Tag: M.W=100-150

Larina, Nina A. published the artcileSynthesis and photochromism of a series of new 2-unsubstituted 3-(2-benzylbenzoyl)quinolin-4(1H)-ones, SDS of cas: 924-99-2, the publication is Tetrahedron (2010), 66(42), 8291-8299, database is CAplus.

Synthesis and characterization of a series of new 2-unsubstituted 3-(2-benzylbenzoyl)quinolin-4(1H)-ones is described. In addition to their potential biol. activity, these compounds exhibit photoreversible photochromic properties in anaerobic conditions. Using the 1 and 2D NMR techniques we demonstrated that the coloration occurred owing to the formation of fluorescent 5a,6-dihydrobenzo[b]acridin-(5H)-ones. The photoreaction is stereoselective and the S,R-isomers are the major products (83%) whereas the S,S-isomers are the minor (6%). In addition, the irreversible formation of two oxidation products, 3-(2-benzoylbenzoyl)quinolin-4(1H)-ones, and acridin-12(5H)-one derivatives was observed in the presence of air.

Tetrahedron published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, SDS of cas: 924-99-2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

de Souza, Alana Gomes published the artcileNeuroprotective effects of dimethyl fumarate against depression-like behaviors via astrocytes and microglia modulation in mice: possible involvement of the HCAR2/Nrf2 signaling pathway, Application of Dimethyl fumarate, the publication is Naunyn-Schmiedeberg’s Archives of Pharmacology, database is CAplus and MEDLINE.

We postulated that di-Me fumarate (DMF) exerts neuroprotective effects against depression-like behaviors through astrocytes and microglia modulation. To ascertain our hypothesis and define the mechanistic pathways involved in effect of DMF on neuroinflammation, we used the depression model induced by chronic unpredictable mild stress (CUMS), in which, the mice were exposed to stressful events for 28 days and from the 14th day they received DMF in the doses of 50 and 100 mg/kg or fluoxetine 10 mg/kg or saline. On the 29th day, the animals were subjected to behavioral tests. Microglia (Iba1) and astrocyte (GFAP) marker expressions were evaluated by immunofluorescence analyzes and the cytokines TNF-α and IL-Iβ by immunoenzymic assay. In addition, computational target prediction, 3D protein structure prediction, and docking calculations were performed with monomethyl fumarate (DMF active metabolite) and the Keap1 and HCAR2 proteins, which suggested that these could be the probable targets related protective effects. CUMS induced anxiety- and depressive-like behaviors, cognitive deficit, decreased GFAP, and increased Iba1, TNF-α, and IL-Iβ expression in the hippocampus. These alterations were reversed by DMF. Thus, it is suggested that one of the mechanisms involved in the antidepressant effect of DMF is neuroinflammatory suppression, through the signaling pathway HCAR2/Nrf2. However, more studies must be performed to better understand the mol. mechanisms of this drug.

Naunyn-Schmiedeberg’s Archives of Pharmacology published new progress about 624-49-7. 624-49-7 belongs to esters-buliding-blocks, auxiliary class Inhibitor,Natural product, name is Dimethyl fumarate, and the molecular formula is C6H8O4, Application of Dimethyl fumarate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Zhao, Shilin published the artcileInfluence of Interactions among Three Biomass Components on the Pyrolysis Behavior, Computed Properties of 517-23-7, the publication is Industrial & Engineering Chemistry Research (2018), 57(15), 5241-5249, database is CAplus.

Pyrolysis experiments between 25 and 800° for three main components (cellulose, hemicellulose, and lignin) mixed in different proportions were conducted on a thermogravimetric analyzer (TGA) and pyrolysis-gas chromatog./mass spectrometer (Py-GC/MS). The interactions between the three main components during the pyrolysis of biomass were explored from two aspects, namely thermogravimetric properties and pyrolysis products. The results indicate that interactions existed among the three biomass components in the co-pyrolysis process. The presence of lignin significantly reduces the pyrolysis rate of cellulose and inhibits the formation of sugars (mainly levoglucosan) in the pyrolysis of cellulose and hemicellulose. However, the existence of cellulose or hemicellulose greatly promotes the pyrolysis of lignin to produce phenolic compounds This finding is meaningful for the application of biomass pyrolysis.

Industrial & Engineering Chemistry Research published new progress about 517-23-7. 517-23-7 belongs to esters-buliding-blocks, auxiliary class Tetrahydrofuran,Ketone,Ester, name is 3-Acetyldihydrofuran-2(3H)-one, and the molecular formula is C6H6N2O, Computed Properties of 517-23-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Jiang, Meifen published the artcileFully Continuous Flow Synthesis of 3-Chloro-4-oxopentyl Acetate: An Important Intermediate for Vitamin B1, Quality Control of 517-23-7, the publication is Organic Process Research & Development (2021), 25(9), 2020-2028, database is CAplus.

A fully continuous flow synthesis of 3-chloro-4-oxopentyl acetate, an important intermediate for vitamin B1, was developed. This continuous flow manufacturing included two chem. transformations and an inline extraction step without intermediate purification and solvent exchange. In this work, the traditional synthetic route for batch operation was efficiently simplified via a series of separated screening tests in flows under various conditions. The authors found that the chlorination reaction can be carried out in only 30 s at room temperature by flow. The decarboxylation/acylation step was also simplified by using a cross-mixer, so that acetic anhydride was no longer required in the acylation reaction. A computational fluid dynamics simulation was carried out to study the improved micromixing of liquid-liquid two-phase streams. Finally, 3-chloro-4-oxopentyl acetate was obtained in a 90% isolated yield with a product purity of 96% and a total residence time of approx. 32 min. This fully continuous process was operated smoothly for 12 h, and approx. 19.1 g of the desired product was generated with a production rate of 1.79 g h^-1.

Organic Process Research & Development published new progress about 517-23-7. 517-23-7 belongs to esters-buliding-blocks, auxiliary class Tetrahydrofuran,Ketone,Ester, name is 3-Acetyldihydrofuran-2(3H)-one, and the molecular formula is C6H8O3, Quality Control of 517-23-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Zhang, Liang published the artcileHydroxymethylation of active methenyl compounds: DMSO as methylene source and H₂O as oxygen source, HPLC of Formula: 517-23-7, the publication is Tetrahedron Letters (2022), 153663, database is CAplus.

A mild and efficient method for hydroxymethylation of active methenyl compounds was described. In this transformation, the widely available solvents DMSO and water served as methylene and oxygen sources, resp. Under promotion of activator and base, the reaction could be used for the construction of a series of α-hydroxymethylated carbonyl compounds R¹COC(CH₂OH)R²R³ [R¹ = Me, Ph, Bn, 2-furyl, 2-thienyl; R² = CN, MeCO, MeO₂C, EtO₂C, t-BuO₂C, PhNHCO; R³ = Me, Et, Bn, etc.; R¹R³ = (CH₂)₃, H₂COCH₂, (CH₂)₄, etc.] with all-carbon quaternary carbon center in good to excellent yield.

Tetrahedron Letters published new progress about 517-23-7. 517-23-7 belongs to esters-buliding-blocks, auxiliary class Tetrahydrofuran,Ketone,Ester, name is 3-Acetyldihydrofuran-2(3H)-one, and the molecular formula is C12H6NNaO4, HPLC of Formula: 517-23-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Zhao, Shilin published the artcileInfluence of Interactions among Three Biomass Components on the Pyrolysis Behavior, Computed Properties of 517-23-7, the publication is Industrial & Engineering Chemistry Research (2018), 57(15), 5241-5249, database is CAplus.

Pyrolysis experiments between 25 and 800° for three main components (cellulose, hemicellulose, and lignin) mixed in different proportions were conducted on a thermogravimetric analyzer (TGA) and pyrolysis-gas chromatog./mass spectrometer (Py-GC/MS). The interactions between the three main components during the pyrolysis of biomass were explored from two aspects, namely thermogravimetric properties and pyrolysis products. The results indicate that interactions existed among the three biomass components in the co-pyrolysis process. The presence of lignin significantly reduces the pyrolysis rate of cellulose and inhibits the formation of sugars (mainly levoglucosan) in the pyrolysis of cellulose and hemicellulose. However, the existence of cellulose or hemicellulose greatly promotes the pyrolysis of lignin to produce phenolic compounds This finding is meaningful for the application of biomass pyrolysis.

Industrial & Engineering Chemistry Research published new progress about 517-23-7. 517-23-7 belongs to esters-buliding-blocks, auxiliary class Tetrahydrofuran,Ketone,Ester, name is 3-Acetyldihydrofuran-2(3H)-one, and the molecular formula is C6H6N2O, Computed Properties of 517-23-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Jiang, Meifen published the artcileFully Continuous Flow Synthesis of 3-Chloro-4-oxopentyl Acetate: An Important Intermediate for Vitamin B1, Quality Control of 517-23-7, the publication is Organic Process Research & Development (2021), 25(9), 2020-2028, database is CAplus.

A fully continuous flow synthesis of 3-chloro-4-oxopentyl acetate, an important intermediate for vitamin B1, was developed. This continuous flow manufacturing included two chem. transformations and an inline extraction step without intermediate purification and solvent exchange. In this work, the traditional synthetic route for batch operation was efficiently simplified via a series of separated screening tests in flows under various conditions. The authors found that the chlorination reaction can be carried out in only 30 s at room temperature by flow. The decarboxylation/acylation step was also simplified by using a cross-mixer, so that acetic anhydride was no longer required in the acylation reaction. A computational fluid dynamics simulation was carried out to study the improved micromixing of liquid-liquid two-phase streams. Finally, 3-chloro-4-oxopentyl acetate was obtained in a 90% isolated yield with a product purity of 96% and a total residence time of approx. 32 min. This fully continuous process was operated smoothly for 12 h, and approx. 19.1 g of the desired product was generated with a production rate of 1.79 g h^-1.

Organic Process Research & Development published new progress about 517-23-7. 517-23-7 belongs to esters-buliding-blocks, auxiliary class Tetrahydrofuran,Ketone,Ester, name is 3-Acetyldihydrofuran-2(3H)-one, and the molecular formula is C6H8O3, Quality Control of 517-23-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Zhao, Shilin published the artcileInfluence of Interactions among Three Biomass Components on the Pyrolysis Behavior, Computed Properties of 517-23-7, the publication is Industrial & Engineering Chemistry Research (2018), 57(15), 5241-5249, database is CAplus.

Pyrolysis experiments between 25 and 800° for three main components (cellulose, hemicellulose, and lignin) mixed in different proportions were conducted on a thermogravimetric analyzer (TGA) and pyrolysis-gas chromatog./mass spectrometer (Py-GC/MS). The interactions between the three main components during the pyrolysis of biomass were explored from two aspects, namely thermogravimetric properties and pyrolysis products. The results indicate that interactions existed among the three biomass components in the co-pyrolysis process. The presence of lignin significantly reduces the pyrolysis rate of cellulose and inhibits the formation of sugars (mainly levoglucosan) in the pyrolysis of cellulose and hemicellulose. However, the existence of cellulose or hemicellulose greatly promotes the pyrolysis of lignin to produce phenolic compounds This finding is meaningful for the application of biomass pyrolysis.

Industrial & Engineering Chemistry Research published new progress about 517-23-7. 517-23-7 belongs to esters-buliding-blocks, auxiliary class Tetrahydrofuran,Ketone,Ester, name is 3-Acetyldihydrofuran-2(3H)-one, and the molecular formula is C6H6N2O, Computed Properties of 517-23-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Jiang, Meifen published the artcileFully Continuous Flow Synthesis of 3-Chloro-4-oxopentyl Acetate: An Important Intermediate for Vitamin B1, Quality Control of 517-23-7, the publication is Organic Process Research & Development (2021), 25(9), 2020-2028, database is CAplus.

A fully continuous flow synthesis of 3-chloro-4-oxopentyl acetate, an important intermediate for vitamin B1, was developed. This continuous flow manufacturing included two chem. transformations and an inline extraction step without intermediate purification and solvent exchange. In this work, the traditional synthetic route for batch operation was efficiently simplified via a series of separated screening tests in flows under various conditions. The authors found that the chlorination reaction can be carried out in only 30 s at room temperature by flow. The decarboxylation/acylation step was also simplified by using a cross-mixer, so that acetic anhydride was no longer required in the acylation reaction. A computational fluid dynamics simulation was carried out to study the improved micromixing of liquid-liquid two-phase streams. Finally, 3-chloro-4-oxopentyl acetate was obtained in a 90% isolated yield with a product purity of 96% and a total residence time of approx. 32 min. This fully continuous process was operated smoothly for 12 h, and approx. 19.1 g of the desired product was generated with a production rate of 1.79 g h^-1.

Organic Process Research & Development published new progress about 517-23-7. 517-23-7 belongs to esters-buliding-blocks, auxiliary class Tetrahydrofuran,Ketone,Ester, name is 3-Acetyldihydrofuran-2(3H)-one, and the molecular formula is C6H8O3, Quality Control of 517-23-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Hess, Stefan published the artcileApproach to the Core Structure of Streptosetin A, Computed Properties of 539-88-8, the main research area is streptosetin A core synthesis.

Streptosetin A (I) belongs to the 3-decalinoyltetramic acids. In contrast to most of other known natural products of this type, the decalin part features a β-hydroxyketone subunit, making an intramol. cycloaddition approach less suitable. We examined an approach where the decalin part would be fashioned by an intramol. aldol addition By using a Diels-Alder reaction between the Rawal diene and a substituted methacrylate, a cyclohexanone was obtained. An organocuprate addition introduced the Et substituent before, the side chain was converted to an enal. However, contrary to our expectations, the aldol reaction led to the condensation product. Other routes to reach the key cyclohexanone were also investigated.

ChemistrySelect published new progress about streptosetin A core synthesis. 539-88-8 belongs to class esters-buliding-blocks, name is Ethyl 4-oxopentanoate, and the molecular formula is C7H12O3, Computed Properties of 539-88-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics