Tag: 300-400

Mukerjee, Anindita; Ranjan, Amalendu P.; Vishwanatha, Jamboor K. published an article in 2014, the title of the article was Non-covalent surface integration: optimising a novel technique for preparing targeted polymeric nanoparticles for cancer therapeutics.SDS of cas: 79642-50-5 And the article contains the following content:

Targeting anticancer drugs to their specific mol. targets is a major challenge in cancer therapy. However, advances in biomedical and protein engineering have led to novel nanoparticle targeting approaches. In this study, we used a novel non-covalent insertion of a homo-bifunctional spacer for targeted delivery of drugs to various cancer cells. Functionalised blank nanoparticles for antibody (targeting agent) conjugation were prepared using different crosslinking spacers (bis[sulfosuccinimidyl] suberate (BS3), Disuccinimidyl glutarate (DSG) and sulfo-N-[ε-maleimidocaproyloxy] sulfosuccinimide ester (s-EMCS)). The concentration of the spacers and the concentration of antibody used for conjugation were optimized using flow cytometry. The optimized and functionalised nanoparticles thus obtained were characterised for percent yield, mean particle size, surface morphol. and percent antibody attachment. Our studies showed the formation of smooth and spherical functionalised poly(D,L-lactide-co-glycolide) (PLGA) nanoparticles which could be successfully conjugated to an antibody, Anti-Annexin A2, for targeting to breast cancer cells. The functionalisation of PLGA nanoparticles for antibody attachment was effectively optimized leading to high percent attachments of 92.8% achieved with BS3. Antibody conjugated PLGA nanoparticles were then evaluated for their targeting potential. Robust intra-cellular uptake of the targeted nanoparticles was observed in breast cancer cell line and in mouse xenograft tumor studies. Our results thus validate that such a novel technique of surface integration may be used for preparing targeted polymeric nanoparticles for cancer therapeutics. The experimental process involved the reaction of Bis(2,5-dioxopyrrolidin-1-yl) glutarate(cas: 79642-50-5).SDS of cas: 79642-50-5

The Article related to non covalent surface integration polymeric nanoparticle cancer therapeutics, Pharmaceuticals: Formulation and Compounding and other aspects.SDS of cas: 79642-50-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On April 9, 2014, He, Chunbai; Lu, Kuangda; Liu, Demin; Lin, Wenbin published an article.Related Products of 1312703-30-2 The title of the article was Nanoscale Metal-Organic Frameworks for the Co-Delivery of Cisplatin and Pooled siRNAs to Enhance Therapeutic Efficacy in Drug-Resistant Ovarian Cancer Cells. And the article contained the following:

Ovarian cancer is the leading cause of death among women with gynecol. malignancies. Acquired resistance to chemotherapy is a major limitation for ovarian cancer treatment. We report here the first use of nanoscale metal-organic frameworks (NMOFs) for the co-delivery of cisplatin and pooled small interfering RNAs (siRNAs) to enhance therapeutic efficacy by silencing multiple drug resistance (MDR) genes and resensitizing resistant ovarian cancer cells to cisplatin treatment. UiO NMOFs with hexagonal-plate morphologies were loaded with a cisplatin prodrug and MDR gene-silencing siRNAs (Bcl-2, P-glycoprotein [P-gp], and survivin) via encapsulation and surface coordination, resp. NMOFs protect siRNAs from nuclease degradation, enhance siRNA cellular uptake, and promote siRNA escape from endosomes to silence MDR genes in cisplatin-resistant ovarian cancer cells. Co-delivery of cisplatin and siRNAs with NMOFs led to an order of magnitude enhancement in chemotherapeutic efficacy in vitro, as indicated by cell viability assay, DNA laddering, and Annexin V staining. This work shows that NMOFs hold great promise in the co-delivery of multiple therapeutics for effective treatment of drug-resistant cancers. The experimental process involved the reaction of Dimethyl 2′-amino-[1,1′:4′,1”-terphenyl]-4,4”-dicarboxylate(cas: 1312703-30-2).Related Products of 1312703-30-2

The Article related to nanoscale metal organic framework cisplatin sirna ovarian cancer antitumor, Pharmaceuticals: Formulation and Compounding and other aspects.Related Products of 1312703-30-2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On February 19, 2019, Lin, Wenbin; He, Chunbai; Lu, Kuangda published a patent.Recommanded Product: 1312703-30-2 The title of the patent was Nanoparticles for photodynamic therapy, X-ray induced photodynamic therapy, radiotherapy, chemotherapy, immunotherapy, and any combination thereof. And the patent contained the following:

Metal-organic frameworks (MOFs) comprising photosensitizers are described. The MOFs can also include moieties capable of absorbing X-rays and/or scintillation. Optionally, the photo sensitizer or a derivative thereof can form a bridging ligand of the MOF. Further optionally, the MOF can comprise inorganic nanoparticles in the cavities or channels of the MOF or can be used in combination with an inorganic nanoparticle. Also described are methods of using MOFs and/or inorganic nanoparticles in photodynamic therapy or in X-ray induced photodynamic therapy, either with or without the co-administration of one or more immunotherapeutic agent and/or one or more chemotherapeutic agent. The experimental process involved the reaction of Dimethyl 2′-amino-[1,1′:4′,1”-terphenyl]-4,4”-dicarboxylate(cas: 1312703-30-2).Recommanded Product: 1312703-30-2

The Article related to nanoparticle photodynamic therapy radiotherapy chemotherapy immunotherapy metal organic framework, Pharmaceuticals: Formulation and Compounding and other aspects.Recommanded Product: 1312703-30-2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On October 31, 2021, Ginzburg, Aurora L.; Blackburn, Richard S.; Santillan, Claudia; Truong, Lisa; Tanguay, Robyn L.; Hutchison, James E. published an article.Application of 6197-30-4 The title of the article was Zinc oxide-induced changes to sunscreen ingredient efficacy and toxicity under UV irradiation. And the article contained the following:

Sunscreen safety and efficacy is generally evaluated based upon the properties of the individual chems. in a formulation. However, the photostability of sunscreens has been shown to be highly dependent on the mixture of chems. present. To better understand how sunscreen formulation influences stability, and to establish a foundation for probing the influence of zinc oxide additives, we formulated five different small-mol. based UV-filter (UV-filter) mixtures with a Sun Protection Factor (SPF) of 15. These mixtures contained active ingredients approved in either the United States or European Union and were designed to represent formulations of actual products on the market. We evaluated the photostability and toxicity of these mixtures in the absence and presence of zinc oxide after UV exposure for two hours. Changes in UV absorbance were minimal for all five small-mol.-based mixtures without zinc oxide. The presence of either micro- or nano-sized zinc oxide caused significant small-mol. photodegradation and the degraded mixtures exhibited higher levels of toxicity in embryonic zebrafish assays. This study suggests that caution must be taken when formulating sunscreens containing both zinc oxide and small-mol. UV-filters to avoid unintended consequences during use. The experimental process involved the reaction of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate(cas: 6197-30-4).Application of 6197-30-4

The Article related to zinc oxide sunscreen ingredient efficacy toxicity uv irradiation, formulation, photodegradation, sunscreen, toxicity, zebrafish, zinc oxide, Pharmaceuticals: Formulation and Compounding and other aspects.Application of 6197-30-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Menegatti, Stefano; Hussain, Mahmud; Naik, Amith D.; Carbonell, Ruben G.; Rao, Balaji M. published an article in 2013, the title of the article was mRNA display selection and solid-phase synthesis of Fc-binding cyclic peptide affinity ligands.Computed Properties of 79642-50-5 And the article contains the following content:

Cyclic peptides are attractive candidates for synthetic affinity ligands due to their favorable properties, such as resistance to proteolysis, and higher affinity and specificity relative to linear peptides. Here we describe the discovery, synthesis and characterization of novel cyclic peptide affinity ligands that bind the Fc portion of human IgG (IgG; hFc). We generated an mRNA display library of cyclic pentapeptides wherein peptide cyclization was achieved with high yield and selectivity, using a solid-phase crosslinking reaction between two primary amine groups, mediated by a homobifunctional linker. Subsequently, a pool of cyclic peptide binders to hFc was isolated from this library and chromatog. resins incorporating the selected cyclic peptides were prepared by on-resin solid-phase peptide synthesis and cyclization. Significantly, this approach results in resins that are resistant to harsh basic conditions of column cleaning and regeneration. Further studies identified a specific cyclic peptide-cyclo[Link-M-WFRHY-K]-as a robust affinity ligand for purification of IgG from complex mixtures The cyclo[Link-M-WFRHY-K] resin bound selectively to the Fc fragment of IgG, with no binding to the Fab fragment, and also bound Igs from a variety of mammalian species. Notably, while the recovery of IgG using the cyclo[Link-M-WFRHY-K] resin was comparable to a Protein A resin, elution of IgG could be achieved under milder conditions (pH 4 vs. pH 2.5). Thus, cyclo[Link-M-WFRHY-K] is an attractive candidate for developing a cost-effective and robust chromatog. resin to purify monoclonal antibodies (mAbs). Finally, our approach can be extended to efficiently generate and evaluate cyclic peptide affinity ligands for other targets of interest. The experimental process involved the reaction of Bis(2,5-dioxopyrrolidin-1-yl) glutarate(cas: 79642-50-5).Computed Properties of 79642-50-5

The Article related to mrna display library cyclic peptide fc binding antibody purification, Immunochemistry: Methods (Including Analysis) and other aspects.Computed Properties of 79642-50-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

van Dongen, Stijn F. M.; Maiuri, Paolo; Marie, Emmanuelle; Tribet, Christophe; Piel, Matthieu published an article in 2013, the title of the article was Triggering Cell Adhesion, Migration or Shape Change with a Dynamic Surface Coating.Category: esters-buliding-blocks And the article contains the following content:

The authors here report a strategy for study of cell dynamics that involves only azido-(PLL-g-PEG) (APP) and the addition of a reactive BCN-RGD peptide to the cell culture medium as a trigger. APP and BCN-RGD allow the noninvasive ‘switching on’ of cell adhesion with very high contrast, because the adhesion mol. is only introduced when desired, leaving the ‘switched off’ surface featureless. To demonstrate the versatility of this approach, the authors show a set of experiments that validate the trigger. Then, the authors combine it with patterned surfaces. Patterns allow for interesting applications where cell adhesion is triggered while cells are already attached to certain areas of the substrate (in situ triggering). As typical applications, the authors show the induction of both single and collective cell migration, create cocultures, and trigger the synchronous control of cell shape change, illustrating dynamic control. The experimental process involved the reaction of Bis(2,5-dioxopyrrolidin-1-yl) glutarate(cas: 79642-50-5).Category: esters-buliding-blocks

The Article related to cell adhesion migration shape dynamic surface coating, Biochemical Methods: Culture and Preservation and other aspects.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On July 31, 2021, Zhang, Yu; Liu, Jia; Yu, Dandan; Zhu, Xinxin; Liu, Xiaoyan; Liao, Jun; Li, Sheng; Wang, Huayi published an article.SDS of cas: 79642-50-5 The title of the article was The MLKL kinase-like domain dimerization is an indispensable step of mammalian MLKL activation in necroptosis signaling. And the article contained the following:

MLKL phosphorylation by RIP3 is the commitment step of necroptosis execution, which could induce MLKL activation featured as MLKL monomer-oligomer transition. Here, we reported that the dimerization of the MLKL kinase-like domain was the direct consequence of RIP3 triggered MLKL-phosphorylation. Two inter-dimer interfaces were found in the crystal structure of human MLKL. Mutations destroying both interfaces could prevent RIP3-induced MLKL oligomerization and necroptosis efficiently. Moreover, we confirmed MLKL self-assembly by the internal coiled-coil region is necessary for MLKL oligomerization and function. The mutations disrupting coiled-coil self-assembly repressed necroptosis, but it did not prevent RIP3-induced dimerization of the MLKL kinase-like domain. So that, MLKL activation is a sequential process, which begins with kinase-like domain dimerization, and followed by internal coiled-coil region self-assembly to form a proper MLKL oligomer. Besides human MLKL, structural and functional anal. showed the kinase-like domain dimerization was conserved among mammalian species, suggesting it is a general step of the RIP3-induced MLKL activation process. The experimental process involved the reaction of Bis(2,5-dioxopyrrolidin-1-yl) glutarate(cas: 79642-50-5).SDS of cas: 79642-50-5

The Article related to mlkl domain dimerization necroptosis signaling, Mammalian Biochemistry: Development and Aging and other aspects.SDS of cas: 79642-50-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On March 7, 2011, McKee, Mireya L.; Evans, Amanda C.; Gerrard, Simon R.; O’Reilly, Rachel K.; Turberfield, Andrew J.; Stulz, Eugen published an article.Name: Bis(2,5-dioxopyrrolidin-1-yl) glutarate The title of the article was Peptidomimetic bond formation by DNA-templated acyl transfer. And the article contained the following:

The efficiencies of DNA-templated acyl transfer reactions between a thioester modified oligonucleotide and a series of amine and thiol based nucleophiles are directly compared. The reactivity of the nucleophile, reaction conditions (solvent, buffer, pH) and linker length all play important roles in determining the efficiency of the transfer reaction. Careful optimization of the system enables the use of DNA-templated synthesis to form stable peptide-like bonds under mild aqueous conditions close to neutral pH. The experimental process involved the reaction of Bis(2,5-dioxopyrrolidin-1-yl) glutarate(cas: 79642-50-5).Name: Bis(2,5-dioxopyrrolidin-1-yl) glutarate

The Article related to peptidomimetic bond formation dna templated acyl transfer, Carbohydrates: Nucleic Acid Chemical Synthesis and other aspects.Name: Bis(2,5-dioxopyrrolidin-1-yl) glutarate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yang, Yong-Qing; Ji, Meng-Chen; Lu, Zheng; Jiang, Mao; Huang, Wei-Wei; He, Xue-Zhi published an article in 2016, the title of the article was Facile access to α,β-dehydroalanine and α,β-dehydroamino butyric acid derivatives from DL-serines and threonines.Recommanded Product: Benzyl 2-(((benzyloxy)carbonyl)amino)acrylate And the article contains the following content:

Not only α,β-dehydroamino acids are important constituents for a number of bioactive peptides in nature, but also they are important building blocks for a variety of synthetic amino acids in organic synthesis. Methods to prepare dehydroamino acids have been reported extensively in the literature; however, efficient and convenient protocols are still required. Here, the authors report a convenient method to prepare dehydroalanine (ΔAla) and dehydroamino butyric acid (ΔAbu) derivatives derived from DL-serines and DL-threonines, resp. 4-Toluenesulfonyl chloride (TsCl) and 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) were employed in this procedure, which carried out activation of hydroxyl group and β-elimination in one pot. Because it is convenient and easy to handle, this method will attract the attention of synthetic chemists. The experimental process involved the reaction of Benzyl 2-(((benzyloxy)carbonyl)amino)acrylate(cas: 59524-07-1).Recommanded Product: Benzyl 2-(((benzyloxy)carbonyl)amino)acrylate

The Article related to dehydroamino acid preparation beta elimination racemic serine threonine, Amino Acids, Peptides, and Proteins: Amino Acids and other aspects.Recommanded Product: Benzyl 2-(((benzyloxy)carbonyl)amino)acrylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On September 30, 2021, Saxe, Jennifer K.; Dean, Stacy; Jones, Randy L.; Mullins, Larry A.; Reynertson, Kurt A. published an article.Electric Literature of 6197-30-4 The title of the article was Development of a novel rinse-off method for improved sunscreen exposure assessment. And the article contained the following:

Recent legislative measures restricting the sale of sunscreens containing certain UV light filtering ingredients (UVFs) have been based on a perception of risk to aquatic life despite the lack of a robust data set to support these decisions. Concerns were focused on the potential for recreational swimmers’ and divers’ sunscreen use to result in exposures to coral already stressed due to climate change, disease, and other local conditions. In published environmental risk assessments for UVFs, exposure estimates were based on episodic environmental monitoring or estimates of typical sunscreen use, arbitrarily assuming the portion rinsed off from skin in seawater. To improve the accuracy of exposure estimates and thereby develop more robust risk assessments, we measured the amount of the UVFs, avobenzone, homosalate, octisalate, octocrylene, and oxybenzone released to seawater from four sunscreen products (two lotions, one spray, one stick) in a novel porcine skin model of typical human sunscreen use. Sunscreen was applied to porcine skin, allowed to briefly dry, then exposed to four rinse cycles in artificial seawater. The mass of each UVF in seawater, partitioned from seawater onto glassware, and extractable from skin after rinsing were determined The proportion rinsed from skin varied by UVF, by formula type, and by application rate. Less than 1.4% of applied octisalate, homosalate, and octocrylene was detected in seawater samples (independent of formula) increasing to an average of 4% and 8% for avobenzone in stick and lotion forms, and to 24% for oxybenzone in lotions. The initial data show substantial differences in rinse-off among formulation types and sunscreen application rates, and stress the importance of using UVF-specific rinse-off values rather than a single value for all UVFs. This new method provides a tool for more robust exposure estimates, with initial data supporting lower rinse-off values than adopted in published risk assessments. Integr Environ Assess Manag 2021;00:1-6. 2021 Johnson & Johnson Consumer Companies Inc. Integrated Environmental Assessment and Management published by Wiley Periodicals LLC on behalf of Society of Environmental Toxicol. & Chem. (SETAC). The experimental process involved the reaction of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate(cas: 6197-30-4).Electric Literature of 6197-30-4

The Article related to sunscreen exposure environmental assessment artificial seawater, aquatic risk, exposure assessment, exposure modeling, personal care products, sunscreens, Essential Oils and Cosmetics: Skin Preparations and other aspects.Electric Literature of 6197-30-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics