Tag: 300-400

An integrated virtual screening and drug repurposing strategy for the discovery of new antimalarial drugs against Plasmodium falciparum phosphatidylinositol 3-kinase was written by Verma, Kanika;Lahariya, Ayush K.;Dubey, Shivangee;Verma, Anil K.;Das, Aparup;Schneider, Kristan A.;Bharti, Praveen K.. And the article was included in Journal of Cellular Biochemistry in 2021.Electric Literature of C17H15NO5 The following contents are mentioned in the article:

The emergence and spread of drug resistance in Plasmodium falciparum, the parasite causing the most severe form of human malaria, is a major threat to malaria control and elimination programs around the globe. With P. falciparum having evolved widespread resistance against a number of previously widely used drugs, currently, artemisinin (ART) and its derivatives are the cornerstones of first-line treatments of uncomplicated malaria. However, growing incidences of ART failure reflect the spread of ART-resistant P. falciparum strains. Despite current efforts to understand the primary cause of ART resistance due to mutations in the Kelch 13 gene (PfK13), the mechanism underlying ART resistance is still not completely unclear and no feasible strategies to counteract the causes and thereby restoring the efficiency of ART have been developed. We use a polypharmacol. approach to identify potential drugs that can be used for the novel purpose (target). Of note, we have designed a multimodal stratagem to identify approved drugs with a potential antimalarial activity using computational drug reprofiling. Our investigations suggest that oxetacaine, simvastatin, repaglinide, aclidinium, propafenone, and lovastatin could be repurposed for malaria control and prevention. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Electric Literature of C17H15NO5).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Electric Literature of C17H15NO5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Preparation of a stable gel-in-crystallized oil-in-gel type structured W₁/O/W₂ double emulsions: effect of internal aqueous phase gelation on the system stability was written by Wang, Wenjuan;Sun, Rui;Dong, Zhe;Ji, Suping;Xia, Qiang. And the article was included in Journal of Dispersion Science and Technology.Reference of 31566-31-1 The following contents are mentioned in the article:

This work reported a strategy to improve the storage stability of W1/O/W2 double emulsions with the combination of the gelled internal aqueous phase, crystallized lipid phase, and gelled external aqueous phase. The composite of κ-carrageenan and locust bean gum (κ-C/LBG) was a suitable gelling agent of the internal aqueous phase. Crystallized oils were formed by the addition of solid lipid (glycerol monostearate, GMS) into the oil phase. The double emulsions fortified by gelled inner droplets were filled in Ca-alginate hydrogel beads. The results demonstrated that GMS formed crystalline layers at the oil-water interface, and its concentration significantly affected the morphol. and droplet size of double emulsions. The total polymer concentration of κ-C/LBG had an effect on the droplet size and entrapment efficiency of double emulsions. Furthermore, thermal stability study (2-21 days) and long-term storage stability study (24 wk) showed that the gelation of the internal aqueous phase with a low concentration of 0.5 wt% κ-C/LBG appreciable increased the retention efficiency of the encapsulated double emulsions compared with the system of the non-gelled internal aqueous phase, which might provide a useful method to promote the production of double emulsions. This study involved multiple reactions and reactants, such as Glyceryl monostearate (cas: 31566-31-1Reference of 31566-31-1).

Glyceryl monostearate (cas: 31566-31-1) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Reference of 31566-31-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Constituent diversity of ethanol extracts from pitaya was written by Ma, Jinghua;Mo, Wei;Zhang, Pangpan;Lai, Yong;Li, Ximei;Zhang, Dangquan. And the article was included in Asia-Pacific Journal of Chemical Engineering in 2020.Application of 1731-94-8 The following contents are mentioned in the article:

Pitaya is rich in nutrition and unique in function and contains vegetable albumin, anthocyanins, rich vitamins, and water soluble dietary fiber, which are rare in fruits and vegetables. However, researches mostly focused on pitaya cultivation, biol. characteristics, fresh-keeping, and lacked analyses about chem. composition of pitaya. Therefore, ethanol extraction and GC/MS were used to extract and identify the bioactive components in pulp and pericarp of red pitaya and white pitaya. The extracting results showed that percentages of ethanol extracts from pulp and pericarp of red pitaya were 14.5% and 12%, whereas those of white pitaya were 16% and 12%. The GC/MS results showed that different kinds of bioactive constituents were identified in fresh pericarp and pulp of red pitaya and white pitaya. In the four ethanol extracts, there are rich polysiloxane plant organosilicon with total contents of 10.09%, 24.21%, 25.77%, and 23.25%. Meanwhile, there are many heterocyclic substances, and the content of pericarp is much higher than that of pulp. The four ethanol extracts also contain some other bioactive ingredients, such as esters, hydrocarbons, alcs., amides, halides, and fatty acids, which can be used as raw materials for biomedicine, advanced cosmetics, and skin care products. This study involved multiple reactions and reactants, such as Methyl nonadecanoate (cas: 1731-94-8Application of 1731-94-8).

Methyl nonadecanoate (cas: 1731-94-8) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Application of 1731-94-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Value-added products from waste plastics using dissolution technique was written by Chaudhary, Amita;Dave, Mohit;Upadhyay, Darshit S.. And the article was included in Materials Today: Proceedings in 2022.Formula: C20H40O2 The following contents are mentioned in the article:

Non-biodegradable plastics polymers, such as low-d. polyethylene (LDPE), polystyrene (PS), and polyvinyl chloride (PVC) are non-biodegradable and release toxic gases into the environment on combustion and after long use. This study includes the screening of a series of organic solvents for solubility parameters of LDPE and PS. The karanja biodiesel is also used as one of the solvents for the dissolution of plastics. In order to decide the best solvent to be used for the dissolution of plastic polymer, rate of dissolution, safety aspect, and cost of the solvent were considered. The solubility factor of LDPE and PS is found to be much closed to acetone, chlorobenzene, and karanja biodiesel. Out of them, karanja biodiesel is considered due to its environment friendly behavior. The output of the study is with three value-added products as high heating value fuel, good composite for low-d. cement, and an oil-adsorbent. The dissolution products obtained are chem. analyzed using FTIR and GC-MS techniques to elucidate their composition The BET and TGA techniques are used for phys. anal., viz., the porosity and thermal stability of the products resp. The findings of dissolution methods in this article are compared with the conventional pyrolysis techniques for these plastics treatment. This study involved multiple reactions and reactants, such as Methyl nonadecanoate (cas: 1731-94-8Formula: C20H40O2).

Methyl nonadecanoate (cas: 1731-94-8) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Formula: C20H40O2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The role of the polar head group and aliphatic tail in the self-assembly of low molecular weight molecules in oil was written by Golodnizky, Daniel;Rosen-Kligvasser, Jasmine;Davidovich-Pinhas, Maya. And the article was included in Food Structure in 2021.Related Products of 31566-31-1 The following contents are mentioned in the article:

The current research explores the involvement of head group size, chem. group type, and aliphatic tail in the mol. self-assembly of various oil structuring agents with similar 18-carbon aliphatic chains and hydroxyl, carbonyl, and/or carboxyl groups, in canola oil. Thermal and mech. analyses at different molar concentrations emphasized the involvement of van der Waals (vdW) interactions and hydrogen bonds (H-bonds) in the self-assembly process. Higher contribution of vdW-forces in the self-assembly was observed when increasing mol. concentration from medium to high. The presence of H-bonds corresponding with organized crystal structures was detected in samples containing hydroxyl or carboxyl groups using nano-structure anal. Absence of such groups led to ordered organization only at high concentrations, implying the involvement of vdW interactions. Polarized images demonstrated curved structures for long head group mols., implying the formation of intermol. H-bonds with neighboring mols. leading to structure curvature. The current results provide exptl. indication to involvement of different forces, i.e. H-bonds and vdW, in the mol. self-assembly of oil structuring agents in oil which can be further exploit while developing new oleogel system based on low mol. weight gelators. This study involved multiple reactions and reactants, such as Glyceryl monostearate (cas: 31566-31-1Related Products of 31566-31-1).

Glyceryl monostearate (cas: 31566-31-1) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Related Products of 31566-31-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Preparation and standardisation of herbal eye dark circle remover was written by Mufseena, P.;Celestin Baboo, R. V.;Shiji Kumar, P. S.. And the article was included in World Journal of Pharmaceutical Research in 2022.Computed Properties of C21H44O5 The following contents are mentioned in the article:

The eye, which is the point of convergence, not only conveys the full range of human emotion but also has a significant impact on how one is perceived in terms of health and beauty. Whenever correlated with other body parts, the skin around the eye is a region without many oil glands and collagen, so it is more inclined to scarce differences and drying out. Addnl. when there is more melanin produced around the eyes than is usual giving them a darker color, the condition is called periorbital hyperpigmentation. The principle objective of this research is to formulate, characterize and evaluate a herbal under-eye cream which consists of the extracts of cucumber (Cucumis sativus), Aloe vera (Aloe barbadensis) and Vitamin E. The cream was prepared by using the cream base, beeswax, liquid paraffin, borax, aloe extract and cucumber extract The prepared formulation was evaluated for different parameters like phys. evaluations, pH, greasiness, phase separation and test for microorganism. The formulation showed good appearance, good pH, no phase separation and microbial growth. Also it is stable at room temperature The formulation containing herbal ingredients showed significant activity. Based upon the result, the formulation is stable and can be safely used as an under eye cream. This study involved multiple reactions and reactants, such as Glyceryl monostearate (cas: 31566-31-1Computed Properties of C21H44O5).

Glyceryl monostearate (cas: 31566-31-1) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Computed Properties of C21H44O5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Variation of anionic moieties of dicationic ionic liquid GC stationary phases: Effect on stability and selectivity was written by Talebi, Mohsen;Patil, Rahul A.;Sidisky, Leonard M.;Berthod, Alain;Armstrong, Daniel W.. And the article was included in Analytica Chimica Acta in 2018.Quality Control of Methyl nonadecanoate The following contents are mentioned in the article:

Dicationic ionic liquids (DILs) are more and more accepted as a new class of high temperature and polar stationary phases for gas chromatog. (GC). This study deals with the effect of seven different fluorosulfonyl derivatized anions associated with two dications: 1,3-di(3-methylimidazolium)-2-methylpropane [2mC₃(mim)₂], and 1,3-di(3-methylimidazolium)-isobutene [i-eneC₄(mim)₂]. Thermophys. properties of the 14 synthesized DILs were evaluated in terms of m.p., viscosity, and thermal stability. The optimal physicochem. properties of 13 DILs allowed preparing 13GC capillary columns. Accordingly, the polarity and selectivity of the DILs were evaluated by determining the Rohrschneider-McReynolds constants and the equivalent chain lengths of C18 fatty acid Me esters (FAMEs). The sym. fluoroalkylsulfonyl and the trifluorosulfonate anions seem to produce the most polar DILs. Compared to classical polyethyleneglycol phases, the DILs showed substantially decreased retention of apolar compounds and a much stronger retention of the polar ones. Unique selectivities were observed with unsaturated FAMEs, polyaromatic hydrocarbons, and bacterial specific FAMEs. The two applications presented included a biodiesel and bacterial FAME analyses. This study involved multiple reactions and reactants, such as Methyl nonadecanoate (cas: 1731-94-8Quality Control of Methyl nonadecanoate).

Methyl nonadecanoate (cas: 1731-94-8) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Quality Control of Methyl nonadecanoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthesis and In Vitro Characterization of Ascorbyl Palmitate-Loaded Solid Lipid Nanoparticles was written by Ledinski, Maja;Maric, Ivan;Peharec Stefanic, Petra;Ladan, Iva;Caput Mihalic, Katarina;Jurkin, Tanja;Gotic, Marijan;Urlic, Inga. And the article was included in Polymers (Basel, Switzerland) in 2022.Synthetic Route of C21H44O5 The following contents are mentioned in the article:

Antitumor applications of ascorbic acid (AA) and its oxidized form dehydroascorbic acid (DHA) can be quite challenging due to their instability and sensitivity to degradation in aqueous media. To overcome this obstacle, we have synthesized solid lipid nanoparticles loaded with ascorbyl palmitate (SLN-AP) with variations in proportions of the polymer Pluronic F-68. SLNs were synthesized using the hot homogenization method, characterized by measuring the particle size, polydispersity, zeta potential and visualized by TEM. To investigate the cellular uptake of the SLN, we have incorporated coumarin-6 into the same SLN formulation and followed their successful uptake for 48 h. We have tested the cytotoxicity of the SLN formulations and free ascorbate forms, AA and DHA, on HEK 293 and U2OS cell lines by MTT assay. The SLN-AP in both formulations have a cytotoxic effect at lower concentrations when compared to ascorbate applied the form of AA or DHA. Better selectivity for targeting tumor cell line was observed with 3% Pluronic F-68. The antioxidative effect of the SLN-AP was observed as early as 1 h after the treatment with a small dose of ascorbate applied (5 μM). SLN-AP formulation with 3% Pluronic F-68 needs to be further optimized as an ascorbate carrier due to its intrinsic cytotoxicity. This study involved multiple reactions and reactants, such as Glyceryl monostearate (cas: 31566-31-1Synthetic Route of C21H44O5).

Glyceryl monostearate (cas: 31566-31-1) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Synthetic Route of C21H44O5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Syzygium aromaticum (clove) essential oil: An alternative for the sanitization of citrus fruit in packinghouses was written by Soraggi Battagin, Tiago;Nicolas Caccalano, Mario;Dilarri, Guilherme;Felipe Cavicchia Zamuner, Caio;Alleoni, Natalia;Leonardo Saldanha, Luiz;Bacci, Mauricio Jr.;Ferreira, Henrique. And the article was included in Journal of Food Processing and Preservation in 2021.Synthetic Route of C20H40O2 The following contents are mentioned in the article:

Citrus canker is a quarentenary disease caused by Xanthomonas citri subsp. citri (X. citri). Thus, sanitization of fresh fruit is a necessary measure before any com. activity. Therefore, we evaluated the clove essential oil (CEO), as an alternative sanitizer for the disinfection of citrus fruit in packinghouses. Tests in vitro and in vivo were carried out to determine the cell inhibitory concentration and to verify the efficacy of the oil for the disinfection of citrus fruits. In in vitro tests, CEO was able to inhibit X. citri when used at 0.75% (volume/volume). In experiments that simulate the sanitization process used in packinghouses, 5% CEO was as effective as the recommended sanitization product based on sodium hypochlorite. GC-MS results showed a high presence of eugenol derivatives as the major compounds of CEO. All results proved that CEO is a potential sanitizer that could be used as an alternative to sodium hypochlorite. Novelty impact statement : Exptl. evidence shows that the clove essential oil (CEO) has the same sanitization efficacy as sodium hypochlorite, which makes of CEO an alternative sanitizer for the decontamination of citrus fruits to be exported to the European Union. CEO is a safer and more sustainable sanitizer for the postharvest disinfection of citrus fruit. This study involved multiple reactions and reactants, such as Methyl nonadecanoate (cas: 1731-94-8Synthetic Route of C20H40O2).

Methyl nonadecanoate (cas: 1731-94-8) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Synthetic Route of C20H40O2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Formulation and characterization of hydroxyethyl cellulose-based gel containing metronidazole-loaded solid lipid nanoparticles for buccal mucosal drug delivery was written by Ho, Hoang Nhan;Le, Hoang Hao;Le, Thien Giap;Duong, Thi Hong Anh;Ngo, Viet Quynh Tram;Dang, Cong Thuan;Nguyen, Van Minh;Tran, Tuan Hiep;Nguyen, Chien Ngoc. And the article was included in International Journal of Biological Macromolecules in 2022.Reference of 31566-31-1 The following contents are mentioned in the article:

Local delivery of drug is a promising strategy to manage periodontitis characterized by chronic inflammation of the soft tissue surrounding the teeth. An optimized system should prolong the drug retention time and exhibit controlled drug permeation through the buccal mucosal layer. This study was aimed to develop hydroxyethyl cellulose (HEC)-based gel containing metronidazole (MTZ) loaded in solid lipid nanoparticles (SLNs), and to enhance the antimicrobial activity of MTZ. SLNs were prepared using a combination method of solvent evaporation and hot homogenization. The results showed that the fabricated SLNs, comprising of Precirol (2.93%, w/v), Tween 80 (1.8%, w/v), and the drug:lipid ratio of 19.3% (weight/weight), were approx. 200 nm in size, with a narrow distribution. The HEC (3%, weight/weight)-based gel formed a smooth, homogeneous structure and had preferable mech. and rheol. properties. Moreover, the MTZ-loaded SLNs-based HEC gel (equivalent to 1% of MTZ, weight/weight) exhibited a sustained in vitro drug release pattern, optimal ex vivo permeability, and enhanced in vitro antimicrobial activity after 24 h of treatment. These findings indicate the potential of the MTZ-loaded SLNs-based HEC formulation for local drug delivery at the buccal mucosa in managing periodontal disease. This study involved multiple reactions and reactants, such as Glyceryl monostearate (cas: 31566-31-1Reference of 31566-31-1).

Glyceryl monostearate (cas: 31566-31-1) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Reference of 31566-31-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics