Tag: M.W=100-150

Jiang, Haiwei; Yan, Rongwei; Cai, Chang; Chen, Xingfan; Zhao, Fenghua; Fan, Liangliang; Xu, Chunbao Charles; Yang, Weiran published the artcile< Hydrothermal liquefaction of Cd-enriched Amaranthus hypochondriacus L. in ethanol-water co-solvent: Focus on low-N bio-oil and heavy metal/metal-like distribution>, Computed Properties of 623-50-7 , the main research area is hydrothermal liquefaction cadmium amaranthus hypochondriacus; ethanol water nitrogen bio oil heavy metal.

The high nitrogen content in bio-oil from protein-rich biomass will cause the possible pollution problems by NOX emissions during combustion. In this study, Cd-enriched Amaranthus hypochondriacus L. (AHL) was treated by hydrothermal liquefaction (HTL) in ethanol-water co-solvent aiming to reduce the nitrogen content of the bio-oil. Besides, aqueous phase recycling (APR) was applied to achieve a higher bio-oil yield. HTL in ethanol-water co-solvent with APR three times resulted in the maximum bio-oil yield (47.26%) and greatly reduced the nitrogenous compounds content of bio-oil. During the APR process, the increase of total nitrogen (TN) content in the aqueous phase indicated that organic-N in the organic phase transformed into NH+4 to the aqueous phase. Acetic acid (13.87-22.37 mg/mL) was dominated in the aqueous phase, leading to a low pH value (6.27-5.29), which could serve as the possible catalyst for the HTL process during APR that can be the reason for the higher bio-oil yield. After the HTL process, Cr, Cu, Cd and Pb remained mostly in bio-char while As was present largely in the aqueous phase. Thus, this study demonstrated that the APR for HTL process in ethanol-water co-solvent can be a hopeful method to dispose the high-protein biomass for improved bio-oil yield and quality.

Fuel published new progress about Alcohols Role: TEM (Technical or Engineered Material Use), USES (Uses). 623-50-7 belongs to class esters-buliding-blocks, and the molecular formula is C4H8O3, Computed Properties of 623-50-7 .

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Randolph, John T.; Voight, Eric A.; Greszler, Stephen N.; Uno, Brice E.; Newton, James N.; Gleason, Kenneth M.; Stolarik, DeAnne; Van Handel, Cecilia; Bow, Daniel A. J.; DeGoey, David A. published the artcile< Prodrug Strategies to Improve the Solubility of the HCV NS5A Inhibitor Pibrentasvir (ABT-530)>, Quality Control of 623-50-7 , the main research area is prodrug pibrentasvir solubility.

A research program to discover solubilizing prodrugs of the HCV NS5A inhibitor pibrentasvir (PIB) identified phosphomethyl analog 2 and trimethyl-lock (TML) prodrug 9. The prodrug moiety is attached to a benzimidazole nitrogen atom via an oxymethyl linkage to allow for rapid and complete release of the drug for absorption following phosphate removal by intestinal alk. phosphatase. These prodrugs have good hydrolytic stability properties and improved solubility compared to PIB, both in aqueous buffer (pH 7) and FESSIF (pH 5). TML prodrug 9 provided superior in vivo performance, delivering high plasma concentrations of PIB in PK studies conducted in mice, dogs, and monkeys. The improved dissolution properties of these phosphate prodrugs provide them the potential to simplify drug dosage forms for PIB-containing HCV therapy.

Journal of Medicinal Chemistry published new progress about Antiviral agents. 623-50-7 belongs to class esters-buliding-blocks, and the molecular formula is C4H8O3, Quality Control of 623-50-7 .

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Campbell, Joseph P.; Rajappan, Sinu C.; Jaynes, Tyler J.; Sharafi, Mona; Ma, Yong-Tao; Li, Jianing; Schneebeli, Severin T. published the artcile< Enantioselective Electrophilic Aromatic Nitration: A Chiral Auxiliary Approach>, Recommanded Product: (S)-Methyl 2-hydroxy-3-methylbutanoate, the main research area is tribenzotriquinacene preparation enantioselective electrophilic aromatic nitration chiral auxiliary; aromatic substitution; chiral auxiliaries; chirality; nitration; noncovalent interactions.

Enantioselective electrophilic aromatic nitration methodol. is needed to advance chirality-assisted synthesis (CAS). Reported here is an enantioselective aromatic nitration strategy operating with chiral diester auxiliaries, and it provides an enantioselective synthesis of a C3v-sym. tribenzotriquinacene (TBTQ). These axially-chiral structures are much sought-after building blocks for CAS, but they were not accessible prior to this work in enantioenriched form without resolution of enantiomers. This nitration strategy controls the stereochem. of threefold nitration reactions from above the aromatic rings with chiral diester arms. Dicarbonyl-to-arenium chelation rigidifies the reaction systems, so that remote stereocenters position the ester-directing groups selectively over specific atoms of the TBTQ framework. Closely guided by computational design, a more selective through-space directing arm was first predicted with d. functional theory (DFT), and then confirmed in the laboratory, to outperform the initial structural design. This enantio- and regioselective TBTQ synthesis opens a new pathway to access building blocks for CAS.

Angewandte Chemie, International Edition published new progress about Aromatic compounds Role: PRP (Properties), SPN (Synthetic Preparation), PREP (Preparation) (tribenzotriquinacenes). 24347-63-5 belongs to class esters-buliding-blocks, and the molecular formula is C6H12O3, Recommanded Product: (S)-Methyl 2-hydroxy-3-methylbutanoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Osminski, Wynter E. G.; Lu, Zhenjie; Zhao, Wenjun; Mohammadlou, Aliakbar; Yin, Xiaopeng; Matthews, Emily C.; Canestraight, Virginia M.; Staples, Richard J.; Allen, Connor J.; Hirschi, Jennifer S.; Wulff, William D. published the artcile< Probing Catalyst Function - Electronic Modulation of Chiral Polyborate Anionic Catalysts>, SDS of cas: 623-50-7 , the main research area is aziridine synthesis aziridiation electronic modulation chiral polyborate catalyst.

Boroxinate complexes of VAPOL and VANOL are a chiral anionic platform that can serve as a versatile staging arena for asym. catalysis. The structural underpinning of the platform is a chiral polyborate core that covalently links together alcs. (or phenols) and vaulted biaryl ligands. The polyborate platform is assembled in situ by the substrate of the reaction, and thus a multiplex of chiral catalysts can be rapidly assembled from various alcs. (or phenols) and bis-phenol ligands for screening of catalyst activity. In the present study, variations in the steric and electronic properties of the phenol/alc. component of the boroxinate catalyst are probed to reveal their effects on the asym. induction in the catalytic asym. aziridination reaction. A Hammett study is consistent with a mechanism in which the two substrates are hydrogen-bonded to the boroxinate core in the enantiogenic step. The results of the Hammett study are supported by a computational study in which it is found that the H-O distance of the protonated imine hydrogen bonded to the anionic boroxinate core decreases with an increase in the electron releasing ability of the phenol unit incorporated into the boroxinate. The results are not consistent with a mechanism in which the boroxinate catalyst functions as a Lewis acid and activates the imine by a Lewis acid/Lewis base interaction.

Journal of Organic Chemistry published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 623-50-7 belongs to class esters-buliding-blocks, and the molecular formula is C4H8O3, SDS of cas: 623-50-7 .

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Shrestha, Bijay; Rose, Brennan T.; Olen, Casey L.; Roth, Aaron; Kwong, Adon C.; Wang, Yang; Denmark, Scott E. published the artcile< A Unified Strategy for the Asymmetric Synthesis of Highly Substituted 1,2-Amino Alcohols Leading to Highly Substituted Bisoxazoline Ligands>, Safety of (S)-Methyl 2-hydroxy-3-methylbutanoate, the main research area is amino alc branched asym synthesis acylation heterocyclization; oxazoline bis preparation; sulfinyl imine diastereoselective addition organolithium.

A general procedure for the asym. synthesis of highly substituted 1,2-amino alcs. I (R1 = R2 = Me, Ph; R1 = Me, i-Pr, Ph, R2 = H; R3 = 4-PhC6H4, 2,6-Me2C6H3, 2-pyridyl, etc.) in high yields and diastereoselectivity which uses organometallic additions of a wide range of nucleophiles to tert-butylsulfinimines as the key step is described. The addition of organolithium reagents to these imines follows a modified Davis model. The diastereoselectivity for this reaction depends significantly on both the nucleophile and electrophile. These highly substituted 1,2-amino alcs. were used to synthesize stereochem. diverse and structurally novel, polysubstituted 2,2′-methylene(bisoxazoline) ligands II (R4 = Me, 4-MeOC6H4CH2, 2-naphthylmethyl) in high yields.

Journal of Organic Chemistry published new progress about Amino alcohols, chiral Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 24347-63-5 belongs to class esters-buliding-blocks, and the molecular formula is C6H12O3, Safety of (S)-Methyl 2-hydroxy-3-methylbutanoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Nasiru, Mustapha Muhammad; Umair, Muhammad; Boateng, Evans Frimpong; Alnadari, Fawze; Khan, Kashif-ur Rehman; Wang, Zhaobin; Luo, Ji; Yan, Wenjing; Zhuang, Hong; Majrashi, Ali; Zhang, Jianhao; Korma, Sameh A. published the artcile< Characterisation of Flavour Attributes in Egg White Protein Using HS-GC-IMS Combined with E-Nose and E-Tongue: Effect of High-Voltage Cold Plasma Treatment Time>, Category: esters-buliding-blocks, the main research area is egg white protein cold plasma headspace gas chromatog; E-nose; E-tongue; PCA; PLS-DA; egg white protein; flavour; high-voltage cold plasma; volatile compounds.

Egg white protein (EWP) is susceptible to denaturation and coagulation when exposed to high temperatures, adversely affecting its flavor, thereby influencing consumers’ decisions. Here, we employ high-voltage cold plasma (HVCP) as a novel nonthermal technique to investigate its influence on the EWP’s flavor attributes using E-nose, E-tongue, and headspace gas-chromatog.-ion-mobilisation spectrometry (HS-GC-IMS) due to their rapidness and high sensitivity in identifying flavor fingerprints in foods. The EWP was investigated at 0, 60, 120, 180, 240, and 300 s of HVCP treatment time. The results revealed that HVCP significantly influences the odor and taste attributes of the EWP across all treatments, with a more significant influence at 60 and 120 s of HVCP treatment. Principal component analyses of the E-nose and E-tongue clearly distinguish the odor and taste sensors’ responses. The HS-GC-IMS anal. identified 65 volatile compounds across the treatments. The volatile compounds’ concentrations increased as the HVCP treatment time was increased from 0 to 300 s. The significant compounds contributing to EWP characterization include heptanal, ethylbenzene, ethanol, acetic acid, nonanal, heptacosane, 5-octadecanal, decanal, p-xylene, and octanal. Thus, this study shows that HVCP could be utilized to modify and improve the EWP flavor attributes.

Molecules published new progress about Cold plasmas (High-Voltage). 623-50-7 belongs to class esters-buliding-blocks, and the molecular formula is C4H8O3, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Jiang, Haiwei; Yan, Rongwei; Cai, Chang; Chen, Xingfan; Zhao, Fenghua; Fan, Liangliang; Xu, Chunbao Charles; Yang, Weiran published the artcile< Hydrothermal liquefaction of Cd-enriched Amaranthus hypochondriacus L. in ethanol-water co-solvent: Focus on low-N bio-oil and heavy metal/metal-like distribution>, Computed Properties of 623-50-7 , the main research area is hydrothermal liquefaction cadmium amaranthus hypochondriacus; ethanol water nitrogen bio oil heavy metal.

The high nitrogen content in bio-oil from protein-rich biomass will cause the possible pollution problems by NOX emissions during combustion. In this study, Cd-enriched Amaranthus hypochondriacus L. (AHL) was treated by hydrothermal liquefaction (HTL) in ethanol-water co-solvent aiming to reduce the nitrogen content of the bio-oil. Besides, aqueous phase recycling (APR) was applied to achieve a higher bio-oil yield. HTL in ethanol-water co-solvent with APR three times resulted in the maximum bio-oil yield (47.26%) and greatly reduced the nitrogenous compounds content of bio-oil. During the APR process, the increase of total nitrogen (TN) content in the aqueous phase indicated that organic-N in the organic phase transformed into NH+4 to the aqueous phase. Acetic acid (13.87-22.37 mg/mL) was dominated in the aqueous phase, leading to a low pH value (6.27-5.29), which could serve as the possible catalyst for the HTL process during APR that can be the reason for the higher bio-oil yield. After the HTL process, Cr, Cu, Cd and Pb remained mostly in bio-char while As was present largely in the aqueous phase. Thus, this study demonstrated that the APR for HTL process in ethanol-water co-solvent can be a hopeful method to dispose the high-protein biomass for improved bio-oil yield and quality.

Fuel published new progress about Alcohols Role: TEM (Technical or Engineered Material Use), USES (Uses). 623-50-7 belongs to class esters-buliding-blocks, and the molecular formula is C4H8O3, Computed Properties of 623-50-7 .

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Randolph, John T.; Voight, Eric A.; Greszler, Stephen N.; Uno, Brice E.; Newton, James N.; Gleason, Kenneth M.; Stolarik, DeAnne; Van Handel, Cecilia; Bow, Daniel A. J.; DeGoey, David A. published the artcile< Prodrug Strategies to Improve the Solubility of the HCV NS5A Inhibitor Pibrentasvir (ABT-530)>, Quality Control of 623-50-7 , the main research area is prodrug pibrentasvir solubility.

A research program to discover solubilizing prodrugs of the HCV NS5A inhibitor pibrentasvir (PIB) identified phosphomethyl analog 2 and trimethyl-lock (TML) prodrug 9. The prodrug moiety is attached to a benzimidazole nitrogen atom via an oxymethyl linkage to allow for rapid and complete release of the drug for absorption following phosphate removal by intestinal alk. phosphatase. These prodrugs have good hydrolytic stability properties and improved solubility compared to PIB, both in aqueous buffer (pH 7) and FESSIF (pH 5). TML prodrug 9 provided superior in vivo performance, delivering high plasma concentrations of PIB in PK studies conducted in mice, dogs, and monkeys. The improved dissolution properties of these phosphate prodrugs provide them the potential to simplify drug dosage forms for PIB-containing HCV therapy.

Journal of Medicinal Chemistry published new progress about Antiviral agents. 623-50-7 belongs to class esters-buliding-blocks, and the molecular formula is C4H8O3, Quality Control of 623-50-7 .

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Campbell, Joseph P.; Rajappan, Sinu C.; Jaynes, Tyler J.; Sharafi, Mona; Ma, Yong-Tao; Li, Jianing; Schneebeli, Severin T. published the artcile< Enantioselective Electrophilic Aromatic Nitration: A Chiral Auxiliary Approach>, Recommanded Product: (S)-Methyl 2-hydroxy-3-methylbutanoate, the main research area is tribenzotriquinacene preparation enantioselective electrophilic aromatic nitration chiral auxiliary; aromatic substitution; chiral auxiliaries; chirality; nitration; noncovalent interactions.

Enantioselective electrophilic aromatic nitration methodol. is needed to advance chirality-assisted synthesis (CAS). Reported here is an enantioselective aromatic nitration strategy operating with chiral diester auxiliaries, and it provides an enantioselective synthesis of a C3v-sym. tribenzotriquinacene (TBTQ). These axially-chiral structures are much sought-after building blocks for CAS, but they were not accessible prior to this work in enantioenriched form without resolution of enantiomers. This nitration strategy controls the stereochem. of threefold nitration reactions from above the aromatic rings with chiral diester arms. Dicarbonyl-to-arenium chelation rigidifies the reaction systems, so that remote stereocenters position the ester-directing groups selectively over specific atoms of the TBTQ framework. Closely guided by computational design, a more selective through-space directing arm was first predicted with d. functional theory (DFT), and then confirmed in the laboratory, to outperform the initial structural design. This enantio- and regioselective TBTQ synthesis opens a new pathway to access building blocks for CAS.

Angewandte Chemie, International Edition published new progress about Aromatic compounds Role: PRP (Properties), SPN (Synthetic Preparation), PREP (Preparation) (tribenzotriquinacenes). 24347-63-5 belongs to class esters-buliding-blocks, and the molecular formula is C6H12O3, Recommanded Product: (S)-Methyl 2-hydroxy-3-methylbutanoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Osminski, Wynter E. G.; Lu, Zhenjie; Zhao, Wenjun; Mohammadlou, Aliakbar; Yin, Xiaopeng; Matthews, Emily C.; Canestraight, Virginia M.; Staples, Richard J.; Allen, Connor J.; Hirschi, Jennifer S.; Wulff, William D. published the artcile< Probing Catalyst Function - Electronic Modulation of Chiral Polyborate Anionic Catalysts>, SDS of cas: 623-50-7 , the main research area is aziridine synthesis aziridiation electronic modulation chiral polyborate catalyst.

Boroxinate complexes of VAPOL and VANOL are a chiral anionic platform that can serve as a versatile staging arena for asym. catalysis. The structural underpinning of the platform is a chiral polyborate core that covalently links together alcs. (or phenols) and vaulted biaryl ligands. The polyborate platform is assembled in situ by the substrate of the reaction, and thus a multiplex of chiral catalysts can be rapidly assembled from various alcs. (or phenols) and bis-phenol ligands for screening of catalyst activity. In the present study, variations in the steric and electronic properties of the phenol/alc. component of the boroxinate catalyst are probed to reveal their effects on the asym. induction in the catalytic asym. aziridination reaction. A Hammett study is consistent with a mechanism in which the two substrates are hydrogen-bonded to the boroxinate core in the enantiogenic step. The results of the Hammett study are supported by a computational study in which it is found that the H-O distance of the protonated imine hydrogen bonded to the anionic boroxinate core decreases with an increase in the electron releasing ability of the phenol unit incorporated into the boroxinate. The results are not consistent with a mechanism in which the boroxinate catalyst functions as a Lewis acid and activates the imine by a Lewis acid/Lewis base interaction.

Journal of Organic Chemistry published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 623-50-7 belongs to class esters-buliding-blocks, and the molecular formula is C4H8O3, SDS of cas: 623-50-7 .

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics