Tag: 300-400

On January 8, 2015, Campos, Sebastien Andre; Harling, John David; Miah, Afjal Hussain; Smith, Ian Edward David published a patent.Computed Properties of 882518-89-0 The title of the patent was Benzothiophene derivatives as estrogen receptor inhibitors and their preparation and use for the treatment of diseases. And the patent contained the following:

The invention relates to benzothiophene derivatives of formula I, which are estrogen receptor inhibitors and which are useful in the treatment of diseases mediated by the estrogen receptor. Compounds of formula I wherein R1 is H, OH, C1-3 alkoxy and halo; R2 is OH and C1-3 alkoxy; X is O and CO; L is a linker; R3 is (un)branched C1-6 alkyl and C3-6 cycloalkyl; R4 is 4-methylthiazol-5-yl, oxazol-5-yl and halo; and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by a multistep procedure (procedure given). All the invention compounds were evaluated for their estrogen receptor alpha (ERa) degradation (data not given). The experimental process involved the reaction of tert-Butyl 2-(2-(2-(tosyloxy)ethoxy)ethoxy)acetate(cas: 882518-89-0).Computed Properties of 882518-89-0

The Article related to benzothiophene preparation estrogen receptor inhibitor treatment disease, Heterocyclic Compounds (One Hetero Atom): Thiophenes and other aspects.Computed Properties of 882518-89-0

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On April 20, 2020, Zhong, Xin; Downs, Craig A.; Li, Yuting; Zhang, Zishan; Li, Yiman; Liu, Binbin; Gao, Huiyuan; Li, Qingming published an article.Recommanded Product: 6197-30-4 The title of the article was Comparison of toxicological effects of oxybenzone, avobenzone, octocrylene, and octinoxate sunscreen ingredients on cucumber plants (Cucumis sativus L.). And the article contained the following:

Oxybenzone (OBZ), avobenzone (AVB), octocrylene (OCR) and octinoxate (OMC) are UV filters commonly added to chem. sunscreens. These UV filters are known to widely contaminate the environment through a variety of anthropogenic sources, including sewage discharge. However, systematic studies of the damage caused by these four UV filters and their toxicopathol. differences in a variety of plant species are lacking. In this study, we demonstrated that irrigation with water containing these four UV filters could significantly inhibit the aboveground growth of cucumber plant. All of the UV filters decreased photosynthesis through nonstomatal factors but via different inhibitory mechanisms. Only OBZ inhibited photosynthesis by directly inhibiting photosynthetic electron transport, while the other three (AVB, OCR, and OMC) inhibited photosynthesis by inhibiting the Calvin-Benson cycle. Addnl., these four UV filters also decreased plant respiration under long-term treatment. Photosynthesis and respiration inhibition led to the over production of reactive oxygen species (ROS) and the formation of lipid peroxidation damage products, which further damaged the structure and function of plant cells, causing secondary pathologies and potentially leading to reduced crop yields. The study also demonstrated that these four UV filters caused different degrees of phototoxic damage to cucumber plants. On the basis of comprehensive evaluation, we speculated that the order of the four UV filters in terms of plant damage was OBZ > AVB > OMC > OCR. Because of the severe damaging effects of these UV filters on plant growth, the application of contaminated biosolids/reclaimed water in agriculture reduces agricultural production and may damage ecosystems. The results of this study can advance recognition of the hazards associated with environmental and agricultural pollution via UV filters and encourage consumers and the industry to limit or reduce the application of cosmetics and over-the-counter drugs containing these substances. The experimental process involved the reaction of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate(cas: 6197-30-4).Recommanded Product: 6197-30-4

The Article related to phytotoxicity oxybenzone avobenzone octocrylene octinoxate sunscreen plant growth, cucumber, electron transport, photosynthesis, ros, respiration, uv filters, Toxicology: Chemicals (Household, Industrial, General) and other aspects.Recommanded Product: 6197-30-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On April 10, 2021, He, Ke; Hain, Ethan; Timm, Anne; Blaney, Lee published an article.Product Details of 6197-30-4 The title of the article was Bioaccumulation of estrogenic hormones and UV-filters in red swamp crayfish (Procambarus clarkii). And the article contained the following:

Estrogenic hormones and organic UV-filters (UV-filters) have attracted increased attention as endocrine disrupting chems. (EDCs) due to their potent estrogenicity and widespread occurrence in the environment. This study investigated the accumulation of three estrogenic hormones and five UV-filters in red swamp crayfish (Procambarus clarkii). Exposure experiments were conducted for 42 days with a mixture of EDCs at two environmentally-relevant design concentrations (i.e., 500 and 5000 ng L-1). The aqueous-phase EDC concentrations decreased over time and were re-established every two days. Within 14 days of exposure, the five UV-filters were measured at 2.2 to 265 ng g-1 (dry weight) in crayfish tail tissue. Only one estrogenic hormone, 17β-estradiol, was detected in the crayfish at 10.4-13.5 ng g-1. No apparent changes were observed for EDC concentrations in the tail tissue over the next four weeks of exposure. The apparent bioaccumulation factors for the EDCs ranged from 23 L (kg tail tissue, dry weight)-1 for 4-methylbenzylidene camphor to 1050 L (kg tail tissue, dry weight)-1 for 2-ethylhexyl-4-methoxycinnamate. EDC input was stopped after 42 days, and the more hydrophobic UV-filters (i.e., octocrylene, 2-ethylhexyl-4-methoxycinnamate, homosalate) were found to be persistent throughout a 14-d elimination period. A lyticase-assisted yeast estrogen screen demonstrated that the residual estrogenic activity of water samples aligned with (or was lower than) predictions from targeted chem. anal. These results suggest that the transformation products did not contribute significant estrogenicity, although further anal. of endocrine disruption outcomes in crayfish is recommended. The experimental process involved the reaction of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate(cas: 6197-30-4).Product Details of 6197-30-4

The Article related to procambarus bioaccumulation uv filter estrogen hormone, bioaccumulation, crayfish, endocrine disrupting chemicals, estrogenic hormones, sunscreen, uv-filters, Toxicology: Chemicals (Household, Industrial, General) and other aspects.Product Details of 6197-30-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On December 1, 2021, Vieira Sanches, Matilde; Oliva, Matteo; De Marchi, Lucia; Cuccaro, Alessia; Puppi, Dario; Chiellini, Federica; Freitas, Rosa; Pretti, Carlo published an article.Electric Literature of 6197-30-4 The title of the article was Ecotoxicological screening of UV-filters using a battery of marine bioassays. And the article contained the following:

The present study aimed to assess the toxicity of seven UV-filters: zinc oxide nanoparticles (nZnO, particle size <100 nm), titanium dioxide nanoparticles (nTiO2, primary particle size 21 nm), 2-ethylhexyl-4-methoxycinnamate (EHMC), 4-methylbenzylidene camphor (4-MBC), avobenzone (AVO), octocrylene (OCTO) and benzophenone-3 (BP-3) on three species: Aliivibrio fischeri (inhibition of bioluminescence), Phaeodactylum tricornutum (growth inhibition) and Ficopomatus enigmaticus (larval development success). Results showed nTiO2 to be the most toxic for P. tricornutum (EC50 0.043 mg L-1), while no effect was observed in A. fischeri and F. enigmaticus. EHMC was the most toxic to A. fischeri (EC50 0.868 mg L-1 (15 min) and 1.06 mg L-1 (30 min)) and the second most toxic to P. tricornutum. For F. enigmaticus, the lowest percentages of correct development resulted from 4-MBC exposure, with EC50 of 0.836 mg L-1. Overall, AVO induced low toxicity to every assessed species and OCTO was the least toxic for F. enigmaticus larvae. Considering the results obtained for F. enigmaticus, further larval development assays were performed with nZnO and EHMC under different light (light vs darkness) and temperature (20 and 25°C) conditions, showing higher percentages of correct development at 25°C, independently on light/darkness conditions. Under different temperature and photoperiod conditions, nZnO was more toxic than EHMC. Overall, nZnO and EHMC were among the most toxic UV filters tested and, when testing the effects of these UV-filters with temperature the results highlight that the impacts are liable to be lessened at higher temperatures (25°C compared with 20°C), in the case of this estuarine polychaete species. Nevertheless, further experiments are necessary to describe the effects of these two UV-filters at different organization levels, to study the toxicity of eventual degradation byproducts and to provide more information on the combination of different stressors. The experimental process involved the reaction of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate(cas: 6197-30-4).Electric Literature of 6197-30-4

The Article related to uv filter battery marine ecotoxicity, inhibition endpoints, inorganic nanoparticled-filters, larval development, organic filters, trophic levels, Toxicology: Chemicals (Household, Industrial, General) and other aspects.Electric Literature of 6197-30-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On September 15, 2022, Martin, Nicolas; Wassmur, Britt; Slomberg, Danielle; Labille, Jerome; Lammel, Tobias published an article.Safety of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate The title of the article was Influence of TiO2 nanocomposite UV filter surface chemistry and their interactions with organic UV filters on uptake and toxicity toward cultured fish gill cells. And the article contained the following:

Aquatic environments have been found to be contaminated with a variety of inorganic and organic UV filters. This includes novel nano-sized titanium dioxide (TiO2) composite particles, which have been increasingly developed and incorporated into com. sunscreens in recent years. So far, relatively little is known about the effects of this novel class of UV filters on aquatic life. Therefore, this study aimed to determine and compare the toxicity of three such nanoparticulate TiO2 UV filters with different surface coatings, namely Eusolex T-Avo (SiO2-coated), T-Lite SF (Al(OH)3/PDMS-coated), and Eusolex T-S (Al2O3/stearic acid-coated) either alone, or in the presence of selected organic UV filters (octinoxate, avobenzone, octocrylene), toward fish using RTgill-W1 cell cultures as an in vitro exptl. model. Besides standard exposure protocols, alternative approaches (i.e., exposure to water accommodated fractions (WAFs), hanging-drop exposure) were explored to account for nanoparticle (NP)-specific fate in the medium and obtain addnl./complementary information on their toxicity in different conditions. The AlamarBlue, CFDA-AM and Neutral Red Retention (NR) assays were used to measure effects on different cellular endpoints. Transmission electron microscopy (TEM) was used to examine NP uptake. Our results showed that none of the TiO2 NP UV filters were cytotoxic at the concentrations tested (0.1-10μg/mL; 24 h) but there were differences in their uptake by the cells. Thus, only the hydrophilic T-AVO was detected inside cells, but the hydrophobic T-Lite SF and T-S were not. In addition, our results show that the presence of NPs (or the used dispersant) tended to decrease organic UV filter toxicity. The level of combination effect depended on both NP-type (surface chem.) and concentration, suggesting that the reduced toxicity resulted from reduced availability of the organic UV filters due to their adsorption to the NP surface. Thus, mixtures of TiO2 NP UV filters and organic UV filters may have a different toxicol. profile compared to the single substances, but probably do not pose an increased hazard. The experimental process involved the reaction of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate(cas: 6197-30-4).Safety of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate

The Article related to titanium dioxide nanocomposite uv filter toxicity fish gill cell, ecotoxicity, interference, mixture, nanoparticle, sunscreen, in vitro, Toxicology: Chemicals (Household, Industrial, General) and other aspects.Safety of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Peng, Xianzhi; Zhu, Zewen; Xiong, Songsong; Fan, Yujuan; Chen, Guangshi; Tang, Caiming published an article in 2020, the title of the article was Tissue Distribution, Growth Dilution, and Species-Specific Bioaccumulation of Organic Ultraviolet Absorbents in Wildlife Freshwater Fish in the Pearl River Catchment, China.Recommanded Product: 6197-30-4 And the article contains the following content:

Tissue distributions and body-size dependent and species-specific bioaccumulation of 12 organic UV absorbents (UVAs) were investigated in 9 species of wildlife freshwater fish from the Pearl River catchment, South China. The concentrations of the 12 UVAs were from 109 to 2320 ng/g lipid weight in the fish tissue samples. The UVAs 2-hydroxy-4-methoxybenzophenone (BP-3), octocrylene (OCR), UV531, and 5 benzotriazole UV stabilizers (UVP, UV329, UV234, UV328, and UV327) were detected in more than half of the fish tissue samples. The UVA UV531 showed an obvious potential for bioaccumulation in the wild freshwater fish, with an estimated bioaccumulation factor (log BAF) and a biota-sediment accumulation factor (BSAF) of 4.54 ± 0.55 and 4.88 ± 6.78, resp. Generally, liver (989 ± 464 ng/g lipid weight) contained the highest level of UVAs, followed in decreasing order by belly fat (599 ± 318 ng/g lipid weight), swimming bladder (494 ± 282 ng/g lipid weight), dorsal muscle (470 ± 240 ng/g lipid weight), and egg (442 ± 238 ng/g lipid weight). The bioaccumulation of UVAs in the freshwater wild fish was species specific and compound dependent. Bottom-dwelling detritus-ingesting omnivorous fish contained obviously higher UVA concentrations, suggesting that detritus/sediment ingestion is a significant pathway for exposure of the wild freshwater fish to the UVAs. The UVAs UV531 and BP-3 demonstrated a potential for growth dilution Metabolism might play a significant role in elimination of the UVAs in the fish tissues, with the highest rate of metabolism in the liver. The UVAs did not demonstrate obvious trophic magnification in the freshwater ecosystem of the Pearl River catchment. More research is warranted to elucidate maternal transfer of the UVAs. Environ Toxicol Chem 2019;00:1-9. © 2019 SETAC. The experimental process involved the reaction of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate(cas: 6197-30-4).Recommanded Product: 6197-30-4

The Article related to bioaccumulation uv absorbent freshwater fish pearl river catchment china, bioaccumulation, bioaccumulative compounds, trophic transfer, Toxicology: Chemicals (Household, Industrial, General) and other aspects.Recommanded Product: 6197-30-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On June 30, 2009, Ren, Sumei; McNamara, Paul; Koharski, David; Hesk, David; Borges, Scott published an article.Category: esters-buliding-blocks The title of the article was Design and synthesis of sulfur-35 agents and their applications for protein labeling. And the article contained the following:

Two new 35S reagents were developed to radiolabel proteins. The first reagent, SMSB (I), acylates the ε-amino group of lysine residues in proteins. The second reagent, MSAPPA (II), labels lysine residues via reductive alkylation. Comparing the two methods, the reductive alkylation method labeled proteins over a broader pH range with higher overall radiochem. yield. More than ten monoclonal antibodies (mAbs) have been labeled with these 35S labeling reagents, the biol. activity of the mAbs was unchanged. The experimental process involved the reaction of tert-Butyl 4-((((benzyloxy)carbonyl)amino)methyl)benzoate(cas: 220851-46-7).Category: esters-buliding-blocks

The Article related to monoclonal antibody 35s radiolabeled preparation, radiolabel smsb msappa preparation acylation reductive alkylation lysine protein, Amino Acids, Peptides, and Proteins: Protein Synthesis and other aspects.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On October 19, 2018, Wang, Chunru; Wang, Taishan; Meng, Haibing published a patent.Application of 1312703-30-2 The title of the patent was Preparation of metallofullerene/photoactive MOF composite for applications in information storage and photovoltaic devices. And the patent contained the following:

The metallofullerene-photoactive MOF composite includes photoactive MOF and metallofullerene, wherein the metallofullerene mols. are entrapped in the photoactive MOF pores via host-guest π-π interaction. The photoactive MOF is a metal-organic framework with a three-dimensional ordered network structure constructed using carboxylate containing azobenzene group as ligand and metal ions as nodes. The experimental process involved the reaction of Dimethyl 2′-amino-[1,1′:4′,1”-terphenyl]-4,4”-dicarboxylate(cas: 1312703-30-2).Application of 1312703-30-2

The Article related to metallofullerene photoactive mof composite information storage photovoltaic device, Inorganic Chemicals and Reactions: Coordination Compounds and other aspects.Application of 1312703-30-2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Mieno, H.; Kabe, R.; Allendorf, M. D.; Adachi, C. published an article in 2018, the title of the article was Thermally activated delayed fluorescence of a Zr-based metal-organic framework.Safety of Dimethyl 2′-amino-[1,1′:4′,1”-terphenyl]-4,4”-dicarboxylate And the article contains the following content:

The 1st metal-organic framework exhibiting thermally activated delayed fluorescence (TADF) was developed. The Zr-based framework (UiO-68-dpa) uses a newly designed linker composed of a terphenyl backbone, an electron-accepting carboxyl group, and an electron-donating diphenylamine and exhibits green TADF emission with a photoluminescence quantum yield of 30% and high thermal stability. The experimental process involved the reaction of Dimethyl 2′-amino-[1,1′:4′,1”-terphenyl]-4,4”-dicarboxylate(cas: 1312703-30-2).Safety of Dimethyl 2′-amino-[1,1′:4′,1”-terphenyl]-4,4”-dicarboxylate

The Article related to zirconium aminoterphenyl mof preparation thermally activated delayed fluorescence, Inorganic Chemicals and Reactions: Coordination Compounds and other aspects.Safety of Dimethyl 2′-amino-[1,1′:4′,1”-terphenyl]-4,4”-dicarboxylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On July 31, 2022, Li, Huai-Ming; Li, Guan-Dong; Li, Jun-Yu; Zhang, Teng published an article.SDS of cas: 1312703-30-2 The title of the article was An Iodine-Functionalized Metal-Organic framework for catalytic alkene bromination. And the article contained the following:

An iodine-functionalized metal-organic framework (MOF), UiO-68-I, was synthesized. UiO-68-I showed good catalytic activity for dibromination of alkenes and alkynes with a low catalyst loading of 1% and was able to be recycled and recovered efficiently. Mechanistic studies suggest that UiO-68-I may trigger the formation of mol. bromine through a radical intermediate and thus accelerate the reaction. The activity and stability of UiO-68-I outperforms most earlier reports on organoiodine catalysts, showing the great potential of iodine-functionalized MOFs as recyclable heterogeneous hypervalent iodine reagents or catalysts. The experimental process involved the reaction of Dimethyl 2′-amino-[1,1′:4′,1”-terphenyl]-4,4”-dicarboxylate(cas: 1312703-30-2).SDS of cas: 1312703-30-2

The Article related to zirconium iodoterphenyldicarboxylate uio 68 mof preparation bromination catalyst, Inorganic Chemicals and Reactions: Coordination Compounds and other aspects.SDS of cas: 1312703-30-2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics