Tag: M.W=100-150

El-Abadelah, Mustafa M. published the artcileHeterocycles [h]-fused onto 4-oxoquinoline-3-carboxylic acid. Part XII: synthesis of 5-fluoro-7-oxodihydro[1,3,4]thiadiazino[5,6-h]quinoline-8-carboxylic acid and ester, Formula: C7H13NO2, the publication is Zeitschrift fuer Naturforschung, B: A Journal of Chemical Sciences (2018), 73(1), 23-28, database is CAplus.

Direct interaction of dithizone with 7-chloro-6-fluoro-8-nitro-4-oxoquinoline-3-carboxylic acid and its ester delivered the corresponding novel 1,3,4-thiadiazino[5,6-h]quinoline-3-carboxylic acid and its ester I [R = H, Et] resp., alternatively latter ester derivative I [R = Et] was hydrolyzed to its acid derivative I [R = H]. Structures of the latter tricyclic hybrids I [R = H, Et] were deduced from anal. and spectral data and confirmed by single crystal X-ray structure determination of the compound I [R = Et]. The synthesized title compounds I [R = H, Et] were evaluated for antibacterial activity against Staphylococcus aureus ATCC 6538 and Escherichia coli ATCC 8739, antifungal activity against Candida albicans. Compound I [R = H] showed moderate activity against Staphylococcus aureus with a MIC value of 25 μg mL^-1 and compounds I [R = H, Et] were inactive against Candida albicans.

Zeitschrift fuer Naturforschung, B: A Journal of Chemical Sciences published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, Formula: C7H13NO2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Saijo, Naoya published the artcileSuccessful treatment with dimethyl fumarate in a child with relapsing-remitting multiple sclerosis., Computed Properties of 624-49-7, the publication is Brain & development (2022), 44(5), 353-356, database is MEDLINE.

INTRODUCTION: Early disease control with disease-modifying drugs is important for improving the prognosis of multiple sclerosis (MS) in children. Dimethyl fumarate (DMF) is an oral disease-modifying drug for MS in adults with relatively stable disease; however, its use in young children has not been heavily documented in the current literature. We report the case of a pediatric patient with relapsing-remitting MS who was treated with DMF. CASE REPORT: A 3-year-old boy with a history of common cold symptoms developed unsteadiness and somnolence. Magnetic resonance imaging revealed multiple white matter lesions. Symptoms were recurrent, and DMF was prescribed at 6 years of age due to a relapse episode with oculomotor disability and facial paralysis. However, disease progression continued, and new lesions were noted at age 7; thus, the dose of DMF was increased to 240 mg/day. No relapse has been observed for over three years; sequelae or severe side effects were absent. CONCLUSIONS: DMF may be a useful oral disease-modifying drug for preventing recurrence in young children with MS.

Brain & development published new progress about 624-49-7. 624-49-7 belongs to esters-buliding-blocks, auxiliary class Inhibitor,Natural product, name is Dimethyl fumarate, and the molecular formula is C6H8O4, Computed Properties of 624-49-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Samir, Eman M.; Mohareb, Rafat M. published the artcile< Novel synthesis of pyran-3-hydrazide derivatives and their uses to the synthesis hydrazide-hydrazone, pyrazole and thiazole derivatives with anticancer activities>, Synthetic Route of 623-50-7 , the main research area is hydrazone pyrazole thiazole pyran hydrazide derivative anticancer activity.

The multi-component reaction of Et acetoacetate with each of malononitrile (3) benzaldehyde (1) in ethanol containing triethylamine gave the Et 6-amino-5-cyano-2-methyl-4-phenyl-4H-pyran-3-carboxylate (4). The latter compound reacted with hydrazine hydrate to give the hydrazide derivative 6. Compound 6 underwent a series of hetero-cyclization reactions to give pyrzole, hydraide-hydrazone, thiazole derivatives The produced compounds tested against cancer cell lines six cancer cell lines and showed that compounds 8b, 10b, 11a, 17a, 21 and 24a were the most cytotoxic compounds Further tests of the latter compounds toward the five tyrosine kinases and Pim-1 kinase showed that compounds 10b, 21 and 24a were the most potent of the tested compounds and compounds 10a, 11a and 17a were of the highest inhibitions toward Pim-1 kinase. The high inhibitions of most of the tested compounds toward the selected cancer cell lines and the tyrosine kinases encourage for future work to be done.

Bulletin of the Chemical Society of Ethiopia published new progress about Antitumor agents. 623-50-7 belongs to class esters-buliding-blocks, and the molecular formula is C4H8O3, Synthetic Route of 623-50-7 .

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kim, Seong Ju; Um, Byung Hwan published the artcile< Effect of thermochemically fractionation before hydrothermal liquefaction of herbaceous biomass on biocrude characteristics>, Formula: C4H8O3, the main research area is Miscanthus kenaf phenol hydrothermal liquefaction high performance liquid chromatog.

Hydrothermal liquefaction (HTL) of fractionated two types herbaceous biomass (kenaf and miscanthus) by dilute acid, organosolv, alk., or demineralization process was carried out under ethanol water co-solvent at 350°C for 30 min to examine the biocrude yield and characteristics. The biocrude properties were comprehensively characterized by HPLC, elemental, GC-MS, and TGA anal. Fractionation technologies before HTL effectively increased biocrude yield up to 38% compared to that of untreated herbaceous biomass (31%), except for organosolv fractionation of miscanthus, especially, HTL after alk. fractionation showed high yield and energy recovery ratio up to 70%. Elemental anal. showed that HHV of biocrude was neg. affected by hydrolysis reaction of high lignin content after dilute acid fractionation. The GC-MS anal. revealed that carbohydrates-derived compound significantly increased in the biocrude obtained after organosolv and alk. fractionation due to holocellulose increases through fractionation process. Addnl., TGA results indicated that the ratio of high-boiling-point compounds in biocrude obtained after demineralization was expanded compared with untreated due to ash removal, which could act as a catalyst.

Renewable Energy published new progress about Biodiesel fuel. 623-50-7 belongs to class esters-buliding-blocks, and the molecular formula is C4H8O3, Formula: C4H8O3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Eliel, Ernest L.; Pietrusiewicz, K. Michal published the artcile< Conformational analysis. Part XLI. Oxanes>, Category: esters-buliding-blocks, the main research area is conformation oxane; pyran tetrahydro conformation.

Conformational free energies for various substituents in 3-substituted oxanes (tetrahydropyrans) were determined by low-temperature 13C NMR spectroscopy and compared with corresponding values in 5-substituted 1,3-dioxanes and in cyclohexanes. Also determined was the value for MeO in 4-methoxyoxane and the value for CHO in cyclohexanecarboxaldehyde.

Polish Journal of Chemistry published new progress about Free energy. 18729-20-9 belongs to class esters-buliding-blocks, and the molecular formula is C7H12O3, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Eliel, Ernest L.; Pietrusiewicz, K. Michal published the artcile< Conformational analysis. Part XLI. Oxanes>, Category: esters-buliding-blocks, the main research area is conformation oxane; pyran tetrahydro conformation.

Conformational free energies for various substituents in 3-substituted oxanes (tetrahydropyrans) were determined by low-temperature 13C NMR spectroscopy and compared with corresponding values in 5-substituted 1,3-dioxanes and in cyclohexanes. Also determined was the value for MeO in 4-methoxyoxane and the value for CHO in cyclohexanecarboxaldehyde.

Polish Journal of Chemistry published new progress about Free energy. 18729-20-9 belongs to class esters-buliding-blocks, and the molecular formula is C7H12O3, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Perez, Lark J.; Ng, Wai-Leung; Marano, Paul; Brook, Karolina; Bassler, Bonnie L.; Semmelhack, Martin F. published the artcile< Role of the CAI-1 Fatty Acid Tail in the Vibrio cholerae Quorum Sensing Response>, Application of C5H10O3, the main research area is Vibrio quorum sensing CAI1 fatty acid tail preparation antibacterial.

Quorum sensing is a mechanism of chem. communication among bacteria that enables collective behaviors. In V. cholerae, the etiol. agent of the disease cholera, quorum sensing controls group behaviors including virulence factor production and biofilm formation. The major V. cholerae quorum-sensing system consists of the extracellular signal mol. called CAI-1 and its cognate membrane bound receptor called CqsS. Here, the ligand binding activity of CqsS is probed with structural analogs of the natural signal. Enabled by the discovery of a structurally simplified analog of CAI-1, a focused library was prepared and analyzed. The mols. were designed to probe the effects of conformational and structural changes along the length of the fatty acid tail of CAI-1. The results, combined with pharmacophore modeling, suggest a mol. basis for signal mol. recognition and receptor fidelity with respect to the fatty acid tail portion of CAI-1. These efforts provide novel probes to enhance discovery of anti-virulence agents for the treatment of V. cholerae.

Journal of Medicinal Chemistry published new progress about Antibacterial agents. 73349-07-2 belongs to class esters-buliding-blocks, and the molecular formula is C5H10O3, Application of C5H10O3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Tokamolthom, Jindarat; Chen, Shui-Tein; Jeyashoke, Narumon; Krisnangkura, Kanit published the artcile< Gas chromatographic separation of R/S-伪-hydroxy fatty acid esters>, Application of C5H10O3, the main research area is hydroxy fatty acid ester enantiomer resolution gas chromatog; wool wax analysis hydroxy fatty acid gas chromatog; pea leaf lipid analysis hydroxy fatty acid gas chromatog.

Gas chromatog. (GC) separations of R/S-伪-hydroxy fatty acids (AHFAs) are carried out on several columns, including 伪-cyclodextrin derivative (Cydex B) chiral column. R/S-AHFAs are well separated on achiral columns (BP 1, nonpolar phase and RTX 2330, very polar phase) as diasteriomeric esters of the optically active alcs., whereas the shorter chain length of the alc. tends to give lower separation factor (伪) on the same column. The longest chain length of alc. used in this study is 2-octanol and its ester shows the highest 伪 on the RTX 2330 capillary column. Thus, the four thermodynamically related column constants (a, b, c and d) of for R- and S-AHFAs standard are determined: ln k’ = a + bn + cT + dnT where k’ is the retention factor, n the equivalent carbon number and T the absolute temperature This equation was used to estimate the equivalent n, and also subsequently used to identify and determine the configuration of AHFAs in wool wax without using a standard AHFA as a reference

Analytica Chimica Acta published new progress about Chromatographic chiral resolution. 73349-07-2 belongs to class esters-buliding-blocks, and the molecular formula is C5H10O3, Application of C5H10O3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xue, Xiuru; Wang, Yanhua; Han, Fu-She published the artcile< A thermoregulated phase-separable chiral Pt nanocatalyst for recyclable asymmetric hydrogenation of α-ketoesters>, Computed Properties of 73349-07-2, the main research area is asym hydrogenation ketoester platinum nanocatalyst chiral ionic liquid; cinchonidine polyethylene glycol chiral ionic liquid catalyst asym hydrogenation.

The design and preparation of a chiral Pt nanocatalyst system possessing thermoregulated phase-separation property and its application in recyclable asym. hydrogenation of α-ketoesters are presented. The catalyst was prepared from polyethylene glycol monomethyl ether and cinchonidine.

Chemical Communications (Cambridge, United Kingdom) published new progress about Carboxylic esters Role: RCT (Reactant), RACT (Reactant or Reagent) (α-ketoesters). 73349-07-2 belongs to class esters-buliding-blocks, and the molecular formula is C5H10O3, Computed Properties of 73349-07-2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Pryde, David C.; Middya, Sandip; Banerjee, Monali; Shrivastava, Ritesh; Basu, Sourav; Ghosh, Rajib; Yadav, Dharmendra B.; Surya, Arjun published the artcile< The discovery of potent small molecule activators of human STING>, Name: Ethyl 2-hydroxyacetate, the main research area is human STING activator preparation oxindole benzothiazine quinoline oxazine benzazepine; Cytokines; Immunotherapy; Interferon genes; STING.

The adaptor protein STING plays a major role in innate immune sensing of cytosolic nucleic acids, by triggering a robust interferon response. Despite the importance of this protein as a potential therapeutic target for serious unmet medical conditions including cancer and infectious disease there remains a paucity of STING ligands. Starting with a benzothiazinone series of weak STING activators (human EC50 ∼10μM) we identified several chemotypes with sub-micromolar STING activity across all the major protein polymorphs. An example compound I, based on an oxindole core structure, demonstrated robust on-target functional activation of STING (human EC50 185 nM) in immortalized and primary cells and a cytokine induction fingerprint consistent with STING activation. Our study has identified several related series of potent small mol. human STING activators with potential to be developed as immunomodulatory therapeutics.

European Journal of Medicinal Chemistry published new progress about Homo sapiens. 623-50-7 belongs to class esters-buliding-blocks, and the molecular formula is C4H8O3, Name: Ethyl 2-hydroxyacetate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics