Tag: 300-400

Migration of photoinitiators, phthalates and plasticizers from paper and cardboard materials into different simulants and foodstuffs was written by Blanco-Zubiaguirre, L.;Zabaleta, I.;Prieto, A.;Olivares, M.;Zuloaga, O.;Elizalde, M. P.. And the article was included in Food Chemistry in 2021.HPLC of Formula: 84-61-7 This article mentions the following:

The migration of photoinitiators, phthalates and plasticizers from two paper and cardboard materials into food simulants (50% and 95% EtOH and Tenax) and foodstuffs (rice, cereals and milk powder) was studied. In the case of liquid simulants migration was observed to reach the equilibrium after 60 min and depended on the material type and the physicochem. parameters of the migrants, whereas the temperature (room temperature and 60°C) did not show significant effects. The study of migration of the compounds from a baking paper to Tenax at high temperatures (150 and 250°C) evidenced an increment of migration when increasing temperature, except for the most volatile analytes. Finally, the migration to foodstuffs was studied using fully validated anal. protocols. Overall, the comparison of the migration rates demonstrated that Tenax was adequate for the simulation of the migration to rice and cereals, but underestimated the migration to infant milk powder, for which 95% EtOH resulted a more suitable simulant. In the experiment, the researchers used many compounds, for example, Dicyclohexyl phthalate (cas: 84-61-7HPLC of Formula: 84-61-7).

Dicyclohexyl phthalate (cas: 84-61-7) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.HPLC of Formula: 84-61-7

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Tissue distribution of phthalates in celery under different cultivation patterns and associated dietary exposure was written by Zhao, Fang;Ma, Zhihong;Ping, Hua;He, Zhaoying;Li, Bingru;Gao, Yuan;Li, Cheng. And the article was included in Environmental Pollution (Oxford, United Kingdom) in 2022.Quality Control of Dicyclohexyl phthalate This article mentions the following:

To investigate tissue distribution, spatial difference, temperature variation, and potential health risks of PAEs in vegetables, celery was used as a model plant. Celery samples were collected from open fields and greenhouses from two provinces in China over four seasons. Celery tissues were analyzed for 16 PAE compounds by gas chromatog.-tandem mass spectrometry. The total content of PAEs was 89.0-1130.3μg kg-1 dry weight (dw) in stems and 155.0-2730.8μg kg-1 dw in leaves. Concentrations of PAEs in celeries showed notable spatial differences (P < 0.05), and the levels in samples from open fields were lower than those in samples from plastic greenhouses. In celeries from greenhouses, higher PAE concentrations were observed for plants grown at high temperatures than in plants grown at low temperatures Discrepancies in tissue distribution indicated different uptake pathways of PAE contaminants. Risk assessments to humans found that both carcinogenic risks and non-carcinogenic risks of PAEs via celery consumption were at an acceptable level. Further research should consider other exposure pathways of PAEs and pay special attention to reducing PAE contents in vegetables. In the experiment, the researchers used many compounds, for example, Dicyclohexyl phthalate (cas: 84-61-7Quality Control of Dicyclohexyl phthalate).

Dicyclohexyl phthalate (cas: 84-61-7) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Quality Control of Dicyclohexyl phthalate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthesis and antiproteasomal activity of novel O-benzyl salicylamide-based inhibitors built from leucine and phenylalanine was written by Jorda, Radek;Dusek, Jan;Reznickova, Eva;Pauk, Karel;Magar, Pratibha P.;Imramovsky, Ales;Krystof, Vladimir. And the article was included in European Journal of Medicinal Chemistry in 2017.Category: esters-buliding-blocks This article mentions the following:

Inhibition of protein degradation is one of strategies for suppression of uncontrolled proliferation of cancer cells. Proteolytic degradation in cells is mainly ensured by proteasome and its inhibition by bortezomib showed benefit in clin. use for the treatment of multiple myeloma. We report here the library of antiproteasomal O-benzyl salicylamides built from leucine and phenylalanine. Prepared compounds displayed antiproliferative activity on K562, CEM and U266 cancer cell lines, ranging from high micromolar to submicromolar GI₅₀ values. The most potent compounds were further assayed for their inhibition of chymotrypsin-like protease activity of the 26S proteasome in U266 cells. The majority of compounds inhibited the proteasome in mid-nanomolar concentrations (IC₅₀ ranging from 57 to 197 nM) and it correlated with cellular potency. In a cell based assay involving green fluorescence protein (GFP) fused to a short degron that is rapidly degraded by a proteasome the compounds induced accumulation of GFP, visualised and quantified by live-cell imaging. Levels of polyubiquitinated proteins in U266 cells treated by compound I were also analyzed by immunoblotting, revealing a typical high mol. mass smear of ubiquitin conjugates. Finally, apoptotic cell death in treated U266 cells was detected biochem. by measuring the activity of caspases 3 and 7 in lysates and by immunoblotting of caspase 7, its substrate poly(ADP-ribose)polymerase, and Mcl-1, which all together showed changes typical for apoptosis. All these observations were in agreement with expected cellular mechanism of action and confirmed proteasome targeting by prepared O-benzyl salicylamides. In the experiment, the researchers used many compounds, for example, (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9Category: esters-buliding-blocks).

(S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

An improved synthesis of β-keto ester units in didemnins, using 2,2′-carbonylbis(3,5-dioxo-4-methyl-1,2,4-oxadiazolidine) was written by Jouin, Patrick;Poncet, Joel;Dufour, Marie Noelle;Maugras, Isabelle;Pantaloni, Antoine;Castro, Bertrand. And the article was included in Tetrahedron Letters in 1988.Application In Synthesis of (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate This article mentions the following:

Activation of N-protected α-amino acids and O-protected α-hydroxy acids ROH [R = Boc-Phe, Z-D–allo-Ile, Z-Val, Boc-MeIle, (S)-Me₂CHCH(OAc)CO, Boc-Pro; Boc = Me₃CO₂C; Z = PhCH₂O₂C] with the title agent gave activated intermediates I in 80-98% yields. Alkylation of I with Li enolates of EtOAc or Me₃CSCOEt gave, after hydrolysis, keto esters RCH₂CO₂Et [R = Boc-Phe, Z-D–allo-Ile (II), Z-Val, Boc-MeIle] and RCHMeCOSCMe₃ [R = (S)-Me₂CHCH(OAc)CO (III), Boc-Pro] in 75-95% yields. Reduction of II with NaBH₄ gave isostatine derivative (3S,4R,5S)-EtO₂CCH₂CH(OH)CH(NHZ)CHMeEt (IV). III and IV are intermediate in the preparation of cyclodepsipeptide didemnin B. In the experiment, the researchers used many compounds, for example, (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9Application In Synthesis of (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate).

(S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Application In Synthesis of (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics