Tag: 300-400

On October 15, 2007, Ramesh, Ramapanicker; De, Kavita; Chandrasekaran, Srinivasan published an article.SDS of cas: 59524-07-1 The title of the article was An efficient synthesis of dehydroamino acids and dehydropeptides from O-Cbz and O-Eoc derivatives of serine and threonine. And the article contained the following:

A simple and efficient method for the synthesis of dehydroamino acids from serine and threonine is reported. Various O-Cbz and O-Eoc derivatives of serine and threonine are prepared using CbzCl (PhCH2OCOCl) and EocCl (EtOCOCl) , resp., and are subjected to an anti-selective elimination on treatment with K2CO3 in DMF at 65° to afford dehydroalanine and dehydroaminobutyric acid derivatives, resp., in excellent yields. The high stability of these carbonate derivatives of serine and threonine allows their use in normal peptide synthesis as protected serine and threonine residues. Peptides synthesized by incorporating O-Cbz or O-Eoc derivatives undergo ready elimination under the reported conditions, to give the corresponding dehydropeptides in excellent yields. The reaction conditions are mild enough not to cause the racemization of other stereogenic centers present in the peptide. The experimental process involved the reaction of Benzyl 2-(((benzyloxy)carbonyl)amino)acrylate(cas: 59524-07-1).SDS of cas: 59524-07-1

The Article related to dehydroamino acid preparation cbz eoc protected serine threonine, dehydropeptide preparation cbz eoc protected serine threonine, anti beta elimination reaction cbz eoc protected serine threonine and other aspects.SDS of cas: 59524-07-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On February 1, 2020, Trujillo-Rodriguez, Maria J.; Anderson, Jared L.; Dunham, Sage J. B.; Noad, Victoria L.; Cardin, Daniel B. published an article.Synthetic Route of 6197-30-4 The title of the article was Vacuum-assisted sorbent extraction: An analytical methodology for the determination of ultraviolet filters in environmental samples. And the article contained the following:

Vacuum-assisted sorbent extraction (VASE) has been applied in combination with gas chromatog.-mass spectrometry for the determination of UV filters in water samples. VASE is a variant of headspace extraction which was developed in conjunction with the sorbent pen (SP) technol. This technique combines the advantages of both stir-bar assisted extraction and headspace solid-phase microextraction The SP traps allowed both reduced pressure in-vial extraction and direct thermal desorption via a unique gas chromatog. injection port. The main parameters that affect the performance of VASE, including both extraction and desorption conditions, were extensively optimized. Under optimum conditions, extraction required 10 mL of sample within 40 mL vials, pH 3.5, ∼30 s of air-evacuation, 14 h incubation at 70°C, stirring at 200 rpm, and a final water management step conducted at ∼ -17°C for 15 min. Optimal thermal desorption required preheating at 260°C for 2 min followed by desorption at 300°C for 2 min. The beneficial effect of reduced-pressure extraction was demonstrated by comparing the UV filter extraction time profiles collected using VASE to an analogous atm. pressure procedure, resulting in up to a 3-fold improvement under optimized conditions. The VASE methodol. enabled simultaneous extractions using different SPs without compromising the method reproducibility, which increases the overall sample throughput. The method was characterized by low limits of detection, from 0.5 to 80 ng L-1, and adequate reproducibility, with inter-SP and inter-day relative standard deviation lower than 14%. Tap and lake water was successfully analyzed with the proposed methodol., resulting in relative recoveries of spiked samples ranging between 70.0 and 120%. The experimental process involved the reaction of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate(cas: 6197-30-4).Synthetic Route of 6197-30-4

The Article related to vacuum assisted sorbent extraction uv filter environment analysis water, environmental analysis, gas chromatography, mass spectrometry, ultraviolet filters, vacuum-assisted sorbent extraction and other aspects.Synthetic Route of 6197-30-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On November 30, 2020, Saunders, Leslie J.; Fitzsimmons, Patrick N.; Nichols, John W.; Gobas, Frank A. P. C. published an article.COA of Formula: C24H27NO2 The title of the article was In vitro-in vivo extrapolation of hepatic and gastrointestinal biotransformation rates of hydrophobic chemicals in rainbow trout. And the article contained the following:

Here we evaluated intestinal biotransformation in rainbow trout using S9 fractions prepared from the upper intestinal (GIT) epithelium. Measured levels of activity determined using standard substrates for phase I and phase II biotransformation enzymes were within 2-fold of activities measured in hepatic S9 fractions. An existing liver only IVIVE model was expanded to consider biotransformation in both the liver and GIT. Relevant IVIVE scaling factors were developed by morphol., histol., and biochem. evaluation of trout intestines. For chems. biotransformed at higher rates by hepatic S9 fractions (i.e., BAP, PYR, EHMC), the liver & GIT model yielded whole-body biotransformation rate constants (kMET) that were within 1.2 to 1.4-fold of those estimated using the liver only model. In contrast to these findings, the mean kMET for OCT obtained using the liver & GIT model was 3.3 times higher than the mean kMET derived using the liver only model and was in good agreement with empirical kMET estimates determined previously for trout (<20% difference). The results of this study suggest that current liver only IVIVE approaches may underestimate in vivo biotransformation rates for chems. that undergo substantial biotransformation in the GIT. The experimental process involved the reaction of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate(cas: 6197-30-4).COA of Formula: C24H27NO2

The Article related to oncorhynchus gastrointestinal tract biotransformation pyrene pyloric cecum, animal alternatives, bioaccumulation, biotransformation, in vitro-in vivo extrapolation, intestinal metabolism, rainbow trout and other aspects.COA of Formula: C24H27NO2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On February 13, 2019, Cao, Chen-Chen; Chen, Cheng-Xia; Wei, Zhang-Wen; Qiu, Qian-Feng; Zhu, Neng-Xiu; Xiong, Yang-Yang; Jiang, Ji-Jun; Wang, Dawei; Su, Cheng-Yong published an article.Related Products of 1312703-30-2 The title of the article was Catalysis through Dynamic Spacer Installation of Multivariate Functionalities in Metal-Organic Frameworks. And the article contained the following:

We demonstrate herein a facile strategy to engineer versatile catalytically active coordination interspace in the same primitive metal-organic framework (MOF) for variable heterogeneous catalysis. Different functional ligands can be reversibly inserted into and removed from proto-LIFM-28 individually or successively to bring in single or binary catalytic sites for specific reactions and switch the parent MOF to multipurpose catalysts. Alc.-oxidation, Knoevenagel-condensation, click, acetal, and Baylis-Hillman reactions are achievable through simple exchange of a single catalytic spacer, while sequential or stepwise reactions are designable via selective combination of two catalytic spacers with different functionalities, thus making proto-LIFM-28 a multivariate MOF for multiuse and economic catalysis. The experimental process involved the reaction of Dimethyl 2′-amino-[1,1′:4′,1”-terphenyl]-4,4”-dicarboxylate(cas: 1312703-30-2).Related Products of 1312703-30-2

The Article related to multivariate metal organic framework dynamic spacer installation preparation, sequential stepwise reaction mof catalyst, oxidation knoevenagel condensation click acetal baylis hillman reaction catalyst and other aspects.Related Products of 1312703-30-2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On January 1, 2018, Zhou, Zilong; Peng, Shanshan; Sui, Minghao; Chen, Shiguang; Huang, Lishi; Xu, Hui; Jiang, Tingting published an article.Formula: C13H14N2O8 The title of the article was Multifunctional nanocomplex for surface-enhanced Raman scattering imaging and near-infrared photodynamic antimicrobial therapy of vancomycin-resistant bacteria. And the article contained the following:

Since vancomycin (Van)-resistant enterococci (VRE) strains first emerged as a serious threat to public health, extensive studies focused on optical imaging and antimicrobial therapy have been performed for monitoring and microbiol. control. In this study, we developed silicon 2,3-naphthalocyanine dihydroxide (Nc) and Van functionalized silica-encapsulated, silver-coated gold nanoparticles (Au@AgNP@SiO2@Nc-Van) as a novel theranostic system for surface-enhanced Raman scattering (SERS) detection and antimicrobial photodynamic therapy (aPDT) of VRE strains. The silver-coated gold nanoparticle, as the SERS-active core, exhibited excellent Raman enhancement efficacy. Results of in vitro bacterial SERS imaging revealed Van-enhanced specific binding affinity toward VRE. Meanwhile, Si(IV) naphthalocyanine, serving as a near-IR (NIR) photosensitizer, was axially linked to the nanoparticle surface, yielding nanostructured hybrid materials that could photoinactivate VRE. Almost 4-5 logs of bacterial reduction were obtained upon in vitro photodynamic therapy of VRE treated with a nanomolar concentration of the nanocomplex. Mouse infection assays were applied for an in vivo evaluation of VRE lethality. Upon near-IR light irradiation, this hybrid nanomaterial caused obvious infection regression and even complete eradication compared to the findings in the non-treated groups. Therefore, this novel nanosystem integrating SERS imaging and noninvasive aPDT has huge potential for applications in theranostics with regard to VRE management. The experimental process involved the reaction of Bis(2,5-dioxopyrrolidin-1-yl) glutarate(cas: 79642-50-5).Formula: C13H14N2O8

The Article related to nir radiation antimicrobial raman scattering imaging, antimicrobial photodynamic therapy, multifunctional nanoparticles, sers imaging, silver-coated gold nanoparticles, vancomycin-resistant enterococci and other aspects.Formula: C13H14N2O8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On February 20, 2022, Duis, Karen; Junker, Thomas; Coors, Anja published an article.Recommanded Product: 6197-30-4 The title of the article was Review of the environmental fate and effects of two UV filter substances used in cosmetic products. And the article contained the following:

A review. Sunscreens containing UV filters, such as octocrylene (OCR) and butyl-methoxydibenzoylmethane (BMDBM), have been increasingly used to protect human skin against UV radiation. Both substances have been detected in monitoring studies in the freshwater and marine environment, and there has been concern about potential effects on aquatic organisms. In the present work, the environmental fate and occurrence, bioaccumulation and ecotoxicity including endocrine effects of OCR and BMDBM are ed focusing on the aquatic environment. The two UV filters have low water solubilities and a high sorption potential. The available data indicate that OCR is poorly biodegradable. BMDBM lacks anaerobic and inherent biodegradability. However, it was biodegraded to variable degrees in simulation studies. Measured concentrations in the freshwater and marine environment were found to vary considerably between sites, depending on the extent of recreational activities or wastewater discharges. While the bioconcentration factor of OCR in fish is below the threshold value for bioaccumulation according to EU REACH, the available data for BMDBM do not allow a definitive conclusion on its bioaccumulation potential. Anal. of the aquatic toxicity data showed that data quality was often limited, e.g. in the case of effect concentrations substantially exceeding maximum achievable dissolved concentrations Up to their limit of water solubility, OCR and BMDBM showed no toxicity to microorganisms, algae, and corals, and no acute toxicity to daphnids and fish. In chronic daphnid tests, OCR was highly toxic, whereas BMDBM lacked toxicity. Reliable water-sediment toxicity tests are required to further evaluate possible effects on benthic invertebrates. The available data do not provide evidence for endocrine effects of the two UV filters on fish. In order to assess potential environmental risks caused by OCR and BMDBM, a validated exposure model for estimating direct emission of UV filters into the aquatic environment and data from systematic, longer-term monitoring studies are needed. The experimental process involved the reaction of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate(cas: 6197-30-4).Recommanded Product: 6197-30-4

The Article related to review octocrylene butylmethoxydibenzoylmethane sunscreen environmental fate wastewater simulation, bioaccumulation, biodegradation, butyl-methoxydibenzoylmethane, ecotoxicity, octocrylene, sunscreens and other aspects.Recommanded Product: 6197-30-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Russ Algar, W.; Krull, Ulrich J. published an article in 2011, the title of the article was Interfacial chemistry and the design of solid-phase nucleic acid hybridization assays using immobilized quantum dots as donors in fluorescence resonance energy transfer.Related Products of 79642-50-5 And the article contains the following content:

The use of quantum dots (QDs) as donors in fluorescence resonance energy transfer (FRET) offer several advantages for the development of multiplexed solid-phase QD-FRET nucleic acid hybridization assays. Designs for multiplexing have been demonstrated, but important challenges remain in the optimization of these systems. In this work, we identify several strategies based on the design of interfacial chem. for improving sensitivity, obtaining lower limits of detection (LOD) and enabling the regeneration and reuse of solid-phase QD-FRET hybridization assays. FRET-sensitized emission from acceptor dyes associated with hybridization events at immobilized QD donors provides the anal. signal in these assays. The minimization of active sensing area reduces background from QD donor PL and allows the resolution of smaller amounts of acceptor emission, thus lowering the LOD. The association of multiple acceptor dyes with each hybridization event can enhance FRET efficiency, thereby improving sensitivity. Many previous studies have used interfacial protein layers to generate selectivity; however, transient destabilization of these layers is shown to prevent efficient regeneration. To this end, we report a protein-free interfacial chem. and demonstrate the specific detection of as little as 2 pmol of target, as well as an improved capacity for regeneration. The experimental process involved the reaction of Bis(2,5-dioxopyrrolidin-1-yl) glutarate(cas: 79642-50-5).Related Products of 79642-50-5

The Article related to interfacial chem nucleic acid hybridization assay quantum dot fret, dna, active area, biosensor, fluorescence resonance energy transfer, immobilization, quantum dots, regeneration, signal enhancement and other aspects.Related Products of 79642-50-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On September 30, 2022, Khokhar, Vaishali; Singh, Hanuman; Haridas, V.; Pandey, Siddharth published an article.Application In Synthesis of tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate The title of the article was Ratiometric Recognition of Protons by a Multiple Tagged Designer Fluorescent Chemosensor. And the article contained the following:

Mol. architecture with different fluorophoric units can offer improved and effective recognition of biol. important analytes. We present here a new strategy for the design of ratiometric chemosensors that operate by photoinduced electron transfer (PET). This ratiometric sensor endowed with tryptophan and anthracene exhibits high sensitivity, excellent selectivity and remarkable reversibility towards recognition of H+ in methanol. This “Turn-On” type behavior is crafted into the mol. by incorporation of bispidine entity. Effective quenching of the fluorescence of the anthracene by the adjacent amine groups of the bispidine results in negligible fluorescence from the anthracene group leading to highly sensitive recognition of protons by the compound as H+ protonate the amine functionalities giving rise to the emergence of the fluorescence from the anthracene group. This, combined with the reduction in the fluorescence from the Trp group by H+, results in highly sensitive ratiometric nature of the response especially at low [H+]. The experimental process involved the reaction of tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate(cas: 227940-70-7).Application In Synthesis of tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate

The Article related to hydrogen proton recognition ratiometric fluorescence chemosensor, bioanalytical sensing, fluorescence-based sensing, photoinduced electron/charge transfer, proton recognition, ratiometric chemosensor and other aspects.Application In Synthesis of tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On January 15, 2021, Azaroff, Alyssa; Monperrus, Mathilde; Miossec, Carole; Gassie, Claire; Guyoneaud, Remy published an article.Formula: C24H27NO2 The title of the article was Microbial degradation of hydrophobic emerging contaminants from marine sediment slurries (Capbreton Canyon) to pure bacterial strain. And the article contained the following:

Despite emerging contaminants (ECs) are more and more monitored in environmental matrixes, there is still a lack of data in marine ecosystems, especially on their fate and degradation potentials. In this work, for the first time, the degradation potential of synthetic musks (galaxolide and tonalide), UV filters (padimate O and octocrylene) and a pharmaceutical compound (carbamazepine) was studied in marine sediment samples, under laboratory conditions using sediment slurry incubations under biotic and abiotic conditions. Min. half life times under biotic conditions were found at 21 days, 129 days and 199 days for padimate O, galaxolide and carbamazepine, resp. Enrichments conducted under anoxic and oxic conditions demonstrated that degradations after one month of incubation either under both biotic and abiotic conditions were limited under anoxic conditions compared to oxic conditions for all the contaminants. Novel aerobic bacteria, able to degrade synthetic musks and UV filters have been isolated. These novel strains were mainly related to the Genus Bacillus. Based on these results, the isolated strains able to degrade such ECs, can have a strong implication in the natural resilience in marine environment, and could be used in remediation processes. The experimental process involved the reaction of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate(cas: 6197-30-4).Formula: C24H27NO2

The Article related to carbamazepine degradation hydrophobicity marine sediment slurry wastewater treatment, degradation, emerging contaminants, marine sediments, musks, pharmaceuticals, pure bacterial strains, uv filters and other aspects.Formula: C24H27NO2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On August 31, 2022, Jin, Yihui; Yuan, Tao; Li, Jiafan; Shen, Zhemin; Tian, Ying published an article.Quality Control of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate The title of the article was Occurrence, health risk assessment and water quality criteria derivation of six personal care products (PCPs) in Huangpu River, China. And the article contained the following:

Personal care products (PCPs) have shown adverse health effects on humans. However, their health risk associated with fish consumption and relevant water quality criteria are still not well documented. This study investigated the occurrence and health risk of six PCPs (triclosan, bisphenol-A, and four commonly used organic UV filters, i.e., homosalate (HMS), 4-methylbenzylidene camphor (4-MBC), oxybenzone (BP-3), and octocrylene (OC)). River water and three trophic levels of fish species were collected from Huangpu River in Shanghai. The concentration range of the six PCPs were 1.48-89.76 ng/L in water and 0.40-10.75 ng/g dry weight in fish. Estimated daily intake (EDI) and target hazard quotient (THQ) of the PCPs indicated that consuming these fish would not pose non-carcinogenic risks. The maximum allowable fish consumption rates ranged from 85 to 1760 and 155 to 3230 meals per mo for children and adults, resp. As to the four organic UV filters, it is the first time to report the fish consumption advisories. Finally, the human health ambient water quality criteria (AWQC) values of HMS, 4-MBC, BP-3, OC, TCS, and BPA (i.e., 0.1218, 0.7311, 0.3494, 0.0477, 235.8, and 154.7 μg/L, resp.) were proposed, and they can serve as a valuable tech. reference for global development and revision of aquatic environmental quality standards for these emerging contaminants. The experimental process involved the reaction of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate(cas: 6197-30-4).Quality Control of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate

The Article related to personal care product health risk assessment water quality criteria, ambient water quality criteria, consumption advisories, fish, health risk assessment, organic uv filters, personal care products and other aspects.Quality Control of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics