Tag: 300-400

Photolytic degradation of benorylate: effects of the photoproducts on cultured hepatocytes was written by Castell, J. V.;Gomez-L., M. J.;Mirabet, V.;Miranda, M. A.;Morera, I. M.. And the article was included in Journal of Pharmaceutical Sciences in 1987.Formula: C17H15NO5 The following contents are mentioned in the article:

The photodegradation of benorylate [4′-(acetamido)phenyl-2-acetoxybenzoate], a drug frequently used in rheumatoid arthritis therapy, has been examined under different sets of exptl. conditions. Several photoproducts have been isolated and identified on the basis of their IR, NMR, and MS spectra. The most significant photochem. process is the photo-Fries rearrangement of benorylate, leading to 5-acetamido-2′-acetoxy-2-hydroxybenzophenone. This compound undergoes a rapid transacylation to the isomeric 5′-acetamido-2′-acetoxy-2-hydroxybenzophenone. A primary culture of rat hepatocytes has been used to evaluate the possible toxicity of these two benzophenones, keeping in mind the following criteria: leakage of cytosolic enzymes, attachment index to culture plates, gluconeogenesis from lactate and fructose, glycogen balance, and albumin synthesis. At the concentrations assayed, neither of the two major photoproducts of benorylate (benzophenones) had significant toxic effects on liver cells in culture. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Formula: C17H15NO5).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Formula: C17H15NO5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On-Chip Neo-Glycopeptide Synthesis for Multivalent Glycan Presentation was written by Mende, Marco;Tsouka, Alexandra;Heidepriem, Jasmin;Paris, Grigori;Mattes, Daniela S.;Eickelmann, Stephan;Bordoni, Vittorio;Wawrzinek, Robert;Fuchsberger, Felix F.;Seeberger, Peter H.;Rademacher, Christoph;Delbianco, Martina;Mallagaray, Alvaro;Loeffler, Felix F.. And the article was included in Chemistry – A European Journal in 2020.Related Products of 604-69-3 The following contents are mentioned in the article:

Single glycan-protein interactions are often weak, such that glycan binding partners commonly use multiple, spatially defined binding sites to enhance binding avidity and specificity. Current array technologies usually neglect defined multivalent display. Laser-based array synthesis technol. allows for flexible and rapid on-surface synthesis of different peptides. By combining this technique with click chem., neo-glycopeptides were produced directly on a functionalized glass slide in the microarray format. D. and spatial distribution of carbohydrates can be tuned, resulting in well-defined glycan structures for multivalent display. The two lectins Con A and langerin were probed with different glycans on multivalent scaffolds, revealing strong spacing-, d.-, and ligand-dependent binding. In addition, the authors could also measure the surface dissociation constant This approach allows for a rapid generation, screening, and optimization of a multitude of multivalent scaffolds for glycan binding. This study involved multiple reactions and reactants, such as (2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 604-69-3Related Products of 604-69-3).

(2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 604-69-3) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Related Products of 604-69-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Probabilistic Neural Network Model for the In Silico Evaluation of Anti-HIV Activity and Mechanism of Action was written by Vilar, Santiago;Santana, Lourdes;Uriarte, Eugenio. And the article was included in Journal of Medicinal Chemistry in 2006.Product Details of 5003-48-5 The following contents are mentioned in the article:

A theor. model has been developed that discriminates between active and nonactive drugs against HIV-1 with four different mechanisms of action for the active drugs. The model was built up using a probabilistic neural network (PNN) algorithm and a database of 2720 compounds The model showed an overall accuracy of 97.34% in the training series, 85.12% in the selection series, and 84.78% in an external prediction series. The model not only correctly classified a very heterogeneous series of organic compounds but also discriminated between very similar active/nonactive chems. that belong to the same family of compounds More specifically, the model recognized 96.02% of nonactive compounds, 94.24% of active compounds that inhibited reverse transcriptase, 97.24% of protease inhibitors, 97.14% of virus uncoating inhibitors, and 90.32% of integrase inhibitors. The results indicate that this approach may represent a powerful tool for modeling large databases in QSAR with applications in medicinal chem. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Product Details of 5003-48-5).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Product Details of 5003-48-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Production of bio-oil from algal biomass and its upgradation to biodiesel using CaO-based heterogeneous catalysts was written by Malpani, M.;Varma, A. K.;Mondal, P.. And the article was included in International Journal of Green Energy in 2016.COA of Formula: C20H40O2 The following contents are mentioned in the article:

The present article deals with the production of bio-oil from algal biomass as well as the preparation and characterization of noble CaO-based heterogeneous catalyst for upgradation of bio-oil to biodiesel. The bio-oil has been extracted from algal biomass using hexane as solvent in soxhlet apparatus and upgraded to biodiesel by transesterification using noble CaO-based heterogeneous catalysts. Catalyst with TiO₂:CaO molar ratio of 0.25 and calcination temperature of 700°C has been found to be most suitable among all the catalysts developed. Characterization of the catalysts has been done by using X-ray diffraction (XRD), scanning electron microscope (SEM), and thermo-gravimetric anal. (TGA). The input–output model has been developed to correlate exptl. and predicted value of biodiesel yield. Optimization of process parameters has been done using response surface methodol. Various properties and elemental composition of algal bio-oil and biodiesel have been determined and compared with biodiesel. This study involved multiple reactions and reactants, such as Methyl nonadecanoate (cas: 1731-94-8COA of Formula: C20H40O2).

Methyl nonadecanoate (cas: 1731-94-8) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.COA of Formula: C20H40O2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Development of novel carbohydrate based compounds for better antipyretic activity was written by Grover, Parul;Singh, Jitender;Mehta, Lovekesh;Kapoor, Garima;Nagarajan, K.. And the article was included in International Journal of Pharmaceutical Sciences and Research in 2021.Synthetic Route of C16H22O11 The following contents are mentioned in the article:

Carbohydrate-based therapeutics are extremely potent, and many carbohydrate-based drugs are in the stage of preclin. or clin. trials. There is a growing interest in developing carbohydrate analogs for novel drug discovery as most of the recently used carbohydrate drugs display significant pharmacol. activities and low toxicity. Also, the search for an antipyretic drug is a never-ending challenge. This research aimed at the development and synthesis of a series of amide-linked sugars (PV1-PV20) by coupling brominated sugars with varying amino acids coupled with nicotinic acid (GP1-GP10). Characterization of the derivatives synthesized was done by IR and NMR Spectroscopy. These congeners were tested to analyze their antipyretic potential, and eight analogs out of twenty showed significant antipyretic activity. Thus, the carbohydrate-based amide derivatives show important action in obstruction and therapy of fever. Further work on these lines may play an important role in maintaining good health at a low cost. This study involved multiple reactions and reactants, such as (2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 604-69-3Synthetic Route of C16H22O11).

(2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 604-69-3) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Synthetic Route of C16H22O11

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

New hypoglycemic agents selected by molecular topology was written by Calabuig, C.;Anton-Fos, G. M.;Galvez, J.;Garcia-Domenech, R.. And the article was included in International Journal of Pharmaceutics in 2004.Computed Properties of C17H15NO5 The following contents are mentioned in the article:

New compounds showing hypoglycemic activity have been designed through a computer aided method based on quant. structure-activity relationship (QSAR) and mol. connectivity. After calculation of topol. indexes for a set of 89 compounds including active and inactive with regards to hypoglycemic action, linear discriminant anal. was performed so that a useful model to predict such an activity was achieved. Later on, the discriminant model was applied on a huge database so that fourteen compounds were selected as potential new hypoglycemics. From them, just five were finally selected for exptl. test on expected hypoglycemic activity. Among the selected compounds, L-arabitol, Acid blue 161, 1,4-butanediol diglycidyl ether and Acid red 151 stand out, which are comparable in potency to standard drugs such as tolbutamide. Acid blue has a glycemia profile similar to that of tolbutamide but does not lead to a severe hypoglycemic condition, while the profile of the other agents is near normality. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Computed Properties of C17H15NO5).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Computed Properties of C17H15NO5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Acetylation of cellulose – Another pathway of natural cellulose aging during library storage of books and papers was written by Potthast, Antje;Ahn, Kyujin;Becker, Manuel;Eichinger, Thomas;Kostic, Mirjana;Boehmdorfer, Stefan;Jeong, Myung Joon;Rosenau, Thomas. And the article was included in Carbohydrate Polymers in 2022.Computed Properties of C16H22O11 The following contents are mentioned in the article:

Gaseous acetic acid is formed under conditions of storage of historic paper objects. Its presence not only promotes hydrolytic cleavage of cellulose, but also causes acetylation of the cellulosic material to very small degree. The acetylation reaction proceeds under ambient conditions and without catalyst. Different anal. methods were used to prove the presence of organic acetates on cellulosic paper matrixes. DESI-MS in combination with ²H-isotopic labeling showed the presence of sugar fragments with different acetylation patterns. A method based on Zemplen saponification was applied and worked also in the presence of a large excess of acetic acid and/or inorganic acetates. The acetylation effect was quantified for model papers and original, naturally aged paper samples. While cellulose acetylation was clearly proven to be another general pathway of paper aging, further studies of this acetylation phenomenon are needed with regard to conservational aspects and suitable paper storage conditions. This study involved multiple reactions and reactants, such as (2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 604-69-3Computed Properties of C16H22O11).

(2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 604-69-3) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Computed Properties of C16H22O11

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Extraction of extracellular lipids from chemoautotrophic bacteria Serratia sp. ISTD04 for production of biodiesel was written by Bharti, Randhir K.;Srivastava, Shaili;Thakur, Indu Shekhar. And the article was included in Bioresource Technology in 2014.Application of 1731-94-8 The following contents are mentioned in the article:

A CO₂ sequestering bacterial strain, Serratia sp. ISTD04, that produces a significant amount of extracellular lipids was isolated from marble mine rocks. ¹⁴C labeling anal. revealed that the rate of assimilation of CO₂ by the strain is 0.756 × 10^-9 μmol CO₂ fixed cell^-1 h^-1. It was found to produce 466 mg/l of extracellular lipid which was characterized using ¹H NMR. After transesterification of lipids, the total saturated and unsaturated FAME was found to be 51% and 49% resp. The major FAME contained in the biodiesel were palmitic acid Me ester (C16:0), oleic acid Me ester (C18:1) and 10-nonadecenoic acid Me ester (C19:1). Biodiesel produced by Serratia sp. ISTD04 is balanced in terms of FAME composition of good quality. It also contained higher proportion of oleic acid (35%) which makes it suitable for utilization in existing engines. Thus, the strain can be harnessed com. to sequester CO₂ into biodiesel. This study involved multiple reactions and reactants, such as Methyl nonadecanoate (cas: 1731-94-8Application of 1731-94-8).

Methyl nonadecanoate (cas: 1731-94-8) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Application of 1731-94-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Conversion of lipids from wet microalgae into biodiesel using sulfonated graphene oxide catalysts was written by Cheng, Jun;Qiu, Yi;Zhang, Jie;Huang, Rui;Yang, Weijuan;Fan, Zhentao. And the article was included in Bioresource Technology in 2017.Recommanded Product: Methyl nonadecanoate The following contents are mentioned in the article:

Four solid acid catalysts including graphene oxide (GO), sulfonated graphene oxide (SGO), sulfonated graphene (SG), and sulfonated active carbon (SAC) were used to convert lipids in wet microalgae into biodiesel. The physiochem. properties of the catalysts were characterized with scanning electron microscope, X-ray diffraction, and thermogravimetric anal. SGO provided the highest conversion efficiency (84.6% of sulfuric acid) of lipids to fatty acid Me esters (FAME). Whereas SAC converted few lipids into FAME. Fourier transform IR spectroscopy, XPS, and elemental anal. revealed that much higher hydrophilic hydroxyl content in SGO catalyst resulted in a considerable higher conversion efficiency of lipids to FAME than that (48.6%) catalyzed by SG, although SO₃H groups (0.44 mmol/g) in SGO were less than those (1.69 mmol/g) in SG. Given its higher SO₃H group content than GO (0.38 mmol/g), SGO had higher conversion efficiency than GO (73.1%), when they had similar hydrophilic hydroxyl contents. This study involved multiple reactions and reactants, such as Methyl nonadecanoate (cas: 1731-94-8Recommanded Product: Methyl nonadecanoate).

Methyl nonadecanoate (cas: 1731-94-8) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Recommanded Product: Methyl nonadecanoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In-source CID mass spectral libraries for the “general unknown” screening of drugs and toxicants was written by Marquet, P.;Venisse, N.;Lacassie, E.;Lachatre, G.. And the article was included in Analusis in 2001.Related Products of 5003-48-5 The following contents are mentioned in the article:

A “general unknown” screening procedure for drugs and toxicants using LC-ES-MS was developed. It involved in-source collision induced dissociation (CID) of the mol. ions (in the neg.-ion mode) or protonated mols. (in the pos.-ion mode) generally obtained from electrospray sources. Spectra were reconstructed by adding, on one hand, a pair of pos. spectra, one without and one with fragmentation, and on the other a pair of neg. spectra acquired in similar conditions. These reconstructed spectra showed at least as many fragments as MS/MS spectra, and sometimes as many as electron-ionization spectra. They were repeatable and reproducible enough to be used for the specific identification of hundreds of mols. Libraries of about 1100 pos. spectra and 500 neg. spectra were constructed and are used routinely, together with chromatog. separation involving a Nucleosil C18, 5 μm column (150 × 1 mm i.d.) and a gradient of acetonitrile in 2 mM, pH 3 ammonium formate as a screening technique complementary to GC-MS and HPLC-DAD. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Related Products of 5003-48-5).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Related Products of 5003-48-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics