Tag: 200-300

Investigation of a new horizon antifungal activity with enhancing the antimicrobial efficacy of ciprofloxacin and its binary mixture via their encapsulation in nanoassemblies: in vitro and in vivo evaluation was written by Abou Taleb, Sally;Darwish, Asmaa Badawy;Abood, Amira;Mohamed, Amany M.. And the article was included in Drug Development Research in 2020.Name: Diphenyl carbonate The following contents are mentioned in the article:

The main goal of this study was to prepare and evaluate nanosponges containing ciprofloxacin (CIP) or its binary mixture with N-acetyl carnosine (NAC). Nanosponges were prepared by ultrasound-assisted synthesis technique using hydroxypropyl βeta-cyclodextrin (HPβ-CD), as the polymer and di-Ph carbonate (DPC) as the crosslinker. Entrapment efficiency (EE%) of CIP or its binary mixture with NAC in nanosponges was deduced spectrophotometrically. Nanosponges were characterized using several methods. EE% of CIP or its binary mixture with NAC inside nanosponges ranged from 98.63 ± 3.1 to 100 ± 0.07%. Particle size of nanosponges ranged from 66.7 to 90.1 nm. Release of drugs from nanosponges was biphasic and the release pattern followed Korsmeyer-Peppas model. Ex vivo and in vivo studies results showed that the antibacterial effect was enhanced with encapsulation of drugs in the nanosponge system. Furthermore, a potent antifungal activity was obtained from all examined formulas against Candida albicans (10231). The study revealed that successful encapsulation of CIP or its binary mixture with NAC in nanosponge formulations has innovated a new promising therapeutic activity for both drugs. This study involved multiple reactions and reactants, such as Diphenyl carbonate (cas: 102-09-0Name: Diphenyl carbonate).

Diphenyl carbonate (cas: 102-09-0) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Name: Diphenyl carbonate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Study on methods for the determination of acidity of 1,1,1,3,3,3-hexafluoroisopropyl methacrylate was written by Yang, Jian;Liu, Hongjian;Zhao, Weijuan;Sun, Xiaobo. And the article was included in Youjifu Gongye in 2015.Safety of 1,1,1,3,3,3-Hexafluoroisopropylmethacrylate The following contents are mentioned in the article:

HFIP-M is a colorless liquid, and its acidity has important influence on its quality. This article explored the methods for the determination of acidity of HFIP-M, adopted 3 kinds of commonly used method. The 3 alternations are: (1) Detection of end point by potential change, i.e., the titration performed by an automatic potentiometric titrator. (2) Visual detection of end point with indicators, and (3) acid in the sample was separated by extraction with water or saturated sodium chloride solution and the acidity determined by alkalimetric titration in the aqueous solution As shown by the exptl. results, for the first method, a clear and sharp inflection was observed potentiometrically at the finally point, and to avoid end point judgment error by the manual titration For the second method, among 3 different indicators tested, methylred was the best one, giving sharp colorchange at the end point, and the results is similar to potentiometric titration method. The last, by using saturated sodium chloride solutions extractant, the results can significantly improve the separation efficiency, however, results is low, and the whole anal. procedure was quite time-consuming and tedious. This study involved multiple reactions and reactants, such as 1,1,1,3,3,3-Hexafluoroisopropylmethacrylate (cas: 3063-94-3Safety of 1,1,1,3,3,3-Hexafluoroisopropylmethacrylate).

1,1,1,3,3,3-Hexafluoroisopropylmethacrylate (cas: 3063-94-3) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Safety of 1,1,1,3,3,3-Hexafluoroisopropylmethacrylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

A paradigm for the efficient synthesis of bio-based polycarbonate with deep eutectic solvents as catalysts by inhibiting the degradation of molecular chains was written by Wang, Weiwei;Yang, Zifeng;Zhang, Yaqin;He, Hongyan;Fang, Wenjuan;Zhang, Zhencai;Xu, Fei. And the article was included in Green Chemistry in 2021.Safety of Diphenyl carbonate The following contents are mentioned in the article:

In this study, an efficient catalytic system composed of deep eutectic solvents (DESs) was developed by adjusting the basicity of hydrogen bond donors (HBDs) to synthesize poly(isosorbide)carbonate (PIC) with high weight average mol. weight (Mw). It was demonstrated that the Mw of PIC prepared by using nearly neutral [EminOH]Cl-2EG was the highest. The results of the transesterification kinetics with different catalysts supported that the transesterification rate was significantly promoted as the basicity of DESs increased but their strong alkalinity inhibited the Mw of PIC. Therefore, the degradation of PIC was investigated to reveal the mechanism of the influence of basicity on the mol. weight of PIC. The strong alkalinity of DESs would cause the depolymerization of the macromol. chains and ultimately limit the mol. weight of the product, proving the exptl. fact that a near-neutral catalyst was more conducive to the Mw of PIC. Finally, a reasonable mechanism of synergistic catalysis was proposed based on 1H NMR spectroscopy, Fourier transform IR spectroscopy (FT-IR) and exptl. results. The metal-free, low-cost, high catalytic activity DES catalyst involved here is a practical candidate for advanced bio-based polycarbonate. This study involved multiple reactions and reactants, such as Diphenyl carbonate (cas: 102-09-0Safety of Diphenyl carbonate).

Diphenyl carbonate (cas: 102-09-0) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Safety of Diphenyl carbonate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Solubilization and changes of physicochemical properties of baicalin by nano sponge, and toxicity of zebrafish liver was written by Song, Jiawen;Long, Jiaying;Xie, Long;Sun, Qiang;Zhang, Linlin;Chen, Huijuan;Deng, Mao;Li, Xiaofang. And the article was included in Journal of Drug Delivery Science and Technology in 2020.HPLC of Formula: 102-09-0 The following contents are mentioned in the article:

As a new type of drug carrier, nano-sponge (NS) can remarkably improve the solubility of poorly soluble drug components, significantly increase the efficacy of drugs and their bioavailability. Baicalin (BA) has many biol. activities, such as anti-inflammatory, bacteriostatic and , etc. But due to its poor solubility, BA cannot play a role in the clinic. Therefore, it is urgent to find a suitable solubilization technol. to improve the solubility of BA. In this paper, we optimized the preparation process of NS based on β-cyclodextrin (β-CD), and then prepared the baicalin nano-sponges (BA-NS). The successful preparation of BA-NS was verified by modern anal. methods. BA loading capacity and efficiency (BLC and BLE), solubilizing effect, in vitro release rate and liver toxicity were investigated. The results showed that the BLC and BLE were 18.02 ± 0.36% and 86.64 ± 0.86%, solubility in water was 31 times than that of pure BA, and release rate in different media could reach 80%. Zebrafish liver toxicity test showed no obvious toxicity. The above results showed that NS had a significant solubilizing effect on BA and was safe and non-toxic, and proved that NS maybe have broad prospects in the research of poorly soluble drugs. This study involved multiple reactions and reactants, such as Diphenyl carbonate (cas: 102-09-0HPLC of Formula: 102-09-0).

Diphenyl carbonate (cas: 102-09-0) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.HPLC of Formula: 102-09-0

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

A designed experiment approach to optimizing the performance of benzoate and phthalate blends in flexible vinyl was written by Strepka, Arron M.;Arendt, William D.;Joshi, Makarand. And the article was included in Annual Technical Conference – Society of Plastics Engineers in 2007.Related Products of 5444-75-7 The following contents are mentioned in the article:

Plasticizer blends are commonly utilized to develop the desired processing and performance properties in flexible vinyl. To increase processing speeds, high solvating phthalates are typically included in these blends. Benzoate esters are high solvating plasticizers that can also be utilized for this purpose. However, the benzoate esters are not drop-in replacements for phthalates and other properties can be affected. An example of this is the increased viscosity commonly experienced in plastisols. The purpose of this paper is to demonstrate the use of designed experiment software to optimize the composition of general purpose and high solvating benzoate plasticizer blends to obtain all desired properties. A resilient flooring plastisol formulation was selected as the model. The following properties were measured on the plastisol: degassing, plastisol viscosity over a range of shear rates, viscosity stability of the plastisol and gelation/fusion characteristics. Stain resistance and tensile properties were evaluated on the fused vinyl film. The data will demonstrate the use of DOE software to develop an optimized plasticizer package that will deliver the desired balance of properties in an efficient and timely manner. This study involved multiple reactions and reactants, such as 2-Ethylhexyl benzoate (cas: 5444-75-7Related Products of 5444-75-7).

2-Ethylhexyl benzoate (cas: 5444-75-7) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Related Products of 5444-75-7

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

High-performance liquid chromatographic enantioseparation of fluorinated cyclic β³-amino acid derivatives on polysaccharide-based chiral stationary phases. Comparison with nonfluorinated counterparts was written by Lajko, Gyula;Orosz, Timea;Kiss, Lorand;Forro, Eniko;Fueloep, Ferenc;Peter, Antal;Ilisz, Istvan. And the article was included in Biomedical Chromatography in 2016.Quality Control of (1R,2R)-Ethyl 2-((tert-butoxycarbonyl)amino)cyclohexanecarboxylate The following contents are mentioned in the article:

The stereoisomers of five fluorinated cyclic β³-amino acid derivatives and their nonfluorinated counterparts were separated on chiral stationary phases containing as chiral selectors cellulose tris-(3,5-dimethylphenyl carbamate), cellulose tris-(3-chloro-4-methylphenyl carbamate), cellulose tris-(4-methylbenzoate), cellulose tris-(4-chloro-3-methylphenyl carbamate), amylose tris-(3,5-dimethylphenyl carbamate) or amylose tris-(5-chloro-2-methylphenyl carbamate). The enantioseparations were carried out in normal-phase mode with n-hexane/alc./alkylamine mobile phases in the temperature range 5-40 °C. The effects of the mobile phase composition, the nature and concentration of the alc. and alkylamine additives, the structures of the analytes and temperature on the separations were investigated. Thermodn. parameters were calculated from plots of ln a vs. 1/T. The Δ(ΔH°) values ranged between -5.0 and +1.6 kJ/mol, while Δ(ΔS°) varied between -12.6 and +5.7 J/mol/K. The enantioseparation was enthalpically controlled, the retention factor and the separation factor decreasing with increasing temperature, but entropically controlled separation was also observed The elution sequence was determined for all of the investigated analytes. This study involved multiple reactions and reactants, such as (1R,2R)-Ethyl 2-((tert-butoxycarbonyl)amino)cyclohexanecarboxylate (cas: 2361926-29-4Quality Control of (1R,2R)-Ethyl 2-((tert-butoxycarbonyl)amino)cyclohexanecarboxylate).

(1R,2R)-Ethyl 2-((tert-butoxycarbonyl)amino)cyclohexanecarboxylate (cas: 2361926-29-4) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Quality Control of (1R,2R)-Ethyl 2-((tert-butoxycarbonyl)amino)cyclohexanecarboxylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Aroma compounds in Chrysanthemum in different florescence and inflorescence parts and aroma releasing was written by Xu, Jin;Li, Yingying;Zheng, Chengshu;Wang, Chao;Yoo, Yongkweon. And the article was included in Xibei Zhiwu Xuebao in 2012.Application of 5444-75-7 The following contents are mentioned in the article:

Aroma components in ‘Jinba’ in different florescence and inflorescence parts were analyzed by Head Solid-phase Micro-extraction and GC/MS technol. The basic structure of the petal cell and the cross-section was observed by the biol. microscope. The results showed that there were 24 components identified at bud stage, 31 at early opening stage, 43 at full opening stage and 22 at declining period. With the flower blooming and senescence, the contents of ketones, terpenes and alcs. raised to the highest at full opening stage, and the contents of alkanes, aldehydes and heterocycles decreased. At full opening stage, there were 31 components identified in the ligulate flower and 50 in the tubular flower. The ligulate flower was probably the most important part that could influence the volatile releasing. The categories of the main aromatic components of ligulate flower in different parts were not change, but their contents were decreased from inner part to outer part. Isocyclocitral, eucalyptol, α-pinene, β-farnesene, and caryophyllene were the characteristic constituents of aroma. The results of microscopic observation showed that aroma was probably emitted from the intercellular space and the adaxial epidermis was the main releasing part. This study involved multiple reactions and reactants, such as 2-Ethylhexyl benzoate (cas: 5444-75-7Application of 5444-75-7).

2-Ethylhexyl benzoate (cas: 5444-75-7) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Application of 5444-75-7

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Study on titanates catalysts supported on silica gel and their application to esterification reaction was written by Wang, Xiaoling;Xu, Jiaye;Yang, Xueting. And the article was included in Xi’an Shiyou Daxue Xuebao, Ziran Kexueban in 2008.Category: esters-buliding-blocks The following contents are mentioned in the article:

The solid supporting catalysts-silica supporting titanates are synthesized by the reactions of titanium tetrachloride firstly with 2- ethylhexanol of different mole ratios and then with silica gel. The reaction conditions are optimized by orthogonal experiments The results show that the preferable conditions are as follows: the titanium tetrachloride to 2-ethylhexanol mole ratio of 1:3; the reaction temperature of 120°; the reaction time of 2 h; and the theoretic solid supporting rate of 20%. The content of titanium in the solid supporting titanate is measured, and the silica supporting catalysts are characterized by IR spectroscopy. The solid supporting catalysts of different amount are applied to the esterification reaction of benzoic acid with 2-ethylhexanol, and the catalysis effect of them is compared with that of titanate. It is found that the the activity of solid supporting catalysts is worse than that of titanate, but among the solid supporting catalysts, the solid supporting catalyst prepared by the titanium tetrachloride to 2-ethylhexanol mole ratio of 1:2 has the best catalyzing effect, and it has also higher activity after being used repeatedly 5 times, which shows the silica supporting catalyst has good stability. This study involved multiple reactions and reactants, such as 2-Ethylhexyl benzoate (cas: 5444-75-7Category: esters-buliding-blocks).

2-Ethylhexyl benzoate (cas: 5444-75-7) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Analysis of leaf volatiles from crabapple (Malus sp.) individuals of different juvenile lengths was written by Wu, Man;Shen, Xiang;Wang, Chao;Dong, Yan;Han, Tian-tian;Wang, Rong. And the article was included in Zhongguo Nongye Kexue (Beijing, China) in 2012.Quality Control of 2-Ethylhexyl benzoate The following contents are mentioned in the article:

The aim of this experiment was to analyze the leaf volatiles of crabapple (Malus sp.) individuals at different juvenile lengths, and obtain their particular leaf volatiles, and provide reference for finding out a new breeding method. Volatiles of leaves from eight different crabapple individuals were evaluated with the method of head space-solid phase micro-extraction and gas chromatog.-mass spectrometry (HS-SPME-GC-MS). Volatiles profiles of them were then compared. Eighty-four kinds of volatiles were detected with varied contents found in different individuals. The major leaf volatiles were 2-fluoro-acetamide, (Z)-3-Hexen-1-ol, di-Et phthalate and (Z)-3-Hexen-1-ol acetate. Ten identical compositions including 3,7-dimethyl-1,3,7-octatriene, decanal, di-Et phthalate, 2,6,10-trimethylpentadecane, 2,6,10-1-tetradecanol; 2,6,10,14-tetramethyl pentadecane, hexadecane, 1-dodecanol; 2,6,10,15-tetramethyl heptadecane and Phthalic acid, diisobutyl ester were detected. Leaf volatiles differ in eight crabapple individuals. But they are all based on esters and hydrocarbons and the highest content is 3-Hexen-1-ol, acetate. The specific volatiles in the precocious crabapple are (2Z)-2-Penten-1-ol, acetate (E)-cyclobutane, 1,3-butadienyl and 5,5-dibutylnonane. This study involved multiple reactions and reactants, such as 2-Ethylhexyl benzoate (cas: 5444-75-7Quality Control of 2-Ethylhexyl benzoate).

2-Ethylhexyl benzoate (cas: 5444-75-7) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Quality Control of 2-Ethylhexyl benzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Aroma profile and sensory properties of ultrasound-treated apple juice and nectar was written by Simunek, Marina;Jambrak, Anet Rezek;Petrovic, Marinko;Juretic, Hrvoje;Major, Nikola;Herceg, Zoran;Hruskar, Mirjana;Vukusic, Tomislava. And the article was included in Food Technology and Biotechnology in 2013.Product Details of 5444-75-7 The following contents are mentioned in the article:

Ultrasonication is a nonthermal food processing method that is used in several applications (extraction, treatment before drying, freezing, inactivation of microorganisms, etc.) in ultrasound processing. The objective of this study is to investigate the effect of high power ultrasound and pasteurization on the aroma profile and sensory properties of apple juice and nectar. Samples were treated according to the exptl. design, with high power sonicator at ultrasound frequency of 20 kHz under various conditions (treatment time: 3, 6 and 9 min, sample temperature: 20, 40 and 60 °C, and amplitude: 60, 90 and 120 μm). The aromatic profiles of juices showed that, compared to the untreated samples of juices and nectars, ultrasonic treatment led to the formation of new compounds (which were not present in the untreated samples) or to the disappearance of compounds that were found in the untreated samples. Samples treated at the highest amplitude (120 μm) were used for evaluation and comparison with untreated and pasteurized samples using electronic tongue study. Principal component anal. confirmed the results of electronic tongue study, which showed that the ultrasound-treated and pasteurized juices had different scores compared to the untreated samples. This study involved multiple reactions and reactants, such as 2-Ethylhexyl benzoate (cas: 5444-75-7Product Details of 5444-75-7).

2-Ethylhexyl benzoate (cas: 5444-75-7) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Product Details of 5444-75-7

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics