Tag: 300-400

On March 31, 2020, Celeiro, Maria; Acerbi, Ruben; Kabir, Abuzar; Furton, Kenneth G.; Llompart, Maria published an article.SDS of cas: 6197-30-4 The title of the article was Development of an analytical methodology based on fabric phase sorptive extraction followed by gas chromatography-tandem mass spectrometry to determine UV filters in environmental and recreational waters. And the article contained the following:

A novel method based on fabric phase sorptive extraction (FPSE) followed by gas chromatog.-tandem mass spectrometry (GC-MS/MS) has been validated for the simultaneous determination of 11 UV filters (ethylhexyl salicylate, benzyl salicylate, homosalate, benzophenone-3, isoamylmethoxycinnamate, 4-methylbenzylidenecamphor, Me anthranilate, etocrylene, 2-ethylhexylmethoxycinnamate, 2-ethylhexyl p-dimethylaminobenzoate, and octocrylene), in natural and recreational waters. Major exptl. parameters affecting FPSE procedure have been optimized to obtain the highest extraction efficiency. Different types and sizes of sol-gel coated FPSE media, sample volume, extraction time, and type and volume of desorption solvent were evaluated. The optimal conditions involved the use of a (2.0 x 2.5) cm2 FPSE device with PDMS based coating for the extraction of 20 mL of water for 20 min. The quant. desorption of the target compounds was performed with 0.5-1 mL of Et acetate. The method was satisfactorily validated in terms of linearity, precision, repeatability and reproducibility. Recovery studies were performed at different concentration levels in real water matrixes to show its suitability, obtaining mean values about 90% and satisfactory precision. LODs were at the low ng L-1 in all cases. Finally, the validated FPSE-GC-MS/MS method was applied to different real samples, including environmental water (lake, river, seawater) and recreational water (swimming-pool), where 8 out of the 11 studied compounds were detected at concentrations between 0.12-123μg L-1. FPSE is proposed as an efficient and simple alternative to other extraction and microextraction techniques for the anal. of UV filters in waters. Since no matrix effects were observed, quantification could be carried out by conventional calibration with standard solutions, without the need to perform the complete FPSE procedure, thus allowing a higher throughput in comparison with other microextraction techniques. The experimental process involved the reaction of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate(cas: 6197-30-4).SDS of cas: 6197-30-4

The Article related to uv filter sorptive extraction gas chromatog tandem mass spectrometry, environmental water, fabric phase sorptive extraction, gas chromatography-tandem mass spectrometry, microextraction, sample preparation, uv filters and other aspects.SDS of cas: 6197-30-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On February 15, 2021, Hascup, Kevin N.; Findley, Caleigh A.; Britz, Jesse; Esperant-Hilaire, Nahayo; Broderick, Sarah O.; Delfino, Kristin; Tischkau, Shelley; Bartke, Andrzej; Hascup, Erin R. published an article.Name: 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate The title of the article was Riluzole attenuates glutamatergic tone and cognitive decline in AβPP/PS1 mice. And the article contained the following:

We have previously demonstrated hippocampal hyperglutamatergic signaling occurs prior to plaque accumulation in AβPP/PS1 mice. Here, we evaluate 2-Amino-6-(trifluoromethoxy) benzothiazole (riluzole) as an early intervention strategy for Alzheimers disease (AD), aimed at restoring glutamate neurotransmission prior to substantial Beta amyloid (Aβ) plaque accumulation and cognitive decline. Male AβPP/PS1 mice, a model of progressive cerebral amyloidosis, were treated with riluzole from 2-6 mo of age. Morris water maze, in vivo electrochem., and immunofluorescence were performed to assess cognition, glutamatergic neurotransmission, and pathol., resp., at 12 mo. Four months of prodromal riluzole treatment in AβPP/PS1 mice resulted in long-lasting procognitive effects and attenuated glutamatergic tone that was observed six months after discontinuing riluzole treatment. Riluzole-treated AβPP/PS1 mice had significant improvement in long-term memory compared to vehicle-treated AβPP/PS1 mice that was similar to normal aging C57BL/6J control mice. Furthermore, basal glutamate concentration and evoked-glutamate release levels, which were elevated in vehicle-treated AβPP/PS1 mice, were restored to levels observed in age-matched C57BL/6J mice in AβPP/PS1 mice receiving prodromal riluzole treatment. Aβ plaque accumulation was not altered with riluzole treatment. This study supports that interventions targeting the glutamatergic system during the early stages of AD progression have long-term effects on disease outcome, and importantly may prevent cognitive decline. Our observations provide preclin. support for targeting glutamate neurotransmission in patients at risk for developing AD. The experimental process involved the reaction of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate(cas: 6197-30-4).Name: 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate

The Article related to riluzole nmda receptor glutamatergic tone ps1 alzheimers disease, alzheimer’s disease (ad), alpha-7 nicotinic acetylcholine receptor (α7nachr), amyloid-beta (aβ), biosensor, learning and memory, prodromal intervention and other aspects.Name: 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Abughrin, Suad E.; Alshana, Usama; Bakirdere, Sezgin published an article in 2022, the title of the article was Magnetic Nanoparticle-Based Dispersive Solid-Phase Microextraction of Three UV Blockers Prior to Their Determination by HPLC-DAD.Category: esters-buliding-blocks And the article contains the following content:

The need for proper handling of environmental samples is significant, owing to their environmental effects on both humans and animals, as well as their immediate surroundings. In the current study, magnetic nanoparticle-based dispersive solid-phase microextraction was combined with high-performance liquid chromatog. using a diode array as the detector (HPLC-DAD) for both the separation and determination of three different UV blockers, namely octocrylene, ethylhexyl methoxycinnamate, and avobenzone. The optimum conditions for the extraction were found to be as follows: Stearic acid magnetic nanoparticles (20 mg) as the sorbent, acetonitrile (100 μL) as the eluent, as well as a sample pH of 2.50, adsorption and desorption time of 1.0 min, with a 3.0 mL sample volume The limits of detection were as low as 0.05 μg mL-1. The coefficient of determination (R2) was above 0.9950, while the percentages of relative recoveries (%RR) were between 81.2 and 112% for the three UV blockers from the environmental water samples and sunscreen products. The experimental process involved the reaction of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate(cas: 6197-30-4).Category: esters-buliding-blocks

The Article related to sunscreen environmental water uv blocker, magnetic nanoparticle dispersive solid phase microextraction hplcdad, hplc-dad, uv blockers, dispersive solid-phase microextraction, magnetic nanoparticles, sunscreen products and other aspects.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Medici, Antonio; Saviano, Lorenzo; Siciliano, Antonietta; Libralato, Giovanni; Guida, Marco; Previtera, Lucio; Di Fabio, Giovanni; Zarrelli, Armando published an article in 2022, the title of the article was Octocrylene: From Sunscreens to the Degradation Pathway during Chlorination Processes: Formation of Byproducts and Their Ecotoxicity Assessment.Product Details of 6197-30-4 And the article contains the following content:

Octocrylene is an organic sunscreen whose main action is to absorb UVB radiation and short UVA wavelengths; it is used in various cosmetic products in order to provide an adequate sun-protection factor or to protect the cosmetic formulations themselves from UV radiation. This filter is believed to be a possible endocrine disruptor and is also questioned due to its allergic and/or photoallergic potential. However, it continues to be widely used, and it has been found in various environments, not least those of swimming pools, where it is evidently released by consumers, to the point that it is now considered an emerging micropollutant. The present investigation presents the possible chem. fate of octocrylene in the typical chlorination conditions of wastewater or swimming pools. A total of 11 disinfection byproducts were identified, and 6 were identified for the first time, and separated by HPLC. These products were identified through careful mass spectrometry studies and 1D and 2D NMR experiments A formation mechanism has been proposed that justifies the chem. structures of all of the compounds identified. The ecotoxicol. assessment of octocrylene and their products was carried out by employing Phaeodactylum tricornutum, Brachionus plicatilis and Aliivibrio fischeri as bioindicators. The ecotoxicity results reveal that toxic byproducts might be generated during the oxidation process, increasing the potential risk to the marine environment. The experimental process involved the reaction of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate(cas: 6197-30-4).Product Details of 6197-30-4

The Article related to octocrylene byproduct ecotoxicity assessment sunscreen chlorination process, aliivibrio fischeri, brachionus plicatilis, phaeodactylum tricornutum, chlorination, degradation byproducts, hypochlorite, octocrylene, water treatment and other aspects.Product Details of 6197-30-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Carboni, Michael; Abney, Carter W.; Liu, Shubin; Lin, Wenbin published an article in 2013, the title of the article was Highly porous and stable metal-organic frameworks for uranium extraction.COA of Formula: C22H19NO4 And the article contains the following content:

Three metal-organic frameworks (MOFs) of the UiO-68 network topol. were prepared using the amino-TPDC or TPDC bridging ligands containing orthogonal phosphorylurea groups (TPDC is p,p’-terphenyldicarboxylic acid), and investigated for sorption of uranium from water and artificial seawater. The stable and porous phosphorylurea-derived MOFs were highly efficient in sorbing uranyl ions, with saturation sorption capacities as high as 217 mg U g-1 which is equivalent to binding one uranyl ion for every two sorbent groups. Coordination modes between uranyl groups and simplified phosphorylurea motifs were investigated by DFT calculations, revealing a thermodynamically favorable monodentate binding of two phosphorylurea ligands to one uranyl ion. Convergent orientation of phosphorylurea groups at appropriate distances inside the MOF cavities is believed to facilitate their cooperative binding with uranyl ions. This work represents the first application of MOFs as novel sorbents to extract actinide elements from aqueous media. The experimental process involved the reaction of Dimethyl 2′-amino-[1,1′:4′,1”-terphenyl]-4,4”-dicarboxylate(cas: 1312703-30-2).COA of Formula: C22H19NO4

The Article related to phosphorylurea terphenyldicarboxylate ligand preparation complexation zirconium, zirconium oxide hydroxide terphenyldicarboxylate phosphorylurea metal organic framework preparation, porous stable metal organic framework uranyl extraction and other aspects.COA of Formula: C22H19NO4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On May 10, 2021, Newar, Rajashree; Akhtar, Naved; Antil, Neha; Kumar, Ajay; Shukla, Sakshi; Begum, Wahida; Manna, Kuntal published an article.Reference of Dimethyl 2′-amino-[1,1′:4′,1”-terphenyl]-4,4”-dicarboxylate The title of the article was Amino Acid-Functionalized Metal-Organic Frameworks for Asymmetric Base-Metal Catalysis. And the article contained the following:

The Authors report a strategy to develop heterogeneous single-site enantioselective catalysts based on naturally occurring amino acids and earth-abundant metals for eco-friendly asym. catalysis. The grafting of amino acids within the pores of a metal-organic framework (MOF), followed by post-synthetic metalation with iron precursor, affords highly active and enantioselective (>99% ee for 10 examples) catalysts for hydrosilylation and hydroboration of carbonyl compounds Impressively, the MOF-Fe catalyst displayed high turnover numbers of up to 10 000 and was recycled and reused more than 15 times without diminishing the enantioselectivity. MOF-Fe displayed much higher activity and enantioselectivity than its homogeneous control catalyst, likely due to the formation of robust single-site catalyst in the MOF through site-isolation. The experimental process involved the reaction of Dimethyl 2′-amino-[1,1′:4′,1”-terphenyl]-4,4”-dicarboxylate(cas: 1312703-30-2).Reference of Dimethyl 2′-amino-[1,1′:4′,1”-terphenyl]-4,4”-dicarboxylate

The Article related to amino acid functionalized iron metal organic framework preparation catalyst, asym base catalysis hydrosilylation hydroboration carbonyl compound, amino acid, enantioselectivity, heterogeneous catalysis, iron, metal-organic frameworks and other aspects.Reference of Dimethyl 2′-amino-[1,1′:4′,1”-terphenyl]-4,4”-dicarboxylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On October 3, 2019, Crew, Andrew P.; Wang, Jing; Berlin, Michael; Dragovich, Peter; Chen, Huifen; Staben, Leanna published a patent.Formula: C17H26O7S The title of the patent was Preparation of bifunctional PROTAC compounds and methods for degradation of targeted BRM proteins. And the patent contained the following:

The present disclosure relates to bifunctional compounds, e.g., I, their pharmaceutically acceptable salts, enantiomers, stereoisomers, solvates, polymorphs and prodrugs which find utility as modulators of switch/sucrose non fermentable-related, matrix-associated, actin-dependent regulator of chromatin subfamily a member 2 (SMARCA2) or Brahma (BRM) (target protein), particularly to bifunctional compounds, which contain on one end a ligand that binds to the Von Hippel-Lindau E3 ubiquitin ligase, and on the other end a moiety which binds the target protein, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The invention exhibits a broad range of pharmacol. activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aggregation or accumulation of the target protein such as SMARCA4-related/deficient cancer, such as lung cancer or non-small cell lung cancer, are treated or prevented with compounds and compositions of the present disclosure. Thus, I was prepared by coupling of 2-[2-[2-[4-[3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl]-1H-pyrazol-1-yl]ethoxy]eth oxy]acetic acid (preparation given) with (2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-[4-(4-methylthiazol-5-yl )benzyl]pyrrolidine-2-carboxamide. A Western blot assay was used to assess the BRM degradation (Dmax and DC50) in SW 1573 cells; I displayed a DC50 ≥ 30 nM and DC50 > 75. The experimental process involved the reaction of tert-Butyl 2-(2-(2-(tosyloxy)ethoxy)ethoxy)acetate(cas: 882518-89-0).Formula: C17H26O7S

The Article related to chimeric mol preparation targeted brm smarca2 degradation ubiquitination, protac modulator preparation targeted ubiquitination brm degradation inhibition antitumor, von hippel lindau dipeptide ligand preparation brm protac inhibition and other aspects.Formula: C17H26O7S

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On October 16, 2015, Wang, Lizhen; Feng, Shaojie; An, Lian; Gu, Guofeng; Guo, Zhongwu published an article.Application In Synthesis of Bis(2,5-dioxopyrrolidin-1-yl) glutarate The title of the article was Synthetic and Immunological Studies of Mycobacterial Lipoarabinomannan Oligosaccharides and Their Protein Conjugates. And the article contained the following:

Lipoarabinomannan (LAM) is one of the major constituents of the Mycobacterium tuberculosis cell wall and an attractive mol. scaffold for antituberculosis drug and vaccine development. In this paper, a convergent strategy was developed for the synthesis of LAM oligosaccharides with an α-1,2-linked dimannopyranose cap at the nonreducing end. The strategy was highlighted by efficient coupling of sep. prepared non-reducing end and reducing end oligosaccharides. Glycosylation were mainly achieved with thioglycoside donors, which gave excellent yields and stereoselectivity even for reactions between complex oligosaccharides. The strategy was utilized to successfully synthesize tetra-, hepta-, and undecasaccharides of LAM from D-arabinose in 10, 15, and 14 longest linear steps and 7.84, 7.50, and 2.59% overall yields, resp. The resultant oligosaccharides with a free amino group at their reducing end were effectively conjugated with carrier proteins, including bovine serum albumin and keyhole limpet hemocyanin (KLH), via a bifunctional linker. Preliminary immunol. studies on the KLH conjugates revealed that they could elicit robust antibody responses in mice and that the antigen structure had some influence on their immunol. property, thus verifying the potential of the oligosaccharides for vaccine development and other immunol. studies. The experimental process involved the reaction of Bis(2,5-dioxopyrrolidin-1-yl) glutarate(cas: 79642-50-5).Application In Synthesis of Bis(2,5-dioxopyrrolidin-1-yl) glutarate

The Article related to antituberculosis vaccine oligosaccharide dimannopyranose stereoselective glycosylation were thioglycoside antibacterial, oligosaccharide preparation mycobacterial lipoarabinomannan immunol protein antibody thioglycoside glycosylation and other aspects.Application In Synthesis of Bis(2,5-dioxopyrrolidin-1-yl) glutarate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On October 7, 1999, Pitts, William J.; Jadhav, Prabhakar K. published a patent.Name: tert-Butyl 4-((((benzyloxy)carbonyl)amino)methyl)benzoate The title of the patent was Preparation of pyrimidinylalkylphenylcarbonylaminopropanoates and related compounds as integrin antagonists. And the patent contained the following:

GT (T = integrin antagonist template; G = specified guanidine mimic), were prepared as antagonists of the αvβ3 integrin, the α2bβ3 integrin, and related cell surface adhesive protein receptors for the inhibition of cell adhesion, treatment of angiogenic disorders, inflammation, bone degradation, cancer metastasis, diabetic retinopathy, thrombosis, restenosis, macular degeneration, and other conditions mediated by cell adhesion and/or cell migration and/or angiogenesis. Thus, 2-[(S)-2,4,6-trimethylphenylsulfonylamino]-3-[4-[2-(2,4-diaminopyrimidin-6-yl)ethyl]phenylcarbonylamino]propionic acid trifluoroacetate was prepared in several steps from L-asparagine. In the αvβ3-vitronectin assay, tested title compounds showed IC50≤10 μM. The experimental process involved the reaction of tert-Butyl 4-((((benzyloxy)carbonyl)amino)methyl)benzoate(cas: 220851-46-7).Name: tert-Butyl 4-((((benzyloxy)carbonyl)amino)methyl)benzoate

The Article related to pyrimidinylalkylphenylcarbonylaminopropanoate preparation integrin antagonist, quinazolinylaminomethylphenylcarbonylaminopropanoate preparation integrin antagonist, cell adhesion inhibitor pyrimidine quinazoline triazine preparation and other aspects.Name: tert-Butyl 4-((((benzyloxy)carbonyl)amino)methyl)benzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On April 30, 2008, Liu, Jie; Yang, Zhigang; Wang, Zhen; Wang, Fei; Chen, Xiaohong; Liu, Xiaohua; Feng, Xiaoming; Su, Zhishan; Hu, Changwei published an article.SDS of cas: 227940-70-7 The title of the article was Asymmetric Direct Aldol Reaction of Functionalized Ketones Catalyzed by Amine Organocatalysts Based on Bispidine. And the article contained the following:

Organocatalysts containing primary-secondary amine based on bispidine and amino acid have been designed to catalyze the asym. direct aldol reaction of functionalized ketones including α-keto phosphonates, α-keto esters, as well as α,α-dialkoxy ketones as aldol reaction acceptors. The corresponding products with chiral tertiary alcs. were obtained in moderate to high yields (up to 97%) and high enantioselectivities (up to 98% ee). A theor. study of transition structures demonstrated that protonated piperidine was important for the reactivity and enantioselectivity of this reaction. The experimental process involved the reaction of tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate(cas: 227940-70-7).SDS of cas: 227940-70-7

The Article related to amino acid bispidine addition, aminobispidine preparation organocatalyst, ketone acetone butanone cyclohexanone direct aldol addition aminobispidine organocatalyst, alc asym preparation b3lyp hartree fock transition state structure and other aspects.SDS of cas: 227940-70-7

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics