Tag: 200-300

One-pot synthesis of 5-alkylthio-3H-1,2-dithiole-3-thiones: advantages and scopes was written by Aimar, Mario L.;De Rossi, Rita H.. And the article was included in Synthesis in 2000.Application of 1190-39-2 This article mentions the following:

The reaction of dialkyl malonate esters, ROCOCHR¹CO₂R [R = H, Me, Et, Pr, i-Pr, Ph, Bu, hexyl, octyl, decyl, benzyl, 2-ethoxyethyl, R¹ = H; R = Et, R¹ = Me, benzyl, Ph, Cl, OMe, Br, Br₂, NO₂], with P₂S₅/S₈ in boiling xylene in the presence of 2-mercaptobenzothiazole/ZnO as catalyst produced the corresponding 5-alkylthio-3H-1,2-dithiole-3-thiones I as major identifiable product. Moderate yields were obtained with malonate esters of primary alcs. The reaction failed with malonate esters of secondary alcs. Regarding the substituent in position two, dialkyl malonates with groups such as CH₃, Ph, CH₂Ph, OCH₃ and Cl afford the corresponding 4-substituted derivatives whereas with Br and NO₂ did not give the expected products. Some mechanistic evidences were described. In the experiment, the researchers used many compounds, for example, malonic acid dibutyl ester (cas: 1190-39-2Application of 1190-39-2).

malonic acid dibutyl ester (cas: 1190-39-2) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Application of 1190-39-2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthesis of aromatic azomethines from anesthesin and derivatives of vanillin and vanillal was written by Dikusar, E. A.;Potkin, V. I.;Kozlov, N. G.;Yuvchenko, A. P.. And the article was included in Vestsi Natsyyanal’nai Akademii Navuk Belarusi, Seryya Khimichnykh Navuk in 2007.Formula: C12H14O4 This article mentions the following:

Novel aromatic azomethines 3-R¹O-4-R²OC₆H₃CH:NR³ (R¹ = Me, Et; R² = H, COMe, PhCH₂CO, BrCH₂CO, PhCO, etc.; R³ = 4-EtO₂CC₆H₄), containing ether and ester groups from vanillin, vanillal and their esters, were synthesized in 90-94% yields by condensation of the corresponding aldehydes 3-R¹O-4-R²OC₆H₃CHO with Et 4-aminobenzoate at reflux in absolute methanol in the absence of any catalyst. In the experiment, the researchers used many compounds, for example, 4-Formyl-2-methoxyphenyl isobutyrate (cas: 20665-85-4Formula: C12H14O4).

4-Formyl-2-methoxyphenyl isobutyrate (cas: 20665-85-4) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Formula: C12H14O4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Small-Molecule TLR8 Antagonists via Structure-Based Rational Design was written by Hu, Zhenyi;Tanji, Hiromi;Jiang, Shuangshuang;Zhang, Shuting;Koo, Kyoin;Chan, Jean;Sakaniwa, Kentaro;Ohto, Umeharu;Candia, Albert;Shimizu, Toshiyuki;Yin, Hang. And the article was included in Cell Chemical Biology in 2018.Application of 525362-07-6 This article mentions the following:

Rational design of drug-like small-mol. ligands based on structural information of proteins remains a significant challenge in chem. biol. In particular, designs targeting protein-protein interfaces have met little success given the dynamic nature of the protein surfaces. Herein, we utilized the structure of a small-mol. ligand in complex with Toll-like receptor 8 (TLR8) as a model system due to TLR8′s clin. relevance. Overactivation of TLR8 has been suggested to play a prominent role in the pathogenesis of various autoimmune diseases; however, there are still few small-mol. antagonists available, and our rational designs led to the discovery of six exceptionally potent compounds with ~picomolar IC₅₀ values. Two X-ray crystallog. structures validated the contacts within the binding pocket. A variety of biol. evaluations in cultured cell lines, human peripheral blood mononuclear cells, and splenocytes from human TLR8-transgenic mice further demonstrated these TLR8 inhibitors′ high efficacy, suggesting strong therapeutic potential against autoimmune disorders. In the experiment, the researchers used many compounds, for example, Methyl 2-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate (cas: 525362-07-6Application of 525362-07-6).

Methyl 2-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate (cas: 525362-07-6) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Application of 525362-07-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chemical constituents analysis in ground part of Gentiana macrophylla pall by SFE-GC-MS was written by Wang, Yanping;Ma, Xiao. And the article was included in Zhongguo Xiandai Yingyong Yaoxue in 2011.Computed Properties of C12H22O4 This article mentions the following:

The objective of this paper is to identify compounds in supercritical fluids extraction of ground part of Gentiana macrophylla Pall. GC-MS was used to analyze the constituents and the sample was extracted by supercritical fluids. The AT-SE54 capillary column (30 m × 0.25 mm × 0.25 μm) was used and inlet temperature was maintained at 260°. The column oven was begun at 80°, then programmed from 80° to 290° at 4° min^-1, and hold for 30 min. Helium at a constant flow rate of 1.2 mL/min^-1 was used as carrier gas. Ion source temperature was 230° and ionization energy was 70 eV. Results show that the total of 72 components were separated and 70 components were identified from flowers of Gentiana macrophylla Pall, accounting for 84.1% of total extractant. A total of 67 components were separated and 66 components were identified from stems and leaves of Gentiana macrophylla Pall, accounting for 93.1% of total extractant. It was concluded that the results will provide important foundation for understanding the constituents and further exploitation for ground part of Gentiana macrophylla Pall. In the experiment, the researchers used many compounds, for example, Dimethyl decanedioate (cas: 106-79-6Computed Properties of C12H22O4).

Dimethyl decanedioate (cas: 106-79-6) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Computed Properties of C12H22O4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

RAFT Polymerization of Vinylthiophene Derivatives and Synthesis of Block Copolymers Having Cross-Linkable Segments was written by Mori, Hideharu;Takano, Ken;Endo, Takeshi. And the article was included in Macromolecules (Washington, DC, United States) in 2009.Formula: C14H12S2 This article mentions the following:

The polymerization of three vinylthiophene derivatives, 2-vinylthiophene (2VT), 3-vinylthiophene (3VT), and 2,5-dibromo-3-vinylthiophene (DB3VT), was carried out by reversible addition-fragmentation chain transfer (RAFT) process using six different chain transfer agents (CTAs). The novel doubly polymerizable monomer, DB3VT, undergoes controlled radical polymerization via the RAFT process, followed by Suzuki coupling reaction. Two dithiobenzoate-type RAFT agents, phenylethyl dithiobenzoate (CTA 2) and cumyl dithiobenzoate (CTA 3), were the most efficient to obtain poly(DB3VT) with controlled mol. weights and low polydispersities (M_w/M_n = 1.05-1.15). Good control of the polymerization of DB3VT was confirmed by the linear increase in the mol. weight with the conversion and the ability to extend the chain by a second addition of the monomer. Chain extension from poly(Me methacrylate) to DB3VT could be well controlled under suitable conditions and provided block copolymers having cross-linkable poly(DB3VT) segments with as-designed chain structures and low polydispersities. The block copolymers were also synthesized by RAFT polymerization of DB3VT using poly(Me acrylate) as a macro-chain transfer agent (macro-CTA). Modifications of the 2,5-dibromide group of poly(DB3VT) by Suzuki coupling reaction using difunctional boronic acid afforded a network material, whereas a soluble composite having an extended π-structure was obtained by the coupling reaction of the block copolymer, poly(Me methacrylate)-b-poly(DB3VT). In the experiment, the researchers used many compounds, for example, Benzyl benzodithioate (cas: 27249-90-7Formula: C14H12S2).

Benzyl benzodithioate (cas: 27249-90-7) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Formula: C14H12S2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Multifunctional poly(amine-ester)-type hyperbranched polymers: lipase-catalyzed green synthesis, characterization, biocompatibility, drug loading and anticancer activity was written by Xu, Fangli;Zhong, Jiaren;Qian, Xueqi;Li, Yanyan;Lin, Xianfu;Wu, Qi. And the article was included in Polymer Chemistry in 2013.Recommanded Product: Dimethyl decanedioate This article mentions the following:

Hyperbranched polymers (HBPs) have attracted more and more attention because of their specially branched architecture and interesting properties. A series of novel poly(amine-ester)-type HBPs were synthesized through CALB-catalyzed polycondensation between triethanolamine (TEOA) and diesters after the optimization of reaction conditions. The precise structure including degree of branching, components percentage, and the controllable terminal structures at the outer surface were determined by FTIR, ¹H NMR, ¹³C NMR, 2D NMR and GPC. The interesting multifunctionality displayed by the poly(amine-ester)-type HBPs was investigated. These HBPs could be degraded efficiently under the catalysis of lipase in weak acid buffer. The amphiphilic HBPs with hydroxyl terminals were able to form multimol. micelles with 250-400 nm diameter, and 0.042 g L^-1 CMC. They were nontoxic to COS-7 cells, while they could effectively inhibit the growth of cancer cells HepG2 with IC₅₀ of 130 μg mL^-1 after an anticancer drug was encapsulated within the micelles. All these results indicated the prepared poly(amine-ester)-type HBPs can serve as multifunctional biomaterials for biomedical applications. In the experiment, the researchers used many compounds, for example, Dimethyl decanedioate (cas: 106-79-6Recommanded Product: Dimethyl decanedioate).

Dimethyl decanedioate (cas: 106-79-6) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Recommanded Product: Dimethyl decanedioate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

A NbO-type metal-organic framework exhibiting high deliverable capacity for methane storage was written by Song, Chengling;Ling, Yajing;Feng, Yunlong;Zhou, Wei;Yildirim, Taner;He, Yabing. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2015.Product Details of 313648-56-5 This article mentions the following:

A Cu-based NbO-type metal-organic framework ZJNU-50 constructed from a tetracarboxylate incorporating phenylethyne as a spacer exhibited an exceptionally high methane working capacity of 184 cm³ (STP) cm^-3 for methane storage. The value is among the highest reported for MOF materials. In the experiment, the researchers used many compounds, for example, Dimethyl 5-ethynylisophthalate (cas: 313648-56-5Product Details of 313648-56-5).

Dimethyl 5-ethynylisophthalate (cas: 313648-56-5) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Product Details of 313648-56-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Transesterification of ethylene carbonate with dimethyl sebacate was written by Zhang, Dan;Li, Jun-hua. And the article was included in Huaxue Shiji in 2014.Recommanded Product: Dimethyl decanedioate This article mentions the following:

The transesterification of ethylene carbonate (EC) and di-Me sebacate (DMS) was investigated over metal acetate catalysts. The main product was proved to be di-Me carbonate (DMC) by GC-MS, which was an environmentally benign chem. intermediate. At the same time, a new kind of aliphatic polyester could be synthesized, which could be biodegraded. This method improved the atom economy, avoiding the formation of byproduct methanol and ethylene glycol and made good use of CO₂. The results showed Li(CH₃COO)·2H₂O had the highest activity. Effects of reaction temperature, catalyst amount, ratio of reactant and reaction time on yields of di-Me carbonate was investigated. When the reaction was carried out 250°C, with mole ratio catalyst to DMS of 0.004, mole ratio of EC to DMS of 3:1, reaction time 3 h, the yield of DMC was 45.7%. In the experiment, the researchers used many compounds, for example, Dimethyl decanedioate (cas: 106-79-6Recommanded Product: Dimethyl decanedioate).

Dimethyl decanedioate (cas: 106-79-6) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Recommanded Product: Dimethyl decanedioate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Alternate and random (co)polymers composed of anthracene and chloromethylstyrene units through controlled radical ring-opening polymerization: Synthesis, post-functionalization, and optical properties was written by Nakabayashi, Kazuhiro;Tsuda, Ayumi;Otani, Hiroshi;Mori, Hideharu. And the article was included in Reactive & Functional Polymers in 2015.Reference of 27249-90-7 This article mentions the following:

A cyclic monomer containing the chloromethyl unit 10-methylene-9,10-dihydroanthryl-9-spiro(4′-chloromethylphenyl)cyclopropane (MDCMS) was polymerized using a controlled radical ring-opening polymerization via a reversible addition-fragmentation chain transfer (RAFT) process to afford a nonconjugated alternate polymer composed of anthracene and chloromethylstyrene (CMS) units. Well-defined random copolymers were obtained through the ring-opening RAFT copolymerization Various functional groups were incorporated into the alternating homopolymer. The alternate polymer containing imidazole rings exhibited fluorescence quenching as a result of charge transfer. Fluorescence resonance energy transfer (FRET) was observed in the alternate polymers containing naphthalene and thiophene rings. The random copolymers obtained by copolymerization followed by post-functionalizations exhibited characteristic optoelectronic properties that differed from those of the alternate polymers. In the experiment, the researchers used many compounds, for example, Benzyl benzodithioate (cas: 27249-90-7Reference of 27249-90-7).

Benzyl benzodithioate (cas: 27249-90-7) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Reference of 27249-90-7

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Aggregations of the compounds having two functional groups such as carboxyl group, hydroxyl group, and/or amino group on the surface of alumina and silica gel, and their influence for selective reactions was written by Ogawa, H.. And the article was included in Transactions of the Materials Research Society of Japan in 1994.Application of 3903-40-0 This article mentions the following:

The adsorption states and selective reactions of compounds such as terephthalic acid (TPA), aliphatic dicarboxylic acids (C_i), 6-aminocaproic acid (6-ACA), and 12-hydroxystearic acid (12-HSA) were ascertained. TPA and C_i chemisorbed on alumina as monocarboxylate anion react with diazomethane to form the corresponding monomethyl esters quant. The selective monomethyl esterification of longer chain acid in a mixture with shorter one occurs on alumina. 6-ACA adsorbed on silica gel and 12-HSA adsorbed on H₂SO₄/silica gel, due to their easier dispersion over the surface, are converted significantly to δ -caprolactam and ω -stearo-1,12-lactone, resp. In the experiment, the researchers used many compounds, for example, 12-Methoxy-12-oxododecanoic acid (cas: 3903-40-0Application of 3903-40-0).

12-Methoxy-12-oxododecanoic acid (cas: 3903-40-0) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Application of 3903-40-0

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics