Tag: 200-300

Synthesis and Antileukemia Activity Evaluation of Benzophenanthridine Alkaloid Derivatives was written by Tang, Yaling;Xu, Xinglian;Li, Jiang;Deng, Lulu;Mu, Shuzhen. And the article was included in Molecules in 2022.Reference of 1190-39-2 This article mentions the following:

Thirty_–three benzophenanthridine alkaloid derivatives (1a_–1u and 2a_–2l) were synthesized, and their cytotoxic activities against two leukemia cell lines (Jurkat Clone E6_–1 and THP_–1) were evaluated in vitro using a Cell Counting Kit_–8 (CCK_–8) assay. Nine of these derivatives (1i_–l, 2a, and 2i_–l) with IC₅₀ values in the range of 0.18_–7.94 μM showed significant inhibitory effects on the proliferation of both cancer cell lines. Anal. of the primary structure_–activity relationships revealed that different substituent groups at the C_–6 position might have an effect on the antileukemia activity of the corresponding compounds In addition, the groups at the C_–7 and C_–8 positions could influence the antileukemia activity. Among these compounds, 2j showed the strongest in vitro antiproliferative activity against Jurkat Clone E6_–1 and THP_–1 cells with good IC50 values (0.52 ± 0.03 μM and 0.48 ± 0.03 μM, resp.), slightly induced apoptosis, and arrested the cell-cycle, all of which suggests that compound 2j may represent a potentially useful start point to undergo further optimization toward a lead compound In the experiment, the researchers used many compounds, for example, malonic acid dibutyl ester (cas: 1190-39-2Reference of 1190-39-2).

malonic acid dibutyl ester (cas: 1190-39-2) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Reference of 1190-39-2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthesis of water-soluble azomethines based on the substituted benzaldehydes of vanillin series and D-(+)-glucosamine hydrochloride was written by Dikusar, E. A.;Potkin, V. I.;Kozlov, N. G.. And the article was included in Russian Journal of General Chemistry in 2009.Computed Properties of C12H14O4 This article mentions the following:

A preparative method for the synthesis of water-soluble azomethines by the reaction of substituted benzaldehydes of vanillin series with D-(+)-glucosamine hydrochloride in the presence of potassium hydrogen carbonate in methanol was developed. In the experiment, the researchers used many compounds, for example, 4-Formyl-2-methoxyphenyl isobutyrate (cas: 20665-85-4Computed Properties of C12H14O4).

4-Formyl-2-methoxyphenyl isobutyrate (cas: 20665-85-4) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Computed Properties of C12H14O4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthesis and crystallization of poly(butylenes succinate-block-butylene sebacate) was written by Kang, Zonghua;Wang, Changlu. And the article was included in Advanced Materials Research (Durnten-Zurich, Switzerland) in 2013.Recommanded Product: Dimethyl decanedioate This article mentions the following:

A series of aliphatic biodegradable poly(butylene succinate-block-butylene sebacate) (PBSuBSe) copolyesters were synthesized by incorporation of PBS_e into the PBS_u mol. chains. The mol. weight, crystallization behaviors and the crystal structure of the copolyesters were investigated by using gel permeation chromatog. (GPC), differential scanning calorimetry (DSC) and wide angle X-ray diffraction (WAXD), resp. The copolyesters might be potentially useful as the biodegradable materials. In the experiment, the researchers used many compounds, for example, Dimethyl decanedioate (cas: 106-79-6Recommanded Product: Dimethyl decanedioate).

Dimethyl decanedioate (cas: 106-79-6) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Recommanded Product: Dimethyl decanedioate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Biological characteristics of Edgeworthia tomentosa (Thunb.) Nakai flowers and antimicrobial properties of their essential oils was written by Sun, Yanfang;Wang, Zhangqi;Li, Boqi;Sharopov, Farukh S.;Wang, Pan;Suen, Yang;Liang, Zongsuo. And the article was included in Natural Product Research in 2018.COA of Formula: C12H14O4 This article mentions the following:

Edgeworthia tomentosa (Thunb.) Nakai belongs to Thymelaeaceae family, its alabastrum is used as the traditional Chinese medicine ‘Buddleja Officinalis Maxim’. The present study was to elucidate the ultrastructure characteristics of the flower, the phytochem. composition of the aroma essential oils (EOs) and the relevant antimicrobial properties. There were exclusive characters of calyx, ovule, anther and pollen grain of the flowers under SEM. A total of 40 phytochem. components representing 98% of the EOs were successfully identified: monoterpenes and sesquiterpenes were the dominant terpenoids according to Kovats retention index and MS database. EOs exhibited a broad spectrum antimicrobial activity against Gram-pos. and Gram-neg. bacteria, the best bacteriostatic effect was against Diplococcus pneumonia with MIC and MBC values ranging between 7.8 and 62.5 and 26.0-71.0 μg/mL, resp. These results demonstrate that the surface microscopic morphol. characteristics of Edgeworthia chrysantha Lindl. flowers, are full-scale chem. composition and antimicrobial properties of the EOs. In the experiment, the researchers used many compounds, for example, 4-Formyl-2-methoxyphenyl isobutyrate (cas: 20665-85-4COA of Formula: C12H14O4).

4-Formyl-2-methoxyphenyl isobutyrate (cas: 20665-85-4) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.COA of Formula: C12H14O4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Quantitative analysis of headspace volatile compounds using comprehensive two-dimensional gas chromatography and their contribution to the aroma of Chardonnay wine was written by Welke, Juliane Elisa;Zanus, Mauro;Lazzarotto, Marcelo;Alcaraz Zini, Claudia. And the article was included in Food Research International in 2014.Quality Control of Dimethyl decanedioate This article mentions the following:

The quant. determination of volatile compounds of Chardonnay wines using HS-SPME-GC × GC/TOFMS along with the determination of odor activity value (OAV) and relative odor contribution (ROC) of volatiles are reported for the first time. The use of GC × GC/TOFMS for the anal. of Chardonnay wine of Serra Gaucha resulted in the tentative identification of 243 compounds, showing the superior performance of this anal. technique for this specific varietal wine, considering that the number of compounds usually separated by 1D-GC for this type of wine is lower. Furthermore, 42 compounds co-eluted in the first dimension and 34 of them were separated in the second dimension, while the others were resolved by spectral deconvolution (8), which indicates that the conventional 1D-GC/MS may result in misleading results. The calculation of OAV and ROC allowed the determination of the volatile compounds that presented the greater contribution to wine aroma. Et octanoate, Et hexanoate, Et butanoate, and beta-damascenone showed the highest OAV and ROC values, although other 43 compounds showed also potential to contribute to wine aroma. Figures of merit of the developed method were: accuracies from 92.4 to 102.6%, repeatability from 1.2% to 13.4%, LOD from 0.001 μg L^– 1 (Et isovalerate and hexanoic acid) to 2.554 μg L^– 1 (Et 3-hydroxybutanoate), LOQ from 0.003 μg L^– 1 (Et isovalerate and hexanoic acid) to 7.582 μg L^– 1 (Et 3-hydroxybutanoate). In the experiment, the researchers used many compounds, for example, Dimethyl decanedioate (cas: 106-79-6Quality Control of Dimethyl decanedioate).

Dimethyl decanedioate (cas: 106-79-6) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Quality Control of Dimethyl decanedioate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Construction of isoxazolone-fused phenanthridines via Rh-catalyzed cascade C-H activation/cyclization of 3-arylisoxazolones with cyclic 2-diazo-1,3-diketones was written by Hu, Wangcheng;He, Xinwei;Zhou, Tongtong;Zuo, Youpeng;Zhang, Shiwen;Yang, Tingting;Shang, Yongjia. And the article was included in Organic & Biomolecular Chemistry in 2021.HPLC of Formula: 33166-79-9 This article mentions the following:

A Rh(III)-catalyzed cascade C-H activation/intramol. cyclization of 3-aryl-5-isoxazolones with cyclic 2-diazo-1,3-diketones was described, leading to the formation of isoxazolo[2,3-f]phenanthridine skeletons I [R¹ = 4-Me, 5-Br, 6-MeO, etc.; R² = H, Me; R³ = H, Me, Ph]. The protocol featured the simultaneous one-pot formation of two new C-C/C-N bonds and one heterocycle in moderate-to-good yields with good functional group compatibility. It was amenable to large-scale synthesis and further transformation. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(m-tolyl)propanoate (cas: 33166-79-9HPLC of Formula: 33166-79-9).

Ethyl 3-oxo-3-(m-tolyl)propanoate (cas: 33166-79-9) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.HPLC of Formula: 33166-79-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Click chemistry-based synthesis and anticancer activity evaluation of novel C-14 1,2,3-triazole dehydroabietic acid hybrids was written by Hou, Wei;Luo, Zhi;Zhang, Guanjun;Cao, Danhui;Li, Di;Ruan, Haoqiang;Ruan, Benfang Helen;Su, Lin;Xu, Hongtao. And the article was included in European Journal of Medicinal Chemistry in 2017.Related Products of 185619-66-3 This article mentions the following:

A concise and efficient synthetic approach has been established to readily access a series of novel C-14 1,2,3-triazole-tethered dehydroabietic acid derivatives in moderate to high yields. In vitro antiproliferative activity evaluation indicated that most of the hybrids exhibited potent inhibitory activities in a variety of cancer cell lines with low micromolar to submicromolar IC₅₀ values. Further studies demonstrated that some of these analogs were also effective against adriamycin-resistant MCF-7 clone at low concentrations in a dose-dependent manner. Notably, the most potent compound I, which possesses a 3-(tert-butoxycarbonylamino)phenyl-substituted triazole moiety, not only exhibited obviously improved IC₅₀ values ranging from 0.7 to 1.2 μM against a panel of tested cancer cells, but also showed very weak cytotoxicity on normal cells. Preliminary mechanism studies indicated that compound I could induce apoptosis in MDA-MB-231 cells and was worth developing into a novel natural product-like anticancer lead by proper structure modification. In the experiment, the researchers used many compounds, for example, tert-Butyl (3-ethynylphenyl)carbamate (cas: 185619-66-3Related Products of 185619-66-3).

tert-Butyl (3-ethynylphenyl)carbamate (cas: 185619-66-3) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Related Products of 185619-66-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Two Competitive but Switchable Organocatalytic Cascade Reaction Pathways: The Diversified Synthesis of Chiral Acetal-Containing Bridged Cyclic Compounds was written by Lv, Xue-Jiao;Chen, Ying-Han;Liu, Yan-Kai. And the article was included in Organic Letters in 2019.Related Products of 33166-79-9 This article mentions the following:

β-Keto esters such as Et benzoylacetate underwent α-oxidation with mCPBA followed by base-mediated Michael addition to hydroxy- or amino-substituted cinnamaldehydes such as trans-o-hydroxycinnamaldehyde, cyclization in the presence of a proline-derived silyl ether, and acetalization in the presence of BF₃·Et₂O to yield methanobenzodioxepines such as I. The sequence avoids the isolation of unstable α-hydroxy-β-keto esters which oxidize to diketo esters on attempted isolation. Reaction of β-keto esters and hydroxy-substituted cinnamaldehydes with omission of mCPBA under similar conditions and yielded benzodioxocinecarboxylates such as II. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(m-tolyl)propanoate (cas: 33166-79-9Related Products of 33166-79-9).

Ethyl 3-oxo-3-(m-tolyl)propanoate (cas: 33166-79-9) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Related Products of 33166-79-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthesis of 4-hydroxy(alkyloyloxy,aryloyloxy)-3-methoxy(ethoxy)phenylmethylene-(2-carboxyphenyl)amines was written by Dikusar, E. A.;Kozlov, N. G.;Potkin, V. I.;Zelenkovskii, V. M.;Malama, A. A.;Dubovik, S. V.. And the article was included in Vestsi Natsyyanal’nai Akademii Navuk Belarusi, Seryya Khimichnykh Navuk in 2005.Reference of 20665-85-4 This article mentions the following:

Schiff bases of general formula 3-R¹O-4-R²OC₆H₃CH:NC₆H₄CO₂H-2 (R¹ = Me, Et; R² = H, MeCO, H₂C:CHCO, 2-ClC₆H₄CO, etc.) were synthesized by condensation of the corresponding 3,4-disubstituted benzaldehydes with 2-aminobenzoic acid. The products were obtained as mixtures of E- and Z-isomers in the 3:2 ratio. The formation enthalpies for both E- and Z-isomers of some of the products were calculated using semiempirical MNDO-PM3 approach confirming the better thermodn. stability of the E-isomers. In the experiment, the researchers used many compounds, for example, 4-Formyl-2-methoxyphenyl isobutyrate (cas: 20665-85-4Reference of 20665-85-4).

4-Formyl-2-methoxyphenyl isobutyrate (cas: 20665-85-4) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Reference of 20665-85-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthesis and Hierarchical Self-Assembly of Diphenylalanine-Based Homopolymer and Copolymers By RAFT Polymerization was written by Yonenuma, Ryo;Ishizuki, Ai;Nakabayashi, Kazuhiro;Mori, Hideharu. And the article was included in Journal of Polymer Science, Part A: Polymer Chemistry in 2019.Application In Synthesis of Benzyl benzodithioate This article mentions the following:

Dipeptide diphenylalanine has attracted significant research interests because of its ability to self-assemble into various nanostructures such as nanotubes, nanowires, and nanoribbons. In this article, we present the synthesis and self-assembly of a novel diphenylalanine-based homopolymer and block/random copolymers by the reversible addition-fragmentation chain transfer (RAFT) polymerization of an acrylamide having a dipeptide moiety. The RAFT polymerization of N-acryloyl-L,L-diphenylalanine (A-Phe-Phe-OH) afforded novel amino acid-based polymers with predetermined mol. weights and relatively narrow-mol. weight distributions. The hierarchical self-assembled structures of poly(A-Phe-Phe-OH), which involve nanorods, larger nanofiber-like microcrystals, and fiber bundles, were characterized by at. force microscopy (AFM), transmission electron microscopy, SEM, and dynamic light scattering measurements. The circular dichroic measurements of poly(A-Phe-Phe-OH) revealed its characteristic chiroptical property, which is affected by the nature of the solvents and the addition of urea and salts via hydrophobic, hydrogen bonding, and electrostatic interactions. Thermo- and pH-responsive block and random copolymers composed of A-Phe-Phe-OH and N-isopropylacrylamide were synthesized by RAFT polymerization, and the thermoresponsive properties and assembled structures of the resulting copolymers were investigated by AFM and turbidity measurements. In the experiment, the researchers used many compounds, for example, Benzyl benzodithioate (cas: 27249-90-7Application In Synthesis of Benzyl benzodithioate).

Benzyl benzodithioate (cas: 27249-90-7) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Application In Synthesis of Benzyl benzodithioate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics