Tag: 200-300

Guven, Melek Naz; Balaban, Burcu; Demirci, Gozde; Yagci Acar, Havva; Okay, Oguz; Avci, Duygu published an article in 2021. The article was titled 《Bisphosphonate-functionalized poly(amido amine) crosslinked 2-hydroxyethyl methacrylate hydrogel as tissue engineering scaffold》, and you may find the article in European Polymer Journal.Application of 51857-17-1 The information in the text is summarized as follows:

The first water soluble, bisphosphonate (BP, not bisphosphonic acid)-functionalized poly(amido amine) macromer (PAA-BP) is synthesized and used as a crosslinker for synthesis of a biodegradable and biocompatible hydrogel for tissue engineering scaffolds. The synthesis of PAA-BP is performed in three steps, the first two giving the control macromers (PAA-NHBoc and PAA-NH2): (i) Michael addition reaction of N,N’-methylene bisacrylamide and N-Boc-1,6-hexanediamine (acrylamide/amine ratios of 1.2), (ii) deprotection of Boc-protected amine groups, (iii) Michael addition reaction of the amine groups with tetra-Et vinylidene bisphosphonate. The degree of BP substitution is 50% and mol. weight of the PAA-BP macromer is found to be 4800 g/mol. These macromers are incorporated into hydrogels by copolymerization with 2-hydroxyethyl methacrylate and the influence of bisphosphonate functionality on hydrogel properties; degradation, swelling, mech. and mineralization, is investigated. The mineralization abilities, hence the mech. properties of the hydrogels are strongly influenced by the BP functionality; PAA-BP forming strong (E = 83 ± 1 kPa) hydrogel-apatite composites, PAA-NH2 also working to a lesser degree (E = 54 ± 3 kPa). Cytocompatibility of the hydrogels is observed on Saos-2 human osteosarcoma, U-2 OS human bone osteosarcoma epithelial, C2C12 mouse myoblast muscle and NIH mouse embryonic fibroblast 3T3 cells. PAA-BP crosslinked hydrogels facilitate adhesion of C2C12 cells after mineralization. In summary, BP-functionalized hydrogel may have a potential impact on bone tissue engineering. In addition to this study using N-Boc-1,6-Diaminohexane, there are many other studies that have used N-Boc-1,6-Diaminohexane(cas: 51857-17-1Application of 51857-17-1) was used in this study.

N-Boc-1,6-Diaminohexane(cas: 51857-17-1) is a compound useful in organic synthesis used in the preparation of mixed self-assembled monolayers (SAMs) that resist adsorption of proteins using the reaction of amines with a SAM that presents interchain carboxylic anhydride groupsApplication of 51857-17-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2018,Schulz-Fincke, Anna-Christina; Tikhomirov, Alexander S.; Braune, Annett; Girbl, Tamara; Gilberg, Erik; Bajorath, Juergen; Blaut, Michael; Nourshargh, Sussan; Guetschow, Michael published 《Design of an Activity-Based Probe for Human Neutrophil Elastase: Implementation of the Lossen Rearrangement To Induce Förster Resonance Energy Transfers》.Biochemistry published the findings.Computed Properties of C10H22N2O2 The information in the text is summarized as follows:

Human neutrophil elastase is an important regulator of the immune response and plays a role in host defense mechanisms and further physiol. processes. The uncontrolled activity of this serine protease may cause severe tissue alterations and impair inflammatory states. The design of an activity-based probe for human neutrophil elastase reported here relies on a sulfonyloxyphthalimide moiety as a new type of warhead which was linker-connected to a coumarin fluorophore. The inhibitory potency of the activity-based probe was assessed against several serine and cysteine proteases and selectivity for human neutrophil elastase (Ki = 6.85 nM) was determined The adequate fluorescent tag of the probe allowed for the in-gel fluorescence detection of human neutrophil elastase in the low nanomolar range. The coumarin moiety and the anthranilic acid function of the probe, produced in the course of a Lossen rearrangement, were part of 2 different FRETs. In the experimental materials used by the author, we found tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3Computed Properties of C10H22N2O2)

Some of the reported applications of tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3) include: synthesis of of a supermacrocycle that self-assemble to form organic nanotubes., preparation of water-soluble unsymmetrical sulforhodamine fluorophores from monobrominated sulfoxanthene dye, synthesis of functionalized porphyrins as biocompatible carrier system for photodynamic therapy (PDT).Computed Properties of C10H22N2O2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2016,Zhang, Liang; Thurber, Greg M. published 《Quantitative Impact of Plasma Clearance and Down-regulation on GLP-1 Receptor Molecular Imaging》.Molecular Imaging and Biology published the findings.Related Products of 51644-96-3 The information in the text is summarized as follows:

Quant. mol. imaging of beta cell mass (BCM) would enable early detection and treatment monitoring of type 1 diabetes. The glucagon-like peptide-1 (GLP-1) receptor is an attractive target due to its beta cell specificity and cell surface location. We quant. investigated the impact of plasma clearance and receptor internalization on targeting efficiency in healthy B6 mice. Four exenatide-based probes were synthesized that varied in mol. weight, binding affinity, and plasma clearance. The GLP-1 receptor internalization rate and in vivo receptor expression were quantified. Receptor internalization (54,000 receptors/cell in vivo) decreased significantly within minutes, reducing the benefit of a slower-clearing agent. The multimers and albumin binding probes had higher kidney and liver uptake, resp. Slow plasma clearance is beneficial for GLP-1 receptor peptide therapeutics. However, for exendin-based imaging of islets, down-regulation of the GLP-1 receptor and non-specific background uptake result in a higher target-to-background ratio for fast-clearing agents.tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3Related Products of 51644-96-3) was used in this study.

Some of the reported applications of tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3) include: synthesis of of a supermacrocycle that self-assemble to form organic nanotubes., preparation of water-soluble unsymmetrical sulforhodamine fluorophores from monobrominated sulfoxanthene dye, synthesis of functionalized porphyrins as biocompatible carrier system for photodynamic therapy (PDT).Related Products of 51644-96-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The author of 《Fluorine-19 NMR spectra and relative thermodynamic stability of mesomeric carbanions obtained from polyfluorophenylmalonic acid derivatives》 were Vlasov, V. M.; Zakharova, O. V.. And the article was published in Zhurnal Organicheskoi Khimii in 1975. Electric Literature of C9H5F5O2 The author mentioned the following in the article:

The 19F NMR spectra of p-RC6F4CH(CO2Et)2 (R = H, F, Br, Me, CF3, CO2Et), p-RC6F4CH(CN)CO2Et (R = H, Cl, Br, F, Me, CF3), p-RC6F4CH(CN)2 (R = H, F, CF3), I (R = CN, CO2Et), and their carbanions (prepared by treatment with NaH) were determined and correlated with the thermodn. stabilities of the carbanions and the acidity of the parent malonate derivativesEthyl 2,3,4,5,6-pentafluorobenzoate(cas: 4522-93-4Electric Literature of C9H5F5O2) was used in this study.

Ethyl 2,3,4,5,6-pentafluorobenzoate(cas: 4522-93-4) belongs to esters.Electric Literature of C9H5F5O2 They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The author of 《Aromatic fluoro derivatives. XLVI. Reaction of pentafluorophenyl derivatives of methane with triphenylmethyl tetrafluoroborate》 were Vlasov, V. M.; Koifman, P. I.; Yakobson, G. G.. And the article was published in Zhurnal Organicheskoi Khimii in 1973. Formula: C9H5F5O2 The author mentioned the following in the article:

C6F5CHCl2 and C6F5CHF2 were unreactive toward Ph3C+ BF4- at 35-60° in CH2Cl2 or ChCl3 containing C6H6, but C6F5CH(OH)Me yielded Ph3CH, Ph3COH, C6F5COMe, and C6F5CHMeOCPh3 under similar conditions; Ph3C+ BF4- and C6F5CH(oEt)2 afforded C6F5CHO and Ph3CH as the major product at 23-5°, along with C6F5CO2Et, Ph3COEt, and MeCHO. A mechanism involving H- transfer was proposed for these reactions. In the experiment, the researchers used Ethyl 2,3,4,5,6-pentafluorobenzoate(cas: 4522-93-4Formula: C9H5F5O2)

Ethyl 2,3,4,5,6-pentafluorobenzoate(cas: 4522-93-4) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Formula: C9H5F5O2 Polyesters are important plastics, with monomers linked by ester moieties.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sun, Bin; Dong, Yue; Lei, Kang; Wang, Jian; Zhao, Liyu; Liu, Min published an article in Bioorganic & Medicinal Chemistry. The title of the article was 《Design, synthesis and biological evaluation of amide-pyridine derivatives as novel dual-target (SE, CYP51) antifungal inhibitors》.COA of Formula: C10H14ClNO2 The author mentioned the following in the article:

Based on the anal. of the squalene cyclooxygenase (SE) and 14α-demethylase (CYP51) inhibitors pharmacophore feature and the dual-target active sites, a series of compounds with amide-pyridine scaffolds have been designed and synthesized to treat the increasing incidence of drug-resistant fungal infections. In vitro evaluation showed that these compounds have a certain degree of antifungal activity. The most potent compounds 11a, 11b with MIC values in the range of 0.125-2 μg/mL had a broad-spectrum antifungal activity and exhibited excellent inhibitory activity against drug-resistant pathogenic fungi. Preliminary mechanism studies revealed that the compound 11b might play an antifungal role by inhibiting the activity of SE and CYP51. Notably compounds did not show the genotoxicity through plasmid binding assay. Finally, this study of mol. docking, ADME/T prediction and the construction of 3D QSAR model were performed. These results can point out the direction for further optimization of the lead compound In the part of experimental materials, we found many familiar compounds, such as H-Phg-OEt.HCl(cas: 59410-82-1COA of Formula: C10H14ClNO2)

H-Phg-OEt.HCl(cas: 59410-82-1) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils. They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market.COA of Formula: C10H14ClNO2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Miller, A. O.; Furin, G. G. published an article on February 28 ,1989. The article was titled 《Reaction of polyfluoro aromatic compounds with sodium nitrite》, and you may find the article in Zhurnal Organicheskoi Khimii.Category: esters-buliding-blocks The information in the text is summarized as follows:

Reaction of C6F5R (R = O2N, cyano, EtO2C) with NaNO2 in DMSO afforded p-RC6F4OH in 80, 90, and 80% yields, resp.; i.e., exclusively products of O substitution. C6HF5 afforded 2,3,5,6-tetrafluorophenol and 2,4,5-trifluoro-6-nitrophenol in a 3:1 ratio. O-substitution products are formed with electron-accepting R. In addition to this study using Ethyl 2,3,4,5,6-pentafluorobenzoate, there are many other studies that have used Ethyl 2,3,4,5,6-pentafluorobenzoate(cas: 4522-93-4Category: esters-buliding-blocks) was used in this study.

Ethyl 2,3,4,5,6-pentafluorobenzoate(cas: 4522-93-4) belongs to esters. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Electric Literature of C11H11NO6On March 18, 2022, Lee, Richmond; Eric Chao, Chi Bong; Ban, Xu; Tan, Siu Min; Yu, Haibo; Hyland, Christopher J. T.; Tan, Choon-Hong published an article in Journal of Organic Chemistry. The article was 《Direct SN2 or SN2X Manifold-Mechanistic Study of Ion-Pair-Catalyzed Carbon(sp3)-Carbon(sp3) Bond Formation》. The article mentions the following:

D. functional theory (DFT) is used in this work to predict the mechanism for constructing congested quaternary-quaternary carbon(sp3)-carbon(sp3) bonds in a pentanidium-catalyzed substitution reaction. Computational mechanistic studies were carried out to investigate the proposed SN2X manifold, which consists of two primary elementary steps: halogen atom transfer (XAT) and subsequent SN2. For the first calculated model on original exptl. substrates, XAT reaction barriers were more kinetically competitive than an SN2 pathway and connect to thermodynamically stable intermediates. Extensive computational screening modeling was then done on various substrate combinations designed to study the steric influence and to understand the mechanistic rationale, and calculations reveal that sterically congested substrates prefer the SN2X manifold over SN2. Different halides as leaving groups were also screened, and it was found that the reactivity increases in the order of I > Br > Cl > F, in agreement with the strength of C-X bonds. However, DFT modeling suggests that chlorides can be a viable substrate for the SN2X process, which should be further explored exptl. ONIOM calculations on the full catalyst model predicted the correct stereochem. outcome, and further catalyst screening with cationic Me4N+ and K+ predicted that pentanidium is still the choice for SN2X C-C bond formation. In the experiment, the researchers used Dimethyl 2-(4-nitrophenyl)malonate(cas: 4033-88-9Electric Literature of C11H11NO6)

Dimethyl 2-(4-nitrophenyl)malonate(cas: 4033-88-9) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Electric Literature of C11H11NO6 They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Yonghong; Ma, Xia; Chau, Ho-Fai; Thor, Waygen; Jiang, Lijun; Zha, Shuai; Fok, Wan-Yiu; Mak, Ho-Nam; Zhang, Junhui; Cai, Jing; Ng, Chi-Fai; Li, Hongguang; Parker, David; Li, Li; Law, Ga-Lai; Wong, Ka-Leung published an article in 2021. The article was titled 《Lanthanide-Cyclen-Camptothecin Nanocomposites for Cancer Theranostics Guided by Near-Infrared and Magnetic Resonance Imaging》, and you may find the article in ACS Applied Nano Materials.Recommanded Product: 51857-17-1 The information in the text is summarized as follows:

We have devised a mol.-to-micellar strategy to incorporate a lanthanide nanoplatform for the delivery of an anticancer drug that simultaneously offers hybrid near-IR (NIR) and magnetic resonance imaging (MRI) capabilities with defined lanthanide(III) ratio control. This cancer-selective lanthanide-based self-assembled nanocomposite (LnNPs) has been synthesized by conjugating lanthanide-cyclen complexes (cycLn) with a well-known drug-camptothecin (CPT) through a redox-sensitive disulfide bond (-ss-). By accurately controlling the ratio of Gd(III) and Yb(III) complexes, we prepared hybrid nanoparticles (Gd/YbNPs) with both NIR and MR imaging properties. The enhanced stability at ultralow critical aggregation concentrations (CACs), simultaneous optical and MR imaging, improved delivery/chemotherapeutic efficiency, and cancer cell selectivity of such nanomicellar theranostic prodrugs in vitro and in vivo have thus been achieved and validated. The work provides a blueprint combining a stimuli-activated NIR luminescence and real-time MR imaging into a safe and biocompatible nanoplatform for selective cancer treatment. The experimental part of the paper was very detailed, including the reaction process of N-Boc-1,6-Diaminohexane(cas: 51857-17-1Recommanded Product: 51857-17-1)

N-Boc-1,6-Diaminohexane(cas: 51857-17-1) is a compound useful in organic synthesis used in the preparation of mixed self-assembled monolayers (SAMs) that resist adsorption of proteins using the reaction of amines with a SAM that presents interchain carboxylic anhydride groupsRecommanded Product: 51857-17-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Gilpin, Anna; Zeng, Yuze; Hoque, Jiaul; Ryu, Ji Hyun; Yang, Yong; Zauscher, Stefan; Eward, William; Varghese, Shyni published an article in 2021. The article was titled 《Self-Healing of Hyaluronic Acid to Improve In Vivo Retention and Function》, and you may find the article in Advanced Healthcare Materials.Electric Literature of C11H24N2O2 The information in the text is summarized as follows:

Convergent advances in the field of soft matter, macromol. chem., and engineering have led to the development of biomaterials that possess autonomous, adaptive, and self-healing characteristics similar to living systems. These rationally designed biomaterials can surpass the capabilities of their parent material. Herein, the modification of hyaluronic acid (HA) to exhibit self-healing properties is described, and its phys. and biol. function both in vitro and in vivo is studied. The in vitro findings showed that self-healing HA designed to undergo self-repair improves lubrication, enhances free radical scavenging, and attenuates enzymic degradation compared to unmodified HA. Longitudinal imaging following intraarticular injection of self-healing HA shows improved in vivo retention despite its low mol. weight Concomitant with these functions, intraarticular injection of self-healing HA mitigates anterior cruciate ligament injury-mediated cartilage degeneration in rodents. This proof-of-concept study shows how incorporation of functional properties such as self-healing can be used to surpass the existing capabilities of biolubricants. In the experiment, the researchers used many compounds, for example, N-Boc-1,6-Diaminohexane(cas: 51857-17-1Electric Literature of C11H24N2O2)

N-Boc-1,6-Diaminohexane(cas: 51857-17-1) is a compound useful in organic synthesis used in the preparation of mixed self-assembled monolayers (SAMs) that resist adsorption of proteins using the reaction of amines with a SAM that presents interchain carboxylic anhydride groupsElectric Literature of C11H24N2O2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics