Tag: M.W=100-150

Xu, Zhen published the artcileOrganocatalytic, Enantioselective Reductive Bis-functionalization of Secondary Amides: One-Pot Construction of Chiral 2,2-Disubstituted 3-Iminoindoline, Computed Properties of 539-88-8, the main research area is organocatalytic enantioselective reductive functionalization secondary amide; one pot stereoselective preparation chiral iminoindoline mol modeling.

We report the first catalytic, enantioselective reductive bis-functionalization of common amides, which provides a facile access to a variety of 2,2-disubstituted 3-iminoindolines in good yields and with excellent enantioselectivities. The reaction conditions are quite mild and can be run on a gram scale. In this one-pot reaction, three C-C bonds, one ring, and one nitrogen-containing tetrasubstituted carbon stereocenter are created in a catalytic enantioselective manner.

Organic Letters published new progress about Amides, secondary Role: RCT (Reactant), RACT (Reactant or Reagent). 539-88-8 belongs to class esters-buliding-blocks, name is Ethyl 4-oxopentanoate, and the molecular formula is C7H12O3, Computed Properties of 539-88-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Misal Castro, Luis C. published the artcileDirect Synthesis of Indoles from Azoarenes and Ketones with Bis(neopentylglycolato)diboron Using 4,4′-Bipyridyl as an Organocatalyst, SDS of cas: 539-88-8, the main research area is azoarene ketone bipyridyl catalyst Fischer indole cyclization; indole preparation.

Multifunctionalized indole derivatives were prepared by reducing azoarenes in the presence of ketones and bis(neopentylglycolato)diboron (B2nep2) with a catalytic amount of 4,4′-bipyridyl under neutral reaction conditions, where 4,4′-bipyridyl acted as an organocatalyst to activate the B-B bond of B2nep2 and form N,N’-diboryl-1,2-diarylhydrazines as a key intermediate. Further reaction of N,N’-diboryl-1,2-diarylhydrazines with ketones afforded N-vinyl-1,2-diarylhydrazines, which rearranged to the corresponding indoles via the Fischer indole mechanism. This organocatalytic system was applied to diverse alkyl cyclic ketones, dialkyl, and alkyl/aryl ketones, including heteroatoms. Me alkyl ketones gave the corresponding 2-methyl-3-substituted indoles in a regioselective manner. This protocol allowed us to expand the preparation of indoles having high compatibility with not only electron-donating and electron-withdrawing groups but also N- and O-protecting functional groups.

Journal of Organic Chemistry published new progress about Diazo compounds, aryl Role: RCT (Reactant), RACT (Reactant or Reagent). 539-88-8 belongs to class esters-buliding-blocks, name is Ethyl 4-oxopentanoate, and the molecular formula is C7H12O3, SDS of cas: 539-88-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Munoz-Olasagasti, M. published the artcileElucidating the roles of acid site nature and strength in the direct conversion of levulinic acid into ethyl valerate: the case of Zr-modified beta zeolite-supported Pd catalysts, Recommanded Product: Ethyl 4-oxopentanoate, the main research area is zirconium zeolite palladium catalyst levulinic acid one pot conversion; surface acidity.

The effects of the nature and strength of surface acid sites on the properties of the catalyst used for the one-pot conversion of levulinic acid to valeric biofuels have been investigated. The acid supports were prepared from a com. beta zeolite (HBEA) modified by partial substitution of Al by Zr atoms. This procedure enables changes in the nature and strength of the acidic sites of the starting zeolite. A constant amount of Pd (2 wt%) was incorporated on these acid supports by the incipient wetness impregnation method. These catalysts were tested in liquid phase reactions and the Pd/HBEA catalyst showed the best catalytic performance, achieving an 80% yield of valeric biofuel after 2 h of the reaction. The fresh catalysts were characterized by DRIFT spectroscopy using pyridine, CD3CN, and CO as probe mols. and by XRD to explain the differences in catalytic performance. The presence of strong Bronsted acid sites (BAS) was shown to be critical for reaching high Et valerate yields since the differences in catalytic behavior and the concentration of these acid sites parallel each other. Up to three types of Lewis acid sites (LAS) of different strengths were also identified. The spent catalyst underwent a simple calcination treatment at 773 K and this was adequate for the recovery of the surface acidity, but the reducibility of the Pd species was affected. This prevented complete recovery of catalytic activity.

Sustainable Energy & Fuels published new progress about Beta zeolites Role: CAT (Catalyst Use), PRP (Properties), USES (Uses). 539-88-8 belongs to class esters-buliding-blocks, name is Ethyl 4-oxopentanoate, and the molecular formula is C7H12O3, Recommanded Product: Ethyl 4-oxopentanoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lombardi, Lorenzo published the artcileAllylic and Allenylic Dearomatization of Indoles Promoted by Graphene Oxide by Covalent Grafting Activation Mode, Formula: C7H12O3, the main research area is indole arylpropenol graphene oxide regioselective diastereoselective allylation dearomatization; arylpropenyl indole preparation green chem; arylpropynol indole graphene oxide regioselective diastereoselective allenylation dearomatization; arylallenyl indole preparation green chem; alcohols; carbocatalysis; dearomatization; graphene oxide; indole.

The site-selective allylative and allenylative dearomatization of indoles with alcs. was performed under carbocatalytic regime in the presence of graphene oxide (GO, 10 wt % loading) as the promoter. Metal-free conditions, absence of stoichiometric additive, environmentally friendly conditions (H2O/CH3CN, 55 C, 6 h), broad substrate scope (33 examples, yield up to 92%) and excellent site- and stereoselectivity characterize the present methodol. Moreover, a covalent activation model exerted by GO functionalities was corroborated by spectroscopic, exptl. and computational evidences. Recovering and regeneration of the GO catalyst through simple acidic treatment was also documented.

Chemistry – A European Journal published new progress about Alcohols, propargyl Role: RCT (Reactant), RACT (Reactant or Reagent). 539-88-8 belongs to class esters-buliding-blocks, name is Ethyl 4-oxopentanoate, and the molecular formula is C7H12O3, Formula: C7H12O3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Seo, Hyowon published the artcileCatalytic Generation and Use of Ketyl Radical from Unactivated Aliphatic Carbonyl Compounds, Quality Control of 539-88-8, the main research area is alc preparation continuous flow batch process; aliphatic ketone aldehyde styrene ketyl radical reductive coupling.

Generation of a ketyl radical from unactivated aliphatic carbonyl compounds is an important strategy in organic synthesis. Herein, catalytic generation and use of a ketyl radical for the reductive coupling of aliphatic carbonyl compounds and styrenes by organic photoredox catalysis is described. This method is applicable to both aliphatic ketones and aldehydes to afford the corresponding tertiary and secondary alcs. in continuous flow and batch. A preliminary mechanistic investigation suggests the catalytic formation of a ketyl radical intermediate.

Organic Letters published new progress about Aliphatic aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 539-88-8 belongs to class esters-buliding-blocks, name is Ethyl 4-oxopentanoate, and the molecular formula is C7H12O3, Quality Control of 539-88-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Donabauer, Karsten published the artcilePhotocatalytic Reductive Radical-Polar Crossover for a Base-Free Corey-Seebach Reaction, Product Details of C7H12O3, the main research area is hydroxymethyl dithiane preparation; dithiane photocatalytic Corey Seebach aldehyde ketone; Corey-Seebach; HAT-catalysis; carbanion; photocatalysis; radical-polar crossover.

A photocatalytic approach to the Corey-Seebach reaction has been described. The presented method operates under mild redox-neutral and base-free conditions giving the desired product with high functional group tolerance. The reaction is enabled by the combination of photo- and hydrogen atom transfer (HAT) catalysis. This catalytic merger allows a C-H to carbanion activation by the abstraction of a hydrogen atom followed by radical reduction The generated nucleophilic intermediate is then capable of adding to carbonyl electrophiles. By this approach, dithianes I (R1 = Me, NCCH2CH2, PhCH2CH2, etc.) were reacted with various aldehydes and ketones R2C(O)R3 [R2 = Et, i-Pr, MeSCH2CH2, R3 = H; R2 = n-Pr, i-Pr, PhCH2CH2, etc., R3 = Me; R2R3 = (CH2)3, (CH2)2O(CH2)2, etc.] giving access to the valuable α-hydroxy dithianes II. The proposed reaction mechanism is supported by emission quenching, radical-radical homocoupling and deuterium labeling studies as well as by calculated redox-potentials and bond strengths.

Chemistry – A European Journal published new progress about Aliphatic aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 539-88-8 belongs to class esters-buliding-blocks, name is Ethyl 4-oxopentanoate, and the molecular formula is C7H12O3, Product Details of C7H12O3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Lixia published the artcileSelective aerobic oxidative cleavage of lignin C-C bonds over novel hierarchical Ce-Cu/MFI nanosheets, Recommanded Product: Ethyl 4-oxopentanoate, the main research area is zeolite MFI supported cerium copper catalyst preparation property; oxidative bond cleavage depolymerization lignin aromatic compound.

The catalytic depolymerization process for lignin to produce value added chems. is often challenged by the limited mass transfer over heterogeneous catalysts, the complex aromatic biopolymer structures, and the high recalcitrance of C-C bonds. Herein, a series of hierarchical MFI nanosheets (MFI-ns) supported metal oxide catalysts have been designed and used for the selectively oxidative cleavage of organosolv lignin. As expected, 81.6% conversion of lignin can be achieved over 15Ce-5Cu/MFI-ns with 294.0 mg g-1 yield of volatile products, including 180.9 mg g-1 of di-Et maleate. Quantum chem. calculation coupled with static adsorption measurements shows that the superior catalytic activities of these catalysts are ascribed to the favorable mass transport of lignin to the active sites by the unique layer structure, and the hierarchical pore sizes distribution, as well as the electronic effect between Cu and Ce components. In addition, the catalytic mechanism for the cleavage of C-C bonds in β-O-4 model probes has been studied via the controlled oxidative degree of model compounds and the isotope-labeling experiments Therefore, this work provides a new insight into the efficient utilization of lignin via the rational design of catalysts.

Applied Catalysis, B: Environmental published new progress about Aromatic compounds Role: SPN (Synthetic Preparation), PREP (Preparation). 539-88-8 belongs to class esters-buliding-blocks, name is Ethyl 4-oxopentanoate, and the molecular formula is C7H12O3, Recommanded Product: Ethyl 4-oxopentanoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Guo, Xuan published the artcileThe Photocatalyst-Free Cross-Dehydrogenative Coupling Reaction Enabled by Visible-Light Direct Excitation of Substrate, HPLC of Formula: 539-88-8, the main research area is aryl tetrahydroisoquinoline ketone photochem dehydrogenation cross coupling reaction; dihydroisoquinolinyl ketone preparation green chem; phosphite aryltetrahydroisoquinolinyl photochem dehydrogenation cross coupling reaction; phosphonyldihydroisoquinoline aryl preparation green chem.

A new photocatalyst-free strategy for the cross-dehydrogenative C-C and C-P coupling reaction was described. This protocol provided a concise method to synthesize various 1-substituted tetrahydroisoquinoline (THIQ) derivatives enabled by visible-light direct excitation of substrates without using any photocatalyst. Moreover, a wide substrate scope demonstrated good synthetic versatility and practicality.

Journal of Organic Chemistry published new progress about Aromatic compounds Role: SPN (Synthetic Preparation), PREP (Preparation). 539-88-8 belongs to class esters-buliding-blocks, name is Ethyl 4-oxopentanoate, and the molecular formula is C7H12O3, HPLC of Formula: 539-88-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Tang, Bo published the artcileHierarchical FAU-Type Hafnosilicate Zeolite as a Robust Lewis Acid Catalyst for Catalytic Transfer Hydrogenation, Related Products of esters-buliding-blocks, the main research area is hafnosilicate zeolite catalyst transfer hydrogenation.

FAU-type hafnosilicate zeolite with a hierarchical structure (Hf-USY) was constructed through a post-synthesis strategy containing the controlled dealumination of the com. H-USY zeolite and the subsequent dry impregnation of the Cp2HfCl2 precursor. The incorporation of Hf ions into the zeolite framework involved the interaction between the silanol groups from framework dealumination and Cp2HfCl2 mols. Characterization results from UV-vis and XPS verified that the incorporated Hf ions mainly existed in the tetrahedrally coordinated form in the zeolite framework. The creation of Lewis acid sites associated with Hf incorporation was confirmed by Fourier transform IR spectroscopy with pyridine and deuterated acetonitrile adsorption. The as-synthesized Hf-USY zeolite served as a highly efficient catalyst in the transfer hydrogenation of Et levulinate to γ-valerolactone, outperforming the Sn- and Zr-silicate analogs. The Hf-USY catalyst also exhibited good performance in the transfer hydrogenation of more challenging substrates such as furanic, aromatic, as well as alkene-substituted carbonyl compounds into the corresponding alcs. The influence of Lewis acid sites, preparation parameters, as well as the hydrogen donor on the catalytic activity of the Hf-USY zeolite was investigated in detail. FAU-type hafnosilicate zeolite with a hierarchical structure is developed as a robust catalyst for the transfer hydrogenation of Et levulinate to γ-valerolactone.

ACS Sustainable Chemistry & Engineering published new progress about Beta zeolites Role: CAT (Catalyst Use), USES (Uses) (dealluminated, Hf-). 539-88-8 belongs to class esters-buliding-blocks, name is Ethyl 4-oxopentanoate, and the molecular formula is C7H12O3, Related Products of esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Connatser, Raynella M. published the artcileApproaches to investigate the role of chelation in the corrosivity of biomass-derived oils, Synthetic Route of 539-88-8, the main research area is chelation investigate role corrosivity biomass derived oil.

The need to provide the U. S. market with a renewable liquid fuel energy source from a non-food feedstock stream has gained considerable traction due to benefits such as improved energy efficiency, reduced environmental impacts, and enhanced national security. Practical achievement of these goals via biomass and bio-waste utilization involves production of liquid intermediates containing corrosive, reactive species like carboxylic acids, ketones, aldehydes, and hydroxyaldehydes. Such mixtures challenge materials of containment, processing, and transport. It is widely recognized that the smaller organic acids, such as acetic and formic, are corrosive and can remove protective surface oxides on alloys used in bio-oil processing infrastructure, and ketones can swell sealing polymers. However, literature shows, and findings herein confirm, larger carboxylic acids and bidentate alcs. are present. This highlights the potential for synergistic, detrimental effects of constituents in bio-oil corrosion, including direct reactivity of small acids compounded with the possibility of mobilization of protective metal oxide layers via chelation by larger acids and oxygenates. The question of whether species beyond small acids can significantly contribute to corrosion requires anal. approaches previously not applied to bio-oil corrosion studies and certainly not previously applied corroboratively. This work introduces a combination of optical, mass spectral, and electrochem. impedance spectroscopies with an incubation approach to study metal mobilization, to facilitate elucidating chelation’s role in bio-oil corrosive pathways. To enable systematic study of these oxygenates’ material compatibility individually and in combination, a model matrix of bio-oil constituents was also developed based on identification of key components of real bio-oils.

Biomass and Bioenergy published new progress about Aldehydes Role: TEM (Technical or Engineered Material Use), USES (Uses). 539-88-8 belongs to class esters-buliding-blocks, name is Ethyl 4-oxopentanoate, and the molecular formula is C7H12O3, Synthetic Route of 539-88-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics