Tag: M.W=100-150

Leng, Yan published the artcileA tannin-derived zirconium-containing porous hybrid for efficient Meerwein-Ponndorf-Verley reduction under mild conditions, Related Products of esters-buliding-blocks, the main research area is reusable zirconium tannin complex catalyst preparation property; carbonyl compound zirconium Meerwein Ponndorf Verley reduction green chem; alc preparation.

Tannins were simply assembled with zirconium in water for the scalable preparation of a heterogeneous zirconium-tannin hybrid catalyst (Zr-tannin) was studied. Various characterizations demonstrated the formation of robust porous inorganic-organic frameworks and strong Lewis acid-base sites in Zr-tannin. The cooperative effect of these acid-base sites and the abundant porosity endowed Zr-tannin with a remarkable catalytic performance for the MPV reduction of a broad range of carbonyl compounds to alcs. with 2-propanol under mild conditions. Moreover, Zr-tannin exhibited good recyclability for at least five reaction cycles. This novel strategy using tannins as the raw materials to construct heterogeneous catalytic materials may have a huge potential for green chem. synthesis due to low cost, nontoxicity, and sustainability.

Green Chemistry published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 539-88-8 belongs to class esters-buliding-blocks, name is Ethyl 4-oxopentanoate, and the molecular formula is C7H12O3, Related Products of esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chen, Yuxin published the artcileDirect use of the solid waste from oxytetracycline fermentation broth to construct Hf-containing catalysts for Meerwein-Ponndorf-Verley reactions, Safety of Ethyl 4-oxopentanoate, the main research area is hafnium based oxytetracycline fermentation broth residue catalyst preparation; alc green preparation; biomass derived carbonyl compound hafnium catalyst Meerwein Ponndorf Verley.

In this study, a novel route of using oxytetracycline fermentation broth residue (OFR) was proposed that OFR was used as the organic ligands to construct a new hafnium based catalyst (Hf-OFR) for Meerwein-Ponndorf-Verley (MPV) reactions of biomass-derived platforms. The acidic groups in OFR were used to coordinate with Hf4+, and the carbon skeleton structures in OFR were used to form the spatial network structures of the Hf-OFR catalyst. The results showed that the synthesized Hf-OFR catalyst could catalyze the MPV reduction of various carbonyl compounds under relatively mild reaction conditions, with high conversions and yields. Besides, the Hf-OFR catalyst could be recycled at least 5 times with excellent stability in activity and structures. The prepared Hf-OFR catalyst possesses the advantages of high efficiency, a simple preparation process, and low cost in ligands. The proposed strategy of constructing catalysts using OFR might be provide new routes for both valuable utilization of the OFR solid waste in the fermentation industry and the construction of efficient catalysts for biomass conversion.

RSC Advances published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 539-88-8 belongs to class esters-buliding-blocks, name is Ethyl 4-oxopentanoate, and the molecular formula is C7H12O3, Safety of Ethyl 4-oxopentanoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Xiaomin published the artcileA novel hafnium-graphite oxide catalyst for the Meerwein-Ponndorf-Verley reaction and the activation effect of the solvent, Application In Synthesis of 539-88-8, the main research area is hafnium graphite oxide catalyst preparation; alc preparation; carbonyl compound Meerwein Ponndorf Verley hydrogenation hafnium graphite oxide.

A novel, efficient, and easily prepared hafnium-graphite oxide (Hf-GO) catalyst was constructed via the coordination between Hf4+ and the carboxylic groups in GO. Prepared catalyst was aplied for synthesis of alcs., e.g., I via hydrogenation of biomass derived carbonyl compounds using Meerwein-Ponndorf-Verley (MPV) reaction. The catalyst gave high efficiency under mild conditions. An interesting phenomenon was found whereby the activity of the catalyst increased gradually in the initial stage during reaction. The solvent, isopropanol, was proved to have an activation effect on the catalyst, and the activation effect varied with different alcs. and temperatures Further characterizations showed that isopropanol played the activation effect via replacing the residual solvent (DMF) in micro- and mesopores during the preparation process, which was hard to be completely removed by common drying process.

RSC Advances published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 539-88-8 belongs to class esters-buliding-blocks, name is Ethyl 4-oxopentanoate, and the molecular formula is C7H12O3, Application In Synthesis of 539-88-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kumaravel, Sakthivel published the artcileRu/TiO2 nanostructured catalysts: synthesis, characterization and catalytic activity towards hydrogenation of ethyl levulinate, Product Details of C7H12O3, the main research area is ruthenium titania ethyl levulinate catalyst hydrogenation nanostructure.

Pristine TiO2 and x% Ru/TiO2 catalysts with different weight% of Ru (x%= 1.5%, 2%, 2.5% and 3%) were synthesized using sol-gel and simple impregnation methods. Different characterization techniques such as X-ray diffraction (XRD), Fourier transform IR spectroscopy (FT-IR), SEM (SEM), High-resolution transmission electron microscope (HR-TEM), Inductively coupled plasma-optical emission spectrometry (ICP-OES) and Thermogravimetry/DTA (TG/DTA) were used to study the physicochem. and morphol. properties. The XRD patterns of the as-prepared pristine TiO2 catalyst showed high crystalline nature. The HR-TEM images revealed that the Ru nanoparticles (NPs) were evenly dispersed on the TiO2 surface. The prepared catalysts were evaluated for their catalytic activity towards the liquid phase hydrogenation of Et levulinate under mild reaction conditions (ambient H2 pressure). Among the various catalysts, 2.5% Ru/TiO2 catalyst showed the maximum catalytic activity of 79% Et levulinate (EL) conversion with 82% selectivity of γ-valerolactone (GVL). The recyclability test revealed that the most active 2.5% Ru/TiO2 also showed the highest stability of the catalyst under optimized exptl. conditions.

Journal of Nanoscience and Nanotechnology published new progress about Attenuated-total-reflectance Fourier-transform IR spectroscopy. 539-88-8 belongs to class esters-buliding-blocks, name is Ethyl 4-oxopentanoate, and the molecular formula is C7H12O3, Product Details of C7H12O3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Lei published the artcileSynthesis and antibacterial evaluation of novel 1,3,4-oxadiazole derivatives containing sulfonate/carboxylate moiety, Synthetic Route of 623-50-7, the main research area is sulfonate carboxylate oxadiazole preparation agrochem antibacterial activity; 1,3,4-oxadiazole derivatives; antibacterial activity; scanning electron microscopy; xanthomonas axonopodis pv. Citri; xanthomonas oryzae pv. oryzae.

Novel sulfonate/carboxylate functionalized 1,3,4-oxadiazole derivatives I (R1 = Me, Et, 2-fluoroethyl; R2 = Ph, 2-fluorophenyl, 4-chlorophenyl, etc.) and II [R1 = Me; R3 = Ph, 4-bromophenyl, N(CH3)2, etc.] were synthesized and evaluated for their antibacterial activities. Antibacterial activity against two phytopathogens, Xanthomonas oryzae pv. oryzae (Xoo) and Xanthomonas axonopodis pv. citri (Xac), was assayed in vitro. The preliminary results indicated that ten compounds including I [R1 = Ph, R2 = Me (A); R1 = 4-fluorophenyl, R2 = Me (B); R1 = 4-chlorophenyl, R2 = Me (C); R1 = 4-bromophenyl, R2 = Me (D); R1 = 4-fluorophenyl, R2 = Et; R1 = 4-chlorophenyl, R2 = Et; R1 = 4-bromophenyl, R2 = Et; R1 = 4-fluorophenyl, R2 = 2-fluoroethyl; R1 = 4-chlorophenyl, R2 = 2-fluoroethyl; R1 = 4-bromophenyl, R2 = 2-fluoroethyl] had good antibacterial activity against Xoo, with EC50 values ranging from 50.1-112.5μM, which was better than those of Bismerthiazol (253.5μM) and thiadiazole copper (467.4μM). Meanwhile, compounds(A), (B), (C), (D) demonstrated good inhibitory effect against Xanthomonas axonopodis pv. citri with EC50 values around 95.8-155.2μM which were better than those of bismerthiazol (274.3μM) and thiadiazole copper (406.3μM). In addition, in vivo protection activity of compounds (B), (C) against rice bacterial leaf blight was 68.6% and 62.3%, resp., which were better than bismerthiazol (49.6%) and thiadiazole copper (42.2%). Curative activity of compounds (B), (C) against rice bacterial leaf blight was 62.3% and 56.0%, which were better than bismerthiazol (42.9%) and thiadiazole copper (36.1%). Through SEM (SEM) anal., it was observed that compound (B) caused the cell membrane of Xanthomonas oryzae pv. oryzae ruptured or deformed. The present results indicated novel derivatives of 4-Ph sulfonate Me 1,3,4-oxadiazole I might be potential antibacterial agents.

Molecules published new progress about Acid chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 623-50-7 belongs to class esters-buliding-blocks, name is Ethyl 2-hydroxyacetate, and the molecular formula is C4H8O3, Synthetic Route of 623-50-7.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chen, Yuxin published the artcileA novel and efficient N-doping carbon supported cobalt catalyst derived from the fermentation broth solid waste for the hydrogenation of ketones via Meerwein-Ponndorf-Verley reaction, Recommanded Product: Ethyl 4-oxopentanoate, the main research area is ketone hydrogenation oxytetracycline fermentation residue carbon nitrogen cobalt catalyst.

Most of the non-noble metal catalysts used for the Meerwein-Ponndorf-Verley (MPV) reaction of carbonyl compounds rely on the addnl. alk. additives during preparation to achieve high efficiency. To solve this problem, in this work, we prepared a novel N-doped carbon supported cobalt catalyst (Co@CN), in which the carriers were derived from the nitrogen-rich organic waste, i.e., oxytetracycline fermentation residue (OFR, obtained from oxytetracycline refining workshop). No addnl. nitrogen sources were used during preparation The results showed that inherent nitrogen in OFR could provide N-containing basic sites, and formed Co-N structures via coordinating with cobalt. The Co-N sites together with the coexisting Co(0) cooperated to catalyze the conversion of Et levulinate (EL) to γ-valerolactone (GVL) by MPV reaction. Co(0) dominated the activation of H in isopropanol, while Co-N dominated the formation of the six-membered ring transition state.

Applied Catalysis, A: General published new progress about Alcohols Role: IMF (Industrial Manufacture), PREP (Preparation). 539-88-8 belongs to class esters-buliding-blocks, name is Ethyl 4-oxopentanoate, and the molecular formula is C7H12O3, Recommanded Product: Ethyl 4-oxopentanoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Bin-Shi published the artcileRh(III)-Catalyzed three-component C-H functionalization reaction with vinylene carbonate: Late-stage C-H esterification of indole derivatives, Application In Synthesis of 623-50-7, the main research area is azaarenylindole vinylene carbonate alc rhodium tandem three component esterification; indolyl acetate preparation regioselective.

An efficient and robust Rh(III)-catalyzed three-component C-H esterification reaction of indole derivatives with vinylene carbonate to access indolyl acetates was developed. This protocol exhibited high efficiency, good yields and excellent functional group tolerance. Significantly, this method provided a powerful approach for the late-stage modification of indole-based substrates and natural alcs.

Tetrahedron Letters published new progress about Acetates Role: SPN (Synthetic Preparation), PREP (Preparation). 623-50-7 belongs to class esters-buliding-blocks, name is Ethyl 2-hydroxyacetate, and the molecular formula is C4H8O3, Application In Synthesis of 623-50-7.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhao, Wenfeng published the artcileAmmonia borane enabled upgrading of biomass derivatives at room temperature, Formula: C7H12O3, the main research area is ammonia borane enabled upgrading biomass derivative room temperature.

Simplifying biomass conversion to valuable products with high efficiency is pivotal for the sustainable development of society. Herein, an efficient catalyst-free system using ammonia borane (AB) as the hydrogen donor is described, which enables controllable reaction selectivity towards four value-added products in excellent yield (82-100%) under very mild conditions. In particular, the system is uniquely efficient to produce γ-valerolactone (GVL) at room temperature Combined in situ NMR and computational studies elucidate the hydrogen transfer mechanism of AB in methanol, the novel pathway of GVL formation from levulinate in water, and a competitive mechanism between reduction and reductive amination in the same system. Moreover, carbohydrates are converted directly into GVL in good yield, using a one-pot, two-step strategy. Products of a rather broad scope are prepared within a short reaction time of 30 min by using this catalyst-free strategy in methanol at room temperature

Green Chemistry published new progress about Beta zeolites Role: CAT (Catalyst Use), USES (Uses) (Sn-containing). 539-88-8 belongs to class esters-buliding-blocks, name is Ethyl 4-oxopentanoate, and the molecular formula is C7H12O3, Formula: C7H12O3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xu, Wen-Yan published the artcileTransition-Metal-Free Valorization of Biomass-derived Levulinic Acid Derivatives: Synthesis of Curcumene and Xanthorrhizol, Computed Properties of 539-88-8, the main research area is valorization biomass levulinic acid curcumene xanthorrhizol methyltetralone synthesis; biomass conversion; levulinic acid derivatives; rac-curcumene; rac-xanthorrhizol; tosylhydrazone.

Levulinic acid (LA) is acknowledged one of the most promising biomass-derived platform mols. and can be transformed into various value-added chems. Here, we report a new reaction process for the valorization of LA derivatives under transition-metal-free condition. The protocol combined with the conversion of the levulinate to tosylhydrazone and base promoted arylation, acylation, and etherification cross-coupling. Moreover, our method was applied to synthesize three biol. active mols., rac-curcumene (I), rac-xanthorrhizol synthetic precursor (II), and rac-4,7-dimethyl-α-tetralone (III). This reaction discloses a new avenue for the high-value utilization of platform mols.

ChemSusChem published new progress about Acylation (acylation of tosylhydrazones with furancarboxaldehydes). 539-88-8 belongs to class esters-buliding-blocks, name is Ethyl 4-oxopentanoate, and the molecular formula is C7H12O3, Computed Properties of 539-88-8.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bermejo, Almudena published the artcileSynthesis of benzopyran derivatives as PPARα and/or PPARγ activators, Product Details of C7H12O3, the main research area is peroxisome proliferator receptor alpha gamma structure activity benzopyran; alkyl hydroxy benzopyran preparation PPARalpha PPARgamma activator lipophilicity; Benzopyrans; PPARα agonism; PPARγ agonism; Polycerasoidol.

The authors describe the synthesis of benzopyran derivatives I [R = n-pentyl, 3-hydroxy-1-Bu, 3-ethoxy-3-oxo-Pr, etc.; R1 = hydroxy, acetoxy; R2 = H, chloro] and II [R3 = hydroxy, n-propyloxy; R4 = H, hydroxy; R5 = 2-carboxyethyl, 4-methylpent-3-enyl, 3-methoxy-3-oxo-Pr, etc.], small polycerasoidol analogs, that are Lipinski’s rule-of-five compliant. In order to confirm key structural features to activate PPARα and/or PPARγ, the authors have adopted structural modifications in the following parts: (i) the benzopyran core (hydrophobic nucleus) by benzopyran-4-one, dihydrobenzopyran or benzopyran-4-ol; (ii) the side chain at the 2-position by shortening to C3, C4 and C5-carbons vs. C-9-carbons of polycerasoidol; and (iii) the carboxylic group (polar head) by oxygenated groups (hydroxyl, acetoxy, epoxide, ester, aldehyde) or non-oxygenated motifs (allyl and alkyl). Benzopyran-4-ones I [R = 3-ethoxy-3-oxo-Pr, 3-hydroxybutyl, 3-hydroxy-3-methylbutyl, R1 = hydroxy, R2 = H; R = 3-acetoxybutyl, R1 = acetoxy, R2 = H] as well as dihydrobenzopyrans II [R3 = hydroxy, R4 = H, R5 = 3-methylbut-3-enyl, 2-carboxyethyl, 3-methoxy-3-oxopropyl] were able to activate hPPARα, whereas benzopyran-4-one I [R = n-pentyl, R1 = hydroxy, R2 = chloro] with C5-carbons in the side chain exhibited hPPARγ agonism. According to our previous docking studies, structure-activity studies confirmed that the hydrophobic nucleus (benzopyran-4-one or dihydrobenzopyran) was essential to activated PPARα and/or PPARγ and the flexible linker (side alkyl chain) should contain at least C5-carbon atoms to activate PPARγ. By contrast, the polar head (“”carboxylic group””) tolerated several oxygenated groups but also non-oxygenated motifs. Taking into account these key structural features, small polycerasoidol analogs might provide potential active mols. useful in the treatment of dyslipidemia and/or type 2 diabetes.

Bioorganic & Medicinal Chemistry published new progress about Aliphatic ketones Role: RCT (Reactant), RACT (Reactant or Reagent). 539-88-8 belongs to class esters-buliding-blocks, name is Ethyl 4-oxopentanoate, and the molecular formula is C7H12O3, Product Details of C7H12O3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics