Tag: 300-400

On June 25, 2019, Zhang, Xingxian published a patent.Reference of tert-Butyl 2-(2-(2-(tosyloxy)ethoxy)ethoxy)acetate The title of the patent was Compound for targeted ubiquitination degradation of EGFR protein and its pharmaceutical composition and application. And the patent contained the following:

Title compounds I [wherein A = (CH2CH2O)nCH2 or (CH)n, n is 1 to 6; B = (CH2)m, m is 1 or 2], and their pharmaceutically acceptable salts thereof, were prepared as EGFR inhibitors, useful in the treatment of cancer (breast cancer, colon cancer, prostate cancer, etc.). Thus, the invention compound I [A = (CH2)3; B = CH2] was prepared and gave PC9 inhibition IC50 value of 0.8444 μM. The experimental process involved the reaction of tert-Butyl 2-(2-(2-(tosyloxy)ethoxy)ethoxy)acetate(cas: 882518-89-0).Reference of tert-Butyl 2-(2-(2-(tosyloxy)ethoxy)ethoxy)acetate

The Article related to heteroaryl antitumor egfr inhibitor preparation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Reference of tert-Butyl 2-(2-(2-(tosyloxy)ethoxy)ethoxy)acetate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Yan-An; Yang, Song; Liu, Qi-Kui; Chen, Gong-Jun; Ma, Jian-Ping; Dong, Yu-Bin published an article in 2016, the title of the article was Pd(0)@UiO-68-AP: chelation-directed bifunctional heterogeneous catalyst for stepwise organic transformations.SDS of cas: 1312703-30-2 And the article contains the following content:

A bifunctional heterogeneous catalyst Pd(0)@UiO-68-AP based on a chelation-directed post-synthetic approach is reported. It exhibits typical heterogeneous catalytic behavior and can promote benzyl alc. oxidation-Knoevenagel condensation in a stepwise way. The experimental process involved the reaction of Dimethyl 2′-amino-[1,1′:4′,1”-terphenyl]-4,4”-dicarboxylate(cas: 1312703-30-2).SDS of cas: 1312703-30-2

The Article related to nanoparticle palladium zirconium uio catalyst preparation knoevenagel reaction oxidation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Nitriles, Isonitriles, and Acyl Cyanides and other aspects.SDS of cas: 1312703-30-2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Huang, Yinyi; Li, Shina; Wu, Chaorong; Wang, Shuo; Wang, Chengyan; Ma, RuiXin published an article in 2020, the title of the article was Interfacial modification by multifunctional octocrylene for high efficiency and stable planar perovskite solar cells.HPLC of Formula: 6197-30-4 And the article contains the following content:

Interfacial modification of the perovskite surface with octocrylene (2-ethylhexyl-2-cyano-3,3-diphenyl-2-propenoate, OCT) is capable of enhancing humidity stability and passivating the defects of perovskite films. In this study, octocrylene can be attached to the surface of the perovskite, and the carbonyl group (C=O) in octocrylene achieved excellent passivation through the Lewis base electron passivation of Pb2+ ions. By increasing the concentration of the octocrylene/IPA solution, the modified device exhibited an optimal PCE of 20.54% and a steady state output PCE of 19.75%. This study shows that the introduction of octocrylene in the preparation of perovskite could effectively enhance the performance of perovskite solar cells. The experimental process involved the reaction of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate(cas: 6197-30-4).HPLC of Formula: 6197-30-4

The Article related to perovskite solar cell octocrylene modification, Electrochemical, Radiational, and Thermal Energy Technology: Energy-Conversion Devices and Their Components and other aspects.HPLC of Formula: 6197-30-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On September 30, 2008, Yang, Zhigang; Liu, Jie; Liu, Xiaohua; Wang, Zhen; Feng, Xiaoming; Su, Zhishan; Hu, Changwei published an article.Recommanded Product: tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate The title of the article was Highly efficient amine organocatalysts based on bispidine for the asymmetric Michael addition of ketones to nitroolefins. And the article contained the following:

A highly diastereoselective and enantioselective Michael addition of cyclohexanone, acetone and other ketones to nitroolefins was developed by the use of an amine organocatalyst based on bispidine. Addnl., a theor. study of transition structures revealed that this bispidine-based primary-secondary amine catalyst could serve through an enamine intermediate and H-bond interaction, which was important for the reactivity and selectivity of this reaction. The experimental process involved the reaction of tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate(cas: 227940-70-7).Recommanded Product: tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate

The Article related to michael stereoselective ketone nitroalkene bispidine catalyst, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Ketones and Derivatives, Including Quinones and Sulfur Analogs and other aspects.Recommanded Product: tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On December 20, 2012, Atamanyuk, Dmytro; Denis, Alexis; Gerusz, Vincent; Ledoussal, Benoit; Bonvin, Yannick; Desroy, Nicolas; Gold, Johan; Moreau, Francois; Oxoby, Mayalen published a patent.Category: esters-buliding-blocks The title of the patent was Preparation of purine derivatives and their use as pharmaceuticals for prevention or treatment of bacterial infections. And the patent contained the following:

The invention relates to the compounds I [wherein A is Ph, naphthyl and 5-10 membered monocyclic or bicyclic unsaturated heterocycle, optionally substituted by a group R1 which is as defined in the application and is itself optionally substitutes by a group R2 which is as defined in the application and is itself optionally substituted by a group R3 which is defined in the application, Y and W, identical or different, are H, (C1-C6) alkyl, (C2-C6) alkenyl, (C2-C6) alkynyl, Ph or 4-10 monocyclic or bicyclic saturated or unsaturated heterocycle, optionally substituted by R1, or Y and/or W form a 4-10 membered cycle with R1, or Y and W form with N a saturated or unsaturated nitrogenous 4-10 membered mono, bi or tricyclic system, fused, bridged or spiro system, said system being optionally substituted by R1, said system being different from morpholine, with the proviso that when Y and A are Ph or heterocycle, W is not H] and their addition salts thereof with acids and bases. The invention also relates to a process and intermediates for their preparation and their use in the antibacterial prevention and therapy, used alone or in association with antibacterials, antivirulence agents or drugs reinforcing the host innate immunity, and pharmaceutical compositions and associations containing them. Thus, 6-[4-(methanesulfonyl)phenyl]purine II was prepared from 2,6-dichloro-9H-purine vis tetrahydropyranylation with 3,4-dihydro-2H-pyran in EtOAc containing catalytic PTSA; Suzuki coupling reaction with [4-(MeSO2)C6H4]B(OH)2 in aqueous DME containing K2CO3 and catalytic Pd(PPh3)4; amination with tert-Bu [(piperidin-4-yl)methyl]carbamate in MeCN containing DIPEA; and N-deprotection with HCl in THF/dioxane. The antibacterial activity of II was determined [IC50 = <300 μM vs. dltA gene of S. aureus]. The experimental process involved the reaction of tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate(cas: 227940-70-7).Category: esters-buliding-blocks

The Article related to purine dimer derivative preparation antibacterial antivirulence agent immunomodulator, Biomolecules and Their Synthetic Analogs: Others, Including Purines, Pyrimidine Nucleic Acid Bases, Flavins, Lignans and other aspects.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On December 31, 2007, Liu, Lijun; Li, Ming published an article.Recommanded Product: tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate The title of the article was A facile synthesis of N-substituted bispidine. And the article contained the following:

A method for the synthesis of the title compounds [i.e., bispidine derivatives, 3,7-diazabicyclo[3.3.1]nonane derivatives] is reported here. Several N-benzyl-N’-(alkyl)bispidine derivatives were synthesized from piperidone in two steps involving a double Mannich reaction. Their structures were determined by spectral anal. This method offers an easy and effective synthesis method for such N-substituted bispidine. The experimental process involved the reaction of tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate(cas: 227940-70-7).Recommanded Product: tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate

The Article related to bispidine bispidinone diazabicyclononane preparation mannich reaction, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Recommanded Product: tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On August 12, 2022, Liu, Jieqing; Li, Jie; Zhang, Peixi; Xia, Yuanxi; Ma, Junjie; Zhang, Ling; Wang, Qiaolai; Zhang, Ziqing published a patent.Related Products of 882518-89-0 The title of the patent was Preparation of icaritin PROTACs as antitumor agents. And the patent contained the following:

The invention relates to preparation of icaritin PROTACs as antitumor agents. In particular, icaritin protacs I [wherein E3 ligand is at least one in lenalidomide or VHL type ligand (V0), linker is at least one of aliphatic chain or PEG chain, described aliphatic chain is -(CH2)n1CO-NH(CH2)n2-, where n1 represents a natural number from 1 to 6, and n2 represents a natural number 4 or 5; described PEG chain is -(CH2CH2O)n1-CH2CO-NH(CH-R1)-, -(CH2CH2O)n1-CH2CO-NH(CH2)n2-, where n1 represents the natural number 2 or 3, R1 is a C5-alkyl group, and n2 represents the natural number 4 or 5] were prepared The present invention also relates to a process for the preparation of the above-mentioned icarisin PROTACs and the use thereof based on the antitumor activity of the target GRIA3. The experimental process involved the reaction of tert-Butyl 2-(2-(2-(tosyloxy)ethoxy)ethoxy)acetate(cas: 882518-89-0).Related Products of 882518-89-0

The Article related to icaritin protac preparation antitumor agent, Heterocyclic Compounds (One Hetero Atom): Benzopyrans (Including Coumarins, Isocoumarins, Chromones, Benzopyrones, Dibenzopyrans, and Other Arenopyrans) and other aspects.Related Products of 882518-89-0

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, He; Gao, Xue-Wang; Wang, Li; Zhao, Xinsheng; Li, Qiu-Yan; Wang, Xiao-Jun published an article in 2019, the title of the article was yeMicrowave-assisted synthesis of urea-containing zirconium metal-organic frameworks for heterogeneous catalysis of Henry reactions.HPLC of Formula: 1312703-30-2 And the article contains the following content:

Herein, facile preparation of a urea-containing UiO-68 isoreticular zirconium metal-organic framework (MOF) with mixed dicarboxylate struts by utilizing a microwave-assisted heating method is reported. It can work as an efficient hydrogen-bond-donating heterogeneous catalyst for Henry reaction of benzaldehydes and nitroalkanes. This mixed strut MOF exhibits improved catalytic activity compared to the pure urea-functionalized linker based analog. The experimental process involved the reaction of Dimethyl 2′-amino-[1,1′:4′,1”-terphenyl]-4,4”-dicarboxylate(cas: 1312703-30-2).HPLC of Formula: 1312703-30-2

The Article related to urea isoreticular zirconium metal organic framework preparation microwave irradiation, phenol preparation, benzaldehyde nitroalkane henry reaction, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Phenols, Thiophenols, and Derivatives Including Phenol and Thiophenol Ethers and Esters and other aspects.HPLC of Formula: 1312703-30-2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Haridas, V.; Sadanandan, Sandhya; Sharma, Yogesh K.; Chinthalapalli, Srinivas; Shandilya, Ashutosh published an article in 2012, the title of the article was Bispidine as a secondary structure nucleator in peptides.Application of 227940-70-7 And the article contains the following content:

Here we describe bispidine as a scaffold for inducing open turn-like and beta sheet conformations on the attached peptides depending on the mode of attachment of peptides to the scaffold. Various bispidine-peptide conjugates were designed and synthesized to demonstrate the versatility of the scaffold. The experimental process involved the reaction of tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate(cas: 227940-70-7).Application of 227940-70-7

The Article related to crystal structure bispidine secondary structure nucleator peptide, Physical Organic Chemistry: Stereochemistry and Stereochemical Relationships, Including Conformational Inversions and Rotational Isomerization and other aspects.Application of 227940-70-7

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On February 13, 2020, Guerin, David J.; Ng, Pui Yee; Wang, Zhongguo; Shelekhin, Tatiana; Caravella, Justin; Zablocki, Mary-Margaret; Downing, Jennifer R.; Li, Hongbin; Ioannidis, Stephanos published a patent.Related Products of 227940-70-7 The title of the patent was Preparation of carboxamides as ubiquitin-specific protease inhibitors. And the patent contained the following:

The present disclosure relates to modulators, such as inhibitors, of at least one pathway chosen from USP28 and USP25, pharmaceutical compositions comprising the inhibitors, and methods of using the inhibitors. The title compounds I [Y = C(R3) and N; R’ = H and Me; R1 = (un)substituted 6-11 membered heteroaryl; R2 = (un)substituted N-linked 4-12 membered heterocyclyl and C-linked 4-12 membered heterocyclyl; each R3 = (independently) H, D, alkyl, alkoxy, etc.; R4 = H, D, alkyl, halo, etc.; n = 0-3; with the proviso] or pharmaceutically acceptable forms thereof, useful as modulators, such as inhibitors, of at least one pathway chosen from USP28 and USP25, and can be useful in the treatment of cancers, among other ailments, were prepared and/or claimed. E.g., a multi-step synthesis of (R)-II and (S)-II, starting from 4-bromo-2-hydroxybenzaldehyde and acrylonitrile, was described. Exemplified compounds I were tested for their USP28 and USP25 activities (data given for representative compounds I). Pharmaceutical composition comprising compound I was claimed. The experimental process involved the reaction of tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate(cas: 227940-70-7).Related Products of 227940-70-7

The Article related to carboxamide heteroaryl preparation ubiquitin specific protease inhibitor usp28 usp25, antitumor usp28 usp25 inhibitor carboxamide amide heteroaryl preparation, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Related Products of 227940-70-7

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics