Tag: 300-400

Raloxifene-loaded solid lipid nanoparticles decorated gel with enhanced treatment potential of osteoporosis was written by Guo, Zhonghua;Qi, Ping;Pei, Donghong;Zhang, Xiuju. And the article was included in Journal of Drug Delivery Science and Technology in 2022.Formula: C21H44O5 The following contents are mentioned in the article:

Osteoporosis is a common metabolic disorder associated with global morbidities and mortalities which make it a big challenge to the public health. Despite the availability of a number of drugs, its treatment is challenging due the drugs associated complications including poor dissolution, abridged permeation, reduced bioavailability and severe toxicities. This study aims to develop Raloxifene HCl-loaded solid lipid nanoparticles (RAL-SLNs) decorated gel in order to address the above-mentioned problems. RAL-SLNs were prepared by high pressure homogenization and evaluated in terms of their size distribution, morphol., zeta potential and drug entrapment using DLS anal., TEM and HPLC. Prior to this, screening of the lipid and surfactant was done based on drug solubility ratio. The optimized SLNs were further incorporated in chitosan gel to develop RAL-SLNs decorated gel (RAL-SLNsG) and were characterized in terms of their rheol. properties, pH and spreadability. In vitro drug release, kinetics of drug release and permeation analyses of the RAL-SLNsG were performed and compared with drug suspension and RAL gel (conventional gel) to check the release and permeation ability of the incorporated dug. Moreover, pharmacokinetics study of the test formulations was performed to check the bioavailability. Addnl., biochem. estimation was done after inducing osteoporosis in rats and their treatment with RAL-SLNsG and RAL gel after transdermal administration and were compared with pos. and neg. control groups. RAL-SLNs were found to have rounded shaped size distribution of 170 nm with -24.5 mV zeta potential and 95% drug entrapment. The RAL-SLNsG has excellent spreadability, optimum and non-Newtonian flow behavior. In vitro release and ex vivo permeation showed 7-fold and 11-fold enhanced properties, as compared to RAL suspension, resp. Bioavailability study revealed 3-fold and 6-fold enhanced bioavailability of the drug when incorporated in SLNs decorated gel as compared to the conventional gel and drug suspension. Finally, the serum level of alk. phosphatase and calcium were found to be significantly reduced in osteoporosis induced rats after treatment with RAL-SLNsG decorated gel as compared to RAL gel. These finding revealed that nanogel has the potential to enhance the permeation and bioavailability of incorporated drug with enhanced anti-osteoporotic effect. This study involved multiple reactions and reactants, such as Glyceryl monostearate (cas: 31566-31-1Formula: C21H44O5).

Glyceryl monostearate (cas: 31566-31-1) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Formula: C21H44O5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Differential accumulation of microbial necromass and plant lignin in synthetic versus organic fertilizer-amended soil was written by Li, Jie;Zhang, Xiaochen;Luo, Jiafa;Lindsey, Stuart;Zhou, Feng;Xie, Hongtu;Li, Yi;Zhu, Ping;Wang, Lichun;Shi, Yuanliang;He, Hongbo;Zhang, Xudong. And the article was included in Soil Biology & Biochemistry in 2020.Recommanded Product: 1731-94-8 The following contents are mentioned in the article:

While it is recognized that the accumulation and turnover of soil organic carbon (SOC) is driven by plant inputs and their subsequent microbial-mediated transformations, the roles of plant residue chem. and microbial processes in controlling SOC dynamics under different fertilizer application regimes have not been well explored. In the present study, amino sugars and lignin phenols were used as biomarkers to investigate the changes in microbial necromass and plant-derived components in a 30-yr cultivated Mollisol (0-20 cm) in response to different fertilizer application treatments, including synthetic fertilizers (NPK, 165 kg N ha^-1, 82.5 kg P₂O₅ ha^-1, and 82.5 kg K₂O ha^-1 per yr), pig manure at two application rates of 30 and 60 t ha^-1 per yr, and combinations of manure and synthetic fertilizers (30 or 60 t ha^-1 manure per yr plus 165 kg N ha^-1, 82.5 kg P₂O₅ ha^-1, and 82.5 kg K₂O ha^-1 per yr). Compared with the unfertilized plot (Control), 30-yr application of synthetic fertilizers increased microbial biomass (161%) and amino sugar production (19.7%), but did not alter lignin phenol and SOC concentrations despite the increased plant input. Comparatively, long term manure applications increased the concentration of SOC (30.8-70.9%), as well as that of amino sugars (82.9-107%) and lignin (96.8-212%) in soil. Nevertheless, despite the enhanced microbial biomass from low to high manure application rate, the proportion of amino sugars in the SOC decreased, reflecting a diluted contribution of microbial necromass in SOC pool buildup at high-rate manure application. On the contrary, the proportions of lignin phenols in the SOC in the manure treatments, as well as the ratios of lignin phenols and amino sugars (0.26-0.42), were larger than that in the NPK treatment (0.22) and increased with increasing manure application rate. Therefore, the manipulation of synthetic or organic fertilizer on SOC dynamics is associated with differential accumulation of microbial necromass and plant lignin in agro-ecosystems. The manure amendment enhanced the contribution of plant-derived components more than microbial necromass to long term SOC accumulation. This study involved multiple reactions and reactants, such as Methyl nonadecanoate (cas: 1731-94-8Recommanded Product: 1731-94-8).

Methyl nonadecanoate (cas: 1731-94-8) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Recommanded Product: 1731-94-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Antioxidant effect of grape seed extract corrects experimental autoimmune encephalomyelitis behavioral dysfunctions, demyelination, and glial activation was written by Mabrouk, Maha;El Ayed, Mohamed;Demosthenes, Amelie;Aissouni, Youssef;Aouani, Ezzedine;Daulhac-Terrail, Laurence;Mokni, Meherzia;Begou, Melina. And the article was included in Frontiers in Immunology in 2022.COA of Formula: C21H44O5 The following contents are mentioned in the article:

Multiple sclerosis (MS), a multifactorial autoimmune disease of the central nervous system (CNS), is characterized by demyelination and chronic inflammation, as well as axonal and neuronal loss. There is no cure for MS, and despite a significant improvement in the therapeutic management of patients during the last 20 years, some symptoms are still resistant to treatment, and the evolution of the disease to progressive form seems still ineluctable. The etiol. of MS is complex and still not fully understood. However, inflammation is a major driver of physiopathol. and oxidative stress contributes to CNS lesions and promotes existing inflammatory response. Plant polyphenols are endowed with many therapeutic benefits through alleviating oxidative stress and inflammation, thus providing neuroprotection in MS. We presently evaluated the curative effect of grape seed extract (GSE) in an exptl. autoimmune encephalomyelitis (EAE) mouse model of MS. Exptl. approach: Six-week-old C57Bl/6J females were subjected to the EAE paradigm (using myelin oligodendrocyte glycoprotein peptide fragment (35-55), complete Freund鈥瞫 adjuvant, and pertussis toxin) and then chronically treated with GSE from day 10 to day 30 post-induction. Clin. score and body weight were monitored daily, while evaluation of sensitive, motor, cognitive, and anxiety-related behaviors was performed weekly. Then, the GSE effect was evaluated on whole brain and spinal cord samples through the evaluation of oxidative stress damage, antioxidant capacities, myelin alteration, astroglial and microglial proliferation, and sirtuin expression. Grape seed extract curative chronic treatment corrected the clin. course of EAE, as well as the mech. hypersensitivity, and avoided the development of EAE mouse thermal cold allodynia. The neuropathol. evaluation showed that GSE reduced oxidative stress in the brain and spinal cord by decreasing the lipid and protein oxidation through correction of the three main antioxidant enzyme activities, namely, superoxide dismutase, catalase, and glutathione peroxidase, as well as restoring normal myelin protein expression and correcting microglial and astroglial protein overexpression and sirtuin downregulation. These data strongly support GSE as an effective therapeutic approach in MS treatment. This study involved multiple reactions and reactants, such as Glyceryl monostearate (cas: 31566-31-1COA of Formula: C21H44O5).

Glyceryl monostearate (cas: 31566-31-1) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.COA of Formula: C21H44O5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Growth and metabolic characteristics of oleaginous microalgal isolates from Nilgiri biosphere Reserve of India was written by Thangavel, Kalaiselvi;Krishnan, Preethi Radha;Nagaiah, Srimeena;Kuppusamy, Senthil;Chinnasamy, Senthil;Rajadorai, Jude Sudhagar;Olaganathan, Gopal Nellaiappan;Dananjeyan, Balachandar. And the article was included in BMC Microbiology in 2018.Product Details of 1731-94-8 The following contents are mentioned in the article:

Renewable energy for sustainable development is a subject of a worldwide debate since continuous utilization of non-renewable energy sources has a drastic impact on the environment and economy; a search for alternative energy resources is indispensable. Microalgae are promising and potential alternate energy resources for biodiesel production Thus, our efforts were focused on surveying the natural diversity of microalgae for the production of biodiesel. The present study aimed at identification, isolation, and characterization of oleaginous microalgae from shola forests of Nilgiri Biosphere Reserve (NBR), the biodiversity hot spot of India, where the microalgal diversity has not yet been systematically investigated. Overall the higher biomass yield, higher lipid accumulation and thermotolerance observed in the isolated microalgal strains have been found to be the desirable traits for the efficient biodiesel production Species composition and diversity anal. yielded ten potential microalgal isolates belonging to Chlorophyceae and Cyanophyceae classes. The chlorophytes exhibited higher growth rate, maximum biomass yield, and higher lipid accumulation than Cyanophyceae. Among the chlorophytes, the best performing strains were identified and represented by Acutodesmus dissociatus (TGA1), Chlorella sp. (TGA2), Chlamydomonadales sp. (TGA3) and Hindakia tetrachotoma (PGA1). The Chlamydomonadales sp. recorded with the highest growth rate, lipid accumulation and biomass yield of 0.28 ± 0. 03 day^-1(μexp), 29.7 ± 0.69% and 134.17 ± 16.87 mg L^-1 day^-1, resp. It was also found to grow well at various temperatures, viz., 25 °C, 35 °C, and 45 °C, indicating its suitability for open pond cultivation. The fatty acid Me ester (FAME) anal. of stationary phase cultures of selected four algal strains by tandem mass spectrograph showed C16:0, C18:1 and C18:3 as dominant fatty acids suitable for biodiesel production All the three strains except for Hindakia tetrachotoma (PGA1) recorded higher carbohydrate content and were considered as potential feed stocks for biodiesel production through hydrothermal liquefaction technol. (HTL). In conclusion, the present investigation is a first systematic study on the microalgal diversity of soil and water samples from selected sites of NBR. The study resulted in isolation and characterization of ten potent oleaginous microalgae and found four cultures as promising feed stocks for biodiesel production Of the four microalgae, Chlamydomonadales sp. (TGA3) was found to be significantly thermo-tolerant and can be considered as promising feedstock for biodiesel production This study involved multiple reactions and reactants, such as Methyl nonadecanoate (cas: 1731-94-8Product Details of 1731-94-8).

Methyl nonadecanoate (cas: 1731-94-8) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Product Details of 1731-94-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Cheminformatics Analysis of Assertions Mined from Literature that Describe Drug-Induced Liver Injury in Different Species was written by Fourches, Denis;Barnes, Julie C.;Day, Nicola C.;Bradley, Paul;Reed, Jane Z.;Tropsha, Alexander. And the article was included in Chemical Research in Toxicology in 2010.Quality Control of 4-Acetamidophenyl 2-acetoxybenzoate The following contents are mentioned in the article:

Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chem. structures is critical to help guide exptl. drug discovery projects toward safer medicines. In this study, the authors have compiled a data set of 951 compounds reported to produce a wide range of effects in the liver in different species, comprising humans, rodents, and nonrodents. The liver effects for this data set were obtained as assertional metadata, generated from MEDLINE abstracts using a unique combination of lexical and linguistic methods and ontol. rules. The authors have analyzed this data set using conventional cheminformatics approaches and addressed several questions pertaining to cross-species concordance of liver effects, chem. determinants of liver effects in humans, and the prediction of whether a given compound is likely to cause a liver effect in humans. The authors found that the concordance of liver effects was relatively low (∼39-44%) between different species, raising the possibility that species specificity could depend on specific features of chem. structure. Compounds were clustered by their chem. similarity, and similar compounds were examined for the expected similarity of their species-dependent liver effect profiles. In most cases, similar profiles were observed for members of the same cluster, but some compounds appeared as outliers. The outliers were the subject of focused assertion regeneration from MEDLINE as well as other data sources. In some cases, addnl. biol. assertions were identified, which were in line with expectations based on compounds’ chem. similarities. The assertions were further converted to binary annotations of underlying chems. (i.e., liver effect vs. no liver effect), and binary quant. structure-activity relationship (QSAR) models were generated to predict whether a compound would be expected to produce liver effects in humans. Despite the apparent heterogeneity of data, models have shown good predictive power assessed by external 5-fold cross-validation procedures. The external predictive power of binary QSAR models was further confirmed by their application to compounds that were retrieved or studied after the model was developed. To the best of the authors’ knowledge, this is the first study for chem. toxicity prediction that applied QSAR modeling and other cheminformatics techniques to observational data generated by the means of automated text mining with limited manual curation, opening up new opportunities for generating and modeling chem. toxicol. data. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Quality Control of 4-Acetamidophenyl 2-acetoxybenzoate).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Quality Control of 4-Acetamidophenyl 2-acetoxybenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Surface Properties and Liquid Crystal Properties of Alkyltetra(oxyethyl) β-D-Glucopyranoside was written by Li, Jiping;Zhang, Jing;Chen, Langqiu;Zhang, Guochao;Liao, Jingyi. And the article was included in Journal of Agricultural and Food Chemistry in 2021.Electric Literature of C16H22O11 The following contents are mentioned in the article:

Hydrophilic alkyl polyglycosides (APGs) and alkyl glycosides (AGs) with anomeric pure are a class of important substitutes for petroleum-based surfactants. Improving their water solubility should make such hydrophilic glycosurfactants have more excellent potential application value. To solve the inherent problem of poor water solubility of traditional alkyl β-D-glucopyranoside (5), a series of alkyltetra(oxyethyl) β-D-glucopyranosides (4a-4g, n = 7-18) were successfully synthesized by introducing tetra(oxyethylene) fragments to carry out the structural modification. The relation between the related structure and the physicochem. properties was further studied, including their hydrophilic-lipophilic balance (HLB), water-solubility, foaming performance, emulsification, hygroscopicity, surface activity, and thermotropic/lyotropic liquid crystal phase behavior. The water solubility gradually decreased as the alkyl chain length increased due to the gradual decrease of their HLB number Octadecyltetra(oxyethyl) β-D-glucopyranoside (4g, n = 18) was insoluble in water at 25°C. Taken together, long-chain alkyl glycosides had good foaming properties and excellent emulsifying properties. Among them, dodecyltetra(oxyethyl) β-D-glucopyranoside (4d, n = 12) had the best foaming performance. In the rapeseed oil/water system, cetyltetra(oxyethyl) β-D-glucopyranoside (4f, n = 16) had the best emulsifying ability. With the increase of the alkyl chain length, the critical micelle concentration (C_cmc), γ_cmc, Γ_max, and hygroscopicity of this series of glycosides showed a downward trend. Differential scanning calorimetry (DSC) and polarizing optical microscopy (POM) showed that the thermal stability increased with the increase of the alkyl chain length, and alkyltetra(oxyethyl) β-D-glucopyranosides (4d-4g, n = 12-18) had the corresponding m.ps. and clearing points. Alkyltetra(oxyethyl) β-D-glucopyranosides (4b-4g, n = 8-18) formed a smectic phase with a typical fan-shaped and focal conic texture during the cooling process. In the water contact experiments, glycosides (4b-4g, n = 8-18) at high concentrations transformed into various lyotropic liquid crystal including hexagonal phase, bicontinuous cubic phase, and lamellar phase phases. Therefore, such green nonionic glycosurfactants alkyltetra(oxyethyl) β-D-glucopyranosides should have potential practical application prospects. This study involved multiple reactions and reactants, such as (2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 604-69-3Electric Literature of C16H22O11).

(2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 604-69-3) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Electric Literature of C16H22O11

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

SDS of cas: 74305-48-9On March 31, 2003, Lucht, S.; Neher, D.; Miteva, T.; Nelles, G.; Yasuda, A.; Hagen, R.; Kostromine, S. published an article in Liquid Crystals. The article was 《Photoaddressable polymers for liquid crystal alignment》. The article mentions the following:

The authors demonstrate reversible photoinduced in situ reorientation of low mol. mass liquid crystals (LCs) by means of photoaddressable polymers (PAPs). These polymers contain mesogenic azobenzene side chains optimized to reorient cooperatively and effectively upon illumination with polarized light. Various low mol. mass LCs were introduced between two PAP layers and these sandwich devices were tested with respect to stability and reversibility of photoinduced orientation. Dissolution of the PAP layer by the low mol. mass LC was observed for several material combinations and systematically investigated. Different anisotropic dyes were added as fluorescence markers in order to monitor the photoinduced LC orientation. With an optimized material combination, more than 10 reversible reorientation processes could be realized with polarized light of either 514 or 405 nm wavelength, without any reduction in alignment quality. Further, microscopic polarized fluorescence patterns could be produced and erased within short exposure times. In the part of experimental materials, we found many familiar compounds, such as 4-n-Pentylphenyl-4-pentylbenzoate(cas: 74305-48-9SDS of cas: 74305-48-9)

4-n-Pentylphenyl-4-pentylbenzoate(cas: 74305-48-9) belongs to esters. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. SDS of cas: 74305-48-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Separation and determination of biphenyl nitrile compounds by microemulsion electrokinetic chromatography with mixed surfactants》 was written by Gong, Suxuan; Bo, Tao; Huang, Lan; Li, Ke An; Liu, Huwei. SDS of cas: 74305-48-9 And the article was included in Electrophoresis on April 30 ,2004. The article conveys some information:

A mixture of six biphenyl nitrile compounds and three related substances with high hydrophobicity and similar structures was successfully separated by microemulsion electrokinetic chromatog. (MEEKC) within 30 min. The microemulsion system contained 100 mM sodium dodecyl sulfate (SDS), 80 mM sodium cholate (SC), 0.81% volume/volume heptane, 7.5% volume/volume n-butanol, 10% volume/volume acetonitrile, and 10 mM borate. The addition of SC, organic modifiers, sample preparation, and temperature all showed remarkable effects on the separation The capacity factor (k) was calculated by using dodecyl benzene as the marker for microemulsion, and the calculated partition coefficient log Po/w of the solutes was at 3.35-7.38. The log k values matched well with the log Po/w with a correlation coefficient of 0.96. The linear correlation coefficients of each compound between peak area and concentration were 0.996-0.998 with the repeatability relative standard deviation value < 1.2% for migration time and < 4.8% for peak area, and the highest theoretic plate number was > 586,000. MEEKC was compared with micellar electrokinetic chromatog. (MEKC) indicating that the former method is more suitable for this separation and can be used for the quality control of biphenyl nitrile compounds in the synthesis of liquid crystals. After reading the article, we found that the author used 4-n-Pentylphenyl-4-pentylbenzoate(cas: 74305-48-9SDS of cas: 74305-48-9)

4-n-Pentylphenyl-4-pentylbenzoate(cas: 74305-48-9) belongs to esters. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. SDS of cas: 74305-48-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Related Products of 227940-71-8On November 6, 2020 ,《A Bispidine-Based Chiral Amine Catalyst for Asymmetric Mannich Reaction of Ketones with Isatin Ketimines》 appeared in Organic Letters. The author of the article were Li, Gonglin; Liu, Mohuizi; Zou, Sijia; Feng, Xiaoming; Lin, Lili. The article conveys some information:

A unique chiral amine organocatalyst with a bispidine structure was found to be efficient for the diastereo- and enantioselective Mannich reaction of isatin ketimines with ketones. A series of 3-substituted 3-amino-2-oxindoles, e.g., I, bearing vicinal tertiary and quaternary chiral stereogenic centers were obtained in excellent yields with excellent dr and ee values. The gram-scale synthesis and transformation of the product showed the practicability of this methodol. In addition, a possible transition state model was proposed to explain the origin of the stereoselectivity. The experimental part of the paper was very detailed, including the reaction process of tert-Butyl 7-benzyl-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate(cas: 227940-71-8Related Products of 227940-71-8)

tert-Butyl 7-benzyl-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate(cas: 227940-71-8) belongs to esters.Related Products of 227940-71-8 They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2022,Chemical Science included an article by Li, Gonglin; Zhang, Yan; Zeng, Hongkun; Feng, Xiaoming; Su, Zhishan; Lin, Lili. Electric Literature of C19H28N2O2. The article was titled 《Water enables diastereodivergency in bispidine-based chiral amine-catalyzed asymmetric Mannich reaction of cyclic N-sulfonyl ketimines with ketones》. The information in the text is summarized as follows:

A diastereodivergent asym. Mannich reaction of cyclic N-sulfonyl ketimines I (R1 = Me, Et, i-Pr, Bn, etc.; R2 = H, 5-OMe, 7-Cl, 6-Me, etc.) with ketones such as cyclohexanone, tert-Bu 4-oxopiperidine-1-carboxylate, thian-4-one, etc. catalyzed by a bispidine-based chiral amine catalyst, in which addnl. water switches the diastereoselectivity efficiently was reported. Synthesis of chiral anti- benzosultams and syn-benzosultams II (X = CH2, O, NCO2t-Bu, etc.) with potential anti-HIV-1 activity is obtained in excellent yields and good to excellent ee values. Control experiments and d. functional theory (DFT) calculations were applied to study the diastereodivergent mechanism, which reveal that the diastereodivergent catalysis should be state-determined, and the water reverses the energies of states to realize the diastereodivergency. The findings are quite new and might inspire more diastereodivergent asym. synthesis. In addition to this study using tert-Butyl 7-benzyl-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate, there are many other studies that have used tert-Butyl 7-benzyl-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate(cas: 227940-71-8Electric Literature of C19H28N2O2) was used in this study.

tert-Butyl 7-benzyl-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate(cas: 227940-71-8) belongs to esters. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. Electric Literature of C19H28N2O2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics