Tag: M.W=100-150

Bailie, Alexandra E. published the artcileSynthesis of quinolone antibiotic analogues: a multistep synthetic chemistry experiment for undergraduates, Related Products of esters-buliding-blocks, the publication is Journal of Chemical Education (2021), 98(10), 3333-3340, database is CAplus.

A multistep synthesis of quinolone antibiotic analogs was developed as a laboratory experiment for intermediate/advanced undergraduate students. Students can synthesize a range of desfluoroenoxacin analogs via a five-step sequence. The experiment includes a range of key practical laboratory techniques including thin-layer chromatog. (TLC), liquid-liquid extraction, trituration, recrystallization and the characterization of compounds by IR and NMR spectroscopy. The experiment provides an opportunity for students to carry out fundamental organic chem. transformations from the curriculum such as the preparation of acyl chlorides, 1,4-conjugate addition-elimination, heterocycle synthesis, nucleophilic aromatic substitution and ester hydrolysis. The five-step sequence does not require column chromatog. and can be adapted to a range of laboratory settings.

Journal of Chemical Education published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, Related Products of esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Brear, Paul published the artcileNovel non-ATP competitive small molecules targeting the CK2 α/β interface, COA of Formula: C6H8O3, the publication is Bioorganic & Medicinal Chemistry (2018), 26(11), 3016-3020, database is CAplus and MEDLINE.

Increased CK2 levels are prevalent in many cancers. Combined with the critical role CK2 plays in many cell-signaling pathways, this makes it a prime target for down regulation to fight tumor growth. Herein, we report a fragment-based approach to inhibiting the interaction between CK2α and CK2β at the α-β interface of the holoenzyme. A fragment, CAM187, with an IC₅₀ of 44μM and a mol. weight of only 257gmol^-1 has been identified as the most promising compound Importantly, the lead fragment only bound at the interface and was not observed in the ATP binding site of the protein when co-crystallized with CK2α. The fragment-like mols. discovered in this study represent unique scaffolds to CK2 inhibition and leave room for further optimization.

Bioorganic & Medicinal Chemistry published new progress about 517-23-7. 517-23-7 belongs to esters-buliding-blocks, auxiliary class Tetrahydrofuran,Ketone,Ester, name is 3-Acetyldihydrofuran-2(3H)-one, and the molecular formula is C6H8O3, COA of Formula: C6H8O3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Hoshino, Yasunobu published the artcileDysregulated B cell differentiation towards antibody-secreting cells in neuromyelitis optica spectrum disorder, Related Products of esters-buliding-blocks, the publication is Journal of Neuroinflammation (2022), 19(1), 6, database is CAplus and MEDLINE.

Anti-aquaporin 4 (AQP4) antibody (AQP4-Ab) is involved in the pathogenesis of neuromyelitis optica spectrum disorder (NMOSD). However, the mechanism involved in AQP4-Ab production remains unclear. We analyzed the immunophenotypes of patients with NMOSD and other neuroinflammatory diseases as well as healthy controls (HC) using flow cytometry. Transcriptome anal. of B cell subsets obtained from NMOSD patients and HCs was performed. The differentiation capacity of B cell subsets into antibody-secreting cells was analyzed. The frequencies of switched memory B (SMB) cells and plasmablasts were increased and that of naive B cells was decreased in NMOSD patients compared with relapsing-remitting multiple sclerosis patients and HC. SMB cells from NMOSD patients had an enhanced potential to differentiate into antibody-secreting cells when cocultured with T peripheral helper cells. Transcriptome anal. revealed that the profiles of B cell lineage transcription factors in NMOSD were skewed towards antibody-secreting cells and that IL-2 signaling was upregulated, particularly in naive B cells. Naive B cells expressing CD25, a receptor of IL-2, were increased in NMOSD patients and had a higher potential to differentiate into antibody-secreting cells, suggesting CD25+ naive B cells are committed to differentiate into antibody-secreting cells. To the best of our knowledge, this is the first study to demonstrate that B cells in NMOSD patients are abnormally skewed towards antibody-secreting cells at the transcriptome level during the early differentiation phase, and that IL-2 might participate in this pathogenic process. Our study indicates that CD25+ naive B cells are a novel candidate precursor of antibody-secreting cells in autoimmune diseases.

Journal of Neuroinflammation published new progress about 624-49-7. 624-49-7 belongs to esters-buliding-blocks, auxiliary class Inhibitor,Natural product, name is Dimethyl fumarate, and the molecular formula is C6H8O4, Related Products of esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Katritzky, Alan R. published the artcileNovel Syntheses of 2,3-Dihydro-1,5-benzothiazepin-4(5H)-ones and 2H-1,4-Benzothiazin-3(4H)-ones, SDS of cas: 19788-49-9, the publication is Journal of Organic Chemistry (2001), 66(20), 6792-6796, database is CAplus and MEDLINE.

Nucleophilic additions of α-mercaptoalkanoate esters and β-mercaptoalkanoate acids to benzoquinone diimines, followed by cyclization with trifluoroacetic acid or 1,3-dicyclohexylcarbodiimide (DCC), provide novel, high-yielding syntheses of 2H-1,4-benzothiazin-3(4H)-ones and 2,3-dihydro-1,5-benzothiazepin-4(5H)-ones, resp.

Journal of Organic Chemistry published new progress about 19788-49-9. 19788-49-9 belongs to esters-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Ester, name is Ethyl 2-mercaptopropanoate, and the molecular formula is C5H10O2S, SDS of cas: 19788-49-9.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Ma, Chi-Wang published the artcileRapid broad spectrum detection of carbapenemases with a dual fluorogenic-colorimetric probe, Product Details of C6H10O3, the publication is Journal of the American Chemical Society (2021), 143(18), 6886-6894, database is CAplus and MEDLINE.

Carbapenems stand as one of the last-resort antibiotics; however, their efficacy is threatened by the rising number and rapid spread of carbapenemases. Effective antimicrobial stewardship thus calls for rapid tests for these enzymes to aid appropriate prescription and infection control. Herein, we report the first effective pan-carbapenemase reporter CARBA-H with a broad scope covering all three Ambler classes. Using a chem. biol. approach, we demonstrated that the absence of the 1β-substituent in the carbapenem core is key to pan-carbapenemase recognition, which led to our rational design and probe development. CARBA-H provides a dual colorimetric-fluorogenic response upon carbapenemase-mediated hydrolysis. A clear visual readout can be obtained within 15 min when tested against a panel of carbapenemase-producing Enterobacteriaceae (CPE) clin. isolates that notably includes OXA-48 and OXA-181-producing strains. Furthermore, CARBA-H can be applied to the detection of carbapemenase activity in CPE-spiked urine samples.

Journal of the American Chemical Society published new progress about 30414-53-0. 30414-53-0 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ketone,Ester, name is Methyl 3-oxovalerate, and the molecular formula is C6H10O3, Product Details of C6H10O3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Shi, Fu-li published the artcileDimethyl fumarate ameliorates autoimmune hepatitis in mice by blocking NLRP3 inflammasome activation, Formula: C6H8O4, the publication is International Immunopharmacology (2022), 108867, database is CAplus and MEDLINE.

Di-Me fumarate (DMF) is a fumaric acid derivative clin. approved for the treatment of some inflammatory diseases, but the underlying mechanism for its therapeutic effects remains incompletely understood. NLR family pyrin domain containing 3 (NLRP3) inflammasome activation has critical roles in innate immune responses to various infections and sterile inflammations. In this study, we aimed to explore whether DMF affects auto-immune hepatitis (AIH) in mice induced by Con A (Con A) by modulating NLRP3 inflammasome activation. The results showed that DMF suppressed the activation of NLRP3 inflammasome activation in lipopolysaccharide-primed murine bone marrow-derived macrophages upon ATP or nigericin treatment, as evidenced by reduced cleavage of pro-caspase-1, release of mature interleukin-1β (IL-1β) and generation of gasdermin D N-terminal fragment (GSDMD-NT). DMF also greatly reduced ASC speck formation upon the stimulation of nigericin or ATP, indicating its inhibitory effect on NLRP3 inflammasome assembly. Consistent with reduced generation of GSDMD-NT, ATP or nigericin-induced pyroptosis was markedly suppressed by DMF. Moreover, DMF treatment alleviated mitochondrial damage induced by ATP or nigericin. Interestingly, all these effects were reversed by the protein kinase A (PKA) pathway inhibitors (H89 and MDL-12330A). Mechanistically, DMF enhanced PKA signaling and thus increased NLRP3 phosphorylation at PKA-specific sites to attenuate its activation. Importantly, DMF decreased serum levels of inflammatory cytokines and ameliorated liver injury in Con A-induced AIH of mice, concomitant with reduced the generation of caspase-1p10 and GSDMD-NT and alleviating mitochondrial aggregation in the liver. Collectively, DMF displayed anti-inflammatory effects by inhibiting NLRP3 inflammasome activation likely through regulating PKA signaling, highlighting its potential application in treating AIH.

International Immunopharmacology published new progress about 624-49-7. 624-49-7 belongs to esters-buliding-blocks, auxiliary class Inhibitor,Natural product, name is Dimethyl fumarate, and the molecular formula is C18H28B2O4, Formula: C6H8O4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Segura, Javier H. published the artcileBoreal tree species affect soil organic matter composition and saprotrophic mineralization rates, COA of Formula: C6H8O3, the publication is Plant and Soil (2019), 441(1-2), 173-190, database is CAplus.

To investigate how different tree species affect the composition of SOM and its mineralization in boreal forest ecosystems. We used pyrolysis GC-MS for mol.-level characterization of the SOM formed under five common boreal tree species at a replicated field experiment ∼50years after plantation. We incubated soil samples at 4, 9, 14 and 19°C and measured inherent CO₂ production and substrate-induced respiration. We then evaluated if the saprotrophic microbial activity and its temperature sensitivity was controlled by the SOM composition The mol. composition of the SOM emerged as key factor influencing SOM properties in plots with different tree species. Most of the variance in the SOM content was explained by the organo-chem. composition of the SOM. More importantly, the fraction of the microbial community able to utilize the native SOM was largely controlled by the SOM organo-chem. composition Temperature sensitivity of CO₂ production (Q₁₀) was not explained by SOM composition However, the microbial access to different SOM pools varied with temperature These results bridge the gap between the paradigms of short-term litter and long-term SOM decomposition showing that, on an intermediate timescale (∼50 years), boreal tree species affect SOM mol. composition and saprotrophic mineralization rates.

Plant and Soil published new progress about 517-23-7. 517-23-7 belongs to esters-buliding-blocks, auxiliary class Tetrahydrofuran,Ketone,Ester, name is 3-Acetyldihydrofuran-2(3H)-one, and the molecular formula is C19H21N3O3S, COA of Formula: C6H8O3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Eberson, Lennart published the artcileElectron transfer reactions in organic chemistry. XXIII. Products, kinetics and inverted spin trapping in the reaction between carboxylates and hexachloroosmate(V) ion, Application In Synthesis of 5340-78-3, the publication is Acta Chemica Scandinavica (1993), 47(11), 1129-37, database is CAplus.

The reaction between carboxylates and hexachloroosmate(V) has been investigated. For carboxylates, RCOO^–, corresponding to radicals R^• which are difficult to oxidize (with E_i larger than ∼9 eV), the reaction gave one-electron oxidation products, as typified by the formation of C-to-N coupling products in good yield from tert-butylcyanoacetate ion. The kinetics of the reaction between the hydrogendiacetate ion and OsCl₆^– in acetonitrile was studied in more detail and found to conform to a kinetic model involving a second-order electron-transfer step between acetate ion (existing in equilibrium with acetic acid and hydrogen-diacetate ion) and OsCl₆^–. Attempts to trap R^• from the carboxylate/hexachloroosmate reaction by α-phenyl-N-tert-butylnitrone (PBN) led only to the formation of acyloxyl spin adducts, presumably via the reaction between PBN^•+ (formed by one-electron oxidation of PBN by the osmate) and the carboxylate ion. Other nucleophiles underwent the same type of reaction, previously denoted inverted spin trapping, and also the more oxidation-resistant spin trap 4-NO₂BPN was shown to possess this type of reactivity.

Acta Chemica Scandinavica published new progress about 5340-78-3. 5340-78-3 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is Ethyltert-butylacetate, and the molecular formula is C8H16O2, Application In Synthesis of 5340-78-3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Li, Jian published the artcileSupramolecular Polydimethylsiloxane Elastomer with Enhanced Mechanical Properties and Self-Healing Ability Engineered by Synergetic Dynamic Bonds, Recommanded Product: 3-Acetyldihydrofuran-2(3H)-one, the publication is ACS Applied Polymer Materials (2021), 3(7), 3373-3382, database is CAplus.

Hydrophobic elastomers are required for use in industry and daily life because of their versatile properties. Developing a hydrophobic elastomer with self-healing abilities and excellent mech. performance has been very challenging because of the mutually exclusive nature of these properties. Herein, supramol. polydimethylsiloxane (PDMS) elastomers with excellent self-healing and mech. properties were designed through the synergetic combination of multistrength H-bonds and disulfide bonds. The hierarchical H-bonds formed with urethane, urea, and 2-ureido-4[1H]-pyrimidinone (UPy) moieties in the backbone of the supramol. polymer endow the resultant polymers with effective reversible crosslinking, whereas during stretching, the dynamic dissociation and reassociation of H-bonds enable polymers with high extensibility and enhanced toughness and recoverability. In addition, disulfide bond exchange under heat enables polymer network rearrangement, thus imbuing the supramol. elastomer with excellent self-healing ability. Based on the extraordinary properties of hydrophobic supramol. PDMS elastomers, some smart materials can be prepared, such as oil/water separation foams and hydrophobic hot-melt adhesives. Therefore, this concept of synergetic dynamic bonds will point out a direction for the development of sustainable, green, and functional materials of the next generation.

ACS Applied Polymer Materials published new progress about 517-23-7. 517-23-7 belongs to esters-buliding-blocks, auxiliary class Tetrahydrofuran,Ketone,Ester, name is 3-Acetyldihydrofuran-2(3H)-one, and the molecular formula is C6H8O3, Recommanded Product: 3-Acetyldihydrofuran-2(3H)-one.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Zapol’skii, Viktor A. published the artcileChemistry of polyhalogenated nitrobutadienes, 14: efficient synthesis of functionalized (Z)-2-allylidenethiazolidin-4-ones, Name: Ethyl 2-mercaptopropanoate, the publication is Beilstein Journal of Organic Chemistry (2014), 1638-1644, 7 pp., database is CAplus and MEDLINE.

The reaction of mercaptoacetic acid esters with pentachloro-2-nitro-1,3-butadiene provides an appropriate precursor for the synthesis of special thiazolidin-4-ones. Applying different anilines as the second constituent for the requisite cyclization step, a series of (Z)-2-allylidenethiazolidin-4-ones I (Ar = 4-ClC₆H₄, 4-MeOC₆H₄, 4-MeC₆H₄) was obtained in yields up to 81%. Some subsequent reactions have been examined too, such as the formation of perfunctionalized 1H-pyrazoles upon treatment with hydrazine. Thiazolidinones are as well known for their physiol. activities as for their application in optoelectronics.

Beilstein Journal of Organic Chemistry published new progress about 19788-49-9. 19788-49-9 belongs to esters-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Ester, name is Ethyl 2-mercaptopropanoate, and the molecular formula is C16H29BO2, Name: Ethyl 2-mercaptopropanoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics