Tag: 300-400

Novel dihydropyridine thioglycosides and their corresponding dehydrogenated forms as potent anti-hepatocellular carcinoma agents was written by Elgemeie, Galal H.;El-Naggar, Dina H.. And the article was included in Nucleosides, Nucleotides & Nucleic Acids in 2018.Electric Literature of C16H22O11 This article mentions the following:

A novel method for preparation of a new class of dihydropyridine thioglycosides and their corresponding dehydrogenated forms, via reaction of piperidinium salts of dihydropyridinethiones with 2,3,4,6-tetra-O-acetyl-α-D-gluco- and galactopyranosyl bromides has been studied. The evaluation of antiproliferative activity against HepG-2 cell lines (liver carcinoma cell lines) of the dihydropyridine thioglycosides and pyridine thioglycosides revealed that many of the thioglycosides have interesting antitumor activities specifically , and . In the experiment, the researchers used many compounds, for example, (2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 4163-60-4Electric Literature of C16H22O11).

(2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 4163-60-4) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Electric Literature of C16H22O11

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Divergent Synthesis of Molecular Winch Prototypes was written by Gisbert, Yohan;Abid, Seifallah;Kammerer, Claire;Rapenne, Gwenael. And the article was included in Chemistry – A European Journal in 2021.Synthetic Route of C18H28BNO4 This article mentions the following:

We report the synthesis of conceptually new prototypes of mol. winches [(η⁵-R₄C₅-bp-XTrzR¹)(Ind₃BH)Ru] [R = 4-FcC₆H₄; bp = 1,1′-biphenyl-4,4′-diyl; X = CH₂NHCOCH₂CH₂(OCH₂CH₂)₈; Trz = 1,2,3-triazole-1,4-diyl; R¹ = 9-triptycenyl (tpc), CH₂CH₂OCOC(C₆₀)CO₂Et, 3,5-C₆H₃(CC-9-tpc)₂, 10,20-(CCtpc)₂Por-Zn] with the ultimate aim to investigate the work performed by a single ruthenium-based mol. motor anchored on a surface by probing its ability to pull a load upon elec.-driven directional rotation. According to a technomimetic design, the motor was embedded in a winch structure, with a long flexible polyethylene glycol chain terminated by an azide hook to connect a variety of mol. loads. The structure of the motor was first derivatized by means of two sequential cross-coupling reactions involving a penta(4-halogenophenyl)cyclopentadienyl hydrotris(indazolyl)borate ruthenium(II) precursor and the resulting benzylamine derivative was next exploited as key intermediate in the divergent synthesis of a family of nanowinch prototypes. A one-pot method involving sequential peptide coupling and Cu-catalyzed azide-alkyne cycloaddition was developed to yield four loaded nanowinches, with load fragments encompassing triptycene, fullerene and porphyrin moieties. In the experiment, the researchers used many compounds, for example, tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzylcarbamate (cas: 330794-35-9Synthetic Route of C18H28BNO4).

tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzylcarbamate (cas: 330794-35-9) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Synthetic Route of C18H28BNO4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Rapid analysis of 13 phthalates in textiles by Py-GC-MS method was written by Bao, Haifeng;Zhao, Hailang;Tan, Yujing. And the article was included in Yinran in 2021.Category: esters-buliding-blocks This article mentions the following:

A method for rapid determination of 13 phthalates in textiles by pyrolysis gas chromatog. mass spectrometry (Py GC-MS) was established. The optimized anal. conditions of the pyrolyzer were the initial temperature of 200 °C, heating to 350 °C at 50 °C/min, holding for 2 min. The linear correlation coefficient was R²>0.99, the detection limit was 0.08-6.17 mg/kg, the recovery was 89.2-97.1%, and the relative standard deviation was 1.2-4.4% (n = 6). The method is simple, rapid, accurate and reliable, which can meet the daily detection requirements of 13 phthalates in textiles. In the experiment, the researchers used many compounds, for example, Dicyclohexyl phthalate (cas: 84-61-7Category: esters-buliding-blocks).

Dicyclohexyl phthalate (cas: 84-61-7) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthesis of enaminone-based vinylogous peptides was written by Senica, Luka;Groselj, Uros;Kasunic, Marta;Kocar, Drago;Stanovnik, Branko;Svete, Jurij. And the article was included in European Journal of Organic Chemistry in 2014.Recommanded Product: 87694-53-9 This article mentions the following:

Vinylogous peptides 3 [E-I or Z-I (Boc = tert-butoxycarbonyl; R¹ = H, Me, Bn; AA = amino acid or peptide)] with a vinyl fragment inserted into the peptide C-N bond were prepared from ynones (II) (R¹ = H, Me, Bn) and enaminones (E-III) (R¹ = H, Me, Bn) that are easily available from Boc-protected α-amino acids. Coupling at the C terminus was achieved by 1,4-addition of amino esters to the C C bond in II or by substitution of the NMe₂ group in III to give N-terminal vinylogous peptides. Coupling at the N terminus of I and III in contrast, required temporary protection of the acidolytically labile enamino moiety. Cyclization of II or III with hydroxylamine, removal of the Boc group with HBr-AcOH, acylation of free amine hydrobromides (IV) (R¹ = H, Me, Bn) with BocGlyOH, and hydrogenolytic deprotection of the enamino moiety in the presence of GlyOMe led to tripeptides with vinylogous amide as the central building block. Thus, the present method enables incorporation of vinylogous amide (building blocks) BBs into oligopeptides. However, the preparation of oligomers with consecutive vinylogous BBs represents the next synthetic challenge to be met. These preliminary results clearly indicate the viability of this synthetic approach, which enables the incorporation of vinylogous amides into a peptide chain. Vinylogous peptides might be interesting or even useful for various applications, for example, in medicinal chem., chem. biol., and in materials science. In the experiment, the researchers used many compounds, for example, (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9Recommanded Product: 87694-53-9).

(S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Recommanded Product: 87694-53-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Peptidomimetic vinyl heterocyclic inhibitors of cruzain effect antitrypanosomal activity was written by Chenna, Bala C.;Li, Linfeng;Mellott, Drake M.;Zhai, Xiang;Siqueira-Neto, Jair L.;Calvet Alvarez, Claudia;Bernatchez, Jean A.;Desormeaux, Emily;Alvarez Hernandez, Elizabeth;Gomez, Jana;McKerrow, James H.;Cruz-Reyes, Jorge;Meek, Thomas D.. And the article was included in Journal of Medicinal Chemistry in 2020.Application In Synthesis of (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate This article mentions the following:

Cruzain, an essential cysteine protease of the parasitic protozoan, Trypanosoma cruzi, is an important drug target for Chagas disease. We describe here a new series of reversible but time-dependent inhibitors of cruzain, composed of a dipeptide scaffold appended to vinyl heterocycles meant to provide replacements for the irreversible reactive “warheads” of vinyl sulfone inactivators of cruzain. Peptidomimetic vinyl heterocyclic inhibitors (PVHIs) containing Cbz-Phe-Phe/homoPhe scaffolds with vinyl-2-pyrimidine, vinyl-2-pyridine, and vinyl-2-(N-methyl)-pyridine groups conferred reversible, time-dependent inhibition of cruzain (K_i* = 0.1-0.4μM). These cruzain inhibitors exhibited moderate to excellent selectivity vs. human cathepsins B, L, and S and showed no apparent toxicity to human cells but were effective in cell cultures of Trypanosoma brucei brucei (EC₅₀ = 1-15μM) and eliminated T. cruzi in infected murine cardiomyoblasts (EC₅₀ = 5-8μM). PVHIs represent a new class of cruzain inhibitors that could progress to viable candidate compounds to treat Chagas disease and human sleeping sickness. In the experiment, the researchers used many compounds, for example, (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9Application In Synthesis of (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate).

(S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Application In Synthesis of (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

New methods for solid phase peptide synthesis of transition-state analog inhibitors of HIV-1 protease and DPP-IV was written by Piron, Jan;Tourwe, Dirk. And the article was included in Letters in Peptide Science in 1995.SDS of cas: 87694-53-9 This article mentions the following:

A new and stereoselective method to synthesize hydroxyethylamine and hydroxymethylamide peptide bond isosteres is developed. The key step is the addition of 2-trimethylsilylthiazole to α-amino aldehydes, followed by transformation to α-hydroxy-β-amino aldehydes. The stereochem. of the addition can be manipulated by the choice of the nitrogen substitution. The isosteres are easily synthesized via solid-phase peptide synthesis, which rapidly gives the desired pseudopeptides. In the experiment, the researchers used many compounds, for example, (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9SDS of cas: 87694-53-9).

(S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.SDS of cas: 87694-53-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Simple and Practical Real-Time Analysis of Solid-Phase Reactions by Thin-Layer Chromatography was written by Wu, Chia-Hui;Chen, Chun C.;Lin, Su-Ching;Wang, Cheng-Chung. And the article was included in Synlett in 2018.HPLC of Formula: 4163-60-4 This article mentions the following:

Solid-phase synthesis is a practical approach for simplifying the time-consuming and routine purification steps in the preparation of numerous naturally occurring mols.; however, studying such reactions is difficult due to the lack of a convenient monitoring method. By using thin-layer chromatog. in conjunction with a photolabile linker on a resin, we developed a convenient and simple method for monitoring solid-phase reactions in real time by thin-layer chromatog. This method provides a user-friendly protocol for examining reaction conditions for solid-state syntheses. In the experiment, the researchers used many compounds, for example, (2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 4163-60-4HPLC of Formula: 4163-60-4).

(2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 4163-60-4) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.HPLC of Formula: 4163-60-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

A light-activated nanotherapeutic with broad-spectrum bacterial recognition to eliminate drug-resistant pathogens was written by Wei, Xiaosong;Gao, Yingchao;Hu, Yuqing;Zhang, Yufei;Zhang, Xinge. And the article was included in Journal of Materials Chemistry B: Materials for Biology and Medicine in 2021.Computed Properties of C16H22O11 This article mentions the following:

Obstinate infections caused by drug-resistant bacteria severely threaten human health. And the emergence of multidrug-resistant bacteria increases the morbidity and mortality of patients, thus necessitating the development of innovative or alternative therapeutics. Here, a light-activated nanotherapeutic with broad-spectrum bacterial recognition is established as an antibiotic-free therapeutic agent against pathogens. The nanotherapeutic with external phenylboronic acid-based glycopolymers increases the stability and biocompatibility and shows the ability of bacterial recognition. Once irradiated with near-IR light, this nanotherapeutic with high photothermal conversion efficiency disrupts the cytoplasmic membrane, thus killing bacterial cells. Importantly, it also eliminates the biofilms formed by both drug-resistant Gram-neg. bacteria (Pseudomonas aeruginosa) and Gram-pos. bacteria (Staphylococcus aureus) effectively. Thus, this antibiotic-free nanotherapeutic with hypotoxicity offers a promising approach to fight increasingly serious antimicrobial resistance. In the experiment, the researchers used many compounds, for example, (2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 4163-60-4Computed Properties of C16H22O11).

(2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 4163-60-4) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Computed Properties of C16H22O11

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics