Tag: 300-400

Park, Jong-Min; Kim, Mi Yeon; Jose, Joachim; Park, Min published an article in 2022, the title of the article was Covalently Immobilized Regenerable Immunoaffinity Layer with Orientation-Controlled Antibodies Based on Z-Domain Autodisplay.Application In Synthesis of Bis(2,5-dioxopyrrolidin-1-yl) glutarate And the article contains the following content:

A regenerable immunoaffinity layer comprising covalently immobilized orientation-controlled antibodies was developed for use in a surface plasmon resonance (SPR) biosensor. For antibody orientation control, antibody-binding Z-domain-autodisplaying Escherichia coli (E. coli) cells and their outer membrane (OM) were utilized, and a disuccinimidyl crosslinker was employed for covalent antibody binding. To fabricate the regenerable immunoaffinity layer, capture antibodies were bound to autodisplayed Z-domains, and then treated with the crosslinker for chem. fixation to the Z-domains. Various crosslinkers, namely disuccinimidyl glutarate (DSG), disuccinimidyl suberate (DSS) and poly (ethylene glycol)-ylated bis (sulfosuccinimidyl)suberate (BS(PEG)5), were evaluated, and DSS at a concentration of 500μM was confirmed to be optimal. The E. coli-cell-based regenerable HRP immunoassay was evaluated employing three sequential HRP treatment and regeneration steps. Then, the Oms of E. coli cells were isolated and layered on a microplate and regenerable OM-based HRP immunoassaying was evaluated. Five HRP immunoassays with four regeneration steps were found to be feasible. This regenerable, covalently immobilized, orientation-controlled OM-based immunoaffinity layer was applied to an SPR biosensor, which was capable of quantifying C-reactive protein (CRP). Five regeneration cycles were repeated using the demonstrated immunoaffinity layer with a signal difference of <10%. The experimental process involved the reaction of Bis(2,5-dioxopyrrolidin-1-yl) glutarate(cas: 79642-50-5).Application In Synthesis of Bis(2,5-dioxopyrrolidin-1-yl) glutarate

The Article related to covalently immobilized regenerable immunoaffinity layer orientation antibody zdomain autodisplay, spr biosensor, z-domains, autodisplay, covalent immobilization, crosslinker, immunoaffinity layer, orientation control, regeneration and other aspects.Application In Synthesis of Bis(2,5-dioxopyrrolidin-1-yl) glutarate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On June 1, 2022, Duque, Alaine; Grau, Jose; Benede, Juan L.; Alonso, Rosa M.; Campanero, Miguel A.; Chisvert, Alberto published an article.Recommanded Product: 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate The title of the article was Low toxicity deep eutectic solvent-based ferrofluid for the determination of UV filters in environmental waters by stir bar dispersive liquid microextraction. And the article contained the following:

In this work, a low toxicity deep eutectic solvent-based ferrofluid is presented for the first time as magnetic fluid to be used as an efficient solvent in liquid-based microextraction techniques. This ferrofluid is made of a hydrophobic deep eutectic solvent, composed by menthol and thymol in a 1:5 molar ratio as carrier solvent, and oleic acid-coated cobalt ferrite (CoFe2O4@oleic acid) magnetic nanoparticles. This material was characterized via magnetism measurement, SEM, IR spectroscopy and d. measurement. The determination of UV filters in environmental water samples was selected as model anal. application to test the extraction performance of this new ferrofluid by employing stir bar dispersive liquid microextraction, prior to liquid chromatog.-tandem mass spectrometry anal. The response surface methodol. was used as a multivariate optimization method for extraction step. Under the optimized conditions, good anal. features were obtained, such as low limits of detection between 7 and 83 ng L-1, good repeatability (relative standard deviations, RSD (%) below 15%), enrichment factors between 46 and 101 and relative recoveries between 80 and 117%, proving the good extraction capability of this ferrofluid. Finally, the method was successfully applied to three environmental waters (beach and river waters), finding trace amounts of the target UV filters. The presented low toxicity deep eutectic solvent-based ferrofluid results to be a good alternative to conventional solvents used in liquid-phase microextraction techniques. The experimental process involved the reaction of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate(cas: 6197-30-4).Recommanded Product: 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate

The Article related to deep eutectic solvent ferrofluid uv filter dispersive liquid microextraction, deep eutectic solvent, ferrofluid, liquid chromatography-tandem mass spectrometry, stir bar dispersive liquid microextraction, uv filters, water samples and other aspects.Recommanded Product: 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On March 7, 2022, Leloire, Maeva; Walshe, Catherine; Devaux, Philippe; Giovine, Raynald; Duval, Sylvain; Bousquet, Till; Chibani, Siwar; Paul, Jean-Francois; Moissette, Alain; Vezin, Herve; Nerisson, Philippe; Cantrel, Laurent; Volkringer, Christophe; Loiseau, Thierry published an article.Reference of Dimethyl 2′-amino-[1,1′:4′,1”-terphenyl]-4,4”-dicarboxylate The title of the article was Capture of Gaseous Iodine in Isoreticular Zirconium-Based UiO-n Metal-Organic Frameworks: Influence of Amino Functionalization, DFT Calculations, Raman and EPR Spectroscopic Investigation. And the article contained the following:

A series of Zr-based UiO-n MOF materials (n = 66, 67, 68) have been studied for iodine capture. Gaseous iodine adsorption was collected kinetically from a home-made set-up allowing the continuous measurement of iodine content trapped within UiO-n compounds, with organic functionalities (-H, -CH3, -Cl, -Br, -(OH)2, -NO2, -NH2, (-NH2)2, -CH2 NH2) by in-situ UV-Vis spectroscopy. This study emphasizes the role of the amino groups attached to the aromatic rings of the ligands connecting the {Zr6O4(OH)4} brick. In particular, the preferential interaction of iodine with lone-pair groups, such as amino functions, has been exptl. observed and is also based on DFT calculations Indeed, higher iodine contents were systematically measured for amino-functionalized UiO-66 or UiO-67, compared to the pristine material (up to 1211 mg/g for UiO-67-(NH2)2). However, DFT calculations revealed the highest computed interaction energies for alkylamine groups (-CH2NH2) in UiO-67 (-128.5 kJ/mol for the octahedral cavity), and pointed out the influence of this specific functionality compared with that of an aromatic amine. The encapsulation of iodine within the pore system of UiO-n materials and their amino-derivatives has been analyzed by UV-Vis and Raman spectroscopy. Authors showed that a systematic conversion of mol. iodine (I2) species into anionic I- ones, stabilized as I-···I2 or I3- complexes within the MOF cavities, occurs when I2@UiO-n samples are left in ambient light. The experimental process involved the reaction of Dimethyl 2′-amino-[1,1′:4′,1”-terphenyl]-4,4”-dicarboxylate(cas: 1312703-30-2).Reference of Dimethyl 2′-amino-[1,1′:4′,1”-terphenyl]-4,4”-dicarboxylate

The Article related to gaseous iodine adsorption isoreticular zirconium uio metal organic framework, amino functionalization zirconium uio mof dft epr spectra, dft calculations, epr spectroscopy, raman spectroscopy, uio-n mof materials, gaseous iodine adsorption, kinetics and other aspects.Reference of Dimethyl 2′-amino-[1,1′:4′,1”-terphenyl]-4,4”-dicarboxylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On July 5, 2021, Sulc, Jakub; Pacheco-Fernandez, Idaira; Ayala, Juan H.; Bajerova, Petra; Pino, Veronica published an article.COA of Formula: C24H27NO2 The title of the article was A green miniaturized aqueous biphasic system prepared with cholinium chloride and a phosphate salt to extract and preconcentrate personal care products in wastewater samples. And the article contained the following:

A miniaturized extraction/preconcentration method based on an aqueous biphasic system (μ-ABS) was developed with reagents commonly used as food additives: cholinium chloride (ChCl) as main extraction phase, K2HPO4 as salting-out agent, and water as the main component (being the sample for analyses). With the aim of obtaining high enrichment factors, miniaturization, and adequate anal. performance, a point in the biphasic region with the lowest amount of ChCl was selected, corresponding to 1.55% (weight/weight) of ChCl, 59.5% (weight/weight) of K2HPO4, and 38.95% (weight/weight) of water. The green μ-ABS (attending to its main elements and performance mode) was used in combination with high-performance liquid chromatog. with diode-array detection (HPLC-DAD) for the determination of 9 personal care products in wastewater samples. The μ-ABS-HPLC-DAD method showed high enrichment factors (up to 100), and quant. extraction efficiencies for those compounds containing OH groups in their structure, which can undergo hydrogen bonding with ChCl. Thus, limits of quantification down to 0.8μg·L-1 and extraction efficiencies between 66.4 and 108% (concentration levels of 1.3 and 13μg·L-1) were reached for the group of parabens and the UV-filter benzophenone-3. The method is characterized by the use of non-harmful reagents and the absence of organic solvents in the entire sample preparation procedure, while being simple, low-cost, easily compatible with HPLC, and highly efficient. The experimental process involved the reaction of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate(cas: 6197-30-4).COA of Formula: C24H27NO2

The Article related to miniaturized aqueous biphasic system cholinium chloride phosphate salt, green chem personal care product wastewater, aqueous biphasic system, cholinium chloride, extraction, high-performance liquid chromatography, personal care products, wastewater and other aspects.COA of Formula: C24H27NO2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Liu, Minglong; Sovrovic, Miha; Suga, Hiroaki; Jongkees, Seino A. K. published an article in 2022, the title of the article was Phosphine addition to dehydroalanine for peptide modification.SDS of cas: 79642-50-5 And the article contains the following content:

Thiols are a functional group commonly used for selective reactions in a biochem. setting because of their high nucleophilicity. Phosphorus nucleophiles can undergo some similar reactions to thiols, but remain underexploited in this setting. In this work we show that phosphine nucleophiles react cleanly and quickly with a dehydroalanine electrophile, itself generated from cysteine, to give a stable adduct in a peptide context. NMR reveals the product to be a phosphonium ion and indicates some backbone conformational constraint, possibly arising from transient carbonyl coordination. The reaction proceeded quickly, with a pseudo-first order rate constant of 0.126 min-1 at 1 mM peptide (80% conversion in 10 min), and with no detectable side products on the peptide. A broad peptide sequence scope and water-soluble phosphines with alkyl as well as aromatic groups were all shown to react efficiently. Phosphine addition proved to be efficient on nisin as a model Dha-containing biol.-derived peptide and on an mRNA-displayed peptide, as well as on TCEP-modified agarose for peptide capture from solution This reaction thus presents a promising approach for modification of peptides for cargo attachment or altered phys. properties in peptide discovery. The experimental process involved the reaction of Bis(2,5-dioxopyrrolidin-1-yl) glutarate(cas: 79642-50-5).SDS of cas: 79642-50-5

The Article related to phosphine addition dehydroalanine peptide modification thiol cysteine, peptide addition phosphine reaction kinetics product distribution decomposition stability, solid phase peptide synthesis phosphine addition, nisin rna peptide phosphine addition and other aspects.SDS of cas: 79642-50-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On July 31, 2021, Foubert, Kenn; Dendooven, Ella; Theunis, Mart; Naessens, Tania; Ivanova, Boryana; Pieters, Luc; Gilissen, Liesbeth; Huygens, Sara; De Borggraeve, Wim; Lambert, Julien; Goossens, An; Aerts, Olivier published an article.Electric Literature of 6197-30-4 The title of the article was The presence of benzophenone in sunscreens and cosmetics containing the organic UV filter octocrylene: A laboratory study. And the article contained the following:

The reason why patients photosensitized to the drug ketoprofen (KP) may develop severe photoallergic skin reactions to octocrylene (OCT), an organic UV filter in sunscreens and cosmetics, remains largely unknown. OCT can be synthesized by using unsubstituted benzophenone (BP), a possible human carcinogen. Purpose: To verify if, and to what extent, BP residues are present in OCT-containing consumer products. The raw material of OCT and 39 skincare products, of which 28 contain OCT, were chem. analyzed for the presence of BP by means of liquid chromatog. Results: In the OCT raw material and in all 28 OCT-containing products the presence of BP could be demonstrated, mostly in concentrations above 10 ppm (0.001%), whereas a majority of OCT-free products (8/11, 73%) did not contain BP. Moreover, BP concentrations significantly increased, in a time- and temperature-dependent manner, likely due to the addnl. degradation of OCT. Photoallergic contact dermatitis from OCT in patients photosensitized to KP might rely on residual BP impurities. Toxicol. and ecol. studies that evaluate the safety of OCT might also need to consider the concomitant presence of BP. The experimental process involved the reaction of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate(cas: 6197-30-4).Electric Literature of 6197-30-4

The Article related to cosmetic environment impurity ketoprofen photocontact allergy octocrylene sunscreen toxicol, unsubstituted benzophenone, cas number 119-61-9, cosmetics, environment, impurities, ketoprofen, octocrylene, photocontact allergy, sunscreens, toxicology and other aspects.Electric Literature of 6197-30-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On June 30, 1999, Stohlmeyer, Michelle M.; Tanaka, Hiroko; Wandless, Thomas J. published an article.Computed Properties of 59524-07-1 The title of the article was A Stereospecific elimination to form dehydroamino acids: synthesis of the phomopsin tripeptide side chain. And the article contained the following:

The authors have developed an efficient and stereospecific method to synthesize trisubstituted and tetrasubstituted α,β-dehydroamino acids from β-hydroxyamino acid derivatives For example, β-hydroxyamino acid I is reacted with SOCl2 in CH2Cl2 to give the sulfamidite II in 100% yield; next, DBU is added to II in CH2Cl2 to give the cis-dehydroamino acid III in 91% yield. The tripeptide side chain of phomopsin was synthesized using this method. The experimental process involved the reaction of Benzyl 2-(((benzyloxy)carbonyl)amino)acrylate(cas: 59524-07-1).Computed Properties of 59524-07-1

The Article related to amino acid dehydro synthesis hydroxyamino acid precursor, sulfamidite intermediate preparation hydroxyamino acid reaction thionyl chloride, elimination stereospecific dbu reaction sulfamidite key step, phomopsin tripeptide side chain synthesis and other aspects.Computed Properties of 59524-07-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Solansky, Martin; Mikulasek, Kamil; Zapletalova, Martina; Petrivalsky, Marek; Chiltz, Annick; Zdrahal, Zbynek; Leborgne-Castel, Nathalie; Lochman, Jan published an article in 2021, the title of the article was The oligomeric states of elicitins affect the hypersensitive response and resistance in tobacco.Synthetic Route of 79642-50-5 And the article contains the following content:

Successful plant defense against microbial pathogens is based on early recognition and fast activation of inducible responses. Key mechanisms include detection of microbe-associated mol. patterns by membrane-localized pattern recognition receptors that induce a basal resistance response. A well-described model of such responses to pathogens involves the interactions between Solanaceae plants and proteinaceous elicitors secreted by oomycetes, called elicitins. It has been hypothesized that the formation of oligomeric structures by elicitins could be involved in their recognition and activation of defensive transduction cascades. In this study, we tested this hypothesis using several approaches, and we observed differences in tobacco plant responses induced by the elicitin β-cryptogein (β-CRY) and its homodimer, β-CRYDIM. We also found that the C-terminal domain of elicitins of other ELI (true-elicitin) clades plays a significant role in stabilization of their oligomeric structure and restraint in the cell wall. In addition, covalently crosslinking β-CRYDIM impaired the formation of signalling complexes, thereby reducing its capacity to elicit the hypersensitive response and resistance in the host plant, with no significant changes in pathogenesis-related protein expression. By revealing the details of the effects of β-CRY dimerization on recognition and defense responses in tobacco, our results shed light on the poorly understood role of elicitins′ oligomeric structures in the interactions between oomycetes and plants. The experimental process involved the reaction of Bis(2,5-dioxopyrrolidin-1-yl) glutarate(cas: 79642-50-5).Synthetic Route of 79642-50-5

The Article related to oligomeric elicitin beta cryptogein hypersensitive response tobacco, nicotiana tabacum , phytophthora , cell wall, elicitin response, suppressor of bir1-1 (sobir1), elicitin β-cry, hypersensitive response, oligomeric structure, resistance, signalling, tobacco and other aspects.Synthetic Route of 79642-50-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On November 20, 2020, Wang, Junchang; Zhang, Yiyue; Zhu, Yirong; Liu, Junru; Chen, Yan; Cao, Xin; Yang, You published an article.Application of 79642-50-5 The title of the article was Total Synthesis and Immunological Evaluation of the Tri-D-glycero-D-manno-heptose Antigen of the Lipopolysaccharide as a Vaccine Candidate against Helicobacter pylori. And the article contained the following:

Helicobacter pylori, the most common cause of chronic gastritis, peptic ulcers and gastric cancers, infects around half of the world’s population. Although the drawbacks of the antibiotic-based combination therapy are emerging, no effective vaccine is available to prevent H. pylori infections. Here, we describe the total synthesis of the unique α-(1→3)-linked triD-glycero-D-manno-heptose antigen from the lipopolysaccharide of H. pylori sero-groups O3, O6 and strains MO19, D2, D4 and D5 based on de novo synthesis of the differentially protected D-glycero-D-manno-heptosyl building blocks. Immunization of mice with the semi-synthetic glycoconjugate elicited a very robust T-cell dependent antigen-specific immune response, resulting in very high titers of IgG1 and IgG2b protective antibody iso-types. The post-immune sera recognized H. pylori NCTC 11637 and bound strongly to the surface of the intact bacteria. The experimental process involved the reaction of Bis(2,5-dioxopyrrolidin-1-yl) glutarate(cas: 79642-50-5).Application of 79642-50-5

The Article related to human serum albumin crm197 diphteria toxin glycoconjugate, antibiotic antigen antitumor combination chemotherapy immunization glycoconjugate ig, lipopolysaccharide glyceromannoheptose antigen immunol synthesis vaccine helicobacter pylori antibacterial and other aspects.Application of 79642-50-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On April 30, 2022, Samaran, Quentin; Raison-Peyron, Nadia; Clark, Evangeline; Svedman, Cecilia; Dahlin, Jakob; Dereure, Olivier; Bruze, Magnus; Bourrain, Jean Luc published an article.Recommanded Product: 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate The title of the article was A new case of photoallergic contact dermatitis caused by benzophenones in magazine covers. And the article contained the following:

Allergic contact dermatitis (ACD) and photoallergic contact dermatitis (PACD) to benzophenone present in printing ink have been reported. However, precise chem. analyses and extended photo-patch tests have not been performed in these cases. To determine which component present in a magazine cover are responsible for a patient’s skin reaction, to determine the primary sensitizer, and precisely diagnose ACD and PACD. After initial photo-patch tests were performed on a patient with a history of reaction to magazine covers after sun exposure, gas chromatog.-mass spectrometry and high-performance liquid chromatog. analyses of the magazine covers, and addnl. photo-patch tests were performed. The first photo-patch test results confirmed PACD to ketoprofen and fenofibrate and evoked PACD to the magazine covers. 4-Me benzophenone (4-MBP) and 1-hydroxy-cyclohexyl-phenyl-ketone (1-HCPK) were found in the magazine cover. Addnl. photo-patch tests confirmed PACD to 1-HCPK and to benzophenone, and photo-aggravated ACD to 4-MBP. The primary sensitizer was ketoprofen. Benzophenones are present in a wide variety of products, without always being listed on the packaging. Patients previously sensitized to other ketones, such as ketoprofen, may react to benzophenones without being able to avoid contact with these mols. New regulations may be needed for more efficient eviction advice. Photoallergic contact dermatitis to covers of a magazine was diagnosed and thorough investigation was necessary to identify the haptens responsible. Chem. analyses of the covers revealed the presence of 4-Me benzophenone (4-MBP) and 1-hydroxy-cyclohexyl-phenyl-ketone (1-HCPK) Photo-patch tests suggested photo-aggravation of contact dermatitis to 4-MBP and benzophenone, and photoallergy to 1-HCPK and ketoprofen. Ketoprofen was the most likely primary sensitizer. The experimental process involved the reaction of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate(cas: 6197-30-4).Recommanded Product: 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate

The Article related to photoallergic contact dermatitis benzophenones magazine cover, 1-hydroxy-cyclohexyl-phenyl-ketone, 4-methyl benzophenone, cas number 119-61-9, cas number 134-84-9, cas number 6197-30-4, ketoprofen, octocrylene, photoallergy, unsubstituted benzophenone and other aspects.Recommanded Product: 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics