Tag: 300-400

On April 20, 2016, Wang, Cheng; Meng, Xiangshi; Gui, Bo published a patent.Reference of Dimethyl 2′-amino-[1,1′:4′,1”-terphenyl]-4,4”-dicarboxylate The title of the patent was Preparation method of light-controlled drug release metal organic framework compound. And the patent contained the following:

The invention provides a preparation method of light-controlled drug release metal organic framework compound, and the present invention makes azo ligand, acetic acid, and zirconium tetrachloride dissolved into N,N-DMF to obtain metal organic framework, and obtains the finished product by adding medicine and beta-cyclodextrin. Beta-cyclodextrin can combine with trans azo in the present invention, thus it makes the system have no release when it does not receive external stimulus, and makes release occur only after receiving UV radiation or adding amantadine, i.e. metal organic framework compound prepared by the present invention is capable of realizing controlled drug release. The experimental process involved the reaction of Dimethyl 2′-amino-[1,1′:4′,1”-terphenyl]-4,4”-dicarboxylate(cas: 1312703-30-2).Reference of Dimethyl 2′-amino-[1,1′:4′,1”-terphenyl]-4,4”-dicarboxylate

The Article related to light controlled drug release metal organic framework compound preparation, Inorganic Chemicals and Reactions: Coordination Compounds and other aspects.Reference of Dimethyl 2′-amino-[1,1′:4′,1”-terphenyl]-4,4”-dicarboxylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On February 9, 1999, Kawata, Mitsuyasu; Morimune, Kosuke; Takewaki, Shunichi; Miyake, Shirou; Yamaguchi, Yuki; Beppu, Yoshinori published a patent.Category: esters-buliding-blocks The title of the patent was Immunoassay of oxamyl, and haptens, their conjugates, and hybridomas for production of antibodies to oxamyl. And the patent contained the following:

Me2NCOC(SMe):NOCONH(CH2)lCO2H (I; l = 6-15), Me2NCOC(SMe):NOCONHR1CO2H [R1 = CH2A (A = cyclohexyl), cyclohexylene, CH2C6H4, C6H4, which may be substituted with 1-2 halo, C1-3 alkyl], Me2NCOC(SMe):NOR2CO2H [II; R2 = (CH2)m (m = 1-3), CH2CONH(CH2)n (n = 1-5), CO(CH2)o (o = 1-5)], or Me3CC(CH2SR3):NOCONH(CH2)pCO2H (R3 = C1-6 alkyl; p = 1-10) are useful as haptens to produce antibodies or their fragments specific to oxamyl (III). The antibodies, their fragments, and conjugates of the haptens with macromols. or labeling agents are useful for immunoassay of III. Hybridomas producing monoclonal antibodies are also claimed. Mouse was immunized with I (l = 5) (preparation given) conjugated with keyhole limpet hemocyanin by the conventional method. Splenic cells of the mouse was fused with myeloma cells to give hybridomas producing a monoclonal antibody OXM6-8. ELISA for III was performed using a microtiter plate coated with OXM6-8 and HRP-labeled II [R2 = CO(CH2)4]. The system was highly specific to III. The experimental process involved the reaction of tert-Butyl 4-((((benzyloxy)carbonyl)amino)methyl)benzoate(cas: 220851-46-7).Category: esters-buliding-blocks

The Article related to oxamyl immunoassay antibody production hapten preparation, hybridoma monoclonal antibody oxamyl immunoassay, Agrochemical Bioregulators: Methods (Including Analysis) and other aspects.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On March 31, 2020, Xing, Xiangyang; Han, Xue; He, Lei; Cheng, Jiali; Zhong, Fuyong; Sun, Jiazheng; Tang, Zhenwu published an article.Application In Synthesis of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate The title of the article was Organic ultraviolet-absorbing materials in street dust from Hefei, China: Concentrations, profiles, and human health risks. And the article contained the following:

Organic UV absorbents (UVAs) are widely found in the environment. However, little is known about UVA distributions in street dust and the risks they pose to human health. We determined the concentrations of 12 UVAs in street dust from cultural, residential, traffic, and industrial areas in Hefei, China. 4-Methylbenzylidene camphor was not detected in the street dust samples. The total concentration range of the 11 other UVAs (S11UVAs) in the street dust samples was 6.42-94.2 ng/g. Octocrylene was the dominant UVA, contributing 53.8% of the S11UVA concentrations The UVA concentrations were higher in dust from the industrial area than in dust from cultural, residential, and traffic areas. Source anal. was performed, and industrial activities and the use of cosmetics and personal care products were found to be the main sources of UVAs in street dust. The health risks posed to humans exposed to UVAs in street dust in Hefei were generally low. More research is required to improve our understanding of the health risks posed to humans exposed to UVAs through other pathways. The experimental process involved the reaction of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate(cas: 6197-30-4).Application In Synthesis of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate

The Article related to human health risk organic uv absorbing material street dust, Air Pollution and Industrial Hygiene: Industrial Hygiene and other aspects.Application In Synthesis of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On January 21, 2020, Matta, Murali K.; Florian, Jeffry; Zusterzeel, Robbert; Pilli, Nageswara R.; Patel, Vikram; Volpe, Donna A.; Yang, Yang; Oh, Luke; Bashaw, Edward; Zineh, Issam; Sanabria, Carlos; Kemp, Sarah; Godfrey, Anthony; Adah, Steven; Coelho, Sergio; Wang, Jian; Furlong, Lesley-Anne; Ganley, Charles; Michele, Theresa; Strauss, David G. published an article.SDS of cas: 6197-30-4 The title of the article was Effect of sunscreen application on plasma concentration of sunscreen active ingredients: a randomized clinical trial. And the article contained the following:

A prior pilot study demonstrated the systemic absorption of 4 sunscreen active ingredients; addnl. studies are needed to determine the systemic absorption of addnl. active ingredients and how quickly systemic exposure exceeds 0.5 ng/mL as recommended by the US Food and Drug Administration (FDA). To assess the systemic absorption and pharmacokinetics of the 6 active ingredients (avobenzone, oxybenzone, octocrylene, homosalate, octisalate, and octinoxate) in 4 sunscreen products under single- and maximal-use conditions. Randomized clin. trial at a clin. pharmacol. unit (West Bend, Wisconsin) was conducted in 48 healthy participants. The study was conducted between Jan. and Feb. 2019. Participants were randomized to 1 of 4 sunscreen products, formulated as lotion (n = 12), aerosol spray (n = 12), nonaerosol spray (n = 12), and pump spray (n = 12). Sunscreen product was applied at 2 mg/cm2 to 75% of body surface area at 0 h on day 1 and 4 times on day 2 through day 4 at 2-h intervals, and 34 blood samples were collected over 21 days from each participant. The primary outcome was the maximum plasma concentration of avobenzone over days 1 through 21. Secondary outcomes were the maximum plasma concentrations of oxybenzone, octocrylene, homosalate, octisalate, and octinoxate over days 1 through 21. Among 48 randomized participants (mean [SD] age, 38.7 [13.2] years; 24 women [50%]; 23 white [48%], 23 African American [48%], 1 Asian [2%], and 1 of unknown race/ethnicity [2%]), 44 (92%) completed the trial. Geometric mean maximum plasma concentrations of all 6 active ingredients were greater than 0.5 ng/mL, and this threshold was surpassed on day 1 after a single application for all active ingredients. The overall maximum plasma concentrations for each active ingredient for each product formulation are shown in the table. The most common adverse event was rash, which developed in 14 participants. In this study conducted in a clin. pharmacol. unit and examining sunscreen application among healthy participants, all 6 of the tested active ingredients administered in 4 different sunscreen formulations were systemically absorbed and had plasma concentrations that surpassed the FDA threshold for potentially waiving some of the addnl. safety studies for sunscreens. These findings do not indicate that individuals should refrain from the use of sunscreen. The experimental process involved the reaction of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate(cas: 6197-30-4).SDS of cas: 6197-30-4

The Article related to sunscreens plasma concentration pharmacokinetics, Pharmacology: Drug Interactions and General Pharmacology and other aspects.SDS of cas: 6197-30-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On November 10, 2022, Yang, Lyu; Li, Guanghui; He, Ying; Li, Yonghong; Tang, Zhenwu published an article.Category: esters-buliding-blocks The title of the article was Occurrence and distribution of organic ultraviolet absorbents in soils and plants from a typical industrial area in South China. And the article contained the following:

Organic UV absorbents (UVAs) have attracted increasing concern due to their ubiquity, bioaccumulation, and potential toxicity. However, available information on their occurrence and transfer in terrestrial environment is still extremely insufficient. In this study, we investigated twelve UVAs in the soils and five terrestrial plant species from a typical industrial area in South China, and found their total concentrations were 5.87-76.1 (median 13.1) and 17.9-269 (median 82.9) ng/g dry weight, resp. Homosalate was dominant in soils while benzophenone and octrizole were predominant in plants, likely due to their complex sources and bioaccumulation preferences. The bioaccumulation factors (BAFs) were further evaluated based on the ratios of UVA concentrations in plants and soils. The observed BAFs of UVAs were compound and species-specific, and most of them were much >1.0, indicating the chems. could be transferred from soils to plants. To the best of our knowledge, this is the first report of organic UVAs in field soil-plant systems, providing information that may improve our understanding of the bioaccumulability of these chems. in terrestrial environment and the associated risks. More studies are needed to investigate the transfer and bioaccumulation of such chems. in soils and terrestrial biota. The experimental process involved the reaction of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate(cas: 6197-30-4).Category: esters-buliding-blocks

The Article related to organic uv absorbent toxicity bioaccumulation soil terrestrial ecosystem pollution, bioaccumulation factors, concentrations, organic ultraviolet absorbents, plant, soil, Fertilizers, Soils, and Plant Nutrition: Soil Pollution and other aspects.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On February 6, 2018, Obata, Shunsuke; Asamitsu, Sefan; Hashiya, Kaori; Bando, Toshikazu; Sugiyama, Hiroshi published an article.Formula: C13H14N2O8 The title of the article was G-Quadruplex Induction by the Hairpin Pyrrole-Imidazole Polyamide Dimer. And the article contained the following:

The G-quadruplex (G4) is one type of higher-order structure of nucleic acids and is thought to play important roles in various biol. events such as regulation of transcription and inhibition of DNA replication. Pyrrole-imidazole polyamides (PIPs) are programmable small mols. that can sequence-specifically bind with high affinity to the minor groove of double-stranded DNA (dsDNA). Herein, we designed head-to-head hairpin PIP dimers and their target dsDNA in a model G4-forming sequence. Using an electrophoresis mobility shift assay and transcription arrest assay, we found that PIP dimers could induce the structural change to G4 DNA from dsDNA through the recognition by one PIP dimer mol. of two duplex-binding sites flanking both ends of the G4-forming sequence. This induction ability was dependent on linker length. This is the first study to induce G4 formation using PIPs, which are known to be dsDNA binders. The results reported here suggest that selective G4 induction in native sequences may be achieved with PIP dimers by applying the same design strategy. The experimental process involved the reaction of Bis(2,5-dioxopyrrolidin-1-yl) glutarate(cas: 79642-50-5).Formula: C13H14N2O8

The Article related to hairpin pyrrole imidazole polyamide dimer dna transition g quadruplex, General Biochemistry: Nucleic Acids and Their Constituents and other aspects.Formula: C13H14N2O8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On June 15, 2016, Dong, Yubin; Li, Yanan; Yang, Song; Liu, Qikui published a patent.Application of 1312703-30-2 The title of the patent was Synthetic method for increasing Pd content of Zr(IV) ions-based metal-organic framework. And the patent contained the following:

The present invention discloses a synthetic method for increasing Pd content of Zr(IV) ions-based metal-organic framework, including reacting an organic ligand (I) and ZrCl4 for coordination polymerization reaction, reacting the product for post-synthesis modification; the post-synthesis modification concretely includes reacting coordinate polymerization reaction product with 2-pyridylaldehyde or salicylaldehyde in an organic solvent in the presence of catalyst of formic acid at a molar ratio of 1: 1-4: 0.1-0.3; centrifugally washing the product, dispersing in an organic solvent, adding palladium nitrate at a molar ratio of 0.8 to 1.2, centrifuging after reaction, drying to obtain powder; dispersing in water, adding sodium borohydride at a molar ratio of 1:0.5-1.5, centrifuging after reaction, washing, drying to obtain product. The prepared compound belongs to the organic-inorganic composite supramol. materials, and the method has simple operation, low cost, and the particle size of nanometer scale, and has very high efficiency as catalytic materials for oxidation of benzyl alc. and for condensation of benzaldehyde. For step 1, the reaction temperature is 60-80 °C, and the reaction lasts for 6-12 h. For step 2, the reaction temperature is 60-80 °C, and the reaction lasts for 0.5-1.5 h while stirring. For step 1 and 2, the solvent is ethanol, acetonitrile or so on. The detailed steps for step 1 comprise: mixing ZrCl4 and organic ligand I at molar ratio of 1:1 in DMF, adding glacial acetic acid, ultrasound processing, drying in oven of 120 °C for 24 h, cooling, centrifuging; dispersing in DMF, soaking at 80 °C, centrifuging; soaking in ethanol at 70 °C, drying at 80 °C to obtain UiO-68-NH2. The preparation method of organic ligand I comprises: using 2,5-dibromo aniline as material, conducting coupled reaction with 4-methoxycarbonyl phenylboronic acid under palladium catalysis to obtain intermediate A; hydrolyzing A under alk. condition to obtain I. The title metal-organic framework can be used in catalytic oxidation of benzyl alc. into benzaldehyde. The experimental process involved the reaction of Dimethyl 2′-amino-[1,1′:4′,1”-terphenyl]-4,4”-dicarboxylate(cas: 1312703-30-2).Application of 1312703-30-2

The Article related to zirconium aminoterphenyldicarboxylic acid mof complex preparation oxidation catalyst, benzenemethanol oxidation benzaldehyde preparation zirconium palladiun mof catalyst, Inorganic Chemicals and Reactions: Coordination Compounds and other aspects.Application of 1312703-30-2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On April 26, 2016, Kutzscher, Christel; Nickerl, Georg; Senkovska, Irena; Bon, Volodymyr; Kaskel, Stefan published an article.Synthetic Route of 1312703-30-2 The title of the article was Proline Functionalized UiO-67 and UiO-68 Type Metal-Organic Frameworks Showing Reversed Diastereoselectivity in Aldol Addition Reactions. And the article contained the following:

Functionalization of dicarboxylate linkers with proline was used to generate catalytically active metal-organic frameworks (MOFs) for diastereoselective aldol addition Due to high robustness and chem. stability, zirconium based MOFs, namely UiO-67 and UiO-68, were chosen as catalyst hosts. During the MOF synthesis, utilizing Boc protected proline functionalized linkers H2bpdc-NHProBoc and H2tpdc-NHProBoc, in situ deprotection of the Boc groups without racemization is achieved, enabling direct application of the enantiopure, homochiral MOFs in catalytic reaction, without further postsynthetic treatment. Solvent screening and kinetic studies as well as cycling tests were used to evaluate the conditions for diastereoselective aldol addition using a model reaction of 4-nitrobenzaldehyde and cyclohexanone. High yields (up to 97%) were achieved in reasonable reaction time using ethanol as solvent. In comparison to homocatalytic reactions catalyzed by L-proline and its derivatives, MOFs showed opposite diastereoselectivity attributed to the catalytic sites in confined pore space rendering this class of materials as promising catalysts for fine chems. production The experimental process involved the reaction of Dimethyl 2′-amino-[1,1′:4′,1”-terphenyl]-4,4”-dicarboxylate(cas: 1312703-30-2).Synthetic Route of 1312703-30-2

The Article related to zirconium dicarboxylate proline mof preparation crystal structure, physisorption aldol addition kinetic recyclability zirconium mof, Inorganic Chemicals and Reactions: Coordination Compounds and other aspects.Synthetic Route of 1312703-30-2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On August 3, 2020, Newar, Rajashree; Begum, Wahida; Antil, Neha; Shukla, Sakshi; Kumar, Ajay; Akhtar, Naved; Balendra; Manna, Kuntal published an article.Quality Control of Dimethyl 2′-amino-[1,1′:4′,1”-terphenyl]-4,4”-dicarboxylate The title of the article was Single-Site Cobalt-Catalyst Ligated with Pyridylimine-Functionalized Metal-Organic Frameworks for Arene and Benzylic Borylation. And the article contained the following:

A highly active single-site heterogeneous cobalt-catalyst is reported based on a porous and robust pyridylimine-functionalized metal-organic frameworks (pyrim-MOF) for chemoselective borylation of arene and benzylic C-H bonds. The pyrim-MOF having UiO-68 topol., constructed from zirconium-cluster secondary building units and pyridylimine-functionalized dicarboxylate bridging linkers, was metalated with CoCl2 followed by treatment of NaEt3BH to give the cobalt-functionalized MOF-catalyst (pyrim-MOF-Co). Pyrim-MOF-Co has a broad substrate scope, allowing the C-H borylation of halogen-, alkoxy-, alkyl-substituted arenes as well as heterocyclic ring systems using B2pin2 or HBpin (pin = pinacolate) as the borylating agent to afford the corresponding arene- or alkyl-boronate esters in good yields. Pyrim-MOF-Co gave a turnover number (TON) of up to 2500 and could be recycled and reused at least 9 times. Pyrim-MOF-Co was also significantly more robust and active than its homogeneous control, highlighting the beneficial effect of active-site isolation within the MOF framework that prevents intermol. decomposition The exptl. and computational studies suggested (pyrim•-)CoI(THF) as the active catalytic species within the MOF, which undergoes a mechanistic pathway of oxidative addition, turnover limiting σ-bond metathesis, followed by reductive elimination to afford the boronate ester. The pyridylimine-functionalized metal-organic framework (pyrim-MOF)-based single-site cobalt-catalyst is efficient for chemoselective borylation of arene and benzylic C-H bonds. The heterogeneous MOF-catalyst is significantly more robust and active than its homogeneous control, highlighting the beneficial effect of active-site isolation within the MOF framework that prevents intermol. decomposition The experimental process involved the reaction of Dimethyl 2′-amino-[1,1′:4′,1”-terphenyl]-4,4”-dicarboxylate(cas: 1312703-30-2).Quality Control of Dimethyl 2′-amino-[1,1′:4′,1”-terphenyl]-4,4”-dicarboxylate

The Article related to metal organic framework cobalt catalyst zirconium pyridylimine arene benzylic, borylation oxidation dft mechanism, Inorganic Chemicals and Reactions: Coordination Compounds and other aspects.Quality Control of Dimethyl 2′-amino-[1,1′:4′,1”-terphenyl]-4,4”-dicarboxylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On March 18, 2015, Liao, Guochao; Zhou, Zhifang; Burgula, Srinivas; Liao, Jun; Yuan, Cheng; Wu, Qiuye; Guo, Zhongwu published an article.Recommanded Product: Bis(2,5-dioxopyrrolidin-1-yl) glutarate The title of the article was Synthesis and Immunological Studies of Linear Oligosaccharides of β-Glucan As Antigens for Antifungal Vaccine Development. And the article contained the following:

Antifungal vaccines have recently engendered considerable excitement for counteracting the resurgence of fungal infections. In this context, β-glucan, which is abundantly expressed on all fungal cell surfaces, functionally necessary for fungi, and immunol. active, is an attractive target antigen. Aiming at the development of effective antifungal vaccines based on β-glucan, a series of its oligosaccharide derivatives was designed, synthesized, and coupled with a carrier protein, keyhole limpet hemocyanin (KLH), to form new semisynthetic glycoconjugate vaccines. In this article, a convergent and effective synthetic strategy using preactivation-based iterative glycosylation was developed for the designed oligosaccharides. The strategy can be widely useful for rapid construction of large oligo-β-glucans with shorter oligosaccharides as building blocks. The KLH conjugates of the synthesized β-glucan hexa-, octa-, deca-, and dodecasaccharides were demonstrated to elicit high titers of antigen-specific total and IgG antibodies in mice, suggesting the induction of functional T cell-mediated immunity. Moreover, it was revealed that octa-, deca-, and dodeca-β-glucans were much more immunogenic than the hexamer and that the octamer was the best among these. The results suggested that the optimal oligosaccharide sequence of β-glucan required for exceptional immunogenicity was a hepta- or octamer and that longer glucans are not necessarily better antigens, a finding that may be of general importance. Most importantly, the octa-β-glucan-KLH conjugate provoked protective immunity against Candida albicans infection in a systemic challenge model in mice, suggesting the great potential of this glycoconjugate as a clin. useful immunoprophylactic antifungal vaccine. The experimental process involved the reaction of Bis(2,5-dioxopyrrolidin-1-yl) glutarate(cas: 79642-50-5).Recommanded Product: Bis(2,5-dioxopyrrolidin-1-yl) glutarate

The Article related to oligosaccharide beta glucan antifungal vaccine, Immunochemistry: Adjuvants, Antigens, Haptens, and Vaccines and other aspects.Recommanded Product: Bis(2,5-dioxopyrrolidin-1-yl) glutarate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics