Tag: M.W=100-150

Tata, Alessandra published the artcileAmbient mass spectrometry for rapid authentication of milk from Alpine or lowland forage, Safety of Dimethyl fumarate, the publication is Scientific Reports (2022), 12(1), 7360, database is CAplus and MEDLINE.

Metabolomics approaches, such as direct anal. in real time-high resolution mass spectrometry (DART-HRMS), allow characterizing many polar and non-polar compounds useful as authentication biomarkers of dairy chains. By using both a partial least squares discriminant anal. (PLS-DA) and a linear discriminant anal. (LDA), this study aimed to assess the capability of DART-HRMS, coupled with a low-level data fusion, discriminate among milk samples from lowland (silages vs. hay) and Alpine (grazing; APS) systems and identify the most informative biomarkers associated with the main dietary forage. As confirmed also by the LDA performed against the test set, DART-HRMS anal. provided an accurate discrimination of Alpine samples; meanwhile, there was a limited capacity to correctly recognize silage- vs. hay-milks. Supervised multivariate statistics followed by metabolomics hierarchical cluster anal. allowed extrapolating the most significant metabolites. Lowland milk was characterised by a pool of energetic compounds, ketoacid derivates, amines and organic acids. Seven informative DART-HRMS mol. features, mainly monoacylglycerols, could strongly explain the metabolomic variation of Alpine grazing milk and contributed to its classification. The misclassification between the two lowland groups confirmed that the intensive dairy systems would be characterised by a small variation in milk composition

Scientific Reports published new progress about 624-49-7. 624-49-7 belongs to esters-buliding-blocks, auxiliary class Inhibitor,Natural product, name is Dimethyl fumarate, and the molecular formula is C40H35N7O8, Safety of Dimethyl fumarate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Stimac, Vlado published the artcileInitial Scale-Up and Process Improvements for the Preparation of a Lead Antibacterial Macrolone Compound, Recommanded Product: Ethyl 3-(dimethylamino)acrylate, the publication is Organic Process Research & Development (2010), 14(6), 1393-1401, database is CAplus.

Macrolones are a novel class of potent antimicrobial agents that consist of a macrolide scaffold to which a quinolone unit is tethered by various linkers to the 4”-O-position of the cladinose sugar. In this paper is described a modified 13-step route to a lead compound in the series. Critical reaction steps in the medicinal chem. route were modified for an initial scale-up process, and as a result, a synthetic procedure suitable for preparation of multi-hundred gram quantities of the final product, with 98% purity, has been developed. The new procedure does not require any purification by column chromatog. for any of the reaction steps. The overall yield was increased from 5-8% in the medicinal chem. route to 27% in the improved procedure.

Organic Process Research & Development published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C12H10FeO4, Recommanded Product: Ethyl 3-(dimethylamino)acrylate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Borrelli, S. published the artcileDelayed and recurrent dimethyl fumarate induced-lymphopenia in patients with multiple sclerosis, HPLC of Formula: 624-49-7, the publication is Multiple Sclerosis and Related Disorders (2022), 103887, database is CAplus and MEDLINE.

Early lymphopenia is a known side effect of di-Me fumarate, a disease-modifying therapy for MS. However, the long-term effects on immune response and the impact on lymphocyte counts when another disease-modifying treatment is introduced, remain unknown. To better understand these specific aspects, we reviewed cases that develop prolonged grade 2 to 4 lymphopenia under di-Me fumarate in Lausanne MS clinic. Retrospective anal. of the 12 patients (10.1%) who discontinued di-Me fumarate because of prolonged lymphopenia amongst the 119 patients treated with di-Me fumarate. We reviewed their demographics, as well as their clin., biol. and MRI characteristics compared to the non-lymphopenic patients, during di-Me fumarate therapy, and within a timeframe of up to 18 mo after switching to another disease-modifying treatment. We also focused on lymphocyte subsets in a subgroup of patients. Compared to non-lymphopenic patients, lymphopenic patients were older at di-Me fumarate initiation (51.4 yo vs 39.7, p = 0.0003) and the majority were male (p = 0.037). Three of them (25%) developed delayed lymphopenia, more than one year after treatment onset. Despite persistent lymphopenia, three patients experienced disease activity. Amongst the nine patients (75%) who were switched to another therapy, five (55.6%) presented recurrent lymphopenia, predominantly with a CD8⁺ T cell decrease. Di-Me fumarate has a long-term impact on lymphocyte biol., even after its discontinuation, with a sustained reduction in CD8+ T cells that may increase opportunistic infection risk, and should be taken in consideration when switching therapies after di-Me fumarate.

Multiple Sclerosis and Related Disorders published new progress about 624-49-7. 624-49-7 belongs to esters-buliding-blocks, auxiliary class Inhibitor,Natural product, name is Dimethyl fumarate, and the molecular formula is C6H8O4, HPLC of Formula: 624-49-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Tandon, Vishnu K. published the artcile“On water” assisted synthesis and biological evaluation of nitrogen and sulfur containing hetero-1,4-naphthoquinones as potent antifungal and antibacterial agents, Recommanded Product: Ethyl 2-mercaptopropanoate, the publication is European Journal of Medicinal Chemistry (2010), 45(6), 2418-2426, database is CAplus and MEDLINE.

2-Chloro-3-(4-methylpiperazin-1-yl)naphthalene-1,4-dione, 2-chloro-3-(pyrrolidin-1-yl)naphthalene-1,4-dione, 2-chloro-3-(piperidin-1-yl)naphthalene-1,4-dione, 2-chloro-3-morpholinonaphthalene-1,4-dione, 2-chloro-3-(2-phenylhydrazinyl)naphthalene-1,4-dione, 2-(allylamino)-3-chloronaphthalene-1,4-dione, 2-(3-chloro-1,4-dioxo-1,4-dihydronaphthalen-2-ylthio)acetic acid, 2-(3-chloro-1,4-dioxo-1,4-dihydronaphthalen-2-ylthio)succinic acid, Me 2-(3-chloro-1,4-dioxo-1,4-dihydronaphthalen-2-ylthio)acetate, 2-chloro-3-(2-mercaptoethylthio)naphthalene-1,4-dione (I), 3-hydroxy-4-methyl-4H-naphtho[2,3-b][1,4]thiazine-5,10-dione, etc, have been synthesized by a green methodol. approach using water as solvent and evaluated for their antifungal and antibacterial activities. Several compounds, e.g., I, were found to have better antifungal activity than clin. prevalent antifungal drugs Fluconazole and Amphotericin-B against Trichophyton mentagrophytes and compounds

European Journal of Medicinal Chemistry published new progress about 19788-49-9. 19788-49-9 belongs to esters-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Ester, name is Ethyl 2-mercaptopropanoate, and the molecular formula is C5H11NO2S, Recommanded Product: Ethyl 2-mercaptopropanoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Tandon, Vishnu K. published the artcileNaphtho[2,3-b][1,4]-thiazine-5,10-diones and 3-substituted-1,4-dioxo-1,4-dihydronaphthalen-2-yl-thioalkanoate derivatives: Synthesis and biological evaluation as potential antibacterial and antifungal agents, SDS of cas: 19788-49-9, the publication is Bioorganic & Medicinal Chemistry Letters (2006), 16(22), 5883-5887, database is CAplus and MEDLINE.

A series of 3-substituted-1,4-dioxo-1,4-dihydronaphthalen-2-yl-thio-alkanoate derivatives and naphtho[2,3-b][1,4]-thiazine-5,10-diones, e.g. I, were synthesized and evaluated for their antibacterial and antifungal activities. The structure-activity relationships of these compounds were studied and the results show that I exhibited better antibacterial activity than Gentamycin in vitro against Staphylococcus aureus. In addition I also imparted marked antifungal activity in vitro against Cryptococcus neoformans, Sporothrix schenckii, and Trichophyton mentagrophytes when compared with Fluconazole. Some other compounds also exhibited significant antibacterial activity in vitro against S. aureus.

Bioorganic & Medicinal Chemistry Letters published new progress about 19788-49-9. 19788-49-9 belongs to esters-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Ester, name is Ethyl 2-mercaptopropanoate, and the molecular formula is C4H6N2, SDS of cas: 19788-49-9.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Fleming, Ian published the artcileReactions of phenyldimethylsilyllithium with β-N,N-dimethylaminoenones, HPLC of Formula: 924-99-2, the publication is Chemical Communications (Cambridge, United Kingdom) (2003), 200-201, database is CAplus and MEDLINE.

Phenyldimethylsilyllithium reacts with the β-(N,N-dimethylamino)carbonyl compounds, e.g., Me₂NCH:CHC(O)R (R = H, Me, OEt), to give the corresponding α,β-unsaturated carbonyl compounds with a β-phenyldimethylsilyl group, e.g., PhMe₂SiCH:CHC(O)R, but in the case of Et N,N-dimethylaminoacrylate, only when the reaction mixture is given a mysteriously brief treatment with Me iodide before workup.

Chemical Communications (Cambridge, United Kingdom) published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, HPLC of Formula: 924-99-2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Dzambaski, Zdravko published the artcile2-Alkylidene-4-oxothiazolidine S-oxides: synthesis and stereochemistry, Safety of Ethyl 2-mercaptopropanoate, the publication is Tetrahedron (2013), 69(31), 6436-6447, database is CAplus.

A series of 5-unsubstituted and 5-substituted 2-alkylidene-4-oxothiazolidine-S-oxides were synthesized by the sulfur-oxidation with m-CPBA. The stereochem. of 5-substituted sulfoxides was determined by means of NMR spectroscopy and DFT theor. calculations It was found that the thermodynamically less stable anti-isomer was initially formed in the course of the oxidation, but it underwent epimerization to the mixture enriched in the more stable syn-isomer, during the work-up process. The higher stability of syn-isomers is ascribed to the stronger hyperconjugative σ_C-H→σ*_S-O interaction vs. the weaker σ_C-C→σ*_S-O delocalization in their anti-counterparts and to the existence of intramol. 1,5-CH···O hydrogen bonds.

Tetrahedron published new progress about 19788-49-9. 19788-49-9 belongs to esters-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Ester, name is Ethyl 2-mercaptopropanoate, and the molecular formula is C5H10O2S, Safety of Ethyl 2-mercaptopropanoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Stojanovic, Milovan published the artcileSynthesis of thiazolidine-fused heterocycles via exo-mode cyclizations of vinylogous N-acyliminium ions, COA of Formula: C5H10O2S, the publication is Organic & Biomolecular Chemistry (2012), 10(3), 575-589, database is CAplus and MEDLINE.

Syntheses of thiazolidine-fused heterocycles via exo-mode cyclizations of vinylogous N-acyliminium ions incorporating heteroatom-based nucleophiles have been examined and discussed. The formation of (5,6)-membered systems was feasible with all nucleophiles tried (O, S and N), while the closing of the five-membered ring was restricted to O- and S-nucleophiles. The closure of a four-membered ring failed. Instead, the bicyclic (5,6)-membered acetal derivative and the tricyclic system with an eight-membered central ring were obtained from the substrates containing O and S nucleophilic moieties, resp. The reaction outcome and stereochem. are rationalized using quantum chem. calculations at B3LYP/6-31G(d) level. The exclusive cis-stereoselectivity in the formation of (5,6)- and (5,5)-membered systems results from thermodn. control, whereas the formation of the eight-membered ring was kinetically controlled.

Organic & Biomolecular Chemistry published new progress about 19788-49-9. 19788-49-9 belongs to esters-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Ester, name is Ethyl 2-mercaptopropanoate, and the molecular formula is C13H17BF3NO2, COA of Formula: C5H10O2S.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Stojanovic, Milovan published the artcileendo-Mode cyclizations of vinylogous N-acyliminium ions as a route to the synthesis of condensed thiazolidines, COA of Formula: C5H10O2S, the publication is Tetrahedron (2011), 67(49), 9541-9554, database is CAplus.

Endo-Mode cyclizations of vinylogous N-acyliminium ions incorporating heteroatom-based nucleophiles have been examined as a route to the synthesis of condensed thiazolidines. The scope of these reactions and stereochem. outcome are discussed and explained using quantum chem. calculations

Tetrahedron published new progress about 19788-49-9. 19788-49-9 belongs to esters-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Ester, name is Ethyl 2-mercaptopropanoate, and the molecular formula is C9H9BrO2, COA of Formula: C5H10O2S.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Starchman, Evangeline S. published the artcileSynthesis of (±)-rupestines B and C by intramolecular Mizoroki-Heck cyclization, Related Products of esters-buliding-blocks, the publication is Tetrahedron Letters (2020), 61(19), 151837, database is CAplus.

The total synthesis of rupestines B and C, I (R = α-Me, β-Me, resp.), two guaipyridine sesquiterpene alkaloids, is reported. These compounds are isolated from Artemisia rupestris L. and have structural similarities to that of cananodine, a guaipyridine alkaloid with activity against two liver cancer cell lines. The synthesis of rupestines B and C was accomplished in six steps using an intramol. Mizoroki-Heck cyclization as the key-step to form the seven-membered carbocycle of the targets.

Tetrahedron Letters published new progress about 30414-53-0. 30414-53-0 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ketone,Ester, name is Methyl 3-oxovalerate, and the molecular formula is C2H4ClNO, Related Products of esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics