Tag: 300-400

Mori, Satoka; Abe, Arisa; Ishikawa, Naoto; Rafique, Abdur; Ito, Yuji published an article in 2021, the title of the article was A novel site-specific chemical conjugation of IgG antibodies by affinity peptide for immunoassays.HPLC of Formula: 79642-50-5 And the article contains the following content:

Recently, there has been an increasing interest in site-specific modifications of antibodies used in immunoassays for disease diagnosis and as antibody therapeutics, such as antibody-drug conjugates. Previously, we established a site-specific chem. conjugation system using an IgG-Fc binding chem. conjugation affinity peptide (CCAP). CCAP could be used only for the modification of human IgG owing to the lack of affinity of CCAP to rodent IgG mols. In this study, novel CCAP reagents are proposed, which can be used for both human and mouse IgG, based on the Staphylococcus aureus protein A domain-derived affinity peptides Z34C and Z33. Compared with the activity of a conventional randomly modified antibody, mouse IgG modified using this method had favorable features in two immunoassays, demonstrating the advantages of the proposed CCAP method in preserving antibody functionality during conjugation. The experimental process involved the reaction of Bis(2,5-dioxopyrrolidin-1-yl) glutarate(cas: 79642-50-5).HPLC of Formula: 79642-50-5

The Article related to staphylococcus aureus igg monoclonal antibodies peptide immunoassay, rpla, antibody, conjugation, immunoassay, peptide, protein a, Placeholder for records without volume info and other aspects.HPLC of Formula: 79642-50-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On September 10, 2021, Li, Wen-Long; Zhang, Zi-Feng; Li, Yi-Fan; Hung, Hayley; Yuan, Yi-Xing published an article.Name: 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate The title of the article was Assessing the distributions and fate of household and personal care chemicals (HPCCs) in the Songhua Catchment, Northeast China. And the article contained the following:

Many household and personal care chems. (HPCCs) are of environmental concern due to their potential toxicity to humans and wildlife. However, few studies investigate the spatiotemporal variations and fate of HPCCs in large-scale river systems. Here, river water and sediment samples from the Songhua River in Northeast China were analyzed for seven classes of HPCCs. Correlation anal. suggested similar sources and environmental behavior for compounds from the same HPCC classes. In the river water, the concentrations of most HPCCs in the cold season were significantly higher than that of the warm season (p < 0.01). Significantly higher levels of target compounds were found in the downstream water samples of a city, suggesting the influence of human activities on the distributions of HPCCs. The concentrations and distributions of most HPCCs were controlled by primary emission sources. The derived dissolved concentrations of HPCCs suggested that small amounts of caffeine and parabens were partitioned onto particles, while large amounts of many other HPCCs were bound to the particle phase. Water-sediment distribution coefficients (log Kd) ranged from 1.59 for caffeine to 3.95 for benzalkonium chloride-C14. This work presents new insights into the environmental behavior of HPCCs and the factors affecting their fate in river systems. The experimental process involved the reaction of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate(cas: 6197-30-4).Name: 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate

The Article related to household personal care chem river water surface sediment, household personal care, river, sediments, solid-liquid partitioning, Placeholder for records without volume info and other aspects.Name: 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On July 15, 2020, Lei, Yanli; Wu, Miaosen; Wang, Junyi; Zhang, Hongtao; Zhan, Xiaobei; Sun, Zhenglong; Wu, Jianrong published an article.Name: Bis(2,5-dioxopyrrolidin-1-yl) glutarate The title of the article was Preparation and property of a biantenna macromolecule based on polysialic acid. And the article contained the following:

Polysialic acid (PSA), an acidic polysaccharide usually exists as a double-chain structure on cell adhesion mols. in vertebrates. The available PSA produced from Escherichia coli fermentation, however, is monochain PSA. In this work, a biomimetic biantenna type PSA (biPSA) was synthesized in vitro under mild conditions, and the terminal nonreducing ends of sialic acid residue were retained. The structure of biPSA was characterized through IR spectroscopy, and NMR, and the double-chain structure of biPSA was confirmed by the doubled mol. weight and particle size of biPSA. Anal. through CD, isothermal titration calorimetry, and thermostability experiments revealed that the obtained biPSA was more stable in aqueous solution than PSA, especially after complexation with Ca2+, which increased the variation in enthalpy and entropy. However, the addition of Cu2+ had a negligible effect on configuration of PSA and biPSA. The addition of Ca2+ promoted cell proliferation in a culture of microglia BV-2 cells with biPSA in medium. By contrast, the addition of Cu2+ had toxic effects. Supplementation with biPSA can maintain cell viability for a longer period than supplementation with monochain PSA. This work indicates that biPSA is a potential substitute for monochain PSA in practical applications. The experimental process involved the reaction of Bis(2,5-dioxopyrrolidin-1-yl) glutarate(cas: 79642-50-5).Name: Bis(2,5-dioxopyrrolidin-1-yl) glutarate

The Article related to biantenna macromol polysialic acid, biantenna structure, biomimetic macromolecule, ncam, polysialic acid, Placeholder for records without volume info and other aspects.Name: Bis(2,5-dioxopyrrolidin-1-yl) glutarate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On July 31, 2021, Meng, Qi; Yeung, Karen; Chan, King Ming published an article.Category: esters-buliding-blocks The title of the article was Toxic effects of octocrylene on zebrafish larvae and liver cell line (ZFL). And the article contained the following:

Octocrylene (OC) is a broad-spectrum UV-absorbing chem. used in sunscreen and other personal care products. Its health effects are a concern because it has been detected in water, fish, humans, and food chains. In vivo and in vitro investigations were performed in zebrafish (Danio rerio) larvae and a zebrafish liver cell line (ZFL), resp., to understand the potential risks and mol. mechanisms of OC toxicity. The 96-h median lethal concentration (LC50) of OC was determined to be 251.8 μM in larvae and 5.5 μM in ZFL cells. Quant. real-time PCR (qRT-PCR) showed that OC induced the expression of genes for CYPs (CYP1A, CYP3A65), estrogen receptors (ERα, ERβ1, GPER), vitellogenin (VTG1), and sex determination (BRCA2, CYP19A, DMRT1, SOX9A), both in vitro and in vivo. A whole-transcriptome sequencing method was used to evaluate the gene expression profile of larvae exposed to OC. OC was found to mediate the biosynthesis of estrogens (such as estriol) and affect the antioxidant pathway (glutathione transferases and peroxisome). These findings clarify the toxic effects and mol. mechanisms of OC and support banning its use in cosmetics. The experimental process involved the reaction of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate(cas: 6197-30-4).Category: esters-buliding-blocks

The Article related to octocrylene toxic effect zebrafish larvae liver cell line, endocrine disruption, gene transcription, rna-seq, sexual differentiation, sunscreen chemicals, Placeholder for records without volume info and other aspects.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On October 1, 2021, Yang, Chao; Ma, Dejun; Lu, Liqing; Yang, Xing; Xi, Zhen published an article.SDS of cas: 882518-89-0 The title of the article was Synthesis of KUE-siRNA Conjugates for Prostate Cancer Cell-Targeted Gene Silencing. And the article contained the following:

The delivery of siRNAs to selectively target cells poses a great challenge in RNAi-based cancer therapy. The lack of suitable cell-targeting methods seriously restricts the advance in delivering siRNAs to extrahepatic tissues. Based on prostate-specific membrane antigen (PSMA)-targeting ligands, we have synthesized a series of lysine-urea-glutamate (KUE)-siRNA conjugates and verified their effective cell uptake and gene silencing properties in prostate cancers. The results indicated that the KUE-siRNA conjugates could selectively enter PSMA+ LNCaP cells, eventually down-regulating STAT3 expression. Based on post-synthesis modification and receptor-mediated endocytosis, this strategy of constructing ligand-siRNA conjugates might provide a general method of siRNA delivery for cell-targeted gene silencing. The experimental process involved the reaction of tert-Butyl 2-(2-(2-(tosyloxy)ethoxy)ethoxy)acetate(cas: 882518-89-0).SDS of cas: 882518-89-0

The Article related to lysine urea glutamate sirna prostate cancer cell gene silencing, kue-sirna conjugates, psma-targeted, rna interference, propargyl analog, prostate cancer, Placeholder for records without volume info and other aspects.SDS of cas: 882518-89-0

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On October 31, 2021, Ren, Lu; Ji, Hongtao; Heuze, Karine; Faure, Bruno; Genin, Emilie; Rousselot Pailley, Pierre; Tron, Thierry published an article.SDS of cas: 6197-30-4 The title of the article was Modulation of laccase catalyzed oxidations at the surface of magnetic nanoparticles. And the article contained the following:

We explored the coupling of laccases to magnetic nanoparticles (MNPs) with different surface chem. coating. Two laccase variants offering two opposite and precise orientations of the substrate oxidation site were immobilized onto core-shell MNPs presenting either aliphatic aldehyde, aromatic aldehyde or azide functional groups at the particles surface. Oxidation capabilities of the six-resulting laccase-MNP hybrids were compared on ABTS and coniferyl alc. Herein, we show that the original interfaces created differ substantially in their reactivities with an amplitude from 1 to > 4 folds depending on the nature of the substrate. Taking enzyme orientation into account in the design of surface modification represents a way to introduce selectivity in laccase catalyzed reactions. The experimental process involved the reaction of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate(cas: 6197-30-4).SDS of cas: 6197-30-4

The Article related to magnetic nanoparticle surface laccase catalyzed oxidation modulation, chemical coating, laccase orientation, magnetic nano-particles, oxidations, Placeholder for records without volume info and other aspects.SDS of cas: 6197-30-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On February 1, 2022, Li, Wen-Long; Zhang, Zi-Feng; Kilgallon, John; Sparham, Chris; Li, Yi-Fan; Yuan, Yi-Xing published an article.Reference of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate The title of the article was Fate of household and personal care chemicals in typical urban wastewater treatment plants indicate different seasonal patterns and removal mechanisms. And the article contained the following:

Studies on the presence and fate of household and personal care chems. (HPCCs) in wastewater treatment plants (WWTPs) are important due to their increasing consumption worldwide. The seasonal patterns and removal mechanisms of HPCCs are not well understood for WWTPs that apply different treatment technologies. To answer these questions, the sewage and sludge samples were taken from 10 typical WWTPs in Northeast China. Levels of UV filters in the influents in the warm season were significantly greater than that of the cold season (p < 0.05). Significant seasonal differences were found for the removals of many HPCCs. Results revealed that the highest removal efficiencies were found for linear alkylbenzene sulfonates with values ranging from 97.2% to 99.7%, and the values were 50.0%-99.9% for other HPCCs. The SimpleTreat model demonstrated that the studied WWTPs were operating with high efficiency at the time of sampling. The sorption of HPCCs to sludge can be strongly associated with their physicochem. parameters. Mass balance calculation suggested that sorption was the dominant mechanism for the removal of antimicrobials, while degradation and/or biotransformation were the other mechanisms for removing the most HPCCs in the WWTPs. This study real the factors influencing the seasonal patterns and removal mechanisms which imply the need for further studies to fully understands the plant and human health implications as sludge could be used in the municipal land application of biosolids. The experimental process involved the reaction of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate(cas: 6197-30-4).Reference of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate

The Article related to hpcc urban wastewater treatment plant seasonal pattern removal mechanism, household and personal care products, modeling, removal, sewage, Placeholder for records without volume info and other aspects.Reference of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Abdi, Sayed Aliul Hasan; Ali, Amena; Sayed, Shabihul Fatma; Nagarajan, Sumathi; Abutahir; Alam, Prawez; Ali, Abuzer published an article in 2022, the title of the article was Sunscreen Ingredient Octocrylene′s Potency to Disrupt Vitamin D Synthesis.HPLC of Formula: 6197-30-4 And the article contains the following content:

Octocrylene is a widely used ingredient in sunscreen products, and it has been observed that the use of sunscreen has been increasing over the last few decades. In this paper, we investigated the way in which sunscreen′s ingredient octocrylene may disrupt normal vitamin D synthesis pathway, resulting in an imbalance in vitamin D levels in the body. The key techniques used for this insilico investigation were mol. docking, mol. dynamic (MD) simulation, and MMPBSA-based assessment. Vitamin D abnormalities have become very common in human health. Unknown exposure to chems. may be one of the important risk factors. In mol. docking anal., octocrylene exhibited a binding energy of -11.52 kcal/mol with vitamin D binding protein (1KXP) and -11.71 for the calcitriol native ligand. Octocrylene had a binding potency of -11.152 kcal/mol with the vitamin D receptor (1DB1), and calcitriol had a binding potency of -8.73 kcal/mol. In addition, octocrylene has shown binding energy of -8.96 kcal/mol with CYP2R1, and the calcitriol binding energy was -10.36 kcal/mol. Regarding stability, the root-mean-square deviation (RMSD), the root-mean-square fluctuation (RMSF), the radius of gyration, hydrogen bonding, and the solvent-accessible surface area (SASA) exhibited that octocrylene has a stable binding pattern similar to calcitriol. These findings revealed that incessant exposure to octocrylene may disrupt normal vitamin D synthesis. The experimental process involved the reaction of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate(cas: 6197-30-4).HPLC of Formula: 6197-30-4

The Article related to vitamin d synthesis octocrylene potency sunscreen ingredient, in silico study, octocrylene, sunscreen’s ingredient, vitamin d disruption, Placeholder for records without volume info and other aspects.HPLC of Formula: 6197-30-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On May 31, 2022, Szeto, Mindy D.; Kokoska, Ryan E.; Maghfour, Jalal; Rundle, Chandler W.; Presley, Colby L.; Harp, Taylor; Hamp, Austin; Wegener, Victoria; Hugh, Jeremy; Dellavalle, Robert P. published an article.Application In Synthesis of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate The title of the article was An analysis of public sunscreen distribution in the United States during the COVID-19 pandemic. And the article contained the following:

The present article is about anal. of public sunscreen distribution in the United States during the COVID-19 pandemic. The COVID-19 pandemic might have significantly affected consumer preferences and societal behavior regarding sun protection and skin cancer. We present a pandemic-era follow-up of previous research published in the Journal of the American Academy of Dermatol. on public use of sunscreen distributed by IMPACT Melanoma, a prominent nationwide sunscreen distributor and nonprofit organization for skin cancer prevention and education. Melanoma’s distribution records from 2020 to 2021 were retrospectively analyzed and compared with those from 2018 to 2019. Health care facilities, public health departments, governmental organizations, parks or recreation centers, educational institutions, nonprofits, and private businesses ordered both sunscreen dispensers and cases of different sunscreen types for public use. Every sector showed decreases in the overall orders of sunscreen dispensers (58%) and cases of sunscreen (68%). Park or recreation center and nonprofit organization total sunscreen and dispenser orders (the most common in 2018-2019) decreased in 2020 to 2021 by 78% and 42%, resp. Orders of hybrid sunscreen grew by 41%, driven primarily by hospitals, which also ordered more sunscreen dispensers and likely experienced increased volume at facilities and outreach events (eg, vaccination drives) during the COVID-19 pandemic. In total, Wyoming, Maine, South Dakota, and Massachusetts received the most dispensers and sunscreens by state population from 2020 to 2021 With social distancing, mask mandates, stay-at home orders, and popularity of outdoor activities in flux, it remains unclear how COVID-19 has affected cumulative UV exposure. Required mask-wearing in public settings might contribute to reduced sunscreen use because combining masks with sunscreens can cause skin irritation, pruritus, and occlusion. Addnl., some may equate mask use to sufficient sun protection, although masks confer unknown and variable UV protection. Further research should directly investigate changes in individuals’ sunscreen application behaviors. Although limited by our 2-yr periods of organizational distribution anal., our findings highlight worrisome trends that may be suggestive of increased sun damage risk and warrant addnl. investigation. Consumer research has suggested that the pandemic has eroded consumer attitudes regarding sun protection, and a large fraction now only uses sunscreen on an as-needed basis (eg, long beach vacations or special occasions). Dermatologists can encourage greater awareness about sun protection for everyday outdoor experiences, for indoors, and during colder months, regardless of COVID-19einduced changes and mask-wearing. Melanoma’s touch-free automated sunscreen dispensers and extensive virtual or online outreach programs will be advantageous. However, melanoma rates continue to rise, and the pandemic’s long-term effects are yet to be seen. As sunscreen application and UV exposure data become available in the near future, further examination of UV-associated skin cancer by state or region may be useful in informing outreach efforts and policy. The experimental process involved the reaction of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate(cas: 6197-30-4).Application In Synthesis of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate

The Article related to covid19 pandemic skin cancer sunscreen united states, History, Education, and Documentation: Other and other aspects.Application In Synthesis of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On June 30, 2020, Guo, Jiatong; Jiang, Wenjie; Li, Qingjiang; Jaiswal, Mohit; Guo, Zhongwu published an article.Product Details of 79642-50-5 The title of the article was Comparative immunological studies of tumor-associated Lewis X, Lewis Y, and KH-1 antigens. And the article contained the following:

Tumor-associated carbohydrate antigens Lewis X (Lex), Lewis Y (Ley), and KH-1 are useful targets for cancer immunotherapy. In this regard, an insight into the structure-immunogenicity relationships of these antigens is important but this has not been systematically investigated yet. In the current study, Lex, Ley, and KH-1 antigens with a lactose unit at the reducing end as a spacer were synthesized and coupled with keyhole limpet hemocyanin (KLH) protein. Immunol. evaluations of the resultant conjugates revealed that they all could elicit robust immune responses while the Ley conjugate could provoke the highest titers of total and IgG antibodies. The binding assays of their antisera to each antigen and to cancer cells showed that each antiserum had extensive cross-reaction with all three antigens as protein conjugates and strong but somewhat antigen-selective binding towards MCF-7 cancer cell. Moreover, none of these antisera had obvious binding to SKMEL-28 cancer cell that does not express Lex, Ley and KH-1. The results of assays of these antisera to mediate complement-dependent cytotoxicity (CDC) to MCF-7 and SKMEL-28 cancer cells were very similar to the results of binding assays. Thus, it was concluded that all three antigens could form effective conjugate vaccines whereas the Ley conjugate induced the most robust immune responses and the antiserum of Lex had the highest binding and cytotoxicity to target cancer cells. In addition, as the antibodies induced by each antigen had extensive cross-reaction with other two antigens, either Lex or Ley or the two combined can be utilized to formulate effective conjugate vaccines for cancer immunotherapy. Another paradigm-shifting discovery of this study is that the presentation of Lex, Ley, and KH-1 antigens on cancer cell can be different from that in synthetic conjugates, which should be taken into consideration during the design and optimization of related cancer vaccines or immunotherapies. The experimental process involved the reaction of Bis(2,5-dioxopyrrolidin-1-yl) glutarate(cas: 79642-50-5).Product Details of 79642-50-5

The Article related to carbohydrate lewisx lewisy kh1 antigen glycoconjugates cancer vaccine immunotherapy, cancer antigen, cancer vaccine, carbohydrate, glycoconjugate, kh-1, lewis x, lewis y, Placeholder for records without volume info and other aspects.Product Details of 79642-50-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics