Tag: M.W=100-150

McCourt, Ruairi O. published the artcileAtmospheric Oxygen Mediated Radical Hydrothiolation of Alkenes, Safety of Ethyl 4-oxopentanoate, the main research area is alkene thiol atm oxygen mediated radical hydrothiolation; green chemistry; hydrothiolation; initiation; radical; thiol-ene.

A mild, metal-free, atm. oxygen-mediated radical hydrothiolation of alkenes (and alkyne) was reported. A variety of sulfur containing motifs including alkanethiols, thiophenols and thioacids undergo an atm. oxygen-mediated radical hydrothiolation reaction with a plethora of alkenes in good yield with excellent functional group compatibility, typically with short reaction times to furnished a range of functionalized products. Biomols. proved tolerant to the conditions and the procedure was robust and easily executable requiring no specialized equipment. Concise mechanistic studies confirmed that the process proceeded through radical intermediates in a thiol-ene reaction manifold. The methodol. offered an efficient “”green”” approach for thiol-ene mediated “”click”” ligation and a milder alternative to thermally initiated hydrothiolation processes.

Chemistry – A European Journal published new progress about Green chemistry. 539-88-8 belongs to class esters-buliding-blocks, name is Ethyl 4-oxopentanoate, and the molecular formula is C7H12O3, Safety of Ethyl 4-oxopentanoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bernhard, Yann published the artcileOne-Pot Synthesis of 2,5-Disubstituted Furans through In Situ Formation of Allenes and Enolization Cascade, Product Details of C7H12O3, the main research area is furan preparation ketoacid enolization cyclization cascade.

A one-pot synthesis of 2,5-disubstituted furans from γ-ketoacids is reported. In situ formation of allenoates by action of chloroformate on carboxylic acid following by enolization of ketone affords furan derivatives by cyclization. The reaction was extended to a wide scope of ketoacids and phosphonium salts. This methodol. was applied on levulinic acid and derivatives, one of the biosourced platform chems.

European Journal of Organic Chemistry published new progress about Carboxylic acids Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 539-88-8 belongs to class esters-buliding-blocks, name is Ethyl 4-oxopentanoate, and the molecular formula is C7H12O3, Product Details of C7H12O3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wei, Duo published the artcileIron-Catalysed Switchable Synthesis of Pyrrolidines vs Pyrrolidinones by Reductive Amination of Levulinic Acid Derivatives via Hydrosilylation, Related Products of esters-buliding-blocks, the main research area is acid amine iron catalyst reductive amination hydrolysis; pyrrolidine preparation; pyrrolidinone preparation; heterocyclic amine preparation.

A selective production of pyrrolidines vs pyrrolidinones via hydrosilylation of levulinic acid and levulinates by switching of the iron complex catalyst was presented. The reactions proceeded efficiently with various anilines and alkylamines under both visible light irradiation and thermal conditions with 43 examples in isolated yields up to 93%. Noticeably, under similar conditions, cyclic amines such as piperidines and azepanes were efficiently synthesized with yields up to 92%, by reaction of anilines with 1,5- or 1,6-keto acids, resp. Similarly, N-arylinsolidoline compounds was prepared from 2-formylbenzoic acid in 57-93% yields.

Advanced Synthesis & Catalysis published new progress about Carboxylic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 539-88-8 belongs to class esters-buliding-blocks, name is Ethyl 4-oxopentanoate, and the molecular formula is C7H12O3, Related Products of esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Hongxia published the artcileThe combination of HT-ac and HBET improves the cognitive and learning abilities of heat-stressed mice by maintaining mitochondrial function through the PKA-CREB-BDNF pathway, Application In Synthesis of 5405-41-4, the main research area is PKA CREB BDNF signaling mitochondria heat stress learning cognition.

The aim was to investigate whether the combination of hydroxytyrosol acetate (HT-ac) and Et β-hydroxybutyrate (HBET) can improve the cognition of heat-stressed mice, meanwhile exploring the mechanism of action. Mice were divided into 5 groups: control, heat-stressed, HT-ac, HBET, and HT-ac + HBET. Mice were gavaged for 21 days and exposed to heat (42.5 ± 0.5°C, RH 60 ± 10%, 1 h day-1) on days 15-21, except for the control group. Results showed that the combination of HT-ac + HBET improved the cognitive and learning abilities of heat-stressed mice, which were tested by Morris water maze, shuttle box, and jumping stage tests. The combination of HT-ac + HBET maintained the integrity of neurons and mitochondria of heat-stressed mice. Likewise, this combination increased the mitochondrial membrane potential, the ATP content, the expression of phosphorylated PKA, BDNF, phosphorylated CREB and Bcl-2, and decreased the expression of Bax, caspase-3, and intracytoplasmic Cyt C in heat-stressed mice.

Food & Function published new progress about Antioxidants. 5405-41-4 belongs to class esters-buliding-blocks, name is Ethyl 3-hydroxybutanoate, and the molecular formula is C6H12O3, Application In Synthesis of 5405-41-4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhao, Guodong published the artcileFenton-like chemistry enables catalytic oxidative desulfurization of thioacetals and thioketals with hydrogen peroxide, COA of Formula: C7H12O3, the main research area is carbonyl compound preparation green chem chemoselective; dithioacetal Fenton oxidative desulfurization cerium catalyst; alc preparation green chem chemoselective; methylthiomethyl ether Fenton oxidative desulfurization cerium catalyst.

A green catalytic approach that exploits Fenton-like chem. (FLC: CeBr3-H2O2) for the oxidative desulfurization of thioacetals RC(S(CH2)nX)R1 (R = R1 = 2,3-dihydro-1H-inden-1-yl, 9H-fluoren-9-yl, etc. R = H, Ph, thiopen-2-yl, etc. R1 Ph, H, n-Bu, n-pr, etc. X = O, NH, n = 1,2,3) and thioketals ROCH2SCH3 (R = Bn, cyclohexyl, cyclopentyl, etc.), and has many competitive advantages including (1) high efficiency (15 min, up to 97% yield), (2) high chemoselectivity with broad substrate scope, (3) greenness (H2O as the sole waste) with outstanding green chem. metrics, and (4) low cost has been reported. Detailed mechanistic studies revealed that the reactive brominating species (RBS, HOBr) generated in situ using Fenton-like chem. (i.e., HO) and bromide reacted with sulfide (thioacetals or thioketals) to form the bromosulfonium intermediate (RR’S-Br), which was attacked by a heteroatom such as sulfur, oxygen or nitrogen to initiate the hydrolysis to carbonyls RC=OR1 or alcs ROH. The released bromide ion (Br-) could be oxidized again by Fenton-like chem. to generate RBS for the next catalytic cycle. This highly efficient, chemoselective, and green approach for oxidative desulfurization is expected to find wide applications in organic synthesis.

Green Chemistry published new progress about Aldehydes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 539-88-8 belongs to class esters-buliding-blocks, name is Ethyl 4-oxopentanoate, and the molecular formula is C7H12O3, COA of Formula: C7H12O3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Qiao, Xin-Chao published the artcileHalf-sandwich ruthenium-based versatile catalyst for both alcohol oxidation and catalytic hydrogenation of carbonyl compounds in aqueous media, Product Details of C6H12O3, the main research area is carbonyl compound preparation; alc preparation oxidation ruthenium catalyst; hydrogenation carbonyl compound ruthenium catalyst.

A series of half-sandwich ruthenium-based catalysts I (R = H, OCH3, CF3, Cl) for both alc., e.g., 1,2,3,4-tetrahydronaphthalen-1-ol oxidation and carbonyl compounds R1C(O)R2 (R1 = C6H5, 3-BrC6H4, 2-pyridyl, etc.; R2 = H, Me, Ph; R1R2 = -(CH2)5-) hydrogenation have been synthesized through metal-induced C-H bond activation based on benzothiazole ligands II. Mol. structures of complexes I (R = H, CF3) were further confirmed by X-ray diffraction anal. All complexes I exhibited high activity for the catalytic oxidation of a variety of alcs. with tBuOOH as oxidants to give carbonyl compounds, e.g., 1,2,3,4-tetrahydronaphthalen-1-one with high yields in water. Moreover, these half-sandwich complexes also showed high efficiency for the catalytic hydrogenation of carbonyl compounds in a methanol-water mixture The catalyst could be reused for at least five cycles without any loss of activity. The catalytic system also worked well for various kinds of substrates with either electron-donating or electron-withdrawing groups.

Applied Organometallic Chemistry published new progress about Carbonyl compounds (organic) Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 5405-41-4 belongs to class esters-buliding-blocks, name is Ethyl 3-hydroxybutanoate, and the molecular formula is C6H12O3, Product Details of C6H12O3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Matos, Jeishla L. M. published the artcileCycloisomerization of Olefins in Water, COA of Formula: C7H12O3, the main research area is bioorthogonal cycloisomerization olefin water; DNA; cobalt; isomerization; kinetics; water chemistry.

Preparative reactions that occur efficiently under dilute, buffered, aqueous conditions in the presence of biomols. find application in ligation, peptide synthesis, and polynucleotide synthesis and sequencing. However, the identification of functional groups or reagents that are mutually reactive with one another, but unreactive with biopolymers and water, is challenging. Shown here are cobalt catalysts that react with alkenes under dilute, aqueous, buffered conditions and promote efficient cycloisomerization and formal Friedel-Crafts reactions. The constraining conditions of bioorthogonal chem. are beneficial for reaction efficiency as superior conversion at low catalyst concentration is obtained and competent rates in dilute conditions are maintained. Efficiency at high dilution in the presence of buffer and nucleobases suggests that these reaction conditions may find broad application.

Angewandte Chemie, International Edition published new progress about Alkylation, homolytic. 539-88-8 belongs to class esters-buliding-blocks, name is Ethyl 4-oxopentanoate, and the molecular formula is C7H12O3, COA of Formula: C7H12O3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Tyler, Jasper L. published the artcileStrain-Release Driven Spirocyclization of Azabicyclo[1.1.0]butyl Ketones, Quality Control of 5405-41-4, the main research area is azetidine spirocycle synthesis spirocyclization desilylation azabicyclobutane; strain release spirocyclization desilylation synthesis azetidine spirocycle; Azabicylo[1.1.0]butanes; Azetidines; Heterocycles; Spiro compounds; Strained molecules.

Due to their intrinsic rigidity, three-dimensionality and structural novelty, spirocyclic mols. have become increasingly sought-after moieties in drug discovery. Herein, we report a strain-release driven synthesis of azetidine-containing spirocycles by harnessing the inherent ring strain of the azabicyclo[1.1.0]butane (ABB) fragment. Novel ABB-ketone precursors bearing silyl-protected alcs. were synthesized in a single step and shown to engage in electrophile-induced spirocyclization-desilylation reactions. Primary, secondary and tertiary silyl ethers were effectively transformed into a library of new spiro-azetidines, with a range of substituents and ring sizes. In addition, the products are generated with synthetically useful ketone and protected-amine functional groups, which provides the potential for further elaboration and for this chem. to be utilized in the rapid assembly of medicinally relevant compounds

Angewandte Chemie, International Edition published new progress about Azabicyclic compounds Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (spirocycles). 5405-41-4 belongs to class esters-buliding-blocks, name is Ethyl 3-hydroxybutanoate, and the molecular formula is C6H12O3, Quality Control of 5405-41-4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Cao, Xi published the artcileEfficient synthesis of γ-valerolactone from ethyl levulinate over Ni/V2O5, Related Products of esters-buliding-blocks, the main research area is valerolactone synthesis solid phase grinding.

Valerolactone (GVL) has been recognized as one of the most value-added chems. derived from biomass. In this work, an efficient Ni/V2O5 catalyst was prepared via solid phase grinding and in-situ reduction The Ni/V2O5 catalyst was employed for catalytic transfer hydrogenation (CTH) of Et levulinate (EL) to GVL using 2-propanol as a hydrogen source. An excellent GVL selectivity of 93.04% at EL conversion of 97.40% could be achieved at 180°C in 4 h using 30% Ni/V2O5 as the catalyst. This catalyst was able to be reused for five times with the GVL selectivity decreased a little. A possible adsorption mechanism of generate active H species in CTH of EL over Ni/V2O5 was proposed.

IOP Conference Series: Materials Science and Engineering published new progress about Solids. 539-88-8 belongs to class esters-buliding-blocks, name is Ethyl 4-oxopentanoate, and the molecular formula is C7H12O3, Related Products of esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Cao, Yuxi published the artcileComparison of bayberry fermented wine aroma from different cultivars by GC-MS combined with electronic nose analysis, HPLC of Formula: 5405-41-4, the main research area is bayberry fermented wine gas chromatog mass spectrometry electronic nose; GC‐MS; bayberry cultivars; bayberry wine fermentation; electronic nose; volatile compounds.

Four bayberry cultivars (Biqi, Dongkui, Wandao, and Dingao) in eastern China were selected to produce the fermented bayberry wine. The volatile flavor compounds in different bayberry wine were compared by gas chromatog.-mass spectrometry (GC-MS) and electronic nose. The results showed that 46 volatile flavor compounds were found in bayberry wine, including 19 esters, 7 alcs., 6 acids, 2 aldehydes, 2 ketones, 3 terpenes, and 7 others compounds The most important contribution to the aroma of bayberry wine was esters and alcs., resp. Differentiation of four kinds of bayberry wine was conducted anal. by E-nose. Sensory evaluation showed that Biqi bayberry wine was highly evaluated for its highest score in color, floral aroma, overall acceptability, and fruity aroma. Our results suggest that there were differences in the flavor characteristics of bayberry wine brewed from different varieties of bayberry. The results of this study will provide valuable information for bayberry wine makers to select raw materials.

Food Science & Nutrition (Hoboken, NJ, United States) published new progress about Alcohols Role: ANT (Analyte), FFD (Food or Feed Use), ANST (Analytical Study), BIOL (Biological Study), USES (Uses). 5405-41-4 belongs to class esters-buliding-blocks, name is Ethyl 3-hydroxybutanoate, and the molecular formula is C6H12O3, HPLC of Formula: 5405-41-4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics