Tag: 300-400

Bajusz, S.; Juhasz, A. published an article in 1976, the title of the article was Synthesis of the new amino acid γ-carboxyglutamic acid and its derivatives.Application In Synthesis of Benzyl 2-(((benzyloxy)carbonyl)amino)acrylate And the article contains the following content:

Treatment of N-tert-butoxycarbonyl- or N-benzyloxycarbonyldehydroalanine benzyl ester with di-tert-butyl malonate gave 68 and 82% of the corresponding blocked DL-γ-carboxyglutamic acid α-benzyl ester γ-tert-butyl ester, which could be deblocked with F3CCO2H. The experimental process involved the reaction of Benzyl 2-(((benzyloxy)carbonyl)amino)acrylate(cas: 59524-07-1).Application In Synthesis of Benzyl 2-(((benzyloxy)carbonyl)amino)acrylate

The Article related to carboxyglutamic acid, dehydroalanine malonate condensation, glutamic acid carboxy, Synthesis of Amino Acids, Peptides, and Proteins: Amino Acids and other aspects.Application In Synthesis of Benzyl 2-(((benzyloxy)carbonyl)amino)acrylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Cao, Cheng; Zhao, Peng; Li, Ze; Chen, Zitian; Huang, Yanyi; Bai, Yu; Li, Xiaoyu published an article in 2014, the title of the article was A DNA-templated synthesis of encoded small molecules by DNA self-assembly.Recommanded Product: 79642-50-5 And the article contains the following content:

We report a novel method for the synthesis of DNA-encoded libraries without the need for discrete DNA template. Reactant DNAs self-assemble to enable chem. reactions and photo-cleavage transfers the product to the DNA terminus, making it suitable for the subsequent affinity-based selection and hit deconvolution. The experimental process involved the reaction of Bis(2,5-dioxopyrrolidin-1-yl) glutarate(cas: 79642-50-5).Recommanded Product: 79642-50-5

The Article related to dna templated synthesis acylthiazolidine dihydropyran self assembly library, Biochemical Methods: Other (Not Covered At Other Subsections) and other aspects.Recommanded Product: 79642-50-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On June 4, 2021, Li, Guosong; Huang, Guanwang; Sun, Ruixia; Curran, Dennis P.; Dai, Wen published an article.Recommanded Product: 6197-30-4 The title of the article was Regioselective Radical Borylation of α,β-Unsaturated Esters and Related Compounds by Visible Light Irradiation with an Organic Photocatalyst. And the article contained the following:

Radical hydroboration reactions have only recently been reported and are still rare. Here the authors describe a photoredox radical hydroboration of α,β-unsaturated esters, amides, ketones, and nitriles with NHC-boranes that uses only an organocatalyst and visible light. The conditions are mild, the substrate scope is broad, and the α/β regioselectivity is high. The reaction requires only the organocatalyst; there is no costly metal, and there are no other additives (base, cocatalyst, initiator). The experimental process involved the reaction of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate(cas: 6197-30-4).Recommanded Product: 6197-30-4

The Article related to unsaturated ester amide nitrile regioselective photochem radical borylation organocatalyst, boryl ester amide nitrile preparation, Organometallic and Organometalloidal Compounds: Boron Compounds and other aspects.Recommanded Product: 6197-30-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On October 17, 2019, Yang, Xiaobao; Jiang, Biao; Sun, Renhong; Ren, Chaowei; Sun, Ning; Kong, Ying; Li, Yan; Chen, Jinju; Yin, Qianqian; Song, Xiaoling; Zhao, Quanju; Qiu, Xing published a patent.Formula: C17H26O7S The title of the patent was Protein degradation targeting compound, anti-tumor application, intermediate thereof and use of intermediate. And the patent contained the following:

The compound (e.g., I) has a degrading effect on a specific target protein, and is mainly composed of three parts: the first part is Small Mols. Binding Protein (SMBP); the second part is a linker unit (LIN); and the third part is a Ubiquitin Ligase Binding Moiety (ULM), wherein SMBP and LIN are covalently bound, and LIN is covalently bound to ULM. The compounds designed and synthesized by the present disclosure have a wide pharmacol. activities, have a function of degrading specific proteins and/or inhibiting activities, and can be used for the treatment of associated tumor. The experimental process involved the reaction of tert-Butyl 2-(2-(2-(tosyloxy)ethoxy)ethoxy)acetate(cas: 882518-89-0).Formula: C17H26O7S

The Article related to protein degradation targeting heteroaryl preparation antitumor smbp lin ulm, small mol binding protein smbp linker lin ulm, Heterocyclic Compounds (More Than One Hetero Atom): Diazepines and other aspects.Formula: C17H26O7S

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On December 31, 1996, Molina, Pedro; Conesa, Carlota; Desamparados Velasco, M. published an article.COA of Formula: C18H17NO4 The title of the article was Iminophosphorane-mediated synthesis of 2-aminoimidazole derivatives. And the article contained the following:

A 1-pot synthesis of 4-substituted 2-aminoimidazoles based on the aza-Wittig reaction of 2-amino-3-azidoacrylates with isocyanates is described. The experimental process involved the reaction of Benzyl 2-(((benzyloxy)carbonyl)amino)acrylate(cas: 59524-07-1).COA of Formula: C18H17NO4

The Article related to aminoimidazole preparation, imidazole amino preparation, aminoazidoacrylate isocyanate aza wittig, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.COA of Formula: C18H17NO4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On July 31, 2019, Knewtson, Kelsey E.; Perera, Chamani; Hymel, David; Gao, Zhe; Lee, Molly M.; Peterson, Blake R. published an article.Computed Properties of 79642-50-5 The title of the article was Antibody-Drug Conjugate that Exhibits Synergistic Cytotoxicity with an Endosome-Disruptive Peptide. And the article contained the following:

Antibody-drug conjugates are an important class of cancer therapeutics. These agents generally bind a specific cell surface receptor, undergo receptor-mediated endocytosis, and enter the endosomal-lysosomal system, where the environment in these organelles facilitates the release of a membrane-permeable cytotoxin. By using a membrane-impermeable cytotoxin, we describe here a method that allows the cytotoxicity of an antibody conjugate to be triggered by co-administration with an endosome-disruptive peptide that exhibits low toxicity. This approach was validated by conjugation of an anionic derivative of the tubulin-binding cytotoxin colchinol Me ether to lysine residues of the HER2-targeting antibody trastuzumab (Herceptin) via a disulfide. When this antibody binds HER2 on SKBR3 breast cancer cells and undergoes endocytosis, the membrane-impermeable cytotoxin is released, but it becomes trapped in endosomes, resulting in relatively low cytotoxicity (IC50 > 1μM). However, co-administration with an essentially nontoxic (IC50 > 10μM) cholesterol-linked endosome-disruptive peptide promotes the release of this small mol. into the cytoplasm, conferring subnanomolar cytotoxic potency (IC50 = 0.11 ± 0.07 nM). Studies of a structurally related fluorophore conjugate revealed that the endosome-disruptive peptide does not substantially enhance cleavage of the disulfide (t1/2 = 8 ± 2 h) within endosomes, suggesting that the mechanism of endosomal escape involves the efflux of some small mols. without facilitating substantial influx of reduced glutathione. The experimental process involved the reaction of Bis(2,5-dioxopyrrolidin-1-yl) glutarate(cas: 79642-50-5).Computed Properties of 79642-50-5

The Article related to cancer antibody drug conjugate synergistic cytotoxicity endosome disruptive peptide, Pharmacology: Effects Of Neoplasm Inhibitors and Cytotoxic Agents and other aspects.Computed Properties of 79642-50-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On July 22, 2021, Tu, Yalin; Sun, Yameng; Qiao, Shuang; Luo, Yao; Liu, Panpan; Jiang, Zhong-Xing; Hu, Yumin; Wang, Zifeng; Huang, Peng; Wen, Shijun published an article.Application of 882518-89-0 The title of the article was Design, Synthesis, and Evaluation of VHL-Based EZH2 Degraders to Enhance Therapeutic Activity against Lymphoma. And the article contained the following:

Traditional EZH2 inhibitors are developed to suppress the enzymic methylation activity, and they may have therapeutic limitations due to the nonenzymic functions of EZH2 in cancer development. Here, we report proteolysis-target chimera (PROTAC)-based EZH2 degraders to target the whole EZH2 in lymphoma. Two series of EZH2 degraders were designed and synthesized to hijack E3 ligase systems containing either von Hippel-Lindau (VHL) or cereblon (CRBN), and some VHL-based compounds were able to mediate EZH2 degradation Two best degraders, YM181 (I) and YM281 (II), induced robust cell viability inhibition in diffuse large B-cell lymphoma (DLBCL) and other subtypes of lymphomas, outperforming a clin. used EZH2 inhibitor EPZ6438 (tazemetostat) that was only effective against DLBCL. The EZH2 degraders displayed promising antitumor activities in lymphoma xenografts and patient-derived primary lymphoma cells. Our study demonstrates that EZH2 degraders have better therapeutic activity than EZH2 inhibitors, which may provide a potential anticancer strategy to treat lymphoma. The experimental process involved the reaction of tert-Butyl 2-(2-(2-(tosyloxy)ethoxy)ethoxy)acetate(cas: 882518-89-0).Application of 882518-89-0

The Article related to lymphoma ezh2 inhibitors degraders vhl crbn ym181 ym281 antitumor, Pharmacology: Effects Of Neoplasm Inhibitors and Cytotoxic Agents and other aspects.Application of 882518-89-0

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On March 20, 2019, Kishimoto, Satoshi; Nakashimada, Yuichi; Yokota, Riri; Hatanaka, Takaaki; Adachi, Motoyasu; Ito, Yuji published an article.Safety of Bis(2,5-dioxopyrrolidin-1-yl) glutarate The title of the article was Site-Specific Chemical Conjugation of Antibodies by Using Affinity Peptide for the Development of Therapeutic Antibody Format. And the article contained the following:

Artificially modified IgG mols. are increasingly utilized in industrial and clin. applications. In the present study, the method of chem. conjugation by affinity peptide (CCAP) for site-specific chem. modification has been developed by using a peptide that bound with high affinity to human IgG-Fc. This method enabled a rapid modification of a specific residue (Lys248 on Fc) in a one-step reaction under mild condition to form a stable amide bond between the peptide and Fc. The monovalent peptide-IgG conjugate not only maintained complete antigen binding but also bound to Fc receptors (FcRn, FcγRI, and FcγRIIIa), indicating that it is a suitable conjugate form that can be further developed into highly functional antibody therapeutics. CCAP was applied for the preparation of an antibody-drug conjugate and a bispecific antibody to demonstrate the usefulness of this method. The experimental process involved the reaction of Bis(2,5-dioxopyrrolidin-1-yl) glutarate(cas: 79642-50-5).Safety of Bis(2,5-dioxopyrrolidin-1-yl) glutarate

The Article related to igg fc heavy chain peptide conjugation drug conjugate bispecific, Pharmacology: Effects Of Neoplasm Inhibitors and Cytotoxic Agents and other aspects.Safety of Bis(2,5-dioxopyrrolidin-1-yl) glutarate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On December 31, 2014, McEnaney, Patrick J.; Fitzgerald, Kelly J.; Zhang, Andrew X.; Douglass, Eugene F. Jr.; Shan, Weifang; Balog, Aaron; Kolesnikova, Mariya D.; Spiegel, David A. published an article.Recommanded Product: Bis(2,5-dioxopyrrolidin-1-yl) glutarate The title of the article was Chemically Synthesized Molecules with the Targeting and Effector Functions of Antibodies. And the article contained the following:

This article reports the design, synthesis, and evaluation of a novel class of mols. of intermediate size (approx. 7000 Da), which possess both the targeting and effector functions of antibodies. These compounds-called synthetic antibody mimics targeting prostate cancer (SyAM-Ps)-bind simultaneously to prostate-specific membrane antigen and Fc gamma receptor I, thus eliciting highly selective cancer cell phagocytosis. SyAMs have the potential to combine the advantages of both small-mol. and biol. therapies, and may address many drawbacks associated with available treatments for cancer and other diseases. The experimental process involved the reaction of Bis(2,5-dioxopyrrolidin-1-yl) glutarate(cas: 79642-50-5).Recommanded Product: Bis(2,5-dioxopyrrolidin-1-yl) glutarate

The Article related to antitumor neoplasm prostate specific membrane antigen, Pharmacology: Effects Of Neoplasm Inhibitors and Cytotoxic Agents and other aspects.Recommanded Product: Bis(2,5-dioxopyrrolidin-1-yl) glutarate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On June 20, 2022, Fagervold, S. K.; Lebaron, P. published an article.Safety of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate The title of the article was Evaluation of the degradation capacity of WWTP sludge enrichment cultures towards several organic UV filters and the isolation of octocrylene-degrading microorganisms. And the article contained the following:

Organic UV filters are present in wastewater treatment plants (WWTPs) due to the use of these compounds in many personal care products (PCPs) and their subsequent release into the wastewater system from showering/bathing. Once in the wastewater system, organic UV filters generally partition into the solid phase but might also undergo other processes, such as degradation by microorganisms. To further understand the fate of organic UV filters in WWTPs, the degradation of 7 UV filters by WWTP sludge was investigated The UV filters 2-ethylhexyl salicylate (ES), homosalate (HS), Bu methoxydibenzoylmethane (BM) and octocrylene (OC) were degraded after 20-60 days. The rest of the filters tested, namely, bis-ethylhexyloxyphenol methoxyphenyl triazine (BEMT), methylene bis-benzotriazolyl tetramethylbutylphenol (MBBT) and diethylhexyl butamido triazone (DBT), did not degrade even after 120 days of incubation. The microbial community from the microcosms degrading ES, HS, OC and BM was transferred every 30 days into new microcosms to enrich for microorganisms capable of utilizing the individual UV filters for growth. The enrichment cultures continued to degrade throughout 20 transfers. The microbial community was clearly different between the enrichments degrading ES, HS, OC and BM, meaning that the microbial community was strongly influenced by the UV filter present. Furthermore, several strains were isolated from OC-degrading cultures and two of these strains, Gordonia sp. strain OC_S5 and Sphingopyxis sp. strain OC_4D, degraded OC with and without other carbon sources present. These experiments show that several organic UV filters can be degraded by a specific set of microorganisms. The lack of degradation observed for BEMT, MBBT and DBT is probably due to limited bioavailability. Indeed, this is the first biodegradation study of these filters, in addition to being the first description of ES and HS degradation in microcosm experiments The experimental process involved the reaction of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate(cas: 6197-30-4).Safety of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate

The Article related to octocrylene degrading microorganism wastewater treatment plant degradation capacity, degradation, pure bacterial strains, uv filters, wastewater sludge, Waste Treatment and Disposal: Physical Treatment Of Aqueous Wastes and other aspects.Safety of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics