Tag: 300-400

Analysis of biological activity and gas chromatography-mass spectrometry study of conventional extraction of Vitex negundo linn. leaves was written by Fatema, Samreen;Ubale, Milind;Farooqui, Mazahar;Arif, Pathan Mohd. And the article was included in Asian Journal of Pharmaceutical and Clinical Research in 2019.Recommanded Product: Methyl nonadecanoate The following contents are mentioned in the article:

The main objective of the present work is to carry out the biol. activity, gas chromatog.-mass spectrometry (GC-MS) studies for the possible compounds present in Vitex negundo. The aqueous extract of V. negundo Linn. was screened for biol. activities such as antimicrobial, antituberculosis (TB), antimalarial, and antioxidant activities. The GC-MS anal. was carried out. The result shows that leaf extract is effective against Escherichia Coli and Bacillus subtitus while neg. results for anti-TB and anti-malarial activity. The antioxidant activity of the leave extract is excellent. The compounds present in the leaf extract of V. negundo are responsible for possessing the biol. activity. This study involved multiple reactions and reactants, such as Methyl nonadecanoate (cas: 1731-94-8Recommanded Product: Methyl nonadecanoate).

Methyl nonadecanoate (cas: 1731-94-8) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Recommanded Product: Methyl nonadecanoate

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Convenient synthesis of long alkyl-chain triazolylglycosides using ionic liquid as dual promoter-solvent: Readily access to non-ionic triazolylglycoside surfactants for evaluation of cytotoxic activity was written by Ketsomboon, Nutthanicha;Saeeng, Rungnapha;Srisook, Klaokwan;Sirion, Uthaiwan. And the article was included in Tetrahedron Letters in 2021.Related Products of 604-69-3 The following contents are mentioned in the article:

A convenient method for the one-pot synthesis of long alkyl-chain triazolylglycosides using ionic liquid as dual promoter and solvent is described via a sequential one-pot two-step glycosidation-CuAAc click reaction. The reaction was carried out using com. available substrates, including glycosyl bromides, sodium azide and various long alkyl-chain alkynes to achieve the corresponding products in moderate to high yields. Furthermore, this approach was successfully applied for the preparation of non-ionic mono-catenary triazolylglycoside surfactants in excellent yields through simple deacetylation. Subsequently, these surfactants were further evaluated for their cytotoxic activity. This study involved multiple reactions and reactants, such as (2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 604-69-3Related Products of 604-69-3).

(2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 604-69-3) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Related Products of 604-69-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Comparative studies of the acute and chronic toxicity of eterylate, benorylate and acetylsalicylic acid was written by Alonso, S.;Priego, J.;Maroto, L.;Ortega, P.. And the article was included in Archivos de Farmacologia y Toxicologia in 1978.Computed Properties of C17H15NO5 The following contents are mentioned in the article:

The acute toxicity of acetylsalicylic acid (I) [50-78-2], was greater than that of benorylate (II) [5003-48-5], and this was greater than that of eterylate (III) [62992-61-4]. In rats given 250 mg I or its equivalent of II or III/100 g, body weight was decreased by I and not affected by II or III. Gastric alterations and kidney lesions were some of the signs of chronic toxicity observed Coagulation time was increased most markedly in II-treated animals. No alterations in blood and liver parameters were noted. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Computed Properties of C17H15NO5).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Computed Properties of C17H15NO5

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Preparation and quality control of benorilate dispersible tablets was written by Zhang, Hua;Xu, Yuhua;Wang, Xiaona;Cheng, Suoming;Wu, Shuxia. And the article was included in Zhongguo Yaoye in 2011.Product Details of 5003-48-5 The following contents are mentioned in the article:

The preparation technol. and the quality control method of benorilate dispersible tablets were studied. The variety of auxiliary materials was selected by the disintegration time as index, and the 5 min accumulation of dissolution was determined by UV spectrophotometry. The optimal prescription was screened by the orthogonal design method. The optimal formulation contained 20% microcrystalline cellulose, 6.0% sodium carboxymethyl starch, 1.0% starch. Benorilate dispersible tablets prepared by the optimal prescription had better dissolution, 90% was dissol. in 15 min and complete disintegration was within 2.5 min, which accorded with the other indexes of the dispersible tablets. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Product Details of 5003-48-5).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Product Details of 5003-48-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthesis of new chiral macrocycles-based glycolipids and its application in asymmetric Michael addition was written by Sabah, Karem J.;Zahid, N. Idayu;Hashim, Rauzah. And the article was included in Research on Chemical Intermediates in 2021.Application of 604-69-3 The following contents are mentioned in the article:

A series of new mix aza- and thia-macrocyclic glycolipids (9, 10, 16 and 17) have been synthesized and their enantiomeric selectivity was studied. The synthesis of the macrocycles involved a simple protection of two hydroxyl groups of the glycolipids followed by building up the mix-heteroatom macrocyclic in simple sequences. The macrocycles and previously investigated analogs (18, 19, 20 and 21) have been applied as phase transfer catalysts in the enantioselective Michael addition of 2-nitropropane to chalcone and showed good-to-excellent enantiomer excess (ee). Among the catalysts, the galactose aza-crown ether-based glycolipid 21 proved to be the most effective with 90% ee. This study involved multiple reactions and reactants, such as (2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 604-69-3Application of 604-69-3).

(2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 604-69-3) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Application of 604-69-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Site-Selective Acylation of Pyranosides with Oligopeptide Catalysts was written by Seitz, Alexander;Wende, Raffael C.;Roesner, Emily;Niedek, Dominik;Topp, Christopher;Colgan, Avene C.;McGarrigle, Eoghan M.;Schreiner, Peter R.. And the article was included in Journal of Organic Chemistry in 2021.Application of 604-69-3 The following contents are mentioned in the article:

Herein, we report the oligopeptide-catalyzed site-selective acylation of partially protected monosaccharides. We identified catalysts that invert site-selectivity compared to N-methylimidazole, which was used to determine the intrinsic reactivity, for 4,6-O-protected glucopyranosides (trans-diols) as well as 4,6-O-protected mannopyranosides (cis-diols). The reaction yields up to 81% of the inherently unfavored 2-O-acetylated products with selectivities up to 15:1 using mild reaction conditions. We also determined the influence of protecting groups on the reaction and demonstrate that our protocol is suitable for one-pot reactions with multiple consecutive protection steps. This study involved multiple reactions and reactants, such as (2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 604-69-3Application of 604-69-3).

(2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 604-69-3) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Application of 604-69-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

QSAR analysis of hypoglycemic agents using the topological indices was written by Murcia-Soler, Miguel;Perez-Gimenez, Facundo;Nalda-Molina, Ricardo;Salabert-Salvador, M. Teresa;Garcia-March, Francisco J.;Cercos-del-Pozo, Rosa Ana;Garrigues, Teresa M.. And the article was included in Journal of Chemical Information and Computer Sciences in 2001.Formula: C17H15NO5 The following contents are mentioned in the article:

The mol. topol. model and discriminant anal. have been applied to the prediction of some pharmacol. properties of hypoglycemic drugs using multiple regression equations with their statistical parameters. Regression anal. showed that the mol. topol. model predicts these properties. The corresponding stability (cross-validation) studies performed on the selected prediction models confirmed the goodness of the fits. The method used for hypoglycemic activity selection was a linear discriminant anal. (LDA). We make use of the pharmacol. distribution diagrams (PDDs) as a visualizing technique for the identification and selection of new hypoglycemic agents, and we tested on rats the predictive ability of the model. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Formula: C17H15NO5).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Formula: C17H15NO5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Differential pulse voltammetry for determination of benorilate in pharmaceutical formulations at carbon paste electrode was written by Wang, Chengyin;Hu, Xiaoya;Chen, Qian;Rong, Guo. And the article was included in Analytical Letters in 2005.SDS of cas: 5003-48-5 The following contents are mentioned in the article:

Benorilate was determined by the differential pulse voltammetry (DPV) using a carbon paste electrode in 1.25 × 10^-3 mol L^-1 KH₂PO₄ and Na₂HPO₄ buffer solution (pH = 6.88, 25°). The anodic peak potential was +1.020 V (vs. SCE). A good linear relationship was realized between the anodic peak currents and benorilate concentrations in the range of 2.0 × 10^-7 to 4.5 × 10^-4 mol L^-1 with the detection limit of 5.0 × 10^-8 mol L^-1. The recovery was 94.3 to 104.6% with the RSD of 3.5% (n = 9). The pharmaceutical preparations, benorilate tablets samples, were determined with desirable results. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5SDS of cas: 5003-48-5).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.SDS of cas: 5003-48-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Benorylate hydrolysis by human plasma and human liver was written by Williams, Faith M.;Moore, U.;Seymour, R. A.;Mutch, E. M.;Nicholson, E.;Wright, P.;Wynne, H.;Plain, P. G.;Rawlins, M. D.. And the article was included in British Journal of Clinical Pharmacology in 1989.Recommanded Product: 4-Acetamidophenyl 2-acetoxybenzoate The following contents are mentioned in the article:

Benorylate (4-acetamido phenyl-O-acetylsalicylate) (I) hydrolysis in vitro by human plasma and by human liver microsomes an cytosol has been investigated. Benorylate was hydrolyzed by a route involving initial hydrolysis of the acetyl group to yield phenetsal followed by hydrolysis to paracetamol and salicylate. Hydrolysis via acetylsalicylate was minor. Benorylate was more actively hydrolyzed by liver cytosol than microsomes and about 10 times faster than plasma. Following a single oral dose benorylate (4 g) to volunteers only salicylate and paracetamol were detected in the plasma. The therapeutic effects of benorylate appear to be mediated by salicylate and paracetamol. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Recommanded Product: 4-Acetamidophenyl 2-acetoxybenzoate).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Recommanded Product: 4-Acetamidophenyl 2-acetoxybenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Determination of two components and their related substances in pediatric benorilate and vitamin B₁ granules by HPLC was written by Lu, Xia;Hu, Mingtong;Yu, Xu. And the article was included in Zhongguo Yiyao Gongye Zazhi in 2015.Synthetic Route of C17H15NO5 The following contents are mentioned in the article:

A HPLC method was established for the determination of benorilate and vitamin B₁, and their related substances, paracetamol, aspirin and salicylic acid, in pediatric benorilate and vitamin B₁ granules. A Kromasil ODS-1 column was used with the mobile phase of methanol: 0.2 mol/L acetic acid/sodium acetate buffer (pH 4.8) by gradient elution, at the detection wavelength of 245 nm. It was linear for benorilate and vitamin B₁ in the concentration ranges of 0.2-2.0 mg/mL and 10-100 μg/mL. Their average recoveries were 100.2% and 99.6%, with RSDs of 0.62% and 1.27%, resp. The LLODs of paracetamol, aspirin and salicylic acid were 0.026, 0.048 and 0.048 μg/mL, resp. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Synthetic Route of C17H15NO5).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Synthetic Route of C17H15NO5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics