Tag: 200-300

Production of 12-hydroxy dodecanoic acid methyl ester using a signal peptide sequence-optimized transporter AlkL and a novel monooxygenase was written by Yoo, Hee-Wang;Kim, Joonwon;Patil, Mahesh D.;Park, Beom Gi;Joo, Sung-yeon;Yun, Hyungdon;Kim, Byung-Gee. And the article was included in Bioresource Technology in 2019.Name: 12-Methoxy-12-oxododecanoic acid This article mentions the following:

In this study, a signal peptide of AlkL was replaced with other signal peptides to improve the soluble expression and thereby facilitate the transport of dodecanoic acid Me ester (DAME) substrate into the E. coli. Consequently, AlkL with signal peptide FadL (AlkL_f) showed higher transport activity toward DAME. Furthermore, the promoter optimization for the efficient heterologous expression of the transporter AlkL_f and alkane monooxygenase (AlkBGT) system was conducted and resulted in increased ω-oxygenation activity of AlkBGT system. Moreover, bioinformatic studies led to the identification of novel monooxygenase from Pseudomonas pelagia (Pel), which exhibited 20% higher activity towards DAME as substrate compared to AlkB. Finally, the construction of a chimeric transporter and the expression of newly identified monooxygenaseenabled the production of 44.8 ± 7.5 mM of 12-hydroxy dodecanoic acid Me ester (HADME) and 31.8 ± 1.7 mM of dodecanedioic acid monomethyl ester (DDAME) in a two-phase reaction system. In the experiment, the researchers used many compounds, for example, 12-Methoxy-12-oxododecanoic acid (cas: 3903-40-0Name: 12-Methoxy-12-oxododecanoic acid).

12-Methoxy-12-oxododecanoic acid (cas: 3903-40-0) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Name: 12-Methoxy-12-oxododecanoic acid

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

A highly porous NbO type metal-organic framework constructed from an expanded tetracarboxylate was written by Cai, Jianfeng;Rao, Xingtang;He, Yabing;Yu, Jancan;Wu, Chuande;Zhou, Wei;Yildirim, Taner;Chen, Banglin;Qian, Guodong. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2014.Name: Dimethyl 5-ethynylisophthalate This article mentions the following:

A novel NbO type microporous metal-organic framework Cu₂L (ZJU-32 (5); H₄L (4) = 5′-((3,5-dicarboxyphenyl)ethynyl)-[1,1′:3′,1”-terphenyl]-4,4”-dicarboxylic acid) constructed from an elaborately designed tetratopic ligand was solvothermally synthesized and structurally characterized. The activated ZJU-32a exhibits high permanent porosity with the Brunauer-Emmett-Teller (BET) surface area of 3831 m² g^-1 and the pore volume of 1.482 cm³ g^-1, enabling it to be a promising material for both methane storage and carbon dioxide capture at room temperature In the experiment, the researchers used many compounds, for example, Dimethyl 5-ethynylisophthalate (cas: 313648-56-5Name: Dimethyl 5-ethynylisophthalate).

Dimethyl 5-ethynylisophthalate (cas: 313648-56-5) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Name: Dimethyl 5-ethynylisophthalate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Shifting Sol-Gel Phase Diagram of a Doubly Thermosensitive Hydrophilic Diblock Copolymer Poly(methoxytri(ethylene glycol) acrylate-co-acrylic acid)-b-poly(ethoxydi(ethylene glycol) acrylate-co-acrylic acid) in Aqueous Solution was written by Jin, Naixiong;Zhang, Hao;Jin, Shi;Dadmun, Mark D.;Zhao, Bin. And the article was included in Macromolecules (Washington, DC, United States) in 2012.Formula: C14H12S2 This article mentions the following:

This article reports that the C-shaped sol-gel phase diagram of a doubly thermosensitive hydrophilic diblock copolymer with each block containing a small amount of weak acid groups in aqueous solution in the moderate concentration range can be readily and reversibly shifted by changing the solution pH. The diblock copolymer, poly(methoxytri(ethylene glycol) acrylate-co-acrylic acid)-b-poly(ethoxydi(ethylene glycol) acrylate-co-acrylic acid) (P(TEGMA-co-AA)-b-P(DEGEA-co-AA)), was synthesized by reversible addition-fragmentation chain transfer polymerization and postpolymn. modification. A 20 wt % aqueous solution of P(TEGMA-co-AA)-b-P(DEGEA-co-AA) with pH of 3.29 underwent sol-to-gel, gel-to-sol, and clear sol-to-cloudy sol transitions at 17° (T_sol-gel), 38° (T_gel-sol), and 55° (T_clouding), resp., upon heating. With the increase of pH, all transition temperatures shifted to high values; for instance, the T_sol-gel, T_gel-sol, and T_clouding were 20, 45, and 63°, resp., at pH = 5.10, and 28, 52, and 77°, resp., at pH = 5.79. Using vial inversion tests, we mapped out sol-gel phase diagrams of the diblock copolymer in aqueous solutions at three pH values (3.29, 5.10, and 5.79, measured at ∼0°); the whole sol-gel phase diagram shifted upward with the increase of pH. When the pH was lowered from 5.79 to 5.10, the diagram shifted back, though there was a 1° difference at each selected concentration, compared with the original curve of pH = 5.10. The tunability of sol-gel-sol-clouding transitions stemmed from the pH dependences of thermosensitive properties of two blocks, which were confirmed by a dynamic light scattering study. The results from small-angle X-ray scattering experiments indicated that spherical micelles of P(TEGMA-co-AA)-b-P(DEGEA-co-AA) in 20 wt % aqueous solutions at selected pH and temperatures were packed into crystalline structures, either body-centered cubic or face-centered cubic, in the gel states. In the experiment, the researchers used many compounds, for example, Benzyl benzodithioate (cas: 27249-90-7Formula: C14H12S2).

Benzyl benzodithioate (cas: 27249-90-7) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Formula: C14H12S2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Large pores generated by the combination of different inorganic units in a zinc hydroxide ethynylene diisophthalate MOF was written by Hausdorf, Steffen;Seichter, Wilhelm;Weber, Edwin;Mertens, Florian O. R. L.. And the article was included in Dalton Transactions in 2009.Safety of Dimethyl 5-ethynylisophthalate This article mentions the following:

A 5,5′-ethynylenediisophthalic acid linker mol. was synthesized and used to form a zinc carboxylate-based metal organic framework (MOF) with very large pores and unit cell volume resulting from the unusual combination of structurally different inorganic units forming the secondary building blocks (SBUs). The structure is the first zinc hydroxide carboxylate structure where the inorganic units do not form layers or ribbons but isolated islands. The structure forms true pores with a significantly narrowed pore entry similar to zeolites. The pores are, thus, not created simply by intersecting channels as in most other MOF structures. Although the pore shape is highly asym. the spherical free volume is with 10.8 Å still large. The stability of the SBUs in respect to exchange and removal of coordinated solvent mols. was studied. In the experiment, the researchers used many compounds, for example, Dimethyl 5-ethynylisophthalate (cas: 313648-56-5Safety of Dimethyl 5-ethynylisophthalate).

Dimethyl 5-ethynylisophthalate (cas: 313648-56-5) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Safety of Dimethyl 5-ethynylisophthalate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chemistry of nitro esters. XVII. Production of mesoxalic acid esters was written by Kochergin, P. M.;Titkova, R. M.. And the article was included in Zhurnal Organicheskoi Khimii in 1994.Name: malonic acid dibutyl ester This article mentions the following:

The preparation of mesoxalic acid esters from monobromomalonates and silver nitrate is described. Thus, bromination of di-Et malonate gave 85% di-Et bromomalonate (I) and 4% di-Et dibromomalonate. I with AgNO₃ in anhydrous EtOH gave AgBr and 77% di-Et mesoxalate via intermediate O₂NOCH(CO₂Et)₂. In the experiment, the researchers used many compounds, for example, malonic acid dibutyl ester (cas: 1190-39-2Name: malonic acid dibutyl ester).

malonic acid dibutyl ester (cas: 1190-39-2) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Name: malonic acid dibutyl ester

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Identification of a series of substituted 2-piperazinyl-5-pyrimidylhydroxamic acids as potent histone deacetylase inhibitors was written by Angibaud, Patrick;Van Emelen, Kristof;Decrane, Laurence;van Brandt, Sven;ten Holte, Peter;Pilatte, Isabelle;Roux, Bruno;Poncelet, Virginie;Speybrouck, David;Queguiner, Laurence;Gaurrand, Sandrine;Marien, Ann;Floren, Wim;Janssen, Lut;Verdonck, Marc;van Dun, Jacky;van Gompel, Jacky;Gilissen, Ron;Mackie, Claire;Du Jardin, Marc;Peeters, Jozef;Noppe, Marc;Van Hijfte, Luc;Freyne, Eddy;Page, Martin;Janicot, Michel;Arts, Janine. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2010.Synthetic Route of C10H20N2O3 This article mentions the following:

Pursuing our efforts in designing 5-pyrimidylhydroxamic acid anti-cancer agents, we have identified a new series of potent histone deacetylase (HDAC) inhibitors. These compounds exhibit enzymic HDAC inhibiting properties with IC₅₀ values in the nanomolar range and inhibit tumor cell proliferation at similar levels. Good solubility, moderate bioavailability, and promising in vivo activity in xenograft model made this series of compounds interesting starting points to design new potent HDAC inhibitors. In the experiment, the researchers used many compounds, for example, tert-Butyl (morpholin-2-ylmethyl)carbamate (cas: 173341-02-1Synthetic Route of C10H20N2O3).

tert-Butyl (morpholin-2-ylmethyl)carbamate (cas: 173341-02-1) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Synthetic Route of C10H20N2O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Efficient synthesis of NIR emitting bis[2-(2′-hydroxylphenyl)benzoxazole] derivative and its potential for imaging applications was written by Wang, Junfeng;Baumann, Hannah;Bi, Xiaoman;Shriver, Leah P.;Zhang, Zhaoda;Pang, Yi. And the article was included in Bioorganic Chemistry in 2020.Name: Methyl 5-methoxy-2-nitrobenzoate This article mentions the following:

Unassymetric bis[2-(2′-hydroxyphenylbenzoxole)] bis(HBO) derivatives with a DPA functionality for zinc binding have been developed with an efficient synthetic route, using the retrosynthetic anal. Comparison of bis(HBO) derivatives with different substitution patterns allows us to verify and optimize their unique fluorescence properties. Upon binding zinc cation, bis(HBO) derivatives give a large fluorescence turn-on in both visible (λ_em ≈ 536 nm) and near-IR (NIR) window (λ_em ≈ 746 nm). The probes are readily excitable by a 488 nm laser, making this series of compounds a suitable imaging tool for in vitro and in vivo study on a confocal microscope. The application of zinc binding-induced fluorescence turn-on is successfully demonstrated in cellular environments and thrombus imaging. In the experiment, the researchers used many compounds, for example, Methyl 5-methoxy-2-nitrobenzoate (cas: 2327-45-9Name: Methyl 5-methoxy-2-nitrobenzoate).

Methyl 5-methoxy-2-nitrobenzoate (cas: 2327-45-9) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Name: Methyl 5-methoxy-2-nitrobenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Novel intramolecular two-substituent migration accompanying indenoquinolone formation was written by Staskun, B.. And the article was included in Tetrahedron in 1972.Quality Control of Ethyl 3-oxo-3-(m-tolyl)propanoate This article mentions the following:

Cyclization of 2,2,4′-trichloro-2′,5′-dimethyl-2-benzoylacetanilide and 2,2,2′,4′-tetrachloro-3′,5′-dimethyl-2-benzoylacetanilide by concentrated H2SO4 gave 1,5-dichloro-4,6-dimethylindeno[1,2,3-de]quinolin-2(3H)-one and 1,4,6-trichloro-5-methyl-7H-dibenz[f,ij]-isoquinolin-2(3H)-one (II), resp. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(m-tolyl)propanoate (cas: 33166-79-9Quality Control of Ethyl 3-oxo-3-(m-tolyl)propanoate).

Ethyl 3-oxo-3-(m-tolyl)propanoate (cas: 33166-79-9) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Quality Control of Ethyl 3-oxo-3-(m-tolyl)propanoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Effect of dicarboxylic acid esters on selective transfer under friction was written by Chigarenko, G. G.;Ponomarenko, A. G.;Barchan, G. P.;Belevantseva, Z. P.. And the article was included in Khimiya i Tekhnologiya Topliv i Masel in 1984.Product Details of 1190-39-2 This article mentions the following:

The addition of dialkyl dicarboxylic acid esters to lubricating oils increase the maximum loading stress before the start of rapid wear (P) and decreases both the friction coefficient (f) and wear (w, 5 h at 0.8 m/s sliding rate, steel 45/bronze bearing). Thus, P,f, and w of a Soviet industrial oil were 19 MPa, 0.096, and 0.0234 g, resp., but when the oil contained 30% dinonyl adipate (I) [151-32-6] P,f, and w became 54 MPa, 0.010, and 0.0017 g, resp. Similar, but less pronounced, lubricity improvement was obtained when instead of I lower mol. diesters were added to the oil. A spectroscopic examination of the spent, I-containing, oil identified copper adipate  [50603-05-9]. Thus, the diesters form salt films on the bearing surfaces. In the experiment, the researchers used many compounds, for example, malonic acid dibutyl ester (cas: 1190-39-2Product Details of 1190-39-2).

malonic acid dibutyl ester (cas: 1190-39-2) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Product Details of 1190-39-2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Optimization of a Novel Series of Ataxia-Telangiectasia Mutated Kinase Inhibitors as Potential Radiosensitizing Agents was written by Min, Jaeki;Guo, Kexiao;Suryadevara, Praveen K.;Zhu, Fangyi;Holbrook, Gloria;Chen, Yizhe;Feau, Clementine;Young, Brandon M.;Lemoff, Andrew;Connelly, Michele C.;Kastan, Michael B.;Guy, R. Kiplin. And the article was included in Journal of Medicinal Chemistry in 2016.Recommanded Product: Methyl 5-methoxy-2-nitrobenzoate This article mentions the following:

We previously reported a novel inhibitor of the ataxia-telangiectasia mutated (ATM) kinase, which is a target for novel radiosensitizing drugs. While our initial lead, compound 4, was relatively potent and nontoxic, it exhibited poor stability to oxidative metabolism and relatively poor selectivity against other kinases. The current study focused on balancing potency and selectivity with metabolic stability through structural modification to the metabolized site on the quinazoline core. We performed extensive structure-activity and structure-property relationship studies on this quinazoline ATM kinase inhibitor in order to identify structural variants with enhanced selectivity and metabolic stability. We show that, while the C-7-methoxy group is essential for potency, replacing the C-6-methoxy group considerably improves metabolic stability without affecting potency. Promising analogs 20, 27g, and 27n were selected based on in vitro pharmacol. and evaluated in murine pharmacokinetic and tolerability studies. Compound 27g possessed significantly improve pharmacokinetics relative to that of 4. Compound 27g was also significantly more selective against other kinases than 4. Therefore, 27g is a good candidate for further development as a potential radiosensitizer. In the experiment, the researchers used many compounds, for example, Methyl 5-methoxy-2-nitrobenzoate (cas: 2327-45-9Recommanded Product: Methyl 5-methoxy-2-nitrobenzoate).

Methyl 5-methoxy-2-nitrobenzoate (cas: 2327-45-9) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Recommanded Product: Methyl 5-methoxy-2-nitrobenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics