Tag: 300-400

On September 7, 2000, Davies, John S.; Enjalbal, Christine; Nguyen, Corrine; Al-Jamri, Loai; Naumer, Christian published an article.Quality Control of Benzyl 2-(((benzyloxy)carbonyl)amino)acrylate The title of the article was The synthesis and properties of Gla- and Phe-containing analogs of cyclic RGD pentapeptides. And the article contained the following:

Cyclopentapeptides containing the Arg-Gly-Asp (RGD) motif have been synthesized using solid-phase assembly of side-chain-protected linear precursors, followed by solution-phase cyclization. The replacement of the Asp residue by γ-carboxyglutamic acid (Gla) is a novel feature which gives rise to an analog which inhibits cell adhesion, yet its congeners do not show activity in binding assays with recombinant integrin receptors. NMR techniques support a β/γ-turn conformation in most of the analogs. The experimental process involved the reaction of Benzyl 2-(((benzyloxy)carbonyl)amino)acrylate(cas: 59524-07-1).Quality Control of Benzyl 2-(((benzyloxy)carbonyl)amino)acrylate

The Article related to rgd cyclopentapeptide analog carboxyglutamate containing synthesis conformation, cell adhesion assay carboxyglutamate containing cyclopentapeptide analog rgd, Amino Acids, Peptides, and Proteins: Poly(Amino Acids) and Peptides and other aspects.Quality Control of Benzyl 2-(((benzyloxy)carbonyl)amino)acrylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On December 15, 2020, Ho, Wai-Kit; Law, Japhet Cheuk-Fung; Zhang, Tong; Leung, Kelvin Sze-Yin published an article.SDS of cas: 6197-30-4 The title of the article was Effects of Weathering on the Sorption Behavior and Toxicity of Polystyrene Microplastics in Multi-solute Systems. And the article contained the following:

Recent studies have demonstrated that weathering modifies the physicochem. properties and sorption behavior of microplastics (MPs). However, little is known about the effects of such weathering on the simultaneous sorption by MPs of different organic pollutants in multi-solute systems. In this study, the role of cosolute properties in the formation of solute multilayers with a hydrophobic primary solute (4-MBC) on pristine and various weathered polystyrene MPs (PSMPs) was examined Three weathered PSMPs were studied namely, UV-irradiated PS (UV-PS), microbially degraded PS (MD-NPS), and UV-irradiated PS with subsequent microbial degradation (MD-UV-PS). The weathered PSMPs generally exhibited higher degree of oxygenated functionalities with less surface hydrophobicity than pristine particles. Our findings showed that the formation of solute multilayers with hydrophobic cosolutes was drastically suppressed in UV-PS due to more severe competition at hydrophobic sorption sites. Nevertheless, hydrophilic cosolutes contributed to solute multilayer formation with 4-MBC on PSMPs after UV irradiation, probably due to the stronger sorption of hydrophilic compounds to the oxidized surfaces of these particles via enhanced H-bonding. Strikingly, the sorption of 4-MBC by MD-UV-PS was notably enhanced when hydrophobic cosolutes were present. The observed synergistic sorption indicates that adhered biofilms and/or organic matter on MD-UV-PS could sorb the hydrophobic cosolute mols., and eventually promote sorption of 4-MBC. Our further toxicity tests revealed that such solute multilayers formed on PSMPs inhibited microalgal growth. These results suggest that the fate and biol. effects of MP-mediated chem. exposure could be strongly affected by weathering processes and coexistence of multiple organic contaminants in natural environments. The experimental process involved the reaction of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate(cas: 6197-30-4).SDS of cas: 6197-30-4

The Article related to polystyrene microplastic weathering sorption multi solute system, algal toxicity, microplastic, multi-solute system, organic uv filter, sorption, weathering, Water: Water Purification (Including Treatment For Industrial Uses) and other aspects.SDS of cas: 6197-30-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On November 17, 2016, Foreman, Kenneth W.; Nguyen, Hanh Nho; Ofori, Leslie Odame; Wanner, Jutta; Werner, Douglas S. published a patent.Application In Synthesis of Benzyl 2-(((benzyloxy)carbonyl)amino)acrylate The title of the patent was Preparation of silicon based drug conjugates and therapeutic uses thereof. And the patent contained the following:

Described herein are silicon based conjugates capable of delivering one or more pay load moieties to a target cell or tissue. Contemplated conjugates may include a silicon-heteroatom core, one or more optional catalytic moieties, a targeting moiety that permits accumulation of the conjugate within a target cell or tissue, one or more pay load moieties (e.g., a therapeutic agent or imaging agent), and two or more non-interfering moieties covalently bound to the silicon-heteroatom core. The silicon based conjugates of formula I [wherein L is a targeting moiety; RP is P, H, or R5; P is a payload moiety or cassette; R5 is independently at each occurrence H, OH, C1-6 alkyl, etc.; Y independently at each occurrence is -LL-G-LL-; LL independently at each occurrence is bond or substituted C1-20 alkylene; G independently at each occurrence is optional catalytic moieties selected from -heteroaryl, -O-heteroaryl, Ph, etc.; R1, R2, R3, and R4 are independently at each occurrence OH, α- or β-amino acid, heterocyclyl, etc.] or pharmaceutically acceptable salt, cocrystal, stereoisomer, metabolite, tautomer, solvate, or hydrate thereof, are claimed and exemplified. Folate receptor targeting conjugate II comprised of two different fluorescent dyes, BODIPY and rhodamine, was prepared from a multistep procedure (preparation given) and used in an imaging study demonstrating endocytosis and Si-O bond cleavage. The study revealed intact II was bound to the surface of folate receptor α expressing KB cells at t = 0 min. At t = 30 min endocytosis of II inside the endosomes was detected and cleavage of the siloxane core was visualized by color separation of the two fluorescent dyes. The experimental process involved the reaction of Benzyl 2-(((benzyloxy)carbonyl)amino)acrylate(cas: 59524-07-1).Application In Synthesis of Benzyl 2-(((benzyloxy)carbonyl)amino)acrylate

The Article related to silicon drug conjugate preparation targeted payload delivery therapeutic, folate receptor targeting conjugate endocytosis hydrolysis fluorescent imaging, Amino Acids, Peptides, and Proteins: Poly(Amino Acids) and Peptides and other aspects.Application In Synthesis of Benzyl 2-(((benzyloxy)carbonyl)amino)acrylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On February 1, 2021, O’Malley, Elissa; McLachlan, Michael S.; O’Brien, Jake W.; Verhagen, Rory; Mueller, Jochen F. published an article.Application In Synthesis of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate The title of the article was The presence of selected UV filters in a freshwater recreational reservoir and fate in controlled experiments. And the article contained the following:

UV filters present in sunscreen and other cosmetics are directly released into the environment during aquatic recreational activities. The extent to which the wide range of UV filters pose a risk to the environment remains unclear. This study investigated the occurrence and dissipation of selected organic UV filters at a recreational site (Enoggera Reservoir, Queensland, Australia) over 12 h. Furthermore, different possible degradation processes were investigated in a controlled off-site experiment with surface water exposed to natural light. Half-lives were estimated for ten UV filters. In Enoggera Reservoir, seven UV filters were detected, of which the most prevalent were octocrylene, avobenzone (BMDBM) and enzacamene (4-MBC). Summed concentrations of the seven UV filters ranged from 7330 ng L-1 at 13:00 h to 2550 ng L-1 at 21:00 h. In the degradation experiment, four UV filters showed no significant change over time. The fate of these compounds in the environment is likely to be mainly influenced by dispersion. Half-lives of the remaining UV filters were 6.6 h for amiloxate (IMC), 20 h for benzophenone 1, 23 h for octinoxate (EHMC), 30 h for 3-benzylidene camphor, 34 h for 4-MBC and 140 h for dioxybenzone (BP8). The degree of susceptibility to photodegradation and biodegradation was generally consistent within a structural class. The fate and half-lives of UV filters are variable and should be considered on a per site basis when assessing environmental risk. The experimental process involved the reaction of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate(cas: 6197-30-4).Application In Synthesis of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate

The Article related to uv filter freshwater photodegradation biodegradation, degradation, environmental half-life, personal care products, sunscreen agents, Water: Water Purification (Including Treatment For Industrial Uses) and other aspects.Application In Synthesis of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On July 31, 1992, Kessler, Horst; Wittmann, Valentin; Koeck, Matthias; Kottenhahn, Matthias published an article.Application In Synthesis of Benzyl 2-(((benzyloxy)carbonyl)amino)acrylate The title of the article was Synthesis of C-glycopeptides by radical addition of glycosyl bromides to dehydroalanine derivatives. And the article contained the following:

Radical addition of glycosyl bromides I (R1 = H, R2 = OAc, tetra-O-acetyl-β-D-galactopyranosyl; R1 = OAc, R2 = H) with urethane-protected dehydroalanine derivatives R3NHC(COR4):CH2 [R3 = 9-fluorenylmethoxycarbonyl (Fmoc), PhCH2O2C (Z), Me3CO2C (Boc), R4 = OCH2Ph; R3 = Fmoc, R4 = Phe-OCH2Ph, D-Phe-OCH2Ph; R3 = Z-Pro, R4 = Ala-OCH2Ph] in the presence of Bu3SnH and AIBN gave C-glycopeptides II as mixtures of stereoisomers at the amino acid chiral center. The stereochem. of the adducts was determined by conversion to lactone derivatives, e.g. III. The experimental process involved the reaction of Benzyl 2-(((benzyloxy)carbonyl)amino)acrylate(cas: 59524-07-1).Application In Synthesis of Benzyl 2-(((benzyloxy)carbonyl)amino)acrylate

The Article related to radical addition glycosyl bromide dehydroalanine, stereochem addition glycosyl radical dehydroalanine, glycopeptide, Amino Acids, Peptides, and Proteins: Poly(Amino Acids) and Peptides and other aspects.Application In Synthesis of Benzyl 2-(((benzyloxy)carbonyl)amino)acrylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On March 1, 2021, Fagervold, S. K.; Rohee, C.; Rodrigues, A. M. S.; Stien, D.; Lebaron, P. published an article.Electric Literature of 6197-30-4 The title of the article was Efficient degradation of the organic UV filter benzophenone-3 by Sphingomonas wittichii strain BP14P isolated from WWTP sludge. And the article contained the following:

Benzophenone-3 (BP3) is a widely used organic UV filter present in many environmental compartments. One way BP3 is released into the environment is through effluents from wastewater treatment plants (WWTPs). These plants are possible sources for degradation activity and WWTP sludge may potentially degrade BP3. Our goal was to identify any BP3 degrading microorganism(s) in WWTP sludge and to investigate whether the degradation was co-metabolic. Initial WWTP sludge microcosms spiked with BP3 showed 100% degradation after 20 days. Multiple transfers of these microcosms, while maintaining a strong selective pressure for BP3 degradation capabilities, resulted in the dominance of one bacterial strain. This strain was identified as Sphingomonas wittichii BP14P and was subsequently isolated. It was shown to degrade BP3 in a growth dependent manner. Strain BP14P utilized BP3 as the sole energy and carbon source and completely degraded BP3 after 7 days in minimal media. We tested the capability of BP14P to degrade nine other UV filters, but the degradation ability seemed to be restricted to BP3. However, whether this specificity is due to the lack of degradation genes, cellular transport or low bioavailability of the other UV filters remained unclear. The efficient degradation of BP3 by a group of bacteria well known for their potential for xenobiotic degradation is an important step forward for a complete risk assessment of the long-term environmental impact of BP3. The experimental process involved the reaction of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate(cas: 6197-30-4).Electric Literature of 6197-30-4

The Article related to benzophenone3 uv filter sphingomonas wittichii degradation wastewater treatment plant, bp3 degradation, growth-dependent, sphingomonas wittichii, sunscreens, Waste Treatment and Disposal: Biological Treatment Of Aqueous Wastes and other aspects.Electric Literature of 6197-30-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On December 15, 2020, Yang, Xiaobao; Jiang, Biao; Song, Xiaoling; Sun, Ning; Ren, Chaowei; Kong, Ying; Zhang, Jianshui; Chen, Jinju; Li, Yan; Zhou, Yuedong published a patent.Reference of tert-Butyl 2-(2-(2-(tosyloxy)ethoxy)ethoxy)acetate The title of the patent was ALK protein regulator and anti-tumor application thereof. And the patent contained the following:

The invention relates a series of compounds designed and synthesized, have a wide range of pharmacol. activities,. The inventive compounds are capable of degrading specific proteins and/or inhibiting their activities, and can be applied to the treatment of tumor and cancer. The experimental process involved the reaction of tert-Butyl 2-(2-(2-(tosyloxy)ethoxy)ethoxy)acetate(cas: 882518-89-0).Reference of tert-Butyl 2-(2-(2-(tosyloxy)ethoxy)ethoxy)acetate

The Article related to alk protein brigatinib alecensa phosphine oxide derivative preparation, antitumor activity brigatinib alecensa phosphine oxide derivative, Organometallic and Organometalloidal Compounds: Phosphorus Compounds and other aspects.Reference of tert-Butyl 2-(2-(2-(tosyloxy)ethoxy)ethoxy)acetate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lotz, Florian; Gerbig, Stefanie; Lotze, Christian; Spengler, Bernhard; Schulz, Sabine published an article in 2020, the title of the article was Autarkic desorption electrospray ionization source for on-site analysis of consumer goods.Reference of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate And the article contains the following content:

A general-purpose desorption electrospray ionization (DESI) source is presented which is not bound to the laboratory site. It allows autarkic operation for a few hours and can be connected to different types of (autarkic or non-autarkic) mass spectrometers via an atm.-pressure interface. Tech. characteristics are described as well as results from direct surface anal. of consumer goods such as plastics, fruit peels or pills, or from living objects such as human skin, demonstrating the detection of various target compounds such as plasticizers, pesticides, drugs, or sun blockers. Quant. anal. is demonstrated for phthalates in plastics. The geometry of the sample, the sample table and the sprayer were modified and characterized for optimization of the method. The autarkic ion source has a total size of 48.4 × 27.0 × 18.0 cm (l x w x h) and a total mass of 7 kg. The source delivers 5.5 bar pressurized air and an adjustable solvent flow rate down to 1.5μl min-1 for the DESI sprayer. A rechargeable 25.6 V battery allows autarkic runtimes of more than 3.5 h. Source optimization and characterization was done on an orbital trapping mass spectrometer. Connected to a portable mass spectrometer, the developed device makes DESI suitable for on-site analyses in e.g. consumer protection, border control or homeland security. The experimental process involved the reaction of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate(cas: 6197-30-4).Reference of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate

The Article related to autarkic desorption electrospray ionization mass spectrometry consumer product drug, Apparatus and Plant Equipment: Instrumentation and Control Apparatus and other aspects.Reference of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On October 20, 2020, Pegoraro, Cesar N.; Harner, Tom; Su, Ky; Ahrens, Lutz published an article.Safety of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate The title of the article was Occurrence and gas-particle partitioning of organic UV-filters in urban air. And the article contained the following:

A retrospective anal. of a comprehensive series of high-volume air samples (n = 70) collected during 2010-2011 in Toronto (Canada) was performed. Seven UV compounds were analyzed by gas chromatog.-tandem mass spectrometry (GC-MS/MS) with sum of concentrations (gas + particle phase) ranging from 80 to 2030 pg/m3. Homosalate (HMS) was the most prevalent organic UV-filter in air (47% of the total concentration), followed by 2-ethylhexyl salicylate (EHS, ~29%), E- and Z-2-ethylhexyl 4-methoxycinnamate (EHMC, ~17%). Ambient air (gas + particle phase) concentrations of organic UV-filters showed a strong seasonality, with peak levels during the summer. An anal. of Clausius-Clapeyron slopes indicated that much of the ambient burden of organic UV-filters are explained by volatilization from terrestrial and aquatic surfaces and supplemented with human activities and use of lotions and sunscreens, containing organic UV-filters, in addition to its use in plastics, textiles, paints, and pesticides. The results showed that organic UV-filters exist mainly in the gas phase with some exceptions, for instance, octocrylene (OCR), which was associated with both gas and particle phases, and avobenzone (AVB), which was predominantly in the particle phase. Lastly, this study revealed the need for basic phys. chem. property data for organic UV-filters, including information on transformation rates and products, for better evaluating their environmental fate and effects. The experimental process involved the reaction of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate(cas: 6197-30-4).Safety of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate

The Article related to occurrence gas particle partitioning organic uv filter urban air, Air Pollution and Industrial Hygiene: Air Pollutants and Air Pollution and other aspects.Safety of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Akin, Brandy L.; Jones, Larry R. published an article in 2012, the title of the article was Characterizing Phospholamban to Sarco(endo)plasmic Reticulum Ca2+-ATPase 2a (SERCA2a) Protein Binding Interactions in Human Cardiac Sarcoplasmic Reticulum Vesicles Using Chemical Cross-linking.Recommanded Product: Bis(2,5-dioxopyrrolidin-1-yl) glutarate And the article contains the following content:

Chem. crosslinking was used to study protein binding interactions between native phospholamban (PLB) and SERCA2a in sarcoplasmic reticulum (SR) vesicles prepared from normal and failed human hearts. Lys27 of PLB was crosslinked to the Ca2+ pump at the cytoplasmic extension of M4 (at or near Lys328) with the homobifunctional crosslinker, disuccinimidyl glutarate (7.7 Å). Crosslinking was augmented by ATP but abolished by Ca2+ or thapsigargin, confirming in native SR vesicles that PLB binds preferentially to E2 (low Ca2+ affinity conformation of the Ca2+-ATPase) stabilized by ATP. To assess the functional effects of PLB binding on SERCA2a activity, the anti-PLB antibody, 2D12, was used to disrupt the phys. interactions between PLB and SERCA2a in SR vesicles. We observed a tight correlation between 2D12-induced inhibition of PLB crosslinking to SERCA2a and 2D12 stimulation of Ca2+-ATPase activity and Ca2+ transport. The results suggest that the inhibitory effect of PLB on Ca2+-ATPase activity in SR vesicles results from mutually exclusive binding of PLB and Ca2+ to the Ca2+ pump, requiring PLB dissociation for catalytic activation. Importantly, the same result was obtained with SR vesicles prepared from normal and failed human hearts; therefore, we conclude that PLB binding interactions with the Ca2+ pump are largely unchanged in failing myocardium. The experimental process involved the reaction of Bis(2,5-dioxopyrrolidin-1-yl) glutarate(cas: 79642-50-5).Recommanded Product: Bis(2,5-dioxopyrrolidin-1-yl) glutarate

The Article related to phospholamban sarcoplasmic reticulum calcium atpase heart sarcoplasmic vesicle crosslinking, Enzymes: Substrates-Cofactors-Inhibitors-Activators-Coenzymes-Products and other aspects.Recommanded Product: Bis(2,5-dioxopyrrolidin-1-yl) glutarate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics