Tag: 300-400

Synthesis of saccharin-glycoconjugates targeting carbonic anhydrase using a one-pot cyclization/deprotection strategy was written by Murray, Akilah B.;Quadri, Marta;Li, Haoxi;McKenna, Robert;Horenstein, Nicole A.. And the article was included in Carbohydrate Research in 2019.Related Products of 604-69-3 The following contents are mentioned in the article:

Carbonic anhydrase IX (CA IX) has been identified as a biomarker and drug target for several malignant tumors due to its role in cancer cell growth and proliferation. Simple cyclic sulfonamides, like saccharin (SAC), have shown up to a 60-fold selectivity towards CA IX over other ubiquitous CA isoforms, with greater selectivity obtained applying the “tail-approach” to derivatize SAC with a methylene triazole linker that connected to a “tail” beta glucoside. These modifications of SAC led to an increased selectivity of more than 1000-fold towards CA IX, whereas clin. available CA inhibitors show little to no isoform selectivity. As part of our interest in the development of new CA inhibitors, we found the existing synthetic protocol, which relies on a N-tert-Bu saccharin intermediate, to be problematic in the final deprotection steps. We therefore describe an alternative approach to the synthesis of these compounds featuring a gentle “one pot” deprotection/cyclization as the final synthetic step, and report new galactosyl and glucosyl conjugates with low to mid nM inhibition of CA IX. This study involved multiple reactions and reactants, such as (2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 604-69-3Related Products of 604-69-3).

(2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 604-69-3) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Related Products of 604-69-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Production and characterization of biodiesel from carbon dioxide concentrating chemolithotrophic bacteria, Serratia sp. ISTD04 was written by Bharti, Randhir K.;Srivastava, Shaili;Thakur, Indu Shekhar. And the article was included in Bioresource Technology in 2014.Quality Control of Methyl nonadecanoate The following contents are mentioned in the article:

A chemolithotrophic bacterium, Serratia sp. ISTD04, enriched in the chemostat in presence of sodium bicarbonate as sole carbon source was evaluated for potential of carbon dioxide (CO₂) sequestration and biofuel production CO₂ sequestration efficiency of the bacterium was determined by enzymic activity of carbonic anhydrase and ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO). Further, Western blot anal. confirmed presence of RuBisCO. The bacterium produced 0.487 and 0.647 mg mg^-1 per unit cell dry weight of hydrocarbons and lipids resp. The hydrocarbons were within the range of C₁₃-C₂₄ making it equivalent to light oil. GC-MS anal. of lipids produced by the bacterium indicated presence of C₁₅-C₂₀ organic compounds that made it potential source of biodiesel after transesterification. GC-MS, FTIR and NMR spectroscopic characterization of the fatty acid Me esters revealed the presence of 55% and 45% of unsaturated and saturated organic compounds resp., thus making it a balanced biodiesel composition This study involved multiple reactions and reactants, such as Methyl nonadecanoate (cas: 1731-94-8Quality Control of Methyl nonadecanoate).

Methyl nonadecanoate (cas: 1731-94-8) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Quality Control of Methyl nonadecanoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Optimization for supercritical CO₂ extraction of tilapia fish head oil by response surface method was written by Zhang, Chunhua;Bao, Bin;Chen, Shanqiao;Shen, Jingjing;Pan, Jing;Tao, Ningping;Wu, Wenhui. And the article was included in Shanghai Haiyang Daxue Xuebao in 2015.Related Products of 1731-94-8 The following contents are mentioned in the article:

The aim is to optimize the extraction process of tilapia fish head oil which is extracted by supercritical CO₂(SC-CO₂) from tilapia fish head. The signal factors were chosen by single-factor experiments and the optimal extraction conditions of tilapia fish oil by SC-CO₂ were optimized by response surface method. Then, the quality and fatty acid composition of tilapia fish head oil were analyzed. The results showed that the optimum conditions were: extraction pressure 36 MPa, extraction temperature 41°C and extraction time 3.1 h, which were better than cooking method, alkali hydrolysis method and enzymic method. The extraction rate under the optimal extraction condition by SC-CO₂ was 79.5%, and the iodine value, POV and acid value were 5.36±0.15 mg/kg, 4.27±0.33 mmol/kg and 139.0±8.9 g/100 g resp. The contents of saturated fatty acid(SFA), mono-unsaturated fatty acid(MUFA) and poly-unsaturated fatty acid(PUFA) were 27.85%, 41.74% and 30.41% resp. The tilapia fish head oil was rich in fatty acid, which indicated excellent nutritional value and functionality. This study involved multiple reactions and reactants, such as Methyl nonadecanoate (cas: 1731-94-8Related Products of 1731-94-8).

Methyl nonadecanoate (cas: 1731-94-8) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Related Products of 1731-94-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Control of starch-lipid interactions on starch digestibility during hot-extrusion 3D printing for starchy foods was written by Liu, Zipeng;Chen, Ling;Zheng, Bo. And the article was included in Food & Function in 2022.Synthetic Route of C21H44O5 The following contents are mentioned in the article:

The nutritional design of personalized starchy foods has become a research hotspot in the field of food science. Driven by the immense functional and nutritional implications of starch-lipid binary interactions, this study is aimed at designing starch digestibility by controlling the interaction between starch and glycerol monostearate (GMS)/stearic acid (SA) using a hot-extrusion 3D printing (HE-3DP) environment. The results indicated that the thermal shear force in the HE-3DP environment promoted hydrophobic interactions between starch and lipids, forming a V-type starch-lipid complex with a compact and ordered structure, thus enhancing enzymic resistance. Compared with GMS, SA with linear hydrophobic chains was inclined to compound with starch to form a more ordered structure. Interestingly, the slowly digestible starch (SDS) and resistant starch (RS) content reached 25.06% when the added SA content was 10%. Besides, correlations between the structural parameters and digestibility were established, which provided crucial information for designing nutritional starchy food systems using HE-3DP. This study involved multiple reactions and reactants, such as Glyceryl monostearate (cas: 31566-31-1Synthetic Route of C21H44O5).

Glyceryl monostearate (cas: 31566-31-1) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Synthetic Route of C21H44O5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Thermal and oxidative stability of Atlantic salmon oil (Salmo salar L.) and complexation with β-cyclodextrin was written by Hadaruga, Daniel I.;Unlusayin, Mustafa;Gruia, Alexandra T.;Birau, Cristina;Rusu, Gerlinde;Hadaruga, Nicoleta G.. And the article was included in Beilstein Journal of Organic Chemistry in 2016.Electric Literature of C20H40O2 The following contents are mentioned in the article:

The thermal and oxidative stability of Atlantic salmon oil (Salmo salar L.) as well as its β-cyclodextrin (β-CD) complexation ability has been verified for the first time. The main omega-3 fatty acids, EPA and DHA, were significantly degraded, even at 50 °C. Their relative concentrations decrease from 6.1% for EPA and 4.1% for DHA to 1.7% and 1.5% after degradation at 150 °C, resp. On the other hand, the relative concentrations of monounsaturated and saturated fatty acids remained constant or slightly increased by a few percent after degradation (e.g., from 10.7% to 12.9% for palmitic acid). Co-crystallization of ASO with β-CD at a host-guest ratio of 1:1 and 3:1 from an ethanol-water mixture and kneading methods has been used for the preparation of β-CD/ASO complexes. The anal. of the complexes by thermogravimetry, differential scanning calorimetry (DSC), and Karl Fischer titration (KFT) as well as the decrease of the “strongly-retained” water content confirm the formation of the inclusion compound Furthermore, the DSC parameters correlate well with the KFT kinetic data for β-CD/ASO complexes. This study involved multiple reactions and reactants, such as Methyl nonadecanoate (cas: 1731-94-8Electric Literature of C20H40O2).

Methyl nonadecanoate (cas: 1731-94-8) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Electric Literature of C20H40O2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Effects of phenacetin, paracetamol, and caffeine on the erosive activity of acetylsalicyclic acid in the rat stomach: dose-response relationships, time course of erosion development, and effects on acid secretion was written by Seegers, A. J. M.;Jager, L. P.;Van Noordwijk, J.. And the article was included in Journal of Pharmacy and Pharmacology in 1979.Quality Control of 4-Acetamidophenyl 2-acetoxybenzoate The following contents are mentioned in the article:

Adult male and female rats were equally susceptible to acetylsalicylic acid (I) [50-78-2]-induced gastric injury. Simultaneous administration of caffeine [58-08-2] or paracetamol (II) [103-90-2] resp. increased or decreased the degree of gastric lesion; phenacetin [62-44-2] administration had no effect. The effects of caffeine and II were dose-dependent and developed after 3-4 h. II or phenacetin pretreatment 1 h before I administration was ineffective. Benorylate [5003-48-5] administration caused no more erosions than equivalent mixtures of I and II. Histamine-stimulated gastric acid output was rapidly diminished during perfusion with I; II and caffeine had no initial effect on this but after 30 min the latter increased secretion to levels observed with caffeine alone. Thus, caffeine potentiates I-induced gastric erosions by stimulating acid secretion, but II inhibits them by preventing their development. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Quality Control of 4-Acetamidophenyl 2-acetoxybenzoate).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Quality Control of 4-Acetamidophenyl 2-acetoxybenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Strong-base ASP compound system and Daqing oil emulsification was written by Jiang, Shanshan;Zhang, Yun;Lu, Xiangguo;Xu, Dianping;Sun, Gang;Li, Yaguang. And the article was included in Daqing Shiyou Dizhi Yu Kaifa in 2015.SDS of cas: 1731-94-8 The following contents are mentioned in the article:

The researches on the stability of the compound system and the strong base, wastage of the agents in the oil phase and effects of the alkali, surfactant and polymer on the lactescence stability are conducted through collecting and analyzing the crude oils from the target layers of Lamadian, Saertu, Xingshugang Oilfields and so on. The study results show that the crude oil from Lamadian Oilfield has the characteristics of rather higher viscosity, higher paraffin content and higher gel content, and moreover the more kinds and quantities of the acid active components. The lactescence stability is pretty, higher and the wastage of the alkali in the oil phase is larger; with the higher content of the heavy components and wider range of the carbon chains, the wastage of the heavy alkyl benzene sulfonate surfactant in the crude oil is larger and the stability of the lactescence is higher; the single-base liquid acts with the oil and generates W/O-type emulsion, while the binary composite system of “alkali/surfactant” and ternary compound system of “alkali/surfactant/polymer” produce O/W-type emulsion. This study involved multiple reactions and reactants, such as Methyl nonadecanoate (cas: 1731-94-8SDS of cas: 1731-94-8).

Methyl nonadecanoate (cas: 1731-94-8) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.SDS of cas: 1731-94-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Dynamics in nutrients, sterols and total flavonoid content during processing of the edible Long-Horned grasshopper (Ruspolia differens Serville) for food was written by Ochieng, Brian O.;Anyango, Joseph O.;Nduko, John M.;Cheseto, Xavier;Mudalungu, Cynthia M.;Khamis, Fathiya M.;Ghemoh, Changeh J.;Egonyu, Peter J.;Subramanian, Sevgan;Nakimbugwe, Dorothy;Ssepuuya, Geoffrey;Tanga, Chrysantus M.. And the article was included in Food Chemistry in 2022.HPLC of Formula: 1731-94-8 The following contents are mentioned in the article:

Long-horned grasshopper (Ruspolia differens Serville) is a tasty delicacy in over 20 African countries. This study evaluated the impact of diverse post-harvest thermal treatment (blanching, boiling, toasting, and deep-frying) on the nutrients, total flavonoid content and sterols preservation of R. differens products. Crude protein, ash, and fiber of R. differens was drastically reduced by deep-frying technique. There was increase in Omega-3 (α-linolenic acid), Omega-6 fatty acid (linoleic and arachidonic acids) and sterols [(22Z)-27-Norergosta-5,22-dien-3β-ol, cholesterol, campesterol, cholest-4-ene-3-one and β-sitosterol] and flavonoids (2-3 folds) during blanching compared to other techniques. The iron and zinc content increased significantly in blanched and boiled products of R. differens. Thus, losses of nutrients, total flavonoid content and sterols during processing of R. differens for food can be mitigated by employing blanching technique, which is cheaper and least time-consuming. The implications of these dietary and therapeutic compounds on human nutrition and health are discussed. This study involved multiple reactions and reactants, such as Methyl nonadecanoate (cas: 1731-94-8HPLC of Formula: 1731-94-8).

Methyl nonadecanoate (cas: 1731-94-8) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.HPLC of Formula: 1731-94-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lactic acid fermentation by cells immobilized on various porous cellulosic materials and their alginate/poly-lactic acid composites was written by Kumar, Mrinal Nishant;Gialleli, Angelika-Ioanna;Masson, Jean Bernard;Kandylis, Panagiotis;Bekatorou, Argyro;Koutinas, Athanasios A.;Kanellaki, Maria. And the article was included in Bioresource Technology in 2014.SDS of cas: 1731-94-8 The following contents are mentioned in the article:

Porous delignified cellulose (or tubular cellulose, abbr. TC) from Indian Mango (Mangifera indica) and Sal (Shorea robusta) wood and Rice husk, and TC/Ca-alginate/polylactic acid composites, were used as Lactobacillus bulgaricus immobilization carriers leading to improvements in lactic acid fermentation of cheese whey and synthetic lactose media, compared to free cells. Specifically, shorter fermentation rates, higher lactic acid yields (g/g sugar utilized) and productivities (g/L d), and higher amounts of volatile byproducts were achieved, while no significant differences were observed on the performance of the different immobilized biocatalysts. The proposed biocatalysts are of food grade purity, cheap and easy to prepare, and they are attractive for bioprocess development based on immobilized cells. Such composite biocatalysts may be used for the co-immobilization of different microorganisms or enzymes (in sep. layers of the biocatalyst), to efficiently conduct different types of fermentations in the same bioreactor, avoiding inhibition problems of chem. or biol. (competition) nature. This study involved multiple reactions and reactants, such as Methyl nonadecanoate (cas: 1731-94-8SDS of cas: 1731-94-8).

Methyl nonadecanoate (cas: 1731-94-8) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. SDS of cas: 1731-94-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Cu^II and Au^III complexes with glycoconjugated dithiocarbamato ligands for potential applications in targeted chemotherapy was written by Pettenuzzo, Nicolo;Brustolin, Leonardo;Coltri, Elisa;Gambalunga, Alberto;Chiara, Federica;Trevisan, Andrea;Biondi, Barbara;Nardon, Chiara;Fregona, Dolores. And the article was included in ChemMedChem in 2019.COA of Formula: C16H22O11 The following contents are mentioned in the article:

This work is focused on the synthesis, characterization, and preliminary biol. evaluation of bio-conjugated Au^III and Cu^II complexes with the aim of overcoming the well-known side effects of chemotherapy by improving the selective accumulation of an anticancer metal payload in malignant cells. For this purpose, carbohydrates were chosen as targeting agents, exploiting the Warburg effect that accounts for the over expression of glucose-transporter proteins (in particular GLUTs) in the phospholipid bilayer of most neoplastic cells. We linked the dithiocarbamato moiety to the C1 position of three different monosaccharides: D-glucose, D-galactose, and D-mannose. Altogether, six complexes with a 1:2 metal-to-ligand stoichiometry were synthesized and in vitro tested as anticancer agents. One of them showed high cytotoxic activity toward the HCT116 colorectal human carcinoma cell line, paving the way to future in vivo studies aimed at evaluating the role of carbohydrates in the selective delivery of whole mols. into cancerous cells. This study involved multiple reactions and reactants, such as (2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 604-69-3COA of Formula: C16H22O11).

(2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 604-69-3) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.COA of Formula: C16H22O11

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics