Tag: M.W=100-150

Parthasarathy, V. published the artcileMelt surface grafting of HDPE with mercaptoesters by thermolysis method, Name: Ethyl 2-mercaptopropanoate, the publication is Polymer Engineering & Science (2010), 50(3), 474-483, database is CAplus.

High-d. polyethylene (HDPE) was graft functionalized with 2 different mercapto esters in an inert atm. at 160°C under different exptl. conditions by thermolysis method. The order of functionalization, crosslinking, and C=C formation reactions were determined from the relative intensities of carbonyl stretching vibration and C-H bending vibrations. FTIR, DSC, and TGA anal. tools were used to characterize mercapto ester-functionalized HDPE. A plausible reaction mechanism is proposed here to explain the exptl. results obtained. POLYM. ENG. SCI., 2010. © 2009 Society of Plastics Engineers.

Polymer Engineering & Science published new progress about 19788-49-9. 19788-49-9 belongs to esters-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Ester, name is Ethyl 2-mercaptopropanoate, and the molecular formula is C5H10O2S, Name: Ethyl 2-mercaptopropanoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Mastorino, Luca published the artcileRisankizumab shows high efficacy and maintenance in improvement of response until week 52, Safety of Dimethyl fumarate, the publication is Dermatologic Therapy (2022), 35(5), e15378, database is CAplus and MEDLINE.

Risankizumab has been recently approved for moderate-to-severe plaque psoriasis; however, real-life studies are scarce. Anal. of possible predictor factors of treatment response are limited to body mass index (BMI) and previous biol. experience. Our objectives were to evaluate the effectiveness and safety of Risankizumab and to investigate on possible predictor factors response. We retrospectively analyzed 166 patients from two centers in Italy who undergone Risankizumab for psoriasis. The proportion of patients achieving a 100%, 90%, 75% of improvement in Psoriasis Area Severity Index (PASI) and PASI <3 were collected at weeks 16, 28, 40, and 52. Study population was analyzed in subgroups to investigate possible predictors of response to Risankizumab since week 40. At the time of anal. 165, 103, 30, and 11 patients had completed 16, 28, 40, and 52 wk of treatment, resp. The mean PASI score decreased from 12.5 ± 5.1 at baseline to 1.9 ± 2.4 at week 16. Similar reductions were observed when considering PASI <3, PASI 75, PASI 90, and PASI 100. Previous biologics failure, different smoking habits, obesity, and joint involvement resulted in a lower response to risankizumab. In particular, significant differences in mean PASI at any time-points was observed between psoriatic arthritis (PSA) and non-PSA patients: 2.7 vs. 1.7 (p = 0.036), 1.9 vs. 0.4 (p = 0.006), and 4.1 vs. 0.5 (p = 0.016) at 16, 28, and 40 wk, resp. No difference in response to risankizumab occurred in the case of involvement of difficult-to-treat areas. In this population, Risankizumab was effective and safe. Smoking habits, joint involvement, obese status, and previous biol. experience may neg. affect treatment response, while difficult body sites involvement have minor impact.

Dermatologic Therapy published new progress about 624-49-7. 624-49-7 belongs to esters-buliding-blocks, auxiliary class Inhibitor,Natural product, name is Dimethyl fumarate, and the molecular formula is C6H8O4, Safety of Dimethyl fumarate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Kozma, Viktoria published the artcileConjugate addition of 1,3-dicarbonyl compounds to maleimides using bifunctional primary amine-(thio)phosphoramide organocatalysts, COA of Formula: C6H8O3, the publication is Molecular Catalysis (2022), 112089, database is CAplus.

Asym. Michael additions of 1,3-dicarbonyl compounds to N-substituted maleimides were carried out using primary amine-(thio)phosphoramide bifunctional chiral organocatalysts derived from optically pure C2-sym. 1,2-diamines. The addition of Et 2-fluoroacetoacetate using the 1,2-diphenylethane-1,2-diamine derived thiophosphoramide catalyst afforded various succinimides substituted with fluorine bearing quaternary carbon in high yields, good diastereomeric ratios and excellent enantiomeric excesses. Alicyclic β-ketoesters provided the diastereomerically pure Michael adducts in good yields and high enantioselectivities, whereas 2,4-pentanedione afforded products with slightly lower enantiomeric excesses. The bulkiness of the N-substituent of the maleimide ring influenced mostly the conversions. The thiophosphoramide catalyst was found also efficient in the addition of Et 2-fluoroacetoacetate to β-nitrostyrenes. Unprecedentedly, during this work the highly enantioselective addition of 1,3-dicarbonyl compounds to maleimides were catalyzed by a primary amine-hydrogen-bond donor groups containing bifunctional organocatalyst. These reactions occurred through enamine intermediate, as evidenced by electrospray-ionization mass spectrometry and NMR spectroscopy.

Molecular Catalysis published new progress about 517-23-7. 517-23-7 belongs to esters-buliding-blocks, auxiliary class Tetrahydrofuran,Ketone,Ester, name is 3-Acetyldihydrofuran-2(3H)-one, and the molecular formula is C6H8O3, COA of Formula: C6H8O3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Chretien, Jacques R. published the artcileGas chromatography of homologous esters. XXX. Unexpected predominancy of polar effects over steric effects in crowded aliphatic esters: a gas-liquid chromatographic appraisal of specific interactions, Application of Ethyltert-butylacetate, the publication is Journal of Chromatography (1985), 324(2), 355-62, database is CAplus.

The chromatog. behavior of sixteen hindered α,α-disubstituted or α,α,α-trisubstituted aliphatic Et or Me esters containing C_4-9 acyl groups is presented. Kovats index increments, on height stationary phases of increasing polarity and the contributions of the Me groups, obtained by progressive substitution are discussed. The polar and steric effects are separated by use of IR and an extended Taft scale (-E‘_s) ranging over 8 powers of 10 for the considered acyl groups. Predominancy of polar effects over steric effects is demonstrated for the congested α,α,α-trisubstituted esters containing C_7-9 acyl groups.

Journal of Chromatography published new progress about 5340-78-3. 5340-78-3 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is Ethyltert-butylacetate, and the molecular formula is C8H16O2, Application of Ethyltert-butylacetate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Cecchetti, Violetta published the artcileStudies on 6-aminoquinolones: synthesis and antibacterial evaluation of 6-amino-8-ethyl- and 6-amino-8-methoxyquinolones, Computed Properties of 924-99-2, the publication is Bioorganic & Medicinal Chemistry (1999), 7(11), 2465-2471, database is CAplus and MEDLINE.

From our quant. structure-activity relationship (QSAR) study on a large set of 6-aminoquinolones, which indicated that a group larger than Me could be allocated at C-8 position, we have synthesized two new series of 6-aminoquinolones characterized by the presence of an Et or a methoxy group at C-8 position. The antibacterial evaluation shows that, while the 8-Et derivatives were devoid of any antibacterial activity, the introduction of methoxy group gave compounds with good antibacterial activity, especially against Gram-pos. bacteria. A tentative explanation of the different behaviors among the 8-substituted analogs is given taking into account both the length and electronic properties of the C-8 groups.

Bioorganic & Medicinal Chemistry published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, Computed Properties of 924-99-2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Robinson, Emma J. published the artcileAqueous Metabolite Trends for the Progression of Nonalcoholic Fatty Liver Disease in Female Bariatric Surgery Patients by Targeted 1H-NMR Metabolomics, Formula: C6H10O3, the publication is Metabolites (2021), 11(11), 737, database is CAplus and MEDLINE.

Determining biomarkers and better characterizing the biochem. progression of nonalcoholic fatty liver disease (NAFLD) remains a clin. challenge. A targeted 1H-NMR study of serum, combined with clin. variables, detected and localized biomarkers to stages of NAFLD in morbidly obese females. Pre-surgery serum samples from 100 middle-aged, morbidly obese female subjects, grouped on gold-standard liver wedge biopsies (non-NAFLD; steatosis; and fibrosis) were collected, extracted, and analyzed in aqueous (D2O) buffer (1H, 600 MHz). Profiled concentrations were subjected to exploratory statistical anal. Metabolites varying significantly between the non-NAFLD and steatosis groups included the ketone bodies 3-hydroxybutyrate (� p = 0.035) and acetone (� p = 0.012), and also alanine (� p = 0.004) and a putative pyruvate signal (� p = 0.003). In contrast, the steatosis and fibrosis groups were characterized by 2-hydroxyisovalerate (� p = 0.023), betaine (� p = 0.008), hypoxanthine (� p = 0.003), taurine (� p = 0.001), 2-hydroxybutyrate (� p = 0.045), 3-hydroxyisobutyrate (� p = 0.046), and increasing medium chain fatty acids. Exploratory classification models with and without clin. variables exhibited overall success rates ca. 75-85%. In the study conditions, inhibition of fatty acid oxidation and disruption of the hepatic urea cycle are supported as early features of NAFLD that continue in fibrosis. In fibrosis, markers support inflammation, hepatocyte damage, and decreased liver function. Complementarity of NMR concentrations and clin. information in classification models is shown. A broader hypothesis that standard-of-care sera can yield metabolomic information is supported.

Metabolites published new progress about 30414-53-0. 30414-53-0 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ketone,Ester, name is Methyl 3-oxovalerate, and the molecular formula is C6H10O3, Formula: C6H10O3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Lee, Jaemin published the artcileGenotypic variation of volatile compounds from flowers of gentians, Computed Properties of 19788-49-9, the publication is Breeding Science (2010), 60(1), 9-17, database is CAplus.

Gentians (Gentiana triflora, G. scabra) are one of the most important ornamental plants, however, repellent odor emitted from their flowers makes them undesirable in indoor floral utilization. It is necessary to understand the component of their flower scent for breeding of new cultivars without repellent odor. Floral scent compounds of gentians were analyzed by the method of Head Space-Solid Phase Micro Extraction with GC-MS (HS-SPME/GC-MS). The level of scent emission from gentian flowers increased with the age of the flower and reached a maximum at three days after anthesis and decreased thereafter. Their flowers emitted volatiles throughout the day, and the amounts were higher at night than during the day. A total of 98 compounds were detected in 13 genotypes examined, and quant. and qual. variations were found. Of these compounds, several kinds of lilac aldehydes (terpenoids) were only detected in G. scabra. The results of principal component anal. showed that cultivars/lines classified in the same species were grouped with each other. Of the 13 genotypes, Ashiro-no-Natsu emitted the most abundant volatiles and has strong unpleasant odor. 2-Methylbutanoic acid is considered to be one of the major constituents responsible for the unpleasant odor of gentians.

Breeding Science published new progress about 19788-49-9. 19788-49-9 belongs to esters-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Ester, name is Ethyl 2-mercaptopropanoate, and the molecular formula is C5H10O2S, Computed Properties of 19788-49-9.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Ma’Radzi, Akmal Hadi published the artcileSynthesis of polyvinyl alcohol stereoblock copolymer via the combination of living cationic polymerization and RAFT/MADIX polymerization using xanthate with vinyl ether moiety, Application of Ethyl 2-mercaptopropanoate, the publication is Polymer (2014), 55(21), 5332-5345, database is CAplus.

Different types of novel xanthates containing a vinyl ether moiety, S-benzyl O-2-(vinyloxy)ethyl carbonodithioate (Xanthate 1) and S-1-(ethoxycarbonyl)ethyl O-2-(vinyloxy)ethyl carbonodithioate (Xanthate 2) were synthesized. In particular, the Xanthate 2 enabled the design of polyvinyl alc. (PVA) stereoblock copolymer via the combination of living cationic vinyl polymerization and RAFT/MADIX polymerization For cationic polymerization of iso-Bu vinyl ether (IBVE) and tert-Bu vinyl ether (TBVE), the polymerizations were conducted under Xanthate 1-HCl adduct/SnCl₄ and Xanthate 1 or 2-CF₃COOH adduct/EtAlCl₂ initiating system in the presence of Et acetate. Both systems proceeded in living polymerization fashion because the calculated M_n of both poly(IBVE) and poly(TBVE) matches with the M_n polymerized assuming that one polymer chain is formed per one mol. of the Xanthate 1 or 2. The resulting poly(TBVE) had a high number average α-end functionality as determined by MALDI-TOF-MS spectrometry. Xanthate 2 is more efficient for the following RAFT/MADIX polymerization of vinyl acetate (VAc). The RAFT/MADIX polymerization of vinyl acetate (VAc) using azobis(isobutyronitrile) (AIBN) at 60 °C was conducted using either poly(IBVE) or poly(TBVE) macro-CTA. The poly(TBVE) macro-CTAs synthesized from the Xanthate 2 were able to polymerize VAc smoothly via RAFT/MADIX polymerization, to prepare well-defined diblock copolymer, poly(TBVE)-b-poly(VAc). The resulting block copolymer was then hydrolyzed using KOH in methanol and followed by acid hydrolysis using HBr gas bubbling. The resulting polymer is and inherently stereoblock-like copolymer, isotactic rich PVA-b-atactic PVA (iPVA-b-aPVA). From the DSC measurement, the iPVA-b-aPVA has one glass transition at 69.5 °C and two m.ps. according to iPVA and aPVA at 237.9 and 198.1 °C, resp. Thus, it can be suggested that the obtained PVA has two different geometries by the combination of living cationic polymerization and RAFT/MADIX polymerization

Polymer published new progress about 19788-49-9. 19788-49-9 belongs to esters-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Ester, name is Ethyl 2-mercaptopropanoate, and the molecular formula is C5H10O2S, Application of Ethyl 2-mercaptopropanoate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Huang, Hanchu published the artcileRadical Cascade-Triggered Controlled Ring-Opening Polymerization of Macrocyclic Monomers, Product Details of C5H10O2S, the publication is Journal of the American Chemical Society (2018), 140(33), 10402-10406, database is CAplus and MEDLINE.

A strategy for the controlled radical ring-opening polymerization of macrocyclic monomers is reported. Key to this approach is an allyl alkylsulfone-based ring-opening trigger that can undergo a radical cascade reaction to extrude sulfur dioxide and generate an alkyl radical for controlled chain propagation. A systematic study correlating reaction conditions with polymer mol. weight and mol. weight distribution allowed excellent control over polymerization The versatility of this radical cascade-triggered ring-opening polymerization approach was further demonstrated through the first radical block copolymerization of macrocyclic monomers, and the incorporation of degradable functionality into the polymer backbone.

Journal of the American Chemical Society published new progress about 19788-49-9. 19788-49-9 belongs to esters-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Ester, name is Ethyl 2-mercaptopropanoate, and the molecular formula is C5H10O2S, Product Details of C5H10O2S.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Yang, Ziyue published the artcileSelf-healing supramolecular waterborne polyurethane dispersions with quadruple hydrogen bonds in main chain, Related Products of esters-buliding-blocks, the publication is Journal of Applied Polymer Science (2020), 137(45), 49413, database is CAplus.

A facile method for preparing supramol. waterborne polyurethane (WPU) based on quadruple hydrogen bonds (4H-WPU) is reported. Herein, 4H-WPU with quadruple hydrogen bonds in main chain were synthesized by poly (1,4-butylene-neopentylene adipate glycol) as soft segment, 2-ureido-4[1H]-pyrimidinone (UPy) functionalized monomer, isophorone diisocyanate, 2,2-Bis(hydroxymethyl)propionic acid (hydrophilic monomer), isophoronediamine, triethylamine (neutralizer), and monoethanolamine (blocking agent) as hard segment. The mol. weight of 4H-WPU was controlled around 18,000 consistently. The properties of 4H-WPU with different content of hydrophilic group, hard segment, and UPy units were characterized and the results could provide the reference for preparing supramol. WPU with high mech. and self-healing performance while maintaining dispersion stability. The tensile strength of 4H-WPU was 10 times of the blank sample. The healing time of scratched 4H-WPU film was inversely proportional to the content of UPy-functionalized monomer and the shortest healing time is 2.5 h at 80°C. Mech. performance of healed films can be restored to more than 90%.

Journal of Applied Polymer Science published new progress about 517-23-7. 517-23-7 belongs to esters-buliding-blocks, auxiliary class Tetrahydrofuran,Ketone,Ester, name is 3-Acetyldihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, Related Products of esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics