Tag: M.W=100-150

Yu, Lu published the artcileRegio- and Enantioselective Formal Hydroamination of Enamines for the Synthesis of 1,2-Diamines, Computed Properties of 924-99-2, the publication is Angewandte Chemie, International Edition (2019), 58(25), 8551-8555, database is CAplus and MEDLINE.

The asym. formal hydroamination of enamines using a CuH catalyst is reported [e.g., enamine I + O-acylhydroxylamine II â†?diamine III (69%, 97:3 e.r.) in presence of (MeO)₂MeSiH as hydride source, Cu(OAc)₂ and (R)-DTBM-SEGPHOS]. The method provides a straightforward and efficient approach to the synthesis of chiral 1,2-dialkyl amines in good yields with high levels of enantioselectivities for a broad range of substrates, and should have significant value for the preparation of mols. bearing a 1,2-diamine motif.

Angewandte Chemie, International Edition published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C12H10O4S, Computed Properties of 924-99-2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Sun, Xianwei published the artcile[1,4]-S- to O-Silyl Migration: Multicomponent Synthesis of α-Thio-Ketones through Chemoselective Transformation of Esters to Ketones with Organolithium Reagents, Recommanded Product: Ethyl 2-mercaptopropanoate, the publication is Chemistry – A European Journal (2013), 19(51), 17589-17594, database is CAplus and MEDLINE.

A [1,4]-S-to-O-silyl migration has been exploited to chemoselectively transform esters into ketones by using organolithium reagents, allowing a multicomponent synthesis of α-(thio)ketones. Mechanistic studies reveal that this migration proceeds in an intramol. manner and is more favorable than a corresponding [1,5]-S-to-O-silyl migration and [1,3]-C-to-O-silyl migration. The resulting α-(thio)alkanone derivatives are valuable building blocks for the synthesis of cyclic or multifunctionalized organosulfur compounds The synthesis of the target compounds was achieved using [(trimethylsilyl)thio]alkanoic acid esters and (alkyl)lithium compounds and alkyl bromides, allyl bromides, iodomethane, propargyl bromide, 2-(bromomethyl)oxirane, 7-oxabicyclo[4.1.0]heptan-2-one (cyclohexene epoxide), etc. as starting materials. The title compounds thus formed included 1-[(phenylmethyl)thio]-2-hexanone, 1-(methylthio)-2-hexanone, 1-[(2-propenyl)thio]-2-propanone, 1-phenyl-2-[(2-propenyl)thio]ethanone, dihydro-3(2H)-thiophenone derivatives The application of this strategy toward a reaction of (thioalkyl)alkanone with amines was demonstrated by the synthesis of 3-(alkylthio)-1H-indole derivatives (Gassman indolization).

Chemistry – A European Journal published new progress about 19788-49-9. 19788-49-9 belongs to esters-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Ester, name is Ethyl 2-mercaptopropanoate, and the molecular formula is C23H43NP2, Recommanded Product: Ethyl 2-mercaptopropanoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Sourabie, A. M. published the artcileRecent advances in volatile sulfur compounds in cheese: thiols and thioesters, Recommanded Product: Ethyl 2-mercaptopropanoate, the publication is ACS Symposium Series (2011), 119-135, database is CAplus.

A review. Among the numerous compounds involved in cheese aroma, sulfur compounds are of particular interest because of their very powerful odors and low perception thresholds. Nevertheless, little attention has been focused until now on the possible presence of polyfunctional thiols in cheese, even if these compounds have been found to be associated with the flavor of different foods, including fermented ones. The difficulty in isolating volatile thiols in cheeses is probably due to the complexity of this matrix and to the very low concentrations of these compounds that make them undetectable using classic means. Consequently, different methods of sample preparation followed by extractions with p-hydroxymercuribenzoate were used to investigate the possible occurrence of thiol compounds in ripened cheeses. The anal. of cheese extracts by GC coupled with pulse flame photometry, MS and olfactometry detections made it possible to identify Et 2-mercaptopropionate (ET2MP) and Et 3-mercaptopropionate (ET3MP) in smear and mold-ripened cheeses for the first time. The presence of ET3MP in cheeses at concentrations of around 3 μg/kg, significantly higher than its perception threshold in cream (723 ppt), suggests that this thiol may significantly contribute to the aroma of these cheeses. Concerning other potent odors that contribute to the aroma of numerous cheeses, we also investigated the ability of Brevibacteria strains to produce S-Me thioesters in the presence of (i) methanethiol, (ii) fatty acids, or (iii) branched-chain amino acids as precursors. All the strains studied were able to yield the corresponding S-Me thioesters (i.e., S-Me thioisovalerate from L-leucine) from precursors. It was interesting to note that the data also showed that other S-Me thioesters e.g., S-Me thioacetate or S-Me thioisobutyrate, were also produced following the addition of an individual precursor (e.g., L-leucine). Enzymic and tracing experiments allowed us to propose the catabolic pathways used by the strains to produce S-Me thioesters.

ACS Symposium Series published new progress about 19788-49-9. 19788-49-9 belongs to esters-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Ester, name is Ethyl 2-mercaptopropanoate, and the molecular formula is C8H15ClN2, Recommanded Product: Ethyl 2-mercaptopropanoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Nomura, Naoki published the artcileEmulsion polymerization of vinyl acetate using iodine-transfer and RAFT radical polymerizations, Related Products of esters-buliding-blocks, the publication is Journal of Polymer Science, Part A: Polymer Chemistry (2013), 51(3), 534-545, database is CAplus.

This study deals with control of the mol. weight and mol. weight distribution of poly(vinyl acetate) by iodine-transfer radical polymerization and reversible addition-fragmentation transfer (RAFT) emulsion polymerizations as the first example. Emulsion polymerization using Et iodoacetate as the chain transfer agent more closely approximated the theor. mol. weights than did the free radical polymerization Although ¹H NMR spectra indicated that the peaks of α- and ω-terminal groups were observed, the mol. weight distributions show a relatively broad range (M_w/M_n = 2.2-4.0). On the other hand, RAFT polymerizations revealed that the dithiocarbamate 7 is an excellent candidate to control the polymer mol. weight (M_n = 9.1 × 10³, M_w/M_n = 1.48), more so than xanthate 1 (M_n = 10.0 × 10³, M_w/M_n = 1.89) under same condition, with accompanied stable emulsions produced. In the M_n vs. conversion plot, M_n increased linearly as a function of conversion. We also performed seed-emulsion polymerization using poly(nonamethylene L-tartrate) as the chiral polyester seed to fabricate emulsions with core-shell structures. The control of polymer mol. weight and emulsion stability, as well as stereoregularity, is also discussed. © 2012 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2012.

Journal of Polymer Science, Part A: Polymer Chemistry published new progress about 19788-49-9. 19788-49-9 belongs to esters-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Ester, name is Ethyl 2-mercaptopropanoate, and the molecular formula is C5H10O2S, Related Products of esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Yang, Feng V. published the artcileParallel synthesis of N-biaryl quinolone carboxylic acids as selective M₁ positive allosteric modulators, SDS of cas: 924-99-2, the publication is Bioorganic & Medicinal Chemistry Letters (2010), 20(2), 531-536, database is CAplus and MEDLINE.

An iterative analog library synthesis approach was employed in the exploration of a quinolone carboxylic acid series of selective M₁ pos. allosteric modulators, and strategies for improving potency and plasma free fraction were identified.

Bioorganic & Medicinal Chemistry Letters published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C18H10F3NO3S2, SDS of cas: 924-99-2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Tkachuk, Volodymyr V. published the artcile2-Carbamimidoylbenzoic Acid as a New Effective and Available Precursor for the Synthesis of Substituted 2-(Pyrimidin-2-yl)-benzoic Acids, COA of Formula: C6H10O3, the publication is Synthesis (2021), 53(2), 371-382, database is CAplus.

A new approach to the synthesis of 2-(pyrimidin-2-yl)benzoic acids I (R = Me, Et, Ph, OH, NH₂) based on the ring contraction of the 2-carbamimidoylbenzoic acid with 1,3-dicarbonyl compounds R¹CH₂C(O)OR² (R¹ = C(O)Me, C(O)Et, C(O)Ph, C(O)OEt, CN; R² = Me, Et), and their synthetic equivalent has been developed. The intramol. condensation of the obtained acids with 1,3-dielectrophiles proceeds with the formation of the 4,6-dihydropyrimido[2,1-a]isoindole-4,6-diones II (R = Me, Et, Ph, NH₂), the pyrrolidone ring of which is easily opened under the action of weak nucleophiles. The reaction of 2-carbamimidoylbenzoic acid with chromones III (R³ = H, CF₃; R⁴ = 4-chlorophenyl, 2-nitrophenyl), which have an aryloxy group at 3-position does not stop at the step of pyrimidine ring formation and undergoes further spontaneous cyclization into 2-(benzo[4,5]furo[3,2-d]pyrimidin-2-yl)benzoic acids IV.

Synthesis published new progress about 30414-53-0. 30414-53-0 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ketone,Ester, name is Methyl 3-oxovalerate, and the molecular formula is C18H10F3NO3S2, COA of Formula: C6H10O3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Kumari, Aruna published the artcileGC-MS analysis of the methanol fraction of Ailanthus excelsa Roxb. fruit, Application of 3-Acetyldihydrofuran-2(3H)-one, the publication is Asian Journal of Pharmaceutical and Clinical Research (2022), 15(6), 51-55, database is CAplus.

The objective of the study was to evaluate the phytochem. compounds present in the methanolic fruit extract of Ailanthus excelsa. Phytochem. screening was carried out using the GC-MS instrument following the standard protocol. GC-MS studies revealed the presence of 65 compounds in fruit extract of Ailanthus excelsa. Among them, highest peak area (37.67%) was obtained for Mome Inositol (Six hydroxyl group polysaccharide) (Retention time 14.873). This study identifies the presence of pharmacol. active compounds which can be constructive for the formulation of novel drugs.

Asian Journal of Pharmaceutical and Clinical Research published new progress about 517-23-7. 517-23-7 belongs to esters-buliding-blocks, auxiliary class Tetrahydrofuran,Ketone,Ester, name is 3-Acetyldihydrofuran-2(3H)-one, and the molecular formula is C6H8O3, Application of 3-Acetyldihydrofuran-2(3H)-one.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Zhu, Yun-fei published the artcileSynthesis of 5-amino-1-cyclopropyl-7-[3,5-dimethyl-1-piperazinyl]-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid (sparfloxacin), COA of Formula: C7H13NO2, the publication is Zhongguo Xinyao Zazhi (2008), 17(9), 757-759, database is CAplus.

A method for the synthesis of the title compound [i.e., 5-amino-1-cyclopropyl-7-(3,5-dimethyl-1-piperazinyl)-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid, fluoroquinolone antibacterial agent] is reported here. Said compound was prepared from 2,3,4,5-tetrafluorobenzoic acid via nitration and acyl chlorination before coupling with Et (dimethylamino)acrylate, cyclopropylamine displacement, cyclization, reduction, hydrolysis and condensation with 2,6-dimethylpiperazine. The overall yield was 34.2%. Compared to a known process, this synthetic sequence eliminates three reaction steps; di-Et malonate condensation, partial hydrolysis decarboxylation and tri-Et orthoformate condensation. Said process has advantages, such as short reaction time, mild reaction conditions, waste reduction, yield increase, and a good prospect for industrial application.

Zhongguo Xinyao Zazhi published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C5H10N2OS, COA of Formula: C7H13NO2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Xie, Haopu published the artcileThermally healable polyurethane with tailored mechanical performance using dynamic crosslinking motifs, Recommanded Product: 3-Acetyldihydrofuran-2(3H)-one, the publication is New Journal of Chemistry (2020), 44(32), 13584-13590, database is CAplus.

Materials with self-healing abilities have gained tremendous attention in recent years but combing excellent mech. performance and splendid self-healing capacity into a single polymer material is still a great challenge. In this study, a self-healing polyurethane (SHP) material was prepared by constructing a dynamic crosslinked network via quadruple hydrogen bonds formed from 5-(2-hydroxyethyl)-6-methyl-2-aminouracil (UPy). The mech. properties of the materials could be conveniently tuned by adjusting the dynamic crosslinked d. The optimal sample, SHP-75, has excellent mech. performance, showing high tensile strength (27.02 MPa), excellent stretchability (1300%), and prominent toughness (111.37 MJ m^-3). Despite such great mech. properties, SHP-75 exhibited superior self-healing abilities and could fully obtain its initial mech. strength after repairing at 80°C for 24 h. A self-healing conductive electrode was further constructed to demonstrate its application prospects in the field of sensing.

New Journal of Chemistry published new progress about 517-23-7. 517-23-7 belongs to esters-buliding-blocks, auxiliary class Tetrahydrofuran,Ketone,Ester, name is 3-Acetyldihydrofuran-2(3H)-one, and the molecular formula is C15H21BO2, Recommanded Product: 3-Acetyldihydrofuran-2(3H)-one.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Wang, Wenliang published the artcileCatalytic fast pyrolysis of cellulose for increasing contents of furans and aromatics in biofuel production, Name: 3-Acetyldihydrofuran-2(3H)-one, the publication is Journal of Analytical and Applied Pyrolysis (2018), 93-100, database is CAplus.

The catalytic fast pyrolysis of cellulose, cellobiose and glucose with the zeolite catalyst of NaY was carried out using thermogravimetric analyzer (TG) and pyrolysis-gas chromatog./mass spectrometry (Py-GC/MS). Results from TG showed that all samples presented significant mass loss at low temperature and exhibited high residual chars with NaY. The activation energies of cellulose, cellobiose and glucose were significantly decreased with NaY. PY-GC/MS showed that saccharides were significantly decreased or even completely eliminated and converted into furans, aromatics, phenols and light oxygenates with NaY. The contents of furans of cellulose, cellobiose and glucose with NaY were increased from 17.48%, 18.79% and 28.77% to 46.71%, 52.11% and 67.81%, resp. Pyrolysis of cellulose and cellobiose presented high selectivity of BTX (Benzene, Toluene, and Xylene). The furans are mainly formed on the surface of NaY by dehydration, fragmentation/retro-aldol condensation, decarbonylation, or decarboxylation. The pyrolysis intermediates of anhydro-oligosaccharides dominated the formation of aromatics and phenols during the catalytic fast pyrolysis of cellulose in the zeolite catalyst pores at the active sites.

Journal of Analytical and Applied Pyrolysis published new progress about 517-23-7. 517-23-7 belongs to esters-buliding-blocks, auxiliary class Tetrahydrofuran,Ketone,Ester, name is 3-Acetyldihydrofuran-2(3H)-one, and the molecular formula is C13H15NO6S, Name: 3-Acetyldihydrofuran-2(3H)-one.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics