Tag: 200-300

Extractables from integrated single-use systems in biopharmaceutical manufacturing. Part I. Study on components (Pall Kleenpak connector and Kleenpak filter capsule) was written by Ding, Weibing;Nash, Rebecca. And the article was included in PDA Journal of Pharmaceutical Science and Technology in 2009.Product Details of 1190-39-2 This article mentions the following:

Single-use systems for manufacturing biopharmaceuticals can include filter capsules, connectors, tubing, and polymeric film biocontainers. In order to tackle the variety of extractable compounds from these fairly complex systems, we first studied such systems’ representative components, and then examined an entire single-use system comprised of filters, connectors, tubing, and biocontainers. This approach greatly simplifies the identification of the extractable compounds from the whole system. The test design was based on common, actual processes conducted under worst-case conditions. Part 1 of this series of papers describes a systematic study of extractables from two components, a sterile connector and a capsule filter, in water and ethanol as model solvent extractants. The complete extractables results were obtained using a combination of qualified anal. methods. The results indicated that the potential for the connector and the capsule filter to release leachable materials in significant amounts into the chem. compatible drug product is very low, taking into account the less vigorous conditions in most processes and dilution effects when compared to the water and ethanol extraction conditions reported here. Application of study results is discussed. In the experiment, the researchers used many compounds, for example, malonic acid dibutyl ester (cas: 1190-39-2Product Details of 1190-39-2).

malonic acid dibutyl ester (cas: 1190-39-2) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Product Details of 1190-39-2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Liquid-crystalline symmetric triblock copolymers was written by Ivanov, M. G.;Boiko, N. I.;Chernikova, E. V.;Richardson, R.;Zhu, X.-M.;Shibaev, V. P.. And the article was included in Polymer Science, Series A in 2011.Safety of Benzyl benzodithioate This article mentions the following:

Sym. fully liquid-crystalline triblock copolymers of various structures containing optically active mesogenic groups are for the first time synthesized via pseudo-living radical reversible addition-fragmentation chain-transfer polymerization Their phase behavior and physicochem. and optical properties are studied. It is shown that, depending on composition, at low temperatures block copolymers can form at temperatures phase-separated structures caused by microsegregation of blocks of different chem. natures and that, with an increase in temperature, these structures can mix to form a cholesteric mesophase characterized by a helical supramol. structure. A model illustrating the mol. packing of block copolymers with a phase-separated lamellar structure is advanced. The effect of the mol. structure of the block copolymers on their optical properties is discussed. In the experiment, the researchers used many compounds, for example, Benzyl benzodithioate (cas: 27249-90-7Safety of Benzyl benzodithioate).

Benzyl benzodithioate (cas: 27249-90-7) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Safety of Benzyl benzodithioate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Oxidative dearomative cross-dehydrogenative coupling of indoles with diverse C-H nucleophiles: efficient approach to 2,2-disubstituted indolin-3-ones was written by Yan, Xue;Tang, Ying-De;Jiang, Cheng-Shi;Liu, Xigong;Zhang, Hua. And the article was included in Molecules in 2020.Product Details of 1190-39-2 This article mentions the following:

The oxidative, dearomative cross-dehydrogenative coupling of indoles with various C-H nucleophiles was developed. This process features a broad substrate scope with respect to both indoles and nucleophiles, affording structurally diverse 2,2-disubstituted indolin-3-ones in high yields (up to 99%). The oxidative dimerization and trimerization of indoles were demonstrated under the same conditions. In the experiment, the researchers used many compounds, for example, malonic acid dibutyl ester (cas: 1190-39-2Product Details of 1190-39-2).

malonic acid dibutyl ester (cas: 1190-39-2) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Product Details of 1190-39-2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

CO₂-expanded liquid assisted self-assembly between Disperse Red 1 and PS-b-P4VP was written by Cheng, Xiaomeng;Zheng, Xiaofang;Zhang, Yaolong;Li, Yu;Li, Hongping;Cao, Renfei;Li, Qianyu. And the article was included in RSC Advances in 2016.COA of Formula: C14H12S2 This article mentions the following:

This work shows that CO₂-expanded liquids (CXLs) facilitate the modulation of morphol. and photoluminescence (PL) performance of the self assembled fluorescent composite (SAFC), which was formed between Disperse Red 1 (DR1) and polystyrene-block-poly(4-vinylpyridine) (PS-b-P4VP) in CO₂-expanded ethanol. We find that the anti-solvent effect of CXLs with increasing pressure could effectively regulate the amount and type of the hydrogen bonds with DR1 units as well as the confinement extent of DR1, along with the structure and fluorescence (FL) behavior of the SAFC. The morphol. and emission behavior of the SAFC was strongly dependent on the CXL pressure and the molar ratio (R) of 4VP to DR1. The SAFC emission revealed a non-monotonic feature against CXL pressure, which increased with a pressure rise below the threshold pressure (P_T) and then decreased at higher pressures above P_T. The maximum FL of SAFC at 5.58 MPa and R = 2800 was enhanced by 3.4-fold compared with that of the pristine mixture Confinement and hydrogen bonds are the two major factors responsible for the pressure dependence of the emission. Moreover, the hydrogen bonds formed between the DR1 and P4VP blocks are the principal contribution to SAFC emission than those between DR1 and ethanol. In the experiment, the researchers used many compounds, for example, Benzyl benzodithioate (cas: 27249-90-7COA of Formula: C14H12S2).

Benzyl benzodithioate (cas: 27249-90-7) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.COA of Formula: C14H12S2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Soluble and Columnar Liquid Crystalline Peropyrenequinones by Coupling of Phenalenones in Cesium Hydroxide was written by Buffet, Noemie;Grelet, Eric;Bock, Harald. And the article was included in Chemistry – A European Journal in 2010.Related Products of 10203-58-4 This article mentions the following:

The oxidative dimerization of 2-alkyl-3-hydroxy-1-phenalenones, the nitrogen-free carbon homologs of N-alkylnaphthalimides, was achieved using cesium hydroxide. This opens access to a new class of intensely long-wavelength absorbing perylenic dyes that adopt columnar liquid-crystalline structures at ambient temperature and that are obtained as separable pairs of centrosym. (transoid) and polar (cisoid) regioisomers. Their light absorption and mesomorphic properties make these compounds promising materials for organic opto-electronics. In the experiment, the researchers used many compounds, for example, Diethyl isobutylmalonate (cas: 10203-58-4Related Products of 10203-58-4).

Diethyl isobutylmalonate (cas: 10203-58-4) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Related Products of 10203-58-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthesis of rigid-rod linkers to anchor chromophores to semiconductor nanoparticles was written by Wang, Dong;Schlegel, James M.;Galoppini, Elena. And the article was included in Tetrahedron in 2002.SDS of cas: 313648-56-5 This article mentions the following:

Four rigid-rod sensitizers, made of a phenylethynyl spacer substituted with a chromophore and two COOR binding groups, were prepared to study dynamics of electron injection at the interface of metal oxide semiconductor nanoparticles. Di-Me Ru(bpy)₂((5-(5-1,10-phenanthrolinyl)ethynyl)isophthalate)²⁺, di-Me Ru(bpy)₂(5-(4-(2,2′-bipyridinyl)ethynyl)isophthalate)²⁺, di-Me 5-(1-pyrenylethynyl)isophthalate, and di-Me 5-(9-anthracenylethynyl)isophthalate were synthesized and characterized. Their absorption spectra, emission spectra, and electrochem. properties have been studied in acetonitrile and hexane solutions at room temperature In the experiment, the researchers used many compounds, for example, Dimethyl 5-ethynylisophthalate (cas: 313648-56-5SDS of cas: 313648-56-5).

Dimethyl 5-ethynylisophthalate (cas: 313648-56-5) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.SDS of cas: 313648-56-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bronsted acid catalyzed amination of 1,3-dicarbonyl compounds by iminoiodanes was written by Tejo, Ciputra;Yeo, Hui Quan;Chan, Philip Wai Hong. And the article was included in Synlett in 2014.Safety of Ethyl 3-oxo-3-(m-tolyl)propanoate This article mentions the following:

A synthetic method to aminate 1,3-dicarbonyl compounds with PhI:NTs using Bronsted acid catalysis is described herein. The method was shown to be applicable to β-keto esters and phosphonates as well as 1,3-diones, providing the corresponding α,α-acyl amino acid derivatives in moderate to excellent yields. E.g., amination of PhCOCH₂CO₂Et with PhI:NTs in the presence of 10 mol% of TFA and 4 Å MS in dichloromethane at 0 °C for 90 min gave 85% aminated product I. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(m-tolyl)propanoate (cas: 33166-79-9Safety of Ethyl 3-oxo-3-(m-tolyl)propanoate).

Ethyl 3-oxo-3-(m-tolyl)propanoate (cas: 33166-79-9) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Safety of Ethyl 3-oxo-3-(m-tolyl)propanoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Organic-inorganic hybrid catalysts based on ordered porous structures for Michael reaction was written by Kubota, Yoshihiro;Ikeya, Hisanori;Sugi, Yoshihiro;Yamada, Takashi;Tatsumi, Takashi. And the article was included in Journal of Molecular Catalysis A: Chemical in 2006.Product Details of 1190-39-2 This article mentions the following:

Two types of organic-inorganic hybrid base catalysts are prepared for the Michael reaction. Organic-functionalized mol. sieves (OFMSs), particularly “amine-immobilized porous silicates”, are designed based on a common idea of immobilizing active catalytic sites on silicate surface. Silicate-organic composite materials (SOCMs), such as “ordered porous silicate-quaternary ammonium composite materials”, are the precursors of ordered porous silicates obtained during the synthesis. The OFMSs are effective when the supports have large pore volume and/or surface area and the reaction is carried out in polar solvents ethanol and DMF. However, the activity of the OFMSs is considerably low in a non-polar solvent such as benzene. In contrast, the SOCMs are remarkably active in benzene. The organic cation-MCM-41 composite is more active than the composite of an organic cation and a microporous silicate such as zeolite beta and ZSM-12. In the SOCM catalysts, (SiO)₃SiO^–(⁺NR₄) moieties located at the accessible sites are considered to play some important roles. The active species are absent in the liquid phase after the reaction. The recycle of the catalyst was possible without significant loss of activity when the substrates are enough reactive. In the experiment, the researchers used many compounds, for example, malonic acid dibutyl ester (cas: 1190-39-2Product Details of 1190-39-2).

malonic acid dibutyl ester (cas: 1190-39-2) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Product Details of 1190-39-2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Jack Chambers’ mixed media paintings from the 1960s and 1970s: Painting technique and condition was written by Helwig, Kate;Thibeault, Marie-Eve;Poulin, Jennifer. And the article was included in Studies in Conservation in 2013.Application of 106-79-6 This article mentions the following:

This study describes the examination and anal. of four mixed media paintings from the 1960s and 1970s by Canadian artist Jack Chambers (1931-1978). The documentary evidence about his materials and methods is summarized and compared with the results of anal. of multilayer paint samples. The combination of Fourier transform IR spectroscopy (FTIR) and gas chromatog.-mass spectrometry (GC-MS) allowed the components of the paint media to be characterized: ortho-phthalate alkyd resins, iso-phthalate alkyd resins, drying oils, dammar, Pinaceae resin, and turpentine were identified in varying proportions. Many pigments and fillers were identified by FTIR and Raman and are enumerated. The effect that Chambers’ complex technique has had on the aging and degradation of the paintings is discussed. The severe cracking of the paint layers in one of the four paintings may be the result of a high proportion of dammar and turpentine diluent mixed with the alkyd paint and may also be related to the type of alkyd resin medium. Different history and environmental conditions may also be factors. In the experiment, the researchers used many compounds, for example, Dimethyl decanedioate (cas: 106-79-6Application of 106-79-6).

Dimethyl decanedioate (cas: 106-79-6) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Application of 106-79-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Identification of a new p53/MDM2 inhibitor motif inspired by studies of chlorofusin was written by Cominetti, Marco M. D.;Goffin, Sarah A.;Raffel, Ewan;Turner, Kerrie D.;Ramoutar, Jordann C.;O’Connell, Maria A.;Howell, Lesley A.;Searcey, Mark. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2015.Related Products of 313648-56-5 This article mentions the following:

Previous studies on the natural product chlorofusin have shown that the full peptide and azaphilone structure are required for inhibition of the interaction between MDM2 and p53. In the current work, the authors utilized the cyclic peptide as a template and introduced an azidonorvaline amino acid in place of the ornithine/azaphilone of the natural product and carried out click chem. with the resulting peptide. From this small library the first ever non-azaphilone containing chlorofusin analog with MDM2/p53 activity was identified. Further studies then suggested that the simple structure of the Fmoc-norvaline amino acid that had undergone a click reaction was also able to inhibit MDM2/p53 interaction. This is an example where studies of a natural product have led to the serendipitous identification of a new small mol. inhibitor of a protein-protein interaction. In the experiment, the researchers used many compounds, for example, Dimethyl 5-ethynylisophthalate (cas: 313648-56-5Related Products of 313648-56-5).

Dimethyl 5-ethynylisophthalate (cas: 313648-56-5) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Related Products of 313648-56-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics