Tag: 300-400

Self-Promoted Glycosylation for the Synthesis of β-N-Glycosyl Sulfonyl Amides was written by Mala, Patrycja;Pedersen, Christian Marcus. And the article was included in European Journal of Organic Chemistry in 2021.Safety of (2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate The following contents are mentioned in the article:

N-Glycosyl N-sulfonyl amides have been synthesized by a self-promoted glycosylation, i. e. without any catalysts, promoters or additives. When the reactions were carried out at lower temperatures a mixture of N- and O-glycosides were observed, where the latter rearranged to give the β-N-glycosides at elevated temperatures By this method sulfonylated asparagine derivatives can be selectively β-glycosylated in high yields by trichloroacetimidate glycosyl donors of different reactivity including protected glucosamine derivatives The chemoselectivity in the glycosylations as well as the rearrangements from O-glycosides to β-N-glycosides gives information of the glycosylation mechanism. This method gives access to glycosyl sulfonyl amides under mild conditions. This study involved multiple reactions and reactants, such as (2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 604-69-3Safety of (2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate).

(2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 604-69-3) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Safety of (2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Use of inhibitors of prostaglandin synthesis in patients with breast cancer was written by Powles, T. J.;Dady, P. J.;Williams, Judith;Easty, G. C.;Coombes, R. C.. And the article was included in Advances in Prostaglandin and Thromboxane Research in 1980.Product Details of 5003-48-5 The following contents are mentioned in the article:

Effects of antiinflammatory and antiosteolytic agents were studied in patients with breast cancer, since it is known that some human breast tumors release osteolytic substances which cause breakdown of bone. Benoral (I) [5003-48-5], an aspirin-paracetamol conjugate, prevented bone metastasis in rats, but I (4 g twice a day for 18 mo) given to patients with breast cancer did not affect overall development of bone metastasis. In breast cancer patients with osteolytic bone metastasis, aspirin [50-78-2] and indomethacin [53-86-1] had no antiosteolytic activity; flurbiprofen [5104-49-4], calcitonin [9007-12-9], and mithramycin [18378-89-7] had some antiosteolytic activity but in terms of cancer therapy this was trivial. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Product Details of 5003-48-5).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Product Details of 5003-48-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Analysis on fatty acid composition of Tamarix chinensis fruit was written by Mahemuti, Maimaitiming;Lu, Shun-zhong;Miliban, Huojia;Maerhaba, Wusiman. And the article was included in Huaxue Yanjiu Yu Yingyong in 2014.Safety of Methyl nonadecanoate The following contents are mentioned in the article:

The aim is to study the chem. composition of fatty acid in Tamarix chinensis fruit. With petroleum ether and di-Et ether as solvent for extraction of fatty acids in Tamarix chinensis fruit, after Me esterification, GC-MS technique was used to detect the composition and content of fatty acids. Two methods identified 18 and 17 kinds of fatty acid components, accounting for 99.33% and 89.65% of total peak area, their basic components were identical, but there were some differences in content. In the petroleum ether and di-Et ether extract, there were palmitic acid(35.61% and 32.77%), linoleic acid(27.26% and 18.76%) and oleic acid(11.33% and 9.15%), and unsaturated fatty acid accounted resp. for 38.65% and 27.94%. Tamarix chinensis fruit was rich in unsaturated fatty acids, with good development value. This study involved multiple reactions and reactants, such as Methyl nonadecanoate (cas: 1731-94-8Safety of Methyl nonadecanoate).

Methyl nonadecanoate (cas: 1731-94-8) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Safety of Methyl nonadecanoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

New desulfured troglitazone derivatives: Improved synthesis and biological evaluation was written by Dupommier, Dorian;Muller, Claire;Comoy, Corinne;Mazerbourg, Sabine;Bordessa, Andrea;Piquard, Eline;Pawlak, Manon;Piquard, Flavian;Martin, Helene;De Fays, Elia;Grandemange, Stephanie;Flament, Stephane;Boisbrun, Michel. And the article was included in European Journal of Medicinal Chemistry in 2020.Recommanded Product: (2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate The following contents are mentioned in the article:

Breast cancer is a major medical threat which cannot be sufficiently addressed by current therapies because of spontaneous or acquired treatment resistance. Besides, triple-neg. breast cancer (TNBC) tumors do not respond to targeted therapies, thus new therapeutic strategies are needed. In this context, we designed and prepared new desulfured troglitazone (TGZ)-derived mols. and evaluated them in vitro for their anti-proliferative activity, with a special focus on triple-neg. breast cancer cell lines. Optimization of the synthetic strategies and deracemization of the lead compound were performed to give highly active compound 10 (I.HCl) with low-micromolar potency. Further studies revealed that this compound triggers apoptosis rather than cell cycle arrest as observed with TGZ. This study involved multiple reactions and reactants, such as (2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 604-69-3Recommanded Product: (2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate).

(2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 604-69-3) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Recommanded Product: (2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Process optimization of rice bran oil by ultrasonic combined extrusion was written by Yu, Jinping;Li, Demin;Xiao, Zhigang;Ma, Tao;Wang, Peng;Wang, Na. And the article was included in Zhongguo Shipin Xuebao in 2016.Reference of 1731-94-8 The following contents are mentioned in the article:

The impact of ultrasonic solid-liquid ratio, ultrasonic power, ultrasonic time, ultrasonic temperature on the extraction efficiency of rice bran oil was researched. Based on rice bran as raw material, extrusion ultrasonic detection was utilized to extract rice bran oil. And the rice bran oil extraction rate, the fatty acid composition and oil quality were compared by organic solvent extraction method and extrusion processing organic solvent extraction method. The results showed that the optimum ultrasonic extraction conditions were material liquid ratio 1:5, power 280 W, time for 20 min and temperature at 50°C. The rice bran oil extraction rate was 96.28% under this condition with the advantages of high extraction efficiency and short extraction time compared with the other two methods. This study involved multiple reactions and reactants, such as Methyl nonadecanoate (cas: 1731-94-8Reference of 1731-94-8).

Methyl nonadecanoate (cas: 1731-94-8) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Reference of 1731-94-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Catalytic ketonization over oxide catalysts. Part VIII. Synthesis of cycloalkanone in cycloketonization of various dialkyl alkanedioates was written by Glinski, Marek;Kaszubski, Michal. And the article was included in Reaction Kinetics and Catalysis Letters in 2004.SDS of cas: 143050-66-2 The following contents are mentioned in the article:

Activity of pure Al₂O₃ has been studied in cycloketonization of title compounds of general formula (CH₂)_n(COOR)₂, where n = 4, 5, 6, 7, 8 and 10 and R = Et, s-Bu and t-Bu at the temperature range 598-723 K in a flow system. The yields of cycloalkanones strongly depend on the size of the ring formed, the structure of alkyl group in ester mol. and on the reaction temperature Cyclopentanone, cyclohexanone and cycloheptanone were obtained with yields 50-60% from the appropriate di-Et esters. The only low yields (<8%) of cyclooctanone, cyclononane and cycloundecanone were achieved. An increase in the order of the ester alkyl group leads in some cases to higher yields of ketones – di-t-Bu hexanedioate yielded 88% of cyclopentanone. This study involved multiple reactions and reactants, such as Di-tert-butyl decanedioate (cas: 143050-66-2SDS of cas: 143050-66-2).

Di-tert-butyl decanedioate (cas: 143050-66-2) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.SDS of cas: 143050-66-2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthesis of a novel resorcin[4]arene-glucose conjugate and its catalysis of the CuAAC reaction for the synthesis of 1,4-disubstituted 1,2,3-triazoles in water was written by Husain, Ali A.;Bisht, Kirpal S.. And the article was included in RSC Advances in 2019.Product Details of 604-69-3 The following contents are mentioned in the article:

The Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) in aqueous media using resorcin[4]arene glycoconjugate (RG) was reported. The eight β-D-glucopyranoside moieties constructed on the resorcin[4]arene upper rim provide a pseudo-saccharide cavity that offers a suitable host environment for water-insoluble hydrophobic azido and/or alkyne substrates in water. The utility of RG was established as an efficient inverse phase transfer catalyst for the CuAAC in water as a green approach for the synthesis of 1,4-disubstituted 1,2,3-triazole species. The catalytic utility of RG (1 mol%) was demonstrated in a multicomponent one-pot CuAAC for various azido/alkyne substrates. The RG acts as a mol. host and a micro-reactor resulting in the 1,4-disubstituted 1,2,3-triazoles in excellent yield. This study involved multiple reactions and reactants, such as (2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 604-69-3Product Details of 604-69-3).

(2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 604-69-3) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Product Details of 604-69-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Total Synthesis of the Echinodermatous Ganglioside LLG-3 Possessing the Biological Function of Promoting the Neurite Outgrowth was written by Wu, Yu-Fa;Tsai, Yow-Fu;Huang, Yuahn-Sieh;Shih, Jing-Feng. And the article was included in Organic Letters in 2020.Computed Properties of C16H22O11 The following contents are mentioned in the article:

A total synthesis of echinodermatous ganglioside LLG-3 with neuritogenic activity was accomplished by a convergent strategy. The synthesis of 2-hydroxyethyl 8-O-Me-α-sialoside 2 was started from the Ph 7,8-di-O-Pico-thiosialoside 5, which can be chemoselectively removed the picoloyl group, and then the Me group in 8-O-MeNeu5Ac moiety was chemoselectively prepared using TMSCHN₂/FeCl₃. For preparation of the terminal disialic unit, oxidative amidation was initially utilized by our group to efficiently construct the α(2,11) linkage of 8-O-Me-Neu5Acα(2,11)Neu5Gc. Herein, we also demonstrate that the synthesized ganglioside LLG-3 exhibited the neuritogenic activity toward the primary cortical neurons and that biol. activity is superior to that of ganglioside DSG-A. This study involved multiple reactions and reactants, such as (2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 604-69-3Computed Properties of C16H22O11).

(2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 604-69-3) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Computed Properties of C16H22O11

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthesis and pharmacological properties of eterylate, a new derivative of acetylsalicylic acid was written by Sunkel, C.;Cillero, F.;Armijo, M.;Pina, M.;Alonso, S.. And the article was included in Arzneimittel-Forschung in 1978.Recommanded Product: 5003-48-5 The following contents are mentioned in the article:

Eterylate (I) [62992-61-4] was prepared by coupling p-(2-hydroxyethoxy)acetanilide [50375-15-0] with o-acetoxybenzoyl chloride [5538-51-2] and tested for antiinflammatory and analgesic activities. The activities of I were similar to those of acetylsalicylic acid and benorylate in equimol. doses. The oral LD₅₀ in mice for I, benorylate, and acetylsalicylic acid, were 3160, 1551, and 1259 mg/kg, resp. The gastrointestinal lesions observed after treatment for 30 days revealed that both I and benorylate were tolerated better than acetylsalicylic acid. Further, I had the advantage of causing less gastric lesioning and less hemorrhaging. Phys. and chem. properties of I are discussed. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Recommanded Product: 5003-48-5).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Recommanded Product: 5003-48-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Esterase activity in rat hepatocytes was written by Williams, Faith M.;Mutch, Elaine;Blain, Peter G.. And the article was included in Biochemical Pharmacology in 1991.Product Details of 5003-48-5 The following contents are mentioned in the article:

Hydrolysis of acetylsalicylate, benorylate, phenetsal, fluazifop Bu, and paraoxon has been studied with freshly isolated rat hepatocytes maintained as a monolayer. Acetylsalicylate and paraoxon were the poorest substrates for hydrolysis, whereas benorylate was hydrolyzed 100-fold faster. Phenetsal and fluazifop Bu were both hydrolyzed at 1/10 of the rate of benorylate. Inhibitor studies with paraoxon, BNPP, and physostigmine indicated the involvement of different carboxylesterase isoenzymes. Studies with acetylsalicylate indicated that uptake of the substrate into the hepatocyte may influence the rate of formation of the hydrolysis product. Studies of hydrolysis in hepatocytes more closely reflect in vivo hepatic hydrolysis than subcellular fractions as cytosolic and microsomal esterases can act in parallel. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Product Details of 5003-48-5).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Product Details of 5003-48-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics