Tag: 300-400

Role of solid lipid nanoparticles as drug delivery vehicles on the pharmacokinetic variability of Erlotinib HCl was written by Rampaka, Rajani;Ommi, Kusuma;Chella, Naveen. And the article was included in Journal of Drug Delivery Science and Technology in 2021.Computed Properties of C21H44O5 The following contents are mentioned in the article:

Erlotinib HCl is approved for the treatment of metastatic non-small cell lung cancer. Owing to its poor aqueous solubility and presystemic metabolism, Erlotinib HCl has poor oral bioavailability. Presence of food shows the variability in pharmacokinetics of erlotinib especially in absorption. The present study is aimed at developing solid lipid nanoparticles for Erlotinib HCl and evaluate their role on the bioavailability and food dependent variability in its absorption. Solid lipid nano particles were formulated by rota evaporation melt method and characterized by zeta sizer, FT-IR spectroscopy, X-ray diffraction and differential scanning calorimetry and In vivo pharmacokinetic studies in SD rats. A sensitive and specific high-performance liquid chromatog. method was developed for the determination drug concentration in rats plasma. The pharmacokinetic data was analyzed using phoenix 32 WinNonlin software. The average particle size and zeta potential of the optimized Erlotinib SLN was found to be 177 nm and -33 mV. All the characterization studies indicated there were no interactions between drug and excipients and the drug is inside the nanoparticles. Linearity was observed for the Erlotinib HCl in rats plasma from 5 to 30μg/mL. In vivo pharmacokinetics study in rat model showed significant increase in the oral bioavailability (2.12-fold) and reduced variability in area under the curve (from 2.5 to 1.4) from fed to fasted state using solid lipid nanoparticles over the plain drug. Solid lipid nanoparticles showed significant improvement in bioavailability along with reduction in pharmacokinetic variability. This study involved multiple reactions and reactants, such as Glyceryl monostearate (cas: 31566-31-1Computed Properties of C21H44O5).

Glyceryl monostearate (cas: 31566-31-1) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Computed Properties of C21H44O5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Molecular-Level Understanding of the Major Fragmentation Mechanisms of Cellulose Fast Pyrolysis: An Experimental Approach Based on Isotopically Labeled Model Compounds was written by Yu, Zaikuan J.;Easton, Mckay W.;Murria, Priya;Xu, Lan;Ding, Duanchen;Jiang, Yuan;Zhang, Jifa;Kenttamaa, Hilkka I.. And the article was included in Journal of Organic Chemistry in 2019.Recommanded Product: 604-69-3 The following contents are mentioned in the article:

Evaluation of the feasibility of various mechanisms possibly involved in cellulose fast pyrolysis is challenging. Therefore, selectively ¹³C-labeled cellotriose, ¹⁸O-labeled cellobiose, and ¹³C- and ¹⁸O-doubly-labeled cellobiose were synthesized and subjected to fast pyrolysis in an atm. pressure chem. ionization source of a linear quadrupole ion trap/orbitrap mass spectrometer. The initial products were immediately quenched, ionized using ammonium cations, and subsequently analyzed using the mass spectrometer. The loss or retention of isotope labels upon pyrolysis unambiguously revealed three major competing mechanisms-sequential losses of glycolaldehyde/ethenediol mols. from the reducing end (the reducing-end unraveling mechanism), hydroxymethylene-assisted glycosidic bond cleavage (HAGBC mechanism), and Maccoll elimination. Important discoveries include the following: reducing-end unraveling is the predominant mechanism occurring at the reducing end, maccoll elimination facilitates the cleaving of aglyconic bonds and it is the mechanism leading to formation of reducing carbohydrates, HAGBC occurs for glycosides but not at the reducing end of cellodextrins, HAGBC and water loss are the predominant reactions for fast pyrolysis of 1,6-anhydrocellodextrins, and HAGBC can proceed after reducing-end unraveling but unraveling does not occur once the HAGBC reaction pathway is initiated. Moreover, hydrolysis was conclusively ruled out for fast pyrolysis of cellobiose, cellotriose, and 1,6-anhydrocellodextrins up to cellotetraosan. No radical reactions were observed This study involved multiple reactions and reactants, such as (2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 604-69-3Recommanded Product: 604-69-3).

(2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 604-69-3) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Recommanded Product: 604-69-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Salicin and Hederacoside C-Based Extracts and UV-Absorbers Co-Loaded into Bioactive Lipid Nanocarriers with Promoted Skin Antiaging and Hydrating Efficacy was written by Lacatusu, Ioana;Balanuca, Brindusa;Serafim, Andrada;Ott, Cristina;Prodana, Mariana;Badea, Nicoleta. And the article was included in Nanomaterials in 2022.SDS of cas: 31566-31-1 The following contents are mentioned in the article:

Conventional and herbal active principles can be combined in a beneficial harmony using their best features and compensating for the certain weaknesses of each. The study will answer the question, “how can willow bark extract (Wbe) or ivy leaf extract (Ile) influence the photoprotective, skin permeation and hydration properties of Bioactive Lipid Nanocarriers (BLN) loaded with UV-filters and selected herbals “. BLN-Wbe/Ile-UV-filters were characterized for particle size, zeta potential, thermal behavior, entrapment efficiency and drug loading. The formulated BLN-hydrogels (HG) were subjected to in vitro release and permeation experiments The in vitro determination of sun protection factors, as well as comparative in vitro photostability tests, rheol. behavior and in vivo hydration status have been also considered for hydrogels containing BLN-Ile/Wbe-UV-filters. Photoprotection of BLN-HG against UVA rays was more pronounced as compared with the UVB (UVA-PF reached values of 30, while the maximum SPF value was 13). The in vitro irradiation study demonstrated the photostability of BLN-HG under UV exposure. A noteworthy cosmetic efficacy was detected by in vivo skin test (hydration effect reached 97% for the BLN-Wbe-UV-filters prepared with pomegranate oil). The research novelty, represented by the first-time co-optation of the active herbal extracts (Wbe and Ile) together with two synthetic filters in the same nanostructured delivery system, will provide appropriate scientific support for the cosmetic industry to design novel marketed formulations with improved quality and health benefices. This study involved multiple reactions and reactants, such as Glyceryl monostearate (cas: 31566-31-1SDS of cas: 31566-31-1).

Glyceryl monostearate (cas: 31566-31-1) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.SDS of cas: 31566-31-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The protective impact of adapted trimebutine maleate-loaded nanostructured lipid carriers for alleviating the severity of acute colitis was written by Motawea, Amira;Abd El Hady, Walaa Ebrahim;Ahmed El-Emam, Ghada. And the article was included in Drug Delivery in 2022.Computed Properties of C21H44O5 The following contents are mentioned in the article:

Nanoparticles for colon-drug delivery were designed and evaluated to solve many discrepancy issues such as high adverse effects of released drugs, insufficient drug amount at diseased areas, and unintentionally premature drug release to noninflamed GIT regions. Herein, the goal of this work was to convert trimebutine maleate (TMB) into nanostructured lipid carriers (NLC) in order to improve its protective effects in ulcerative colitis. NLC of TMB was prepared by the hot homogenization followed by ultra-sonication method. A full 42-factorial design was used to estimate the produced TMB-NLC. The study design included the exploration of the impact of two independent variables namely lipid mix amount and ratio (glyceryl mono stearate and capryol 90), surfactant concentration (0.5, 1, 1.5, and 2%), on the particle size, polydispersity index, and the entrapment efficiency (EE%). The protective activity of F9 was examined through macroscopical scores, histopathol. changes, immunohistochem. localization of tumor necrosis factor-α (TNF-α) and examination of oxidative stress such as reduced glutathione (GSH), superoxide dismutase (SOD), and malondialdehyde (MDA) against acetic acid-induced colitis in rats. Consistent with our expectations, the orally administered optimized formula (F9) alleviated the severity of colitis in acetic acid-induced rat model of colitis likely owing to the controlled release compared to free TMB. We aimed to develop TMB-loaded NLC for the treatment of acute colitis with the goal of providing a superior drug safety profile over long-term remission and maintenance therapy. This study involved multiple reactions and reactants, such as Glyceryl monostearate (cas: 31566-31-1Computed Properties of C21H44O5).

Glyceryl monostearate (cas: 31566-31-1) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Computed Properties of C21H44O5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Design, characterization and evaluation of floating microencapsules of ilaprazole by hot melt granulation method was written by Kajale, Archana D.;Gawande, Shilpa R.;Channawar, Madhuri A.;Raut, Pratiksha;Junghari, Kalyani;Satpute, Snehal. And the article was included in Pharmaceutical and Chemical Journal in 2022.Formula: C21H44O5 The following contents are mentioned in the article:

Microencapsulation is described as a process of enclosing micron-sized particles of solids or droplets of liquids or gasses in an inert shell, which in turn isolates and protects them from the external environment. Hot-melt granulation (HMG) has gained interest in the pharmaceutical field as a processing technol. capable of producing solid dispersions with a high degree of drug-polymer interactions. The simultaneous mech. and thermal shear of samples achieved by HMG can noticeably modify drug properties such as solubility, poor taste, and flow-ability, while producing sustained drug delivery systems. In Hot Melt Granulation Amount of meltable binder is 10%-30% weight/weight with respect to that of fine solid particles is used. A Meltable binder suitable for melt a granulation has a m.p. typically within the range of 60-80 °C. Hydrophilic Meltable binders are used for preparation of immediate-release dosage forms while the hydrophobic Meltable binders are preferred for prolonged-release formulations. The current work elaborates the mechanism of hot melt granulation over traditional method for sustained release of drug and long lasting effect. In the present study stearic acid, Glyceryl monosterate, Cetyl alc. were used as base and various polymers like HPMC K100 M, Guargum, Xanthum gum, were used in various concentrations From this formulations HPMC K100 M in the concentration of 2% (I12) gives sustain drug release as 100.76% for 12 h and follows zero order kinetics. Where other polymers i.e. Xanthum gum Guargum, were not able to retain the drug release for 12 h in various concentrations This study involved multiple reactions and reactants, such as Glyceryl monostearate (cas: 31566-31-1Formula: C21H44O5).

Glyceryl monostearate (cas: 31566-31-1) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Formula: C21H44O5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Fabrication of ultrastable water-in-oil high internal phase emulsion as versatile delivery vehicle through synergetic stabilization was written by Tang, Xiang-Yi;Wang, Zhi-Ming;Yu, Di;Yu, Shu-Juan;Meng, He-Cheng;Zhang, Tao;Chen, Hua-Lei;Yang, Zhan-Wei;Yang, Qing-Yu;Li, Lili. And the article was included in Food Hydrocolloids in 2022.COA of Formula: C21H44O5 The following contents are mentioned in the article:

Bioactive substances possess superior antioxidant, anti-hypertensive, and anti-tumor activities. However, their susceptibility to degrade at low pH often limit their application. Compare with the conventional oil-in-water (W/O) emulsions, the lack of natural hydrophobic stabilizers resulted in difficulties in fabricating water-in-oil (W/O) high internal phase emulsion (HIPE). Further, the instability of W/O HIPE also limit its industrial application in food industry. In the present study, a natural, conventional, eco-friendly, and structured W/O HIPE was developed using glyceryl monostearate (GMS) as emulsifier and beeswax and gellan gum as structurant. The system with the synergetic effect of emulsifier and structurant, accounted for 0.25 wt % of GMS and hydrogel, and 1.25 wt % of beeswax in total system endowed the W/O HIPE with biphasic rigid network and impressive storage stability. The microstructures of these newly developed W/O HIPEs could be controlled by the beeswax concentration (cb), GMS concentration (cg), and aqueous phase volume (Φ). Moreover, the GMS-based emulsion encapsulation improved the retention rate of betanin by 36.68% after 7 days of storage. Meanwhile, this emulsion gel could prevent the nucleophilic attack of hydrogen ions against betanin at room temperature under a low pH environment, which greatly improved the stability of betanin under highly acid conditions. Furthermore, the GMS stabilized W/O HIPE possessed pH-sensitive, which could achieve controlled-release of both hydrophilic and hydrophobic functional compounds in an in vitro simulated release assay. This study involved multiple reactions and reactants, such as Glyceryl monostearate (cas: 31566-31-1COA of Formula: C21H44O5).

Glyceryl monostearate (cas: 31566-31-1) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.COA of Formula: C21H44O5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Characterisation of a Novel Acetyl Xylan Esterase (BaAXE) Screened from the Gut Microbiota of the Common Black Slug (Arion ater) was written by Madubuike, Henry;Ferry, Natalie. And the article was included in Molecules in 2022.Product Details of 604-69-3 The following contents are mentioned in the article:

Acetyl xylan esterases (AXEs) are enzymes capable of hydrolyzing the acetyl bonds in acetylated xylan, allowing for enhanced activity of backbone-depolymerizing enzymes. Bioprospecting novel AXE is essential in designing enzyme cocktails with desired characteristics targeting the complete breakdown of lignocellulose. In this article, we report the characterization of a novel AXE identified as Gene_id_40363 in the metagenomic library analyzed from the gut microbiota of the common black slug. The conserved domain description was identified with an NCBI BLASTp search using the translated nucleotide sequence as a query. The activity of the recombinant enzyme was tested on various synthetic substrates and acetylated substrates. The protein sequence matched the conserved domain described as putative hydrolase and aligned closely to an uncharacterized esterase from Buttiauxella agrestis, hence the designation as BaAXE. BaAXE showed low sequence similarity among characterized CE family proteins with an available 3D structure. BaAXE was active on 4-nitrophenyl acetate, reporting a specific activity of 78.12 U/mg and a Km value of 0.43 mM. The enzyme showed optimal activity at 40°C and pH 8 and showed high thermal stability, retaining over 40% activity after 2 h of incubation from 40°C to 100°C. BaAXE hydrolyzed acetyl bonds, releasing acetic acid from acetylated xylan and β-D-glucose pentaacetate. BaAXE has great potential for biotechnol. applications harnessing its unique characteristics. In addition, this proves the possibility of bioprospecting novel enzymes from understudied environments. This study involved multiple reactions and reactants, such as (2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 604-69-3Product Details of 604-69-3).

(2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 604-69-3) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Product Details of 604-69-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Continuous production of raloxifene hydrochloride loaded nanostructured lipid carriers using hot-melt extrusion technology was written by Muhindo, Derick;Ashour, Eman A.;Almutairi, Mashan;Joshi, Poorva H.;Repka, Michael A.. And the article was included in Journal of Drug Delivery Science and Technology in 2021.Reference of 31566-31-1 The following contents are mentioned in the article:

The aim of this study was to utilize a continuous process for the production of orally administered raloxifene hydrochloride (RX-HCl) loaded nanostructured lipid carrier (NLC) formulations for extended drug release using hot-melt extrusion (HME) technol. coupled with probe sonication, and also to evaluate the in vitro characteristics of the prepared NLCs. Preparation of the NLCs using HME technol. involved two main steps, first formation of a pre-emulsion after extrusion and then size reduction of the pre-emulsion using probe sonication to obtain the NLCs. A screw speed of 100 rpm and a barrel temperature of 85°C, were used in the extrusion process. NLCs prepared by HME technol. showed a lower particle size compared to those prepared by the conventional probe sonication method. The prepared NLCs had high entrapment efficiency values (>90%). In vitro drug release was evaluated using dialysis bag diffusion technique and USP apparatus I. Overall, the RX-HCl loaded NLCs had a higher rate of drug release than the pure drug. The release profile for the F4-3 NLC formulations and pure drug at the beginning and end of the stability study were comparable. The particle size of the prepared NLCs remained stable over the storage period and all PDI and zeta potential values were ≤ 0.5 and in the range of -15 to -30 mV, resp., indicating good phys. stability of the formulations. In summary, HME technol. and probe sonication were successfully used to prepare RX-HCl loaded NLC formulations with shorter processing times as compared to the conventional probe sonication method, which makes this technique a uniquely more industry-friendly method. This study involved multiple reactions and reactants, such as Glyceryl monostearate (cas: 31566-31-1Reference of 31566-31-1).

Glyceryl monostearate (cas: 31566-31-1) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Reference of 31566-31-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Resource recovery from waste coffee grounds using ultrasonic-assisted technology for bioenergy production was written by Mofijur, M.;Kusumo, F.;Fattah, I. M. Rizwanul;Mahmudul, H. M.;Rasul, M. G.;Shamsuddin, A. H.;Mahlia, T. M. I.. And the article was included in Energies (Basel, Switzerland) in 2020.Synthetic Route of C20H40O2 The following contents are mentioned in the article:

Biodiesel is a proven alternative fuel that can serve as a substitute for petroleum diesel due to its renewability, non-toxicity, sulfur-free nature and superior lubricity. Waste-based non-edible oils are studied as potential biodiesel feedstocks owing to the focus on the valorisation of waste products. Instead of being treated as municipal waste, waste coffee grounds (WCG) can be utilized for oil extraction, thereby recovering an energy source in the form of biodiesel. This study evaluates oil extraction from WCG using ultrasonic and Soxhlet techniques, followed by biodiesel conversion using an ultrasonic-assisted transesterification process. It was found that n-hexane was the most effective solvent for the oil extraction process and ultrasonic-assisted technol. offers a 13.5% higher yield compared to the conventional Soxhlet extraction process. Solid-to-solvent ratio and extraction time of the oil extraction process from the dried waste coffee grounds (DWCG) after the brewing process was optimized using the response surface methodol. (RSM). The results showed that predicted yield of 17.75 weight % of coffee oil can be obtained using 1:30 w/v of the mass ratio of DWCG-ton-hexane and 34 min of extraction time when 32% amplitude was used. The model was verified by the experiment where 17.23 weight % yield of coffee oil was achieved when the extraction process was carried out under optimal conditions. The IR absorption spectrum anal. of WCG oil determined suitable functional groups for biodiesel conversion which was further treated using an ultrasonic-assisted transesterification process to successfully convert to biodiesel. This study involved multiple reactions and reactants, such as Methyl nonadecanoate (cas: 1731-94-8Synthetic Route of C20H40O2).

Methyl nonadecanoate (cas: 1731-94-8) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Synthetic Route of C20H40O2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Crystallization and Melting Behavior of Mixtures of Pure Monoacylglycerols and Diacylglycerols was written by Nicholson, Reed A.;Mazzanti, Gianfranco;Marangoni, Alejandro G.. And the article was included in Crystal Growth & Design in 2022.Quality Control of Glyceryl monostearate The following contents are mentioned in the article:

This differential scanning calorimetry survey provides a valuable exploratory map. It identifies the mixtures of pure mono- and diacylglycerols (MAGs and DAGs), proportions, and temperatures needed for planning deeper crystallog. characterizations. Monopalmitin and monostearin produced a eutectic mixture The formation of solid-solution crystals at all concentrations was observed for the mixtures of 1-monolinolein and 1-monoolein. The range of proportions at which MAGs formed solid solutions was reduced when structural differences between fatty acid moieties increased. 1-Monopalmitin formed solid solutions with 1-monoolein when less than 19.3% 1-monopalmitin was present. Addnl., low amounts of 1-monoolein ( < 10.1%) formed solid solutions with 1-monopalmitin while causing 1-monopalmitin α crystals to transition to higher melting polymorphs. The mixtures of diolein and 1-monoolein formed solid solutions up to a 1-monoolein concentration of 50% and melted sep. at greater 1-monoolein concentrations Furthermore, 1-monopalmitin formed solid solutions with diolein only when 1-monopalmitin was present below 3.7%. The formation of solid solutions was not observed between 1-monopalmitin and palmitoyl-oleoyl-glycerol. The addition of palmitoyl-oleoyl-glycerol, however, caused a polymorphic transformation in 1-monpalmitin to the β′ form. For diolein + 1-monoolein, 1-monopalmitin + 1-monoolein, and diolein + palmitoyl-oleoyl-glycerol mixtures, at low concentrations, higher-melting species always had a solid-state partial solubility in lower-melting species. At higher concentrations, it phase separated, melting as a sep. component. This study involved multiple reactions and reactants, such as Glyceryl monostearate (cas: 31566-31-1Quality Control of Glyceryl monostearate).

Glyceryl monostearate (cas: 31566-31-1) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Quality Control of Glyceryl monostearate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics