Tag: 300-400

On May 31, 2020, O’Malley, Elissa; O’Brien, Jake W.; Verhagen, Rory; Mueller, Jochen F. published an article.Application In Synthesis of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate The title of the article was Annual release of selected UV filters via effluent from wastewater treatment plants in Australia. And the article contained the following:

We assessed the annual release of UV filters from wastewater treatment plant effluent in Australia and evaluated the removal of these chems. during wastewater treatment. Effluent samples were collected from 33 sites alongside matching influent samples. Sample collection predominately occurred during the Australian Census in August 2016, which allowed for accurate per capita normalization of the results. A subset of sites was also sampled over the Southern Hemisphere summer (Dec.-Feb.) period. Five UV filters were detected with at least one detected in 95% of effluent samples. The summed concentration of UV filters ranged from 130 ng L-1 to 8400 ng L-1 and averaged 2800 (±1900) ng L-1. Of the target UV filters, 2-phenylbenzimidazole-5-sulfonic acid (PBSA) and benzophenone 4 (BP4) showed the lowest removal efficiencies (11 ± 36% and 51 ± 43%, resp.) across all sites and were the most abundant in effluent. Average estimated removal efficiencies of the other compounds were between 59 (±24) % (4-methylbenzylidene camphor (4-MBC)) and 74 (±22) % (benzophenone 1 (BP1)). We did not find a trend in seasonal differences in the per capita release of UV filters in effluent samples. We estimate that approx. 40% of UV filter loads measured in influent are breaking through to the effluent resulting in the release of approx. 20 kg day-1 of the selected UV filters into the aquatic environment from treated wastewater effluent in Australia. The experimental process involved the reaction of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate(cas: 6197-30-4).Application In Synthesis of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate

The Article related to uv filter wastewater treatment plant effluent australia, australia, effluent, personal care products, sunscreen, uv filters, wastewater treatment, Waste Treatment and Disposal: Physical Treatment Of Aqueous Wastes and other aspects.Application In Synthesis of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On July 23, 2008, Abdo, Mohannad; Knapp, Spencer published an article.Reference of Benzyl 2-(((benzyloxy)carbonyl)amino)acrylate The title of the article was Biomimetic Seleninates and Selenonates. And the article contained the following:

The synthesis of a variety of pyranose-, nucleoside-, (amino acid)-, and polyhydric-based seleninic and selenonic acids by DMDO oxidation of the corresponding selenoesters is reported, as well as some unusual coupling reactions of the seleninate and selenonate functionality with biol. nucleophilic groups (sulfhydryl, indole, phenol, imidazole, carboxamide) that are found in proteins and enzyme active sites. The experimental process involved the reaction of Benzyl 2-(((benzyloxy)carbonyl)amino)acrylate(cas: 59524-07-1).Reference of Benzyl 2-(((benzyloxy)carbonyl)amino)acrylate

The Article related to glycoside seleninic selenonic acid preparation, amino acid seleninic selenonic acid preparation, nucleoside seleninic selenonic acid preparation, Carbohydrates: Nucleosides and Nucleotides, Cobalamins, Riboflavin and other aspects.Reference of Benzyl 2-(((benzyloxy)carbonyl)amino)acrylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On February 19, 2014, Bezouska, Karel; Kubinkova, Zuzana; Stribny, Jiri; Volfova, Barbora; Pompach, Petr; Kuzma, Marek; Sirova, Milada; Rihova, Blanka published an article.Recommanded Product: 79642-50-5 The title of the article was Dimerization of an Immunoactivating Peptide Derived from Mycobacterial hsp65 Using N-Hydroxysuccinimide Based Bifunctional Reagents Is Critical for Its Antitumor Properties [Retraction of document cited in CA157:510077]. And the article contained the following:

This article has been retracted with the agreement of the authors due to evidence of scientific misconduct on the part of the first author. The experimental process involved the reaction of Bis(2,5-dioxopyrrolidin-1-yl) glutarate(cas: 79642-50-5).Recommanded Product: 79642-50-5

The Article related to retraction hsp65 peptide dimerization hydroxysuccinimide linker antitumor immunomodulator, Pharmacology: Effects Of Inflammation Inhibitors and Immune Agents and other aspects.Recommanded Product: 79642-50-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On October 17, 2012, Bezouska, Karel; Kubinkova, Zuzana; Stribny, Jiri; Volfova, Barbora; Pompach, Petr; Kuzma, Marek; Sirova, Milada; Rihova, Blanka published an article.Quality Control of Bis(2,5-dioxopyrrolidin-1-yl) glutarate The title of the article was Dimerization of an Immunoactivating Peptide Derived from Mycobacterial hsp65 Using N-Hydroxysuccinimide Based Bifunctional Reagents Is Critical for Its Antitumor Properties. And the article contained the following:

We have shown previously that a short pentapeptide derived from the mycobacterial heat shock protein hsp65 can be highly activating for the immune system based on its strong reactivity with the early activation antigen of lymphocytes CD69. Here, we investigated an optimal form of presentation of this antigen to the cells of the immune system. Four different forms of the dimerized heptapeptide LELTEGY, and of the control inactive dimerized heptapeptide LELLEGY that both contained an extra UV active glycine-tyrosine sequence, were prepared using dihydroxysuccinimidyl oxalate (DSO), dihydroxysuccinimidyl tartarate (DST), dihydroxysuccinimidyl glutarate (DSG), and dihydroxysuccinimidyl suberate (DSS), resp. Heptapeptides dimerized through DST and DSG linkers had optimal activity in CD69 precipitation assay. Moreover, dimerization of active heptapeptide resulted in a remarkable increase in its proliferation activity and production of cytokines in vitro. Furthermore, while DST and DSG dimerized heptapeptides both significantly enhanced the cytotoxicity of natural killer cells in vitro, only the DSG dimerized compound was active in suppressing growth of melanoma tumors in mice and in enhancing the cytotoxic activity of tumor infiltrating lymphocytes ex vivo. Thus, while the dimerization of the immunoactive peptide caused a dramatic increase in its immunoactivating properties, its in vivo anticancer properties were influenced by the chem. nature of linker used for its dimerization. The experimental process involved the reaction of Bis(2,5-dioxopyrrolidin-1-yl) glutarate(cas: 79642-50-5).Quality Control of Bis(2,5-dioxopyrrolidin-1-yl) glutarate

The Article related to hsp65 peptide dimerization hydroxysuccinimide linker antitumor immunomodulator, Pharmacology: Effects Of Inflammation Inhibitors and Immune Agents and other aspects.Quality Control of Bis(2,5-dioxopyrrolidin-1-yl) glutarate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On September 30, 1994, Crossley, Maxwell J.; Stamford, Andrew W. published an article.Recommanded Product: Benzyl 2-(((benzyloxy)carbonyl)amino)acrylate The title of the article was Studies directed towards the total synthesis of anticapsin and related compounds. II. Diels-Alder addition of N-acyl dehydroalanine esters to 1-trimethylsilyloxycyclohexa-1,3-diene. And the article contained the following:

In a study directed towards the total synthesis of anticapsin I and related compounds, the Diels-Alder addition of N-acyl dehydroalanine esters CH2:C(NHR1)CO2R2 [II; R1 = benzyloxycarbonyl (Cbz), Boc, CF3CO, R2 = benzyl (Bzl); R1 = Ac, R2 = Me] and dehydropeptide III to cyclohexa-1,3-diene IV was investigated. The cycloadditions were highly regioselective; the Diels-Alder reaction of II with IV gave bicyclo[2.2.2]oct-5-ene-2-carboxylate derivatives V and VI in moderate to good yields, whereas the Diels-Alder reaction of III with IV gave cycloadducts VII, VIII, IX and X. A modest stereoselectivity was observed in the reactions, with the endo-adducts favored over the exo-adducts by a ratio of 1.5-3.3:1. Adducts V (R1 = Cbz, Boc; R2 = Bzl) and underwent stereoselective epoxidation to the less hindered face of the olefinic double bond. Reaction of the resultant epoxides with TiCl4 afforded carbolactones, thereby allowing the assignment of endo stereochem. to adducts V (R1 = Cbz, Boc; R2 = Bzl). The stereochem. of the remaining adducts was assigned by the use of 1H NMR spectroscopy. The experimental process involved the reaction of Benzyl 2-(((benzyloxy)carbonyl)amino)acrylate(cas: 59524-07-1).Recommanded Product: Benzyl 2-(((benzyloxy)carbonyl)amino)acrylate

The Article related to diels alder cycloaddition acyl dehydroalanine cyclohexadiene, anticapsin total synthesis, Amino Acids, Peptides, and Proteins: Poly(Amino Acids) and Peptides and other aspects.Recommanded Product: Benzyl 2-(((benzyloxy)carbonyl)amino)acrylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On August 4, 2022, Wu, Liang; Deng, Yijun published a patent.Recommanded Product: 882518-89-0 The title of the patent was Targeting chimeric compound, pharmaceutical composition, preparation method and use. And the patent contained the following:

A targeting chimeric compound, a pharmaceutical composition comprising same, a preparation method therefor and use thereof. The targeting chimeric compound is as represented by general formula I [wherein X = CH or N; A = CH=CH, N=N, S, O, or NH; L1 = a bond; L2 = a bond or CO; R1 = OH, alkylsulfonyl, B(OH)2, CO2H, etc.; R2 = independently OH, alkylsulfonyl, CO2H, etc.; R3 and R4 = independently H, alkyl, alkoxy, haloalkyl, etc.; m = 0-5]. Compared with fulvestrant in the prior art, the targeting chimeric compound has comparable or even better proliferative inhibitory activity on estrogen receptor α in mutant drug-resistant cells, and thus is expected to show a comparable or even better therapeutic effect on therapy. The experimental process involved the reaction of tert-Butyl 2-(2-(2-(tosyloxy)ethoxy)ethoxy)acetate(cas: 882518-89-0).Recommanded Product: 882518-89-0

The Article related to targeting chimeric pharmaceutical composition preparation estrogen receptor inhibitor, Amino Acids, Peptides, and Proteins: Poly(Amino Acids) and Peptides and other aspects.Recommanded Product: 882518-89-0

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Crossley, Maxwell J.; Stamford, Andrew W. published an article in 1993, the title of the article was Concise, stereocontrolled synthesis of the C4 epimers of anticapsin and bacilysin: revision of the configurations of the natural products.Formula: C18H17NO4 And the article contains the following content:

The structures of anticapsin and bacilysin were shown to be I (R = H, H-Ala) rather than the reported C4 epimers II (R = H, H-L-Ala, R1 = H) via concise, stereocontrolled syntheses of II. Thus, Diels-Alder reaction of dehydroalanine ZNHC(CO2CH2Ph):CH2 (Z = PhCH2O2C) with 1-trimethylsilyloxy-1,3-cyclohexadiene regiospecifically gave a mixture of bicyclooctene stereoisomers, which were epoxidized to give endo epoxides III. Desilylation of III and alkoxide-induced ring cleavage gave racemic II (R = Z, R1 = CH2Ph) and its C2 epimer, which were separated by fractional crystallization Coupling of racemic II (R = H, R1 = Me) with Z-L-Ala-OH, separation of diastereomeric dipeptides, and deprotection gave (+)-II (R = H-Ala, R1 = H). The experimental process involved the reaction of Benzyl 2-(((benzyloxy)carbonyl)amino)acrylate(cas: 59524-07-1).Formula: C18H17NO4

The Article related to mol structure anticapsin bacilysin, asym synthesis anticapsin bacilysin diastereomer, Amino Acids, Peptides, and Proteins: Poly(Amino Acids) and Peptides and other aspects.Formula: C18H17NO4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On December 22, 1992, Berti, Federico; Ebert, Cynthia; Gardossi, Lucia published an article.Application of 59524-07-1 The title of the article was One-step stereospecific synthesis of α,β-dehydroamino acids and dehydropeptides. And the article contained the following:

Dehydroamino acids and dehydropeptides were prepared by a one-pot reaction of hydroxy amino acid derivatives employing (EtO)2POCl in the presence of NaH. The reaction is stereospecific and proceeds without racemization. Thus, dehydration of R-Thr-OMe (R = Z, Z-Ala; Z = PhCH2O2C) gave (Z)-RNHC(CO2Me):CHMe in 75-80% yields. The experimental process involved the reaction of Benzyl 2-(((benzyloxy)carbonyl)amino)acrylate(cas: 59524-07-1).Application of 59524-07-1

The Article related to dehydroamino acid peptide, hydroxy amino acid dehydration chlorophosphate, Amino Acids, Peptides, and Proteins: Poly(Amino Acids) and Peptides and other aspects.Application of 59524-07-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On September 3, 1990, Paquet, Alenka published an article.Application of 59524-07-1 The title of the article was Preparation of dehydroalanine peptides from bis(2,2,2-trichloroethyl) and diphenyl phosphonoserine derivatives. And the article contained the following:

Preparation of dehydroalanine peptides from the corresponding bis(2,2,2-trichloroethyl) and di-Ph phosphonoserine derivatives by treatment with various organic bases is described. The experimental process involved the reaction of Benzyl 2-(((benzyloxy)carbonyl)amino)acrylate(cas: 59524-07-1).Application of 59524-07-1

The Article related to phosphonoserine peptide elimination base, dehydroalanine peptide, Amino Acids, Peptides, and Proteins: Poly(Amino Acids) and Peptides and other aspects.Application of 59524-07-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On May 1, 2022, Cadena-Aizaga, M. Isabel; Montesdeoca-Esponda, Sarah; Sosa-Ferrera, Zoraida; Santana-Rodriguez, Jose Juan published an article.Formula: C24H27NO2 The title of the article was Occurrence and environmental hazard of organic UV filters in seawater and wastewater from Gran Canaria Island (Canary Islands, Spain). And the article contained the following:

Organic UV filters are used in personal care products, but they are also added to industrial products and are constantly released to the environment. This study analyses the occurrence of 8 widely used organic UV filters in seawater from three beaches on the Gran Canaria Island (Spain) and in three wastewater treatment plants (WWTPs) by taking samples from influents and effluents. It also discusses the target compounds’ post-treatment removal efficiencies. Sampling was carried out for 6 mo and analytes were extracted by solid phase extraction with Sep-pak C18 cartridges. They were determined by ultra-high performance liquid chromatog. coupled to mass spectrometry in tandem. The potential environmental hazard associated with the found concentrations was also assessed for marine organisms. Different target compounds were detected on the analyzed beaches and in the wastewater. Benzophenone-3 (BP3) was the most recurrent compound in the seawater samples (frequency detection of 83%) and also in wastewater influents and effluents (measured in all the samples). However, the highest concentrations for seawater (172μg L-1) and influent wastewater (208μg L-1) corresponded to octocrylene, while methylene bis-benzotriazolyltetramethylbutylphenol was the compound most concentrated in secondary treatment effluent (34.0μg L-1) and BP3 in tertiary treatment effluent (8.07μg L-1). All the analyzed samples showed that at least one target UV filter was present. Regarding the removal efficiencies of these compounds in the studied WWTPs, consistent differences between the target compounds were observed in influent concentration terms, where the average removal rates were higher than 50% for most of the compounds Conventional treatment is unable to completely remove many studied compounds, while tertiary treatment acts as an addnl. elimination for some of them. An environmental hazard quotient above 1 was found for octocrylene, benzophenone-3 and 4-methylbenzylidene camphor, which indicates a potential high hazard for living species if these compounds are present. The experimental process involved the reaction of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate(cas: 6197-30-4).Formula: C24H27NO2

The Article related to environmental hazard organic uv filters seawater wastewater, environmental hazard assessment, organic ultraviolet filters, seawater, solid phase extraction, wastewater, Water: Water Purification (Including Treatment For Industrial Uses) and other aspects.Formula: C24H27NO2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics