Tag: M.W=100-150

Ferorelli, S.; Loiodice, F.; Tortorella, V.; Amoroso, R.; Bettoni, G.; Conte-Camerino, D.; De Luca, A. published the artcile< Isosteres of chiral clofibric acid analogs: synthesis, resolution, absolute configuration and HPLC detection of the optical purity>, COA of Formula: C5H10O3, the main research area is clofibric acid analog isostere preparation resolution; configuration absolute clofibric acid analog; resolution clofibric acid analog isostere.

Both racemic and enantiomeric forms of some isosteres of chiral clofibric acid analogs have been synthesized. Also, the absolute configuration has been established by chem. correlation and the optical purity determined by a simple HPLC procedure. The isosteric substitution of the ether oxygen atom of α-aryloxy alkanoic acids with sulfur, amino and methylene groups lead to compounds in which both biol. activity and stereoselectivity regarding chloride channel are highly reduced.

Farmaco published new progress about Absolute configuration. 73349-07-2 belongs to class esters-buliding-blocks, and the molecular formula is C5H10O3, COA of Formula: C5H10O3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Dongil, Ana B.; Bachiller-Baeza, Belen; Guerrero-Ruiz, Antonio; Rodriguez-Ramos, Inmaculada published the artcile< Graphite oxide as support for the immobilization of Ru-BINAP: Application in the enantioselective hydrogenation of methylacetoacetate>, Name: (R)-Methyl 2-hydroxybutanoate, the main research area is methyl acetoacetate hydrogenation catalyst modified graphite oxide support.

Graphite oxide (GO), previously functionalized with an alkoxysilane or with an isocyanate, and a chiral amine, was used as support for the immobilization of the homogeneous Ru-BINAP complex. The functionalized supports and the hybrid catalysts were characterized by XRD, NMR, TG, DRIFTS and XPS techniques. Among the hybrid catalysts the more active and enantioselective in the hydrogenation of Me acetoacetate is the sample prepared over the nonfunctionalized GO. The catalytic performance can be interpreted in terms of the metal complex interacting with the O functional groups or with the chiral amine at its different locations, anchored covalently onto the Cl pendant positions or via acid-base interaction at the O functional groups.

Catalysis Communications published new progress about Catalyst supports. 73349-07-2 belongs to class esters-buliding-blocks, and the molecular formula is C5H10O3, Name: (R)-Methyl 2-hydroxybutanoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Adam, Waldemar; Fell, Rainer T.; Hoch, Ute; Saha-Moeller, Chantu R.; Schreier, Peter published the artcile< Kinetic resolution of chiral α-hydroperoxy esters by horseradish peroxidase-catalyzed enantioselective reduction to α-hydroxy esters>, COA of Formula: C5H10O3, the main research area is kinetic resolution chiral hydroperoxy ester; horseradish peroxidase catalyzed enantioselective reduction; hydroxy ester.

The kinetic resolution of the Me α-hydroperoxy esters 4 has been investigated by horseradish peroxidase (HRP)-catalyzed reduction to the corresponding optically active α-hydroxy esters 5 in the presence of guaiacol. The method allows for the first time the preparation of enantiomerically pure (ee > 97%) Me (R)-2-hydroperoxybutyrate (4a). The HRP enzyme is sensitive to the steric demand of the ester alkyl side chain, as manifested by Et (ee > 97%) and iso-Pr (ee 79%), while the tert-Bu derivative is not accepted by the enzyme (no reduction).

Tetrahedron: Asymmetry published new progress about Chiral recognition. 73349-07-2 belongs to class esters-buliding-blocks, and the molecular formula is C5H10O3, COA of Formula: C5H10O3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Patel, Meena V.; Peltier, Hillary M.; Matulenko, Mark A.; Koenig, John R.; C. Scanio, Marc J.; Gum, Rebecca J.; El-Kouhen, Odile F.; Fricano, Meagan M.; Lundgaard, Greta L.; Neelands, Torben; Zhang, Xu-Feng; Zhan, Cenchen; Pai, Madhavi; Ghoreishi-Haack, Nayereh; Hudzik, Thomas; Gintant, Gary; Martin, Ruth; McGaraughty, Steve; Xu, Jun; Bow, Daniel; Kalvass, John C.; Kym, Philip R.; DeGoey, David A.; Kort, Michael E. published the artcile< Discovery of (R)-(3-fluoropyrrolidin-1-yl)(6-((5-(trifluoromethyl)pyridin-2-yl)oxy)quinolin-2-yl)methanone (ABBV-318) and analogs as small molecule Nav1.7/ Nav1.8 blockers for the treatment of pain>, COA of Formula: C4H8O3, the main research area is quinoline preparation sodium channel blocker SAR pharmacokinetic.

An effort to identify selective, CNS-penetrant Nav1.7 blockers with oral activity, improved selectivity, good drug-like properties, and safety led to the discovery of 2-substituted quinolines I [R = piperazine-1-carbonyl, cyclobutylcarbamoyl, 2-oxo-2-(1-piperidyl)ethoxy, etc.; R1 = 4-NCC6H4, 2-pyridyl, 5-(trifluoromethyl)-2-pyridyl, etc.] and quinolones II [R2 = 4-NCC6H4, 4-NCC6H4O; R3 = 1-piperidylmethyl, 1-piperidylmethyl] as potent small mol. Nav1.7 blockers. The design of these mols. focused on maintaining potency at Nav1.7, improving selectivity over the hERG channel, and overcoming phospholipidosis observed with the initial leads. The structure-activity relationship (SAR) studies leading to the discovery of compound I [R = (3R)-3-fluoropyrrolidine-1-carbonyl, R1 = 5-(trifluoromethyl)-2-pyridyl] were described herein. The compound I [R = (3R)-3-fluoropyrrolidine-1-carbonyl, R1 = 5-(trifluoromethyl)-2-pyridyl] displayed robust in vivo efficacy in both inflammatory and neuropathic rodent models of pain. The compound I [R = (3R)-3-fluoropyrrolidine-1-carbonyl, R1 = 5-(trifluoromethyl)-2-pyridyl] also inhibited Nav1.8, another sodium channel isoform that was an active target for the development of new pain treatments.

Bioorganic & Medicinal Chemistry published new progress about Amides Role: PAC (Pharmacological Activity), PKT (Pharmacokinetics), RCT (Reactant), SPN (Synthetic Preparation), THU (Therapeutic Use), BIOL (Biological Study), RACT (Reactant or Reagent), PREP (Preparation), USES (Uses). 623-50-7 belongs to class esters-buliding-blocks, and the molecular formula is C4H8O3, COA of Formula: C4H8O3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Portnova, Svetlana V.; Kuzmina, Natalia S.; Yamshchikova, Yulia F.; Krasnykh, Eugene L. published the artcile< Density and Viscosity of Glycolic, Lactic, and Malic Acid Esters>, Quality Control of 623-50-7 , the main research area is density kinematic viscosity aliphatic ester glycolic lactic malic acid.

Densities and viscosities were measured as a function of temperature for 12 esters of glycolic, DL-lactic, and DL-malic acids and linear chain alcs. C1-C5. The d. and kinematic viscosity were obtained using a pycnometer and a Pinkevitch capillary viscometer in a temperature range of 293.15-363.15 K with accuracies of 0.1 and 0.35%, resp. The obtained data were used for dynamic viscosity calculation It was demonstrated that the viscosity-temperature dependence of esters was described by the ASTM D341 model with an average absolute relative deviation of 1%. The temperature dependence of dynamic viscosity was fitted using the Arrhenius-like equation and Vogel-Fulcher-Tammann (VFT) model. It was found that the adjustable parameters A and B have the similar value for compounds in one homologous series. These parameters were taken as constant for each series of esters of the corresponding acids. The dynamic viscosity-temperature dependence of esters was better described by the VFT model than the Arrhenius-like equation. The capabilities of some group-additivity methods for predicting d. have been reviewed and compared with exptl. results.

Journal of Chemical & Engineering Data published new progress about Aliphatic diesters Role: PEP (Physical, Engineering or Chemical Process), PRP (Properties), SPN (Synthetic Preparation), PROC (Process), PREP (Preparation). 623-50-7 belongs to class esters-buliding-blocks, and the molecular formula is C4H8O3, Quality Control of 623-50-7 .

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Fernandes, Alessandra A. G.; Leonarczyk, Ives A.; Ferreira, Marco A. B.; Dias, Luiz Carlos published the artcile< Diastereoselectivity in the boron aldol reaction of α-alkoxy and α,β-bis-alkoxy methyl ketones>, Recommanded Product: (S)-Methyl 2-hydroxy-3-methylbutanoate, the main research area is diastereoselective boron aldol alkoxy Me ketone synthesis DFT.

In this work, using DFT calculations, we investigated the 1,4 and 1,5 asym. induction in boron enolate aldol reactions of α-alkoxy and α,β-bisalkoxy Me ketones. We evaluated the steric influence of alkyl substituents at the α position and the stereoelectronic influence of the oxygen protecting groups at the α and β positions. Theor. calculations revealed the origins of the 1,4 asym. induction in terms of the nature of the β-substituent. The synergistic effect between the α,β-syn and α,β-anti-bisalkoxy stereocenters was elucidated. In the presence of the β-alkoxy center, the reaction proceeds through the Goodman-Paton 1,5-stereoinduction model, experiencing a minor influence of the α-alkoxy center.

Organic & Biomolecular Chemistry published new progress about Aldol addition, stereoselective. 24347-63-5 belongs to class esters-buliding-blocks, and the molecular formula is C6H12O3, Recommanded Product: (S)-Methyl 2-hydroxy-3-methylbutanoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Liu, Aiyao; Liu, Jiang; Mei, Haibo; Roschenthaler, Gerd-Volker; Han, Jianlin published the artcile< Selectfluor-promoted twofold sulfination of alcohols for synthesis of sulfinic ester from diaryldisulfides>, Category: esters-buliding-blocks, the main research area is diaryl disulfide alc Selectfluor oxidative sulfination; alkyl arylsulfinate preparation.

An oxidative two-fold sulfination of alc. with Selectfluor as an efficient oxidant was developed. This reaction proceeded smoothly achieving the unprecedented sulfination transformation of varieties of diaryldisulfides and alcs. under simple conditions, affording the corresponding sulfinic esters in excellent yields. The current reaction provided a new and convenient strategy for the preparation of sulfinic esters.

Youji Huaxue published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 623-50-7 belongs to class esters-buliding-blocks, and the molecular formula is C4H8O3, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Battistelli, Noemi; Perpetuini, Giorgia; Piva, Andrea; Pepe, Alessia; Sidari, Rossana; Wache, Yves; Tofalo, Rosanna published the artcile< Cultivable microbial ecology and aromatic profile of ""mothers"" for Vino cotto wine production>, Reference of 623-50-7 , the main research area is Vino cotto wine microbial ecol aromatic profile; Acetic acid bacteria; Aroma compounds; Lactic acid bacteria; Osmotolerant yeast; Vino cotto.

The aim of the present study was to assess the cultivable microbiota of “”mothers”” of Vino cotto collected from production of different years 1890, 1895, 1920, 1975, 2008. A total of 73 yeasts and 81 bacteria were isolated. Starmerella lactis-condensi, Starmerella bacillaris, Hanseniaspora uvarum, Saccharomyces cerevisiae, Hanseniaspora guillermondi and Metschnikowia pulcherrima were identified. Bacteria isolates belonged to lactic acid bacteria (Lactiplantibacillus plantarum and Pediococcus pentosaceus) and acetic acid bacteria (Gluconobacter oxydans). Remarkable biodiversity was observed for Starm. bacillaris, as well as L. plantarum and G. oxydans. Organic acids and volatile compounds were also determined Malic and succinic acids were the main ones with values ranging from 8.49 g/L to 11.76 g/L and from 4.15 g/L to 7.73 g/L resp., while citric acid was present at low concentrations (<0.2 g/L) in all samples. Esters and higher alcs. were the main volatile compounds detected followed by alkanes. This study permits to better understand the microbial communities associated to this product and could be considered a starting point for the definition of tailored starter cultures to improve the quality of Vino cotto preserving its typical traits. Food Research International published new progress about Gluconobacter oxydans. 623-50-7 belongs to class esters-buliding-blocks, and the molecular formula is C4H8O3, Reference of 623-50-7 .

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Reyes, Laura; Nikitine, Clemence; Vilcocq, Lea; Fongarland, Pascal published the artcile< Autocatalyzed and heterogeneously catalyzed esterification kinetics of glycolic acid with ethanol>, Quality Control of 623-50-7 , the main research area is glycolic acid ethanol amberlyst catalyst esterification kinetics.

The chem. equilibrium and reaction kinetics in homogeneously and heterogeneously catalyzed systems were investigated for the reversible esterification reaction of glycolic acid with ethanol. In a first approach, the thermodn. equilibrium of the reaction was established for temperatures between 50°C and 75°C. To differentiate catalytic from homogeneous contribution, the esterification was first studied without a catalyst and the data obtained were then used to model the autocatalyzed homogeneous reaction kinetics. The impact of different com. solid catalysts such as zeolites, oxides and ion exchange resins on the esterification reaction was also investigated. For the latter, the amount of total acid sites was quantified in order to correlate this parameter to the reaction rate and glycolic acid conversion. Finally, the effects of catalyst loading, temperature, presence of water and recyclability were examined for the most efficient catalyst, Amberlyst 70. Moreover, a kinetic adjustment of the exptl. results was carried out by fitting the data to a pseudo-homogeneous model and comparing to adsorption-based models.

Reaction Chemistry & Engineering published new progress about Activation energy. 623-50-7 belongs to class esters-buliding-blocks, and the molecular formula is C4H8O3, Quality Control of 623-50-7 .

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Nasiru, Mustapha Muhammad; Umair, Muhammad; Boateng, Evans Frimpong; Alnadari, Fawze; Khan, Kashif-ur Rehman; Wang, Zhaobin; Luo, Ji; Yan, Wenjing; Zhuang, Hong; Majrashi, Ali; Zhang, Jianhao; Korma, Sameh A. published the artcile< Characterisation of Flavour Attributes in Egg White Protein Using HS-GC-IMS Combined with E-Nose and E-Tongue: Effect of High-Voltage Cold Plasma Treatment Time>, Category: esters-buliding-blocks, the main research area is egg white protein cold plasma headspace gas chromatog; E-nose; E-tongue; PCA; PLS-DA; egg white protein; flavour; high-voltage cold plasma; volatile compounds.

Egg white protein (EWP) is susceptible to denaturation and coagulation when exposed to high temperatures, adversely affecting its flavor, thereby influencing consumers’ decisions. Here, we employ high-voltage cold plasma (HVCP) as a novel nonthermal technique to investigate its influence on the EWP’s flavor attributes using E-nose, E-tongue, and headspace gas-chromatog.-ion-mobilisation spectrometry (HS-GC-IMS) due to their rapidness and high sensitivity in identifying flavor fingerprints in foods. The EWP was investigated at 0, 60, 120, 180, 240, and 300 s of HVCP treatment time. The results revealed that HVCP significantly influences the odor and taste attributes of the EWP across all treatments, with a more significant influence at 60 and 120 s of HVCP treatment. Principal component analyses of the E-nose and E-tongue clearly distinguish the odor and taste sensors’ responses. The HS-GC-IMS anal. identified 65 volatile compounds across the treatments. The volatile compounds’ concentrations increased as the HVCP treatment time was increased from 0 to 300 s. The significant compounds contributing to EWP characterization include heptanal, ethylbenzene, ethanol, acetic acid, nonanal, heptacosane, 5-octadecanal, decanal, p-xylene, and octanal. Thus, this study shows that HVCP could be utilized to modify and improve the EWP flavor attributes.

Molecules published new progress about Cold plasmas (High-Voltage). 623-50-7 belongs to class esters-buliding-blocks, and the molecular formula is C4H8O3, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics