethyl 2-mercaptopropanoate, and the molecular formula is C5H10O2S, SDS of cas: 19788-49-9.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Ru, Tingting published the artcileA method for synthesis of 2H-[1, 4]oxazole triazine [2, 3, 4]-6-quinoline carboxylic acid derivatives by microwave, Quality Control of 924-99-2, the publication is Huagong Shikan (2014), 28(1), 15-17, database is CAplus.

The new method was introduced for synthesis of quinolinelactone compounds by microwave. The reaction was simple, high efficient and clean. Using the microwave heating, a series of oxazoletriazine [2, 3, 4]-6-quinoline carboxylic acid derivatives were synthesized, and the compounds were characterized by IR, ¹H NMR and mass spectrometry.

Huagong Shikan published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, Quality Control of 924-99-2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Wuckelt, Jorg published the artcileLactam analogs of pentalene. A new one-pot synthesis of pyrrolo[3,2-b]pyrrole-2,5-diones deriving from pulvinic acid, Name: Ethyltert-butylacetate, the publication is Tetrahedron Letters (1997), 38(30), 5269-5272, database is CAplus.

A new and convenient one-pot synthesis of a variety of N-aryl lactam analogs I (R¹ = Ph, 4-MeOC₆H₄, 4-O₂NC₆H₄, 3-F₃CC₆H₄, 4-MeC₆H₄, R² = Ph, CH₂Ph, CMe₃, 2-thienyl, etc.) of pentalene has been developed. Pulvinic acid dilactams I are of interest due to their electronic and optical features and as synthetic pigments.

Tetrahedron Letters published new progress about 5340-78-3. 5340-78-3 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is Ethyltert-butylacetate, and the molecular formula is C9H7NO2, Name: Ethyltert-butylacetate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Pasquini, Serena published the artcileInvestigations on the 4-Quinolone-3-carboxylic Acid Motif. 4. Identification of New Potent and Selective Ligands for the Cannabinoid Type 2 Receptor with Diverse Substitution Patterns and Antihyperalgesic Effects in Mice, Related Products of esters-buliding-blocks, the publication is Journal of Medicinal Chemistry (2011), 54(15), 5444-5453, database is CAplus and MEDLINE.

Exptl. evidence suggests that selective CB2 receptor modulators may provide access to antihyperalgesic agents devoid of psychotropic effects. Taking advantage of previous findings on structure-activity/selectivity relationships for a class of 4-quinolone-3-carboxamides, further structural modifications of the heterocyclic scaffold were explored, leading to the discovery of the 8-methoxy derivative 4a endowed with the highest affinity and selectivity ever reported for a CB2 ligand. The compound, evaluated in vivo in the formalin test, behaved as an inverse agonist by reducing at a dose of 6 mg/kg the second phase of the formalin-induced nocifensive response in mice.

Journal of Medicinal Chemistry published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, Related Products of esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics