Tag: 300-400

Spectroscopic identification and GC-MS analysis of Merremia tridentata roots for Anti diabetic and anti bacterial drug identification was written by Thirunavukkarasu, K.;Rajkumar, P.;Selvaraj, S.;Kumaresan, S.. And the article was included in International Journal of TechnoChem Research in 2016.SDS of cas: 1731-94-8 The following contents are mentioned in the article:

Methanol extracts of roots of Merremia tridentata using soxhlet device was my present study. The crude extracts was analyzed by GC-MS, results need different peaks. Using standard reference from NIST, finding the presence of 10 phytochem. compounds with anti diabetic and antibacterial activities. The major phyto constituents were Dodecanoic acid (14.22), Tridecanoic acid, 12methyl-Me ester (15.05), undecanoic acid, 10 Me Me ester, Tetra decanoic acid. Hexa decanoic acid, 14-Me, Me ester, 10-octa undecanoic acid, Me ester(12.78), Nona decanoic acid, Me ester, Heneicosanoic acid, 20-oxo Me ester, Hexa decanoic acid, Me ester (22.92), Hepta decanoic acid, 16-Me lmethyl ester.s. Phytochem. anal. were made for the extracts to confirm the phytochem. existing in the roots. The isolated compound and its structural confirmation were made using FTIR -ATR techniques. The biol. activities are based on pass online Databases. Isolation and Identification of antidiabetic and antibacterial compound helps to approach herbal as an alternate remedy. This study involved multiple reactions and reactants, such as Methyl nonadecanoate (cas: 1731-94-8SDS of cas: 1731-94-8).

Methyl nonadecanoate (cas: 1731-94-8) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.SDS of cas: 1731-94-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Total Synthesis of a Partial Structure from Arabinogalactan and Its Application for Allergy Prevention was written by Krumb, Matthias;Jaeger, Maximilian;Voss, Alice;Immig, Loreen;Peters, Karin;Kowalczyk, Danuta;Bufe, Albrecht;Opatz, Till;Holst, Otto;Vogel, Christian;Peters, Marcus. And the article was included in Chemistry – A European Journal in 2021.Category: esters-buliding-blocks The following contents are mentioned in the article:

Arabinogalactan, a micro-heterogeneous polysaccharide occurring in plants, is known for its allergy-protective activity, which could potentially be used for preventive allergy treatment. New treatment options are highly desirable, especially in a preventive manner, due to the constant rise of atopic diseases worldwide. The structural origin of the allergy-protective activity of arabinogalactan is, however, still unclear and isolation of the polysaccharide is not feasible for pharmaceutical applications due to a variation of the activity of the natural product and contaminations with endotoxins. Therefore, a pentasaccharide partial structure was selected for total synthesis and subsequently coupled to a carrier protein to form a neoglycoconjugate. The allergy-protective activity of arabinogalactan could be reproduced with the partial structure in subsequent in vivo experiments This is the first example of a successful simplification of arabinogalactan with a single partial structure while retaining its allergy-preventive potential. This study involved multiple reactions and reactants, such as (2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 604-69-3Category: esters-buliding-blocks).

(2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 604-69-3) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Analysis of benorilate metabolites in in rabbit plasma by using capillary electrophoresis-chemiluminescence was written by Gan, Tingting;Chen, Hua;Xia, Zhining;Jiang, Xuemei;Zhang, Rong;Xin, Longtao;Yu, Yanlin. And the article was included in Fenxi Ceshi Xuebao in 2006.Quality Control of 4-Acetamidophenyl 2-acetoxybenzoate The following contents are mentioned in the article:

An anal. method based on online coupling of capillary electrophoresis with chemiluminescence detection was established to monitor the active metabolites of benorilate in rabbit plasma. The optimized conditions in electrophoresis were determined after evaluating various controlling factors, which were running buffer containing 5 mmol/L β-cyclodextrin and 5 mmol/L luminol of 12 mmol/L borax-4 mmol/L sodium hydroxide and 13 kV running voltage, and the sample solution was injected 3 s with electronic mode. Under the optimized conditions, the concentrations of paracetamol in rabbit plasma in different time were determined The linear range of paracetamol in rabbit plasma was about 0.1-5.0 mg/L, with the determination limit of 3.81 × 10^-2 mg/L (signal-to-noise ratio is 3). The average recoveries and RSD (n = 4) for peak area were 90-115% and 2.1-2.9%, resp. The characteristics of this method are high speed, simply and sensitive, and it is suitable for the anal. of biol. samples to determine the drug’s concentration in plasma. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Quality Control of 4-Acetamidophenyl 2-acetoxybenzoate).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Quality Control of 4-Acetamidophenyl 2-acetoxybenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Phyto-sesquiterpene lactones DET and DETD-35 induce ferroptosis in vemurafenib sensitive and resistant melanoma via GPX4 inhibition and metabolic reprogramming was written by Chang, Meng-Ting;Tsai, Li-Chu;Nakagawa-Goto, Kyoko;Lee, Kuo-Hsiung;Shyur, Lie-Fen. And the article was included in Pharmacological Research in 2022.Quality Control of Glyceryl monostearate The following contents are mentioned in the article:

Acquired resistance to vemurafenib (PLX4032) is a thorny issue in BRAF^V600E mutant melanoma therapy. Ferroptotic programmed cell death is a potential strategy for combating therapy-resistant cancers. This study uncovers the adaptation and abnormal upregulation of PUFAs and bioactive oxylipin metabolism in PLX4032 resistant melanoma cells. Phyto-sesquiterpene lactone, DET, and its derivative, DETD-35, induced lipid ROS accumulation and triggered ferroptotic cell death in PLX4032 sensitive (A375) and resistant (A375-R) BRAF^V600E melanoma cells by reprogramming glutathione and primary metabolisms, lipid/oxylipin metabolism, and causing mitochondrial damage in which DETD-35 showed superior efficiency to DET. Author discovered that DET and DETD-35 are a new type of GPX4 enzyme inhibitor through non-covalent binding. This study provides new insight into the therapeutic mechanisms of both DET and DETD-35 to combat PLX4032 sensitive/resistant BRAF^V600E mutant melanomas via targeting GPX4 and ferroptosis. This study involved multiple reactions and reactants, such as Glyceryl monostearate (cas: 31566-31-1Quality Control of Glyceryl monostearate).

Glyceryl monostearate (cas: 31566-31-1) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Quality Control of Glyceryl monostearate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthesis of podophyllotoxin-glycosyl triazoles via click protocol mediated by silver (I)-N-heterocyclic carbenes and their anticancer evaluation as topoisomerase-II inhibitors was written by Nerella, Srinivas;Kankala, Shravankumar;Gavaji, Brahmeshwari. And the article was included in Natural Product Research in 2021.Synthetic Route of C16H22O11 The following contents are mentioned in the article:

Herein we report the regioselective synthesis of podophyllotoxin-Glycosyl triazole hybrids catalyzed by Ag(I)-N-heterocyclic carbene (Ag(I)-NHC) in a short reaction time (âˆ?0 min) at ambient conditions. In principle, it is the first report of Click alkyne-azide cycloaddition catalyzed by Ag(I)-NHC catalyst and moreover, this new methodol. yielded good results when compared with traditional CuAAC in terms of reaction time and selectivity. The synthesized compounds were further explored for in vitro anticancer activity against four human cancer cell lines Du145, HeLa, A-549, and MCF-7 and found that these synthesized compounds possess significant anticancer activity. Further, the compounds and were identified as promising leads due to their better activity across all cell lines than that of the standard drug etoposide. Mol. docking studies of I & II with DNA Topoisomerase-II were revealed that the free energy calculations of active compounds were in good agreement with observed IC₅₀ values. This study involved multiple reactions and reactants, such as (2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 604-69-3Synthetic Route of C16H22O11).

(2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 604-69-3) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Synthetic Route of C16H22O11

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthesis of [¹⁵N₄] purine labeled cytokinin glycosides derived from zeatins and topolins with 9-β-D, 7-β-D-glucopyranosyl, or 9-β-D-ribofuranosyl group was written by Tranova, Lenka;Bucek, Jan;Zatloukal, Marek;Cankar, Petr;Styskala, Jakub. And the article was included in Journal of Labelled Compounds and Radiopharmaceuticals in 2019.HPLC of Formula: 604-69-3 The following contents are mentioned in the article:

Synthesis of [¹⁵N₄] purine labeled cytokinine glycosides derived from zeatins and topolins containing a 9-β-D-, 7-β-D-glucopyranosyl, or 9-β-D-ribofuranosyl group is described. These N⁶-substituted adenine derivatives are intended as internal analytic standards for phytohormone anal. All labeled compounds were prepared from 6-chloro[¹⁵N₄]purine. The equilibrium reaction of 6-chloro[¹⁵N₄]purine with acetobromo-α-D-glucose gave isomeric 7-β-D– and 9-β-D-chloro glucosyl precursors, which were treated with the corresponding amines to get desired labeled cytokinin 7-β-D– and 9-β-D-glucopyranosides. Cytokinins containing 9-β-D-ribofuranosyl group were obtained by direct enzymic transglycosylation reaction of cytokinins (7) prepared from 6-chloro[¹⁵N₄] purine. This study involved multiple reactions and reactants, such as (2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 604-69-3HPLC of Formula: 604-69-3).

(2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 604-69-3) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.HPLC of Formula: 604-69-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Influences of different sugar ligands on targeted delivery of liposomes was written by Zhang, Changmei;Chen, Zhong;Li, Wenhua;Liu, Xiaoying;Tang, Shukun;Jiang, Lei;Li, Minghui;Peng, Haisheng;Lian, Mingming. And the article was included in Journal of Drug Targeting in 2020.SDS of cas: 604-69-3 The following contents are mentioned in the article:

Ligands are an important part of targeted drug delivery systems. Optimized ligands not only improve the target efficiency, but also enhance therapeutical effect of drugs. In our research, five sugar mols. (Mannose, Galactose, Glucose, Malt disaccharide, and Maltotriose) conjugated PEG₆₀₀-DSPE were synthesized, of which polysaccharides were first discovered by us as sugar ligands to modify liposomes, which interacts with over expressive GLUT on cancer cells. DiO was encapsulated as fluorescent probe to evaluate their cellular uptake abilities of targeting C6 glioma cells, and the distribution in different visceral organs of rats. The results demonstrated that Malt disaccharide and Glucose-PEG₆₀₀-DSPE had the strong efficiency of cellular uptake by C6 glioma cells. The distribution and accumulation of liposomes showed that different sugars modified liposomes could target different visceral organs in rats. It has provided a novel idea for ligand selectivity and optimization of nanocarriers for tumor targeted therapy. This study involved multiple reactions and reactants, such as (2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 604-69-3SDS of cas: 604-69-3).

(2S,3R,4S,5R,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 604-69-3) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.SDS of cas: 604-69-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Fatty acids methyl esters: Complementary measurements and comprehensive analysis of vaporization thermodynamics was written by Zaitsau, Dzmitry H.;Pimerzin, Andrey A.;Verevkin, Sergey P.. And the article was included in Journal of Chemical Thermodynamics in 2019.Computed Properties of C20H40O2 The following contents are mentioned in the article:

Vapor pressures of Me decanoate, Me undecanoate, Me tetradecanoate, Me hexadecanoate and Me octadecanoate were measured by using the static technique. Vapor pressures of Me dodecanoate, Me tridecanoate, Me tetradecanoate, Me heptadecanoate, and Me octadecanoate were measured by using the transpiration method. In the present work, vapor pressures of Me esters of the saturated fatty acids from Me propanoate to Me eicosanoate were collected from the literature. These data together with own complementary results were used for validation of methods for assessment of the difference Δ^g_lC^o_p,m required for the correct adjustment of vaporization enthalpies to the reference temperature 298.15 K. The evaluated vaporization enthalpies for esters from Me propanoate to Me eicosanoate demonstrate impeccable linear chain-length dependence. The CH₂ group contributions for different homologous series were derived and compared. Quant. anal. of dispersion interactions in the long-chained esters have been performed. This study involved multiple reactions and reactants, such as Methyl nonadecanoate (cas: 1731-94-8Computed Properties of C20H40O2).

Methyl nonadecanoate (cas: 1731-94-8) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Computed Properties of C20H40O2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

GC-MS rapid screening of eight non-steroidal anti-inflammatory drugs in health foods and traditional Chinese medicines was written by Zhu, Xiao-hong;Li, Tao;Ma, Peng-fei;Zhu, Jian-rong;Yan, Yu;Liu, Hai-jing. And the article was included in Yaowu Fenxi Zazhi in 2012.Reference of 5003-48-5 The following contents are mentioned in the article:

A GC-MS method for detection of non-steroidal anti-inflammatory drugs that illegally added in health foods and traditional Chinese medicines was established. Samples were extracted and enriched by using solvent extraction or liquid-liquid extraction method. Qual. detection was carried out by GC-MS and Scan mode. In addition, quant. anal. was performed using Selected ion monitoring (SIM) mode. The anal. capillary column was DP-5 ms (30 m×0.25 mm×0.25 μm). The oven temperature was set at 120°C (1 min) initially, it was programmed to rise to 230°C at 10°C·min^-1, and then rise to 270°C at 15°C·min^-1 20 min). The EI ion source was selected and the solvent was delayed by 2.5 min. The MS scanning was set at the range of 40-350 amu. Under the selected chromatog. conditions, 8 kinds of chem. drugs could get a better separation within 30 min. Then paracetamol and diclofenac sodium were detected in two batches of samples. This method was rapid, accurate, and selective, which was suitable for fast qual. detection of drugs added illegally. This study involved multiple reactions and reactants, such as 4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5Reference of 5003-48-5).

4-Acetamidophenyl 2-acetoxybenzoate (cas: 5003-48-5) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Reference of 5003-48-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Accelerated Non-Enzymatic Fatty Acid Esterification during Microdroplet Collision: A Method for Enhanced Sustainability was written by Basuri, Pallab;Kumar, Jenifer Shantha;Das, Subhashree;Pradeep, Thalappil. And the article was included in ACS Sustainable Chemistry & Engineering in 2022.Application In Synthesis of Glyceryl monostearate The following contents are mentioned in the article:

Accelerated non-enzymic and metal-free “reaction and extraction” of sugar esters at the interface of two immiscible liquid microdroplets is demonstrated. The bimol. reaction occurs by collision of microdroplets originating from two home-built electrospray sonic ion sources, carrying sugar mols. in water and long-chain fatty acids in toluene, resp. Our method shows that the rate of reaction is enhanced ~10⁷ times in comparison to the bulk, initiated by ultrasonic activation. Such a high rate of reaction in the microdroplets can be attributed to factors such as surface activity, concentration enhancement, partial solvation, and temperature-assisted dehydration of the species occurring in microdroplets. We provide evidence for an interfacial nucleophilic addition-elimination reaction mechanism. This method of synthesis is extended to 18 similar reactions. Microdroplet synthesis offers a sustainable method for biphasic reactions, eliminating the need for phase transfer reagents and activating agents such as acids/bases, metals, or enzymes. This study involved multiple reactions and reactants, such as Glyceryl monostearate (cas: 31566-31-1Application In Synthesis of Glyceryl monostearate).

Glyceryl monostearate (cas: 31566-31-1) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Application In Synthesis of Glyceryl monostearate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics