Tag: 300-400

General and Chemoselective N-Transacylation of Secondary Amides by Means of Perfluorinated Anhydrides was written by Rota, Paola;Allevi, Pietro;Colombo, Raffaele;Costa, Maria L.;Anastasia, Mario. And the article was included in Angewandte Chemie, International Edition in 2010.HPLC of Formula: 6730-10-5 This article mentions the following:

The utility of chemoselective N-transacylation of secondary amides has a broad scope in synthetic chem. Secondly, the two-step replacement of acyl groups of secondary amides with a different on through the formation of a trifluoro intermediate allows one to prepare simple acyl analogs of a variety of pharmaceutical interest. Further, this reaction is useful in anal. protocols where N-transacylation can be overlooked due to puzzling results. In the experiment, the researchers used many compounds, for example, (2S,3S,4R,5S,6R)-3-Acetamido-6-(acetoxymethyl)tetrahydro-2H-pyran-2,4,5-triyl triacetate (cas: 6730-10-5HPLC of Formula: 6730-10-5).

(2S,3S,4R,5S,6R)-3-Acetamido-6-(acetoxymethyl)tetrahydro-2H-pyran-2,4,5-triyl triacetate (cas: 6730-10-5) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.HPLC of Formula: 6730-10-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Characteristics and risk assessment of organophosphate esters and phthalates in soils and vegetation from Dalian, northeast China was written by Wang, Yan;Zhang, Zihao;Bao, Meijun;Xu, Yue;Zhang, Lijie;Tan, Feng;Zhao, Hongxia. And the article was included in Environmental Pollution (Oxford, United Kingdom) in 2021.Computed Properties of C20H26O4 This article mentions the following:

We investigated the concentration, composition, and potential risk of organophosphate esters (OPEs) and phthalates (PAEs) in soils and vegetation from rural areas of Dalian, Northeast China. The residues of total OPEs and PAEs in soils were in the range of 33.1-136 ng/g dw (dry weight) and 465-5450 ng/g dw, while the values in plants were 140-2360 ng/g dw and 2440-21800 ng/g dw, resp. The concentrations of both chems. in the plant rhizosphere soils were significantly lower than those in the bulk soils, suggesting an enhanced degradation or uptake by plant. The contaminations in soils also varied for different land use types with the concentrations generally higher in paddy soils than those in maize soils. The OPE and PAE concentrations in plant leaves were slightly higher than those in their corresponding roots. The bioconcentration factors of OPEs & PAEs were significantly neg. correlated with their octanol-water partition coefficients A hazard assessment suggested potential medium to high risks from tricresyl phosphate (TMPP) and di-Bu phthalate (DNBP) for the agricultural soils in Dalian of China. Although the ecol. risks of OPEs and PAEs in the rhizosphere soils were lower than those in the bulk soils, the relevant risk could still endanger human health via oral intake of these plants. The daily dietary intakes of OPEs and PAEs via vegetable and rice consuming were estimated, and the result suggests a higher exposure risk via ingestion of leafy vegetable than rice. In the experiment, the researchers used many compounds, for example, Dicyclohexyl phthalate (cas: 84-61-7Computed Properties of C20H26O4).

Dicyclohexyl phthalate (cas: 84-61-7) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Computed Properties of C20H26O4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Selective Promotion of Adhesion of Shewanella oneidensis on Mannose-Decorated Glycopolymer Surfaces was written by Young, Thomas D.;Liau, Walter T.;Lee, Calvin K.;Mellody, Michael;Wong, Gerard C. L.;Kasko, Andrea M.;Weiss, Paul S.. And the article was included in ACS Applied Materials & Interfaces in 2020.Recommanded Product: 4163-60-4 This article mentions the following:

Using glycopolymer surfaces, the authors have stimulated Shewanella oneidensis bacterial colonization and induced where the bacteria attach on a mol. pattern. When the Me α-D-mannopyranoside competitor was codeposited with the cell culture, however, the mannose-based polymer was not significantly different from bare gold surfaces. The necessity for equilibration between Me α-D-mannopyranoside and the cell culture to remove the enhancement suggests that the retention of cells on glycopolymer surfaces is kinetically controlled and is not a thermodn. result of the cluster glycoside effect. The MshA lectin appears to facilitate the improved adhesion observed The findings that the surfaces studied here can induce stable initial attachment and influence the ratio of bacterial strains on the surface may be applied to harness useful microbial communities. In the experiment, the researchers used many compounds, for example, (2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 4163-60-4Recommanded Product: 4163-60-4).

(2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 4163-60-4) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Recommanded Product: 4163-60-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthesis of diketopiperazines with on-resin N-methylation and cyclative release was written by Brunel, F. M.;Spatola, A. F.. And the article was included in Journal of Peptide Research in 2004.HPLC of Formula: 87694-53-9 This article mentions the following:

Enantiomerically pure N-methylated diketopiperazines (DKP) can be obtained by treating a N-methylated resin-bound dipeptide with 20% piperidine in DMF via a process known as cyclative release. N-methylated resin-bound dipeptides can be formed from N-methylated precursors or N-methylation can be selectively performed on the resin. When on-resin N-methylation was performed on the C-terminal side of the dipeptide, diastereomers were formed. Yet the cyclative release is shown to be a stereoselective process, as seen using preformed N-methylated amino acids. The procedure was also applied to synthesize the pseudodiketopiperazine cyclo(Pheψ[CH₂NH]Leu). When comparing nonmethylated, monomethylated and bismethylated derivatives, we find that N-methylation results in a dramatic increase in solubility In the experiment, the researchers used many compounds, for example, (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9HPLC of Formula: 87694-53-9).

(S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.HPLC of Formula: 87694-53-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Effect of the CH₂NH and CH₂NAc peptide bond isosteres on the antagonistic and histamine releasing activities of a luteinizing hormone-releasing hormone analog was written by Hocart, Simon J.;Nekola, Mary V.;Coy, David H.. And the article was included in Journal of Medicinal Chemistry in 1988.HPLC of Formula: 87694-53-9 This article mentions the following:

The effect of the CH₂NH and CH₂NAc peptide bond isosteres on the antagonistic and histamine releasing activities of the LH-RH antagonist [N-Ac-D-Nal¹,D-Phe^2,3,D-Arg⁶,Phe⁷,D-Ala¹⁰]LH-RH [Nal = 3-(2-naphthyl)alanine] was investigated. The moieties introduced by facile, racemization-free solid-phase synthesis in an attempt to reduce the histamine releasing activity inherent to the most potent analogs while retaining high antiovulatory activity. The ψ(CH₂NH] isostere was incorporated at each CONH site with the exception of 8-9, which involves proline, by reductive alkylation with a protected amino acid aldehyde in the presence of NaBH₃CN during conventional solid-phase peptide synthesis. The ψ[CH₂NH] group was extremely resistant to derivatization and could only be partially acetylated to give ψ[CH₂NAc]. The analogs were cleaved from the resin with simultaneous deprotection by anhydrous HF and purified to homogeneity in 2 stages: gel permeation followed by preparative reversed-phase liquid chromatog. The analogs were assayed in standard rat antiovulatory and in vitro histamine release assays. The isosteres caused a loss of the antiovulatory activity of the antagonist at the 50-μg dose when incorporated at the positions 1-2, 2-3, 3-4, and 7-8. Incorporation at the other positions resulted in a less marked reduction in activity relative to the unmodified parent analog. No significant effect was noted on the potent histamine releasing activity of the analogs. In the experiment, the researchers used many compounds, for example, (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9HPLC of Formula: 87694-53-9).

(S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.HPLC of Formula: 87694-53-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Using the 3-Diethylaminobenzyl Group as a Photocage in Aqueous Solution was written by Ding, Xiong;Wang, Pengfei. And the article was included in Journal of Organic Chemistry in 2018.Name: (2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate This article mentions the following:

Authors have demonstrated that the 3-diethylaminobenzyl (DEABn) photolabile protecting group (PPG) is an effective and structurally simple PPG for releasing mols. in aqueous environment. In general, the photoreaction is clean, and the released substrate and the PPG product, i.e., 3-diethylaminobenzyl alc., are obtained in high yield. The clean photoreaction can also be achieved under mild ambient conditions with sunlight, while the reactant is stable under indoor lighting. Release of two substrates from one PPG chromophore in aqueous solution has been demonstrated to be feasible. Authors have also compared the uncaging properties of the DEABn and the widely used o-nitrobenzyl (o-NB) group, given their comparable structural simplicity. With its clean and efficient photochem. reaction, DEABn should find wide applications, including in the basic and applied research areas where o-NB and its various derivatives are widely used. In the experiment, the researchers used many compounds, for example, (2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 4163-60-4Name: (2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate).

(2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 4163-60-4) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Name: (2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Design and synthesis of novel protease inhibitors. Tripeptide α’,β’-epoxyketones as nanomolar inactivators of the proteasome was written by Spaltenstein, Andrew;Leban, Johann J.;Huang, Jim J.;Reinhardt, Kelli R.;Viveros, O. Humberto;Sigafoos, Jim;Crouch, Ronald. And the article was included in Tetrahedron Letters in 1996.Product Details of 87694-53-9 This article mentions the following:

Tripeptide epoxy ketones I and II (Z = PhCH₂O₂C) were prepared stereospecifically starting from N-tert-butoxycarbonyl-L-phenylalanine. Diastereomer I inhibited the chymotrypsin-like activity of porcine endothelial cell derived proteasome at low nanomolar concentrations In the experiment, the researchers used many compounds, for example, (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9Product Details of 87694-53-9).

(S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Product Details of 87694-53-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Degraded polysaccharides from Porphyra haitanensis: purification, physico-chemical properties, antioxidant and immunomodulatory activities was written by Huo, Yun-Feng;Li, Yin-Ting;Xia, Wei;Wang, Chong;Xie, Yuan-Yuan;Wang, Yan-Bo;Zhou, Tao;Fu, Ling-Lin. And the article was included in Glycoconjugate Journal in 2021.COA of Formula: C16H22O11 This article mentions the following:

Abstract: To explore effect of the structural properties of porphyra haitanensis polysaccharide on its biol. activity, degraded porphyra polysaccharides were separated and purified by Cellulose DEAE-52 and Sephadex G-100 chromatog., obtaining three purified components (P1, P2 and P3). All the three components were sulfate polysaccharides containing the repeating units of → 3 β-D-galactose 3,6-anhydro-α-L-galactose 1 →, and → 3 β-D-galactose 1 → 4 α-L-galactose-6-S 1 →, and → 3 6-O-methyl-β-D-galactose 1 → 4 3,6-anhydro-α-L-galactose 1 →. The mol. weight of the three fractions was measured to be 300.3, 130.4 and 115.1 kDa, resp. Their antioxidant activity was investigated by the determination of the free radical scavenging effect and ferric reducing power. It was found that P1, P2 and P3 possessed marked antioxidant activity. It was also found that they appreciably enhanced the proliferation, phagocytic ability and nitric oxide secretion in RAW264.7 cells. Lower mol. weight and higher sulfate content were beneficial to bioactivities of P. haitanensis polysaccharides. Overall, P2 and P3 possess superior immuno-modulatory activity to that of P1 and PHP. Thus, the current work will provide the basis for the better utilization of P. haitanensis to develop the related functional foods. Graphical abstract: [graphic not available: see fulltext]. In the experiment, the researchers used many compounds, for example, (2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 4163-60-4COA of Formula: C16H22O11).

(2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 4163-60-4) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. COA of Formula: C16H22O11

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Progress against Escherichia coli with the Oxazolidinone Class of Antibacterials: Test Case for a General Approach To Improving Whole-Cell Gram-Negative Activity was written by Takrouri, Khuloud;Cooper, Harold D.;Spaulding, Adnrew;Zucchi, Paula;Koleva, Bilyana;Cleary, Dillon C.;Tear, Westley;Beuning, Penny J.;Hirsch, Elizabeth B.;Aggen, James B.. And the article was included in ACS Infectious Diseases in 2016.COA of Formula: C18H28BNO4 This article mentions the following:

Novel antibacterials with activity against the Gram-neg. bacteria associated with nosocomial infections, including Escherichia coli and other Enterobacteriaceae, are urgently needed due to the increasing prevalence of multidrug-resistant strains. A major obstacle that has stalled progress on nearly all small-mol. classes with potential for activity against these species has been achieving sufficient whole-cell activity, a difficult challenge due to the formidable outer membrane and efflux barriers intrinsic to these species. Using a set of compound design principles derived from available information relating physicochem. properties to Gram-neg. entry or activity, we synthesized and evaluated a focused library of oxazolidinone analogs, a currently narrow spectrum class of antibacterials active only against Gram-pos. bacteria. In this series, we have explored the effectiveness for improving Gram-neg. activity by identifying and combining beneficial structural modifications in the C-ring region. We have found polar and/or charge-carrying modifications that, when combined in hybrid C-ring analogs, appear to largely overcome the efflux and/or permeability barriers, resulting in improved Gram-neg. activity. In particular, those analogs least effected by efflux and the permeation barrier had significant zwitterionic character. In the experiment, the researchers used many compounds, for example, tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzylcarbamate (cas: 330794-35-9COA of Formula: C18H28BNO4).

tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzylcarbamate (cas: 330794-35-9) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.COA of Formula: C18H28BNO4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The effect of monosaccharides on self-assembly of benzenetricarboxamides was written by Wang, Jue;Qi, Wenjing;Chen, Guosong. And the article was included in Chinese Chemical Letters in 2019.Formula: C16H22O11 This article mentions the following:

The interaction between monosaccharides exhibits an important role in the assembly of monosaccharide-containing mols. In this work, three common monosaccharides, glucose, galactose and mannose, are employed to investigate the effect of monosaccharide on the self-assembly of benzenetricarboxamide (BTA) core-containing mols. In the presence of monosaccharides, three benzenetricarboxamide derivatives aggregate into different ordered structures. When alanine linkers are introduced to these mols. between the core and the monosacchride, morphologies of three types of monosaccharide BTAs turned to disordered, meanwhile their structures become similar with the increase of the length of alanine linkers, indicating the disappearance of the monosaccharide effects. In the experiment, the researchers used many compounds, for example, (2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 4163-60-4Formula: C16H22O11).

(2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 4163-60-4) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Formula: C16H22O11

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics