Tag: 300-400

On April 2, 2015, Dikshit, Dinesh Kumar; Kumar, K. S. Anil; Dikshit, Madhu; Barthwal, Manoj Kumar; Misra, Ankita; Jain, Manish published a patent.Name: tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate The title of the patent was Preparation of 3,7-diazabicyclo[3.3.1]nonane carboxamides as antithrombotic agents. And the patent contained the following:

The present invention relates to the 3,7-diazabicyclo[3.3.1]nonane carboxamides of formula I as anti-thrombotic (anti-platelet) agents and process for preparation thereof. The invention also relates to use of these moieties as inhibitors of collagen induced platelet adhesion and aggregation mediated through collagen receptors both in vitro and in vivo. Compounds of formula I wherein R’ is II and III; R is alkyl, acyl, tosyl, etc; R” is halo, cyano, lower alkyl, etc.; R1 is H and lower alkyl; R2 is lower alkyl and aryl; R3 is tert-butyloxycarbonyl and benzyloxycarbonyl groups; are claimed. Example compound IV was prepared by acylation of N-Bocbispidine with N-benzylpyroglutamic acid. The invention compounds were evaluated for their antithrombotic activity (some data given). The experimental process involved the reaction of tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate(cas: 227940-70-7).Name: tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate

The Article related to preparation pyroglutamyldiazabicyclononane carboxamide antithrombotic, collagen induced platelet adhesion aggregation inhibitor preparation pyroglutamyldiazabicyclononane carboxamide and other aspects.Name: tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On November 30, 2021, Ruvolo, Eduardo; Rohr, Mathias; Oliveira, Sergio; Nogueira, Luciano; Carvalho, Jose; Cole, Curtis published an article.Name: 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate The title of the article was Multi-laboratory study of hybrid diffuse reflectance spectroscopy to assess sunscreen SPF and UVA-PFs. And the article contained the following:

Proof-of-principle studies have established the use of Hybrid Diffuse Reflectance Spectroscopy (HDRS) methods to assess both UV-A Protection Factor (UVA-PF) and Sun Protection Factor (SPF) indexes in individual laboratories Multiple laboratories evaluated 23 emulsions and two spray sunscreen products to evaluate repeatability and accuracy of assessment of SPF and UVA-PF values, using HDRS test systems from various manufacturers using different designs. All of the laboratories reported similar SPF and UVA-PF values within a narrow range of values to establish the reliability of the HDRS methodol. across laboratories, independent of equipment manufacturer or operator. HDRS test methodol. provides a reliable objective instrumental estimation of sunscreen SPF and UVA-PF. These data were provided to ISO-TC217 WG7 to substantiate the ongoing development of an ISO Standard HDRS Method. The experimental process involved the reaction of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate(cas: 6197-30-4).Name: 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate

The Article related to hybrid diffuse reflectance spectroscopy spf uva protection factor, diffuse reflectance spectroscopy, multi-laboratory ring test, sunscreen protection factor, ultraviolet-a protection factor and other aspects.Name: 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On March 30, 2019, Hernychova, Lucie; Rosulek, Michal; Kadek, Alan; Mareska, Vaclav; Chmelik, Josef; Adamkova, Ljubina; Grobarova, Valeria; Sebesta, Ondrej; Kukacka, Zdenek; Skala, Kristian; Spiwok, Vojtech; Cerny, Jan; Novak, Petr published an article.Computed Properties of 79642-50-5 The title of the article was The C-type lectin-like receptor Nkrp1b: Structural proteomics reveals features affecting protein conformation and interactions. And the article contained the following:

Here, we characterized the Nkrp1b structure and structural features that affect its interactions. To study the Nkrp1b protein structure and the functional importance of its stalk, two Nkrp1b protein variants differing by the presence of the stalk were prepared These variants were studied using a combination of structural mass spectrometry approaches with computational modeling to derive structural models. In addition, information about biol. activity and localization in mammalian cells was acquired using scanning microscopy techniques and western blotting. Based on these methods, we obtained the structure of Nkrp1b ectodomain in its monomeric and dimeric conformations, identified the dimerization interface, and determined disulfide connections within the mol. We found that Nkrp1b occurs as a mixture of monomers and homodimers, both in vitro and in vivo. Despite the long-standing assumption that Nkrp1 proteins are homodimers connected by disulfide bonds in the stalk region, our data showed that both Nkrp1b protein variants form monomers and homodimers irresp. of the presence of the stalk. Using a unique combination of computational, biochem., and biol. methods, we revealed the structural conformation and behavior of Nkrp1b in its native state. In addition, it is a first report utilizing the intermol. chem. crosslinking of light- and heavy-labeled protein chains together with ion mobility-mass spectrometry to design the structural models of protein homodimers. The experimental process involved the reaction of Bis(2,5-dioxopyrrolidin-1-yl) glutarate(cas: 79642-50-5).Computed Properties of 79642-50-5

The Article related to proteome nkrp1b oligomerization disulfide bond protein conformation interaction, chemical cross-linking, homodimers, ion mobility, natural killer cells, nkrp1b, structural mass spectrometry and other aspects.Computed Properties of 79642-50-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On March 31, 2020, Saunders, Leslie J.; Hoffman, Alex D.; Nichols, John W.; Gobas, Frank A. P. C. published an article.Application of 6197-30-4 The title of the article was Dietary Bioaccumulation and Biotransformation of Hydrophobic Organic Sunscreen Agents in Rainbow Trout. And the article contained the following:

The present study investigated the dietary bioaccumulation and biotransformation of hydrophobic organic sunscreen agents, 2-ethylhexyl-4-methoxycinnamate (EHMC) and octocrylene (OCT), in rainbow trout using a modified Organization for Economic Co-operation and Development 305 dietary bioaccumulation test that incorporated nonbiotransformed reference chems. Trout were exposed to 3 dietary concentrations of each chem. to investigate the relationship between dietary exposure concentration and observed accumulation and depuration. Both EHMC and OCT were significantly biotransformed, resulting in mean in vivo whole-body biotransformation rate constants (kMET) of 0.54 ± 0.06 and 0.09 ± 0.01 d-1, resp. The kMET values generated for both chems. did not differ between dietary exposure concentrations, indicating that chem. concentrations in the fish were not high enough to saturate biotransformation enzymes. Both somatic and luminal biotransformation substantially reduce EHMC and OCT bioaccumulation potential in trout. Biomagnification factors (BMFs) and bioconcentration factors (BCFs) of EHMC averaged 0.0035 kg lipid kg lipid-1 and 396 L kg-1, resp., whereas those of OCT averaged 0.0084 kg lipid kg lipid-1 and 1267 L kg-1. These values are 1 to 2 orders of magnitude lower than the BMFs and BCFs generated for reference chems. of similar log KOW. In addition, for both chems., derived BMFs and BCFs fell below established bioaccumulation criteria (1.0 kg lipid kg lipid-1 and 2000 L kg-1, resp.), suggesting that EHMC ad OCT are unlikely to bioaccumulate to a high degree in aquatic biota. The experimental process involved the reaction of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate(cas: 6197-30-4).Application of 6197-30-4

The Article related to dietary bioaccumulation biotransformation hydrophobic organic sunscreen rainbow trout, bioaccumulation, biomagnification, biotransformation, sunscreens, toxicokinetics, ultraviolet filters and other aspects.Application of 6197-30-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On August 9, 2021, Stanley, Philip M.; Haimerl, Johanna; Thomas, Christopher; Urstoeger, Alexander; Schuster, Michael; Shustova, Natalia B.; Casini, Angela; Rieger, Bernhard; Warnan, Julien; Fischer, Roland A. published an article.Category: esters-buliding-blocks The title of the article was Host-guest interactions in metal-organic framework isoreticular series for molecular photocatalytic CO2 reduction. And the article contained the following:

A strategy to improve homogeneous mol. catalyst stability, efficiency, and selectivity is the immobilization on supporting surfaces or within host matrixes. Herein, we examine the co-immobilization of a CO2 reduction catalyst [ReBr(CO)3(4,4′-dcbpy)] and a photosensitizer [Ru(bpy)2(5,5′-dcbpy)]Cl2 using the isoreticular series of metal-organic frameworks (MOFs) UiO-66, -67, and -68. Specific host pore size choice enables distinct catalyst and photosensitizer spatial location-either at the outer MOF particle surface or inside the MOF cavities-affecting catalyst stability, electronic communication between reaction center and photosensitizer, and consequently the apparent catalytic rates. These results allow for a rational understanding of an optimized supramol. layout of catalyst, photosensitizer, and host matrix. The experimental process involved the reaction of Dimethyl 2′-amino-[1,1′:4′,1”-terphenyl]-4,4”-dicarboxylate(cas: 1312703-30-2).Category: esters-buliding-blocks

The Article related to metal organic framework photosensitizer photocatalytic carbon dioxide reduction, host-guest systems, hybrid materials, metal-organic frameworks, molecular catalysis, solar fuel production and other aspects.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On October 18, 2002, Huttenloch, Oliver; Laxman, Eltepu; Waldmann, Herbert published an article.Electric Literature of 227940-70-7 The title of the article was Solid-phase development of chiral phosphoramidite ligands for enantioselective conjugate addition reactions. And the article contained the following:

The development of a method for the optimization of chiral ligands for the steric steering of enantioselective Cu-catalyzed conjugate additions of Zn-alkyls to enones is described. The method is based on combinatorial principles and solid-phase techniques. It includes the combinatorial synthesis of chiral bispidine-derived ligands embodying a phosphoramidite group on the solid phase and their study in immobilized form in the conjugate addition of ZnEt2 to cyclohexenone as test reaction. The best identified ligands were also synthesized sep. and studied in its soluble form. The results obtained for the polymer-bound ligands correctly mirrored the performance of the soluble ligands. The library embodied members giving ee values varying between 3 and 67%. The positional scanning approach proved to be invalid for the study of the ligand system, indicating that this approach in general should be applied with care. Taken together, the method allowed for rapid and efficient optimization of the ligands and led to the development of the 1st enantioselective, Cu-catalyzed conjugate addition reaction with a polymer-bound ligand. The experimental process involved the reaction of tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate(cas: 227940-70-7).Electric Literature of 227940-70-7

The Article related to copper catalyzed conjugate addition diethylzinc cyclohexenone chiral phosphoramidite ligand, phosphoramidite ligand preparation combinatorial chem catalyst conjugate addition diethylzinc and other aspects.Electric Literature of 227940-70-7

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Santos, Luiz F. A.; Iglesias, Amadeu H.; Gozzo, Fabio C. published an article in 2011, the title of the article was Fragmentation features of intermolecular cross-linked peptides using N-hydroxy- succinimide esters by MALDI- and ESI-MS/MS for use in structural proteomics.Electric Literature of 79642-50-5 And the article contains the following content:

The use of mass spectrometry coupled with chem. crosslinking of proteins has become one of the most useful tools for proteins structure and interactions studies. One of the challenges in these studies is the identification of the cross-linked peptides. The interpretation of the MS/MS data generated in crosslinking experiments using N-hydroxy succinimide esters is not trivial once a new amide bond is formed allowing new fragmentation pathways, unlike linear peptides. Intermol. cross-linked peptides occur when two different peptides are connected by the cross-linker and they yield information on the spatial proximity of different domains (within a protein) or proteins (within a complex). In this article, the authors report a detailed fragmentation study of intermol. cross-linked peptides, generated from a set of synthetic peptides, using both ESI and MALDI to generate the precursor ions. The fragmentation features observed here can be helpful in the interpretation and identification of cross-linked peptides present in crosslinking experiments and be further implemented in search engine’s algorithms. Copyright © 2011 John Wiley & Sons, Ltd. The experimental process involved the reaction of Bis(2,5-dioxopyrrolidin-1-yl) glutarate(cas: 79642-50-5).Electric Literature of 79642-50-5

The Article related to maldi mass spectrometry fragmentation intermol crosslinked peptide hydroxysuccinimide ester, electrospray ionization mass spectrometry fragmentation intermol crosslinked peptide hydroxysuccinimide and other aspects.Electric Literature of 79642-50-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On January 31, 2019, Bolek, Sylwia; Ignatowska, Jolanta published an article.Reference of Benzyl 2-(((benzyloxy)carbonyl)amino)acrylate The title of the article was Ring opening reactions of cyclic sulfamidates. Synthesis of β-fluoroaryl alanines and derivatives of 4,4-difluoroglutamic acid. And the article contained the following:

Ring opening reactions of (I) (R1 = Boc, Cbz, Fmoc, trityl, R2 = Et; R1 = Cbz, R2 = Bn; Boc = tert-butoxycarbonyl, Cbz = benzyloxycarbonyl, Fmoc = 9-fluorenylmethoxycarbony, Trityl = CPh3) with copper complex formed between Cu, TMEDA and BrCF2CO2Et lead to optically active 4,4-difluoroglutamic acid derivatives (II) (R1 and R2 as above) in moderate yields. Reaction of cyclic sulfamidates I with fluoro substituted arylmagnesium chlorides proceed via copper catalyzed 1,4-addition of Grignard reagent to dehydroalanine (III), formed in situ. Fluorinated organozinc derivatives were unreactive towards I regardless of the reaction conditions; instead product of reaction of I with DMF was isolated. The experimental process involved the reaction of Benzyl 2-(((benzyloxy)carbonyl)amino)acrylate(cas: 59524-07-1).Reference of Benzyl 2-(((benzyloxy)carbonyl)amino)acrylate

The Article related to fluoroaryl alanine synthesis, difluoroglutamic acid synthesis, cyclic sulfamidate ring opening reaction mechanism copper complex catalyst, addition grignard reagent dehydroalanine copper catalyst and other aspects.Reference of Benzyl 2-(((benzyloxy)carbonyl)amino)acrylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On January 1, 2021, Carve, Megan; Nugegoda, Dayanthi; Allinson, Graeme; Shimeta, Jeff published an article.Recommanded Product: 6197-30-4 The title of the article was A systematic review and ecological risk assessment for organic ultraviolet filters in aquatic environments. And the article contained the following:

Organic UV filters (OUVFs) are used in a wide range of manufactured products including personal care (e.g. sunscreens) and plastic items. This review summarizes the available data regarding the toxic effects of OUVFs on marine and freshwater organisms and generates the predicted no-effect concentration (PNEC) values necessary for assessing ecol. risk. Through a systematic search of the literature, 89 studies were identified and ecotoxicol. data extracted Collectively, these studies described toxicity testing with 39 OUVF from 10 structural classes, with derivatives of benzophenones (49%) and camphors (16%) most studied. There was a bias towards selecting freshwater species (61%), and evaluating single OUVF effects (87%) rather than OUVF mixtures Short-term (acute) experimentation (58%) was marginally more common than long-term (chronic) testing (42%). Reproductive, developmental, genetic, and neurol. toxicity were the most commonly identified effects in aquatic organism, and were associated with mol. interactions with steroid receptors, DNA, or the production of reactive oxygen species. Species sensitivity distribution and/or assessment factors were used to calculate PNECs for 22 OUVFs and the risk quotients for 12 OUVFs. When using maximum concentrations, high risk was observed for six OUVFs in marine environments (4-methylbenzylidene-camphor, octocrylene, padimate-O, benzophenone-1, and oxybenzone, ethylhexyl-4-methoxycinnamate), and for four OUVFs in freshwater environments (ethylhexyl-4-methoxycinnamate, octocrylene, avobenzone and oxybenzone). When using median concentrations, a risk to marine environments was observed for oxybenzone. The results of this review underline that there is limited knowledge of the pathol. effects of OUVFs and their metabolites in aquatic environments, and this inhibits the development of informed water-quality guidelines. The experimental process involved the reaction of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate(cas: 6197-30-4).Recommanded Product: 6197-30-4

The Article related to meta analysis organic uv filter ecotoxicity aquatic environment, emerging pollutant, predicted no effect concentration (pnec), taxonomic trends, toxicity, uv filter, ultraviolet light stabilizer and other aspects.Recommanded Product: 6197-30-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lacatusu, Ioana; Balanuca, Brindusa; Serafim, Andrada; Ott, Cristina; Prodana, Mariana; Badea, Nicoleta published an article in 2022, the title of the article was Salicin and Hederacoside C-Based Extracts and UV-Absorbers Co-Loaded into Bioactive Lipid Nanocarriers with Promoted Skin Antiaging and Hydrating Efficacy.Reference of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate And the article contains the following content:

Conventional and herbal active principles can be combined in a beneficial harmony using their best features and compensating for the certain weaknesses of each. The study will answer the question, “how can willow bark extract (Wbe) or ivy leaf extract (Ile) influence the photoprotective, skin permeation and hydration properties of Bioactive Lipid Nanocarriers (BLN) loaded with UV-filters and selected herbals “. BLN-Wbe/Ile-UV-filters were characterized for particle size, zeta potential, thermal behavior, entrapment efficiency and drug loading. The formulated BLN-hydrogels (HG) were subjected to in vitro release and permeation experiments The in vitro determination of sun protection factors, as well as comparative in vitro photostability tests, rheol. behavior and in vivo hydration status have been also considered for hydrogels containing BLN-Ile/Wbe-UV-filters. Photoprotection of BLN-HG against UVA rays was more pronounced as compared with the UVB (UVA-PF reached values of 30, while the maximum SPF value was 13). The in vitro irradiation study demonstrated the photostability of BLN-HG under UV exposure. A noteworthy cosmetic efficacy was detected by in vivo skin test (hydration effect reached 97% for the BLN-Wbe-UV-filters prepared with pomegranate oil). The research novelty, represented by the first-time co-optation of the active herbal extracts (Wbe and Ile) together with two synthetic filters in the same nanostructured delivery system, will provide appropriate scientific support for the cosmetic industry to design novel marketed formulations with improved quality and health benefices. The experimental process involved the reaction of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate(cas: 6197-30-4).Reference of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate

The Article related to skin antiaging hydration lipid nanocarrier salicin hederacoside uv absorbers, uva and uvb filters, lipid nanostructured hydrogels, photoprotection, photostability, skin health promoting extracts and other aspects.Reference of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics