Tag: 200-300

In 2011,Pharma Chemica included an article by Naidu, K. Reddi Mohan; Reddy, C. Bhupendra; Rasheed, S.; Raju, C. Naga. Category: esters-buliding-blocks. The article was titled 《Synthesis and bioassay of 2-substituted-1,3,2-oxazaphosphole 2-ones》. The information in the text is summarized as follows:

A series of new phosphorus heterocycles has been synthesized by the condensation of octahydro-1H-indol(3aS,7aS)-2-yl(2S) methanol with phosphorus oxychloride in the presence of triethylamine in dry THF, followed by the reaction with various phenols and amino acid ester hydrochlorides. All the title compounds were characterized by elemental and spectral analyses. Their antimicrobial activity was also evaluated. In the part of experimental materials, we found many familiar compounds, such as H-Phg-OEt.HCl(cas: 59410-82-1Category: esters-buliding-blocks)

H-Phg-OEt.HCl(cas: 59410-82-1) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Pentafluorophenyl compounds. I. Preparation and reactions of bis(pentafluorophenyl)cadmium》 was published in Chemische Berichte in 1967. These research results belong to Schmeisser, Martin; Weidenbruch, Manfred. Quality Control of Ethyl 2,3,4,5,6-pentafluorobenzoate The article mentions the following:

Cd(C6F5)2 (I) was prepared by thermal decarboxylation of Cd(O2CC6F5)2 or by treatment of C6F5Li with CdCl2. I formed 1:1-complexes with 2,2′-bipyridyl and 2,2′-biquinolyl. Treatment of I with BzCl yielded BzC6F5 (II), and I with AcCl gave AcC6F5. II was also obtained on treatment of I with C6F5COCl in C6H6, while in PhMe C6F5COC6H4Me was obtained. In the experiment, the researchers used many compounds, for example, Ethyl 2,3,4,5,6-pentafluorobenzoate(cas: 4522-93-4Quality Control of Ethyl 2,3,4,5,6-pentafluorobenzoate)

Ethyl 2,3,4,5,6-pentafluorobenzoate(cas: 4522-93-4) belongs to esters. Esters are more polar than ethers but less polar than alcohols. Quality Control of Ethyl 2,3,4,5,6-pentafluorobenzoate They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Electric Literature of C11H24N2O2In 2020 ,《Peptoid-based siderophore mimics as dinuclear Fe3+ chelators》 was published in Dalton Transactions. The article was written by D’Amato, Assunta; Ghosh, Pritam; Costabile, Chiara; Della Sala, Giorgio; Izzo, Irene; Maayan, Galia; De Riccardis, Francesco. The article contains the following contents:

A practical synthesis of preorganized tripodal enterobactin/corynebactin-type ligands (consisting of a C3-sym. macrocyclic peptoid core, three catecholamide coordinating units, and C2, C4, and C6 spacers) is reported. The formation of complexes with Fe3+ was investigated by spectrophotometric (UV-Vis) and spectrometric (ESI, neg. ionization mode) methods and corroborated by theor. (DFT) calculations Preliminary studies revealed the intricate interplay between the conformational chirality of cyclic trimeric peptoids and metal coordination geometry of mononuclear species similar to that of natural catechol-based siderophores. Exptl. results demonstrated the unexpected formation of unique dinuclear Fe3+ complexes. The results came from multiple reactions, including the reaction of N-Boc-1,6-Diaminohexane(cas: 51857-17-1Electric Literature of C11H24N2O2)

N-Boc-1,6-Diaminohexane(cas: 51857-17-1) is used to prepare 1,3-Bis[6-(Boc-amino)hexyl]urea by reacting with carbonyl dichloride in the presence of triethylamine. Further, it is used as a reagent for the introduction of a C6-spacer.Electric Literature of C11H24N2O2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2022,Perrone, Maria Grazia; Vitale, Paola; Miciaccia, Morena; Ferorelli, Savina; Centonze, Antonella; Solidoro, Roberta; Munzone, Cristina; Bonaccorso, Carmela; Fortuna, Cosimo Gianluca; Kleinmanns, Katrin; Bjoerge, Line; Scilimati, Antonio published an article in Pharmaceuticals. The title of the article was 《Fluorochrome Selection for Imaging Intraoperative Ovarian Cancer Probes》.Name: N-Boc-1,6-Diaminohexane The author mentioned the following in the article:

The identification and removal of all gross and microscopic tumor to render the patient disease free represents a huge challenge in ovarian cancer treatment. The presence of residual disease is an independent neg. prognostic factor. Herein, we describe the synthesis and the “”in vitro”” evaluation of compounds as cyclooxygenase (COX)-1 inhibitors, the COX-1 isoform being an ovarian cancer biomarker, each bearing fluorochromes with different fluorescence features. Two of these compounds N-[4-(9-dimethylimino-9H-benzo[a]phenoxazin-5-ylamino) butyl]-2-(3,4-bis(4-methoxyphenyl)isoxazol-5-yl)acetamide chloride (RR11) and 3-(6-(4-(2-(3,4-bis(4-methoxyphenyl)isoxazole-5-yl)acetamido)butyl)amino-6-oxohexyl)-2-[7-(1,3-dihydro-1,1-dimethyl-3-Et 2H-benz[e]indolin-2-yl-idene)-1,3,5-heptatrienyl]-1,1-dimethyl-3-(6-carboxilato-hexyl)-1H-benz[e]indolium chloride, 23 (MSA14) were found to be potent and selective inhibitors of cyclooxygenase (COX)-1 “”in vitro””, and thus were further investigated “”in vivo””. The IC50 values were 0.032 and 0.087 μM for RR11 and 23 (MSA 14), resp., whereas the COX-2 IC50 for RR11 is 2.4 μM while 23 (MSA14) did not inhibit COX-2 even at a 50 μM concentration Together, this represented selectivity index = 75 and 874, resp. Structure-based virtual screening (SBVS) performed with the Fingerprints for Ligands and Proteins (FLAP) software allowed both to differentiate highly active compounds from less active and inactive structures and to define their interactions inside the substrate-binding cavity of hCOX1. Fluorescent probes RR11 and 23 (MSA14), were used for preliminary near-IR (NIR) fluorescent imaging (FLI) in human ovarian cancer (OVCAR-3 and SKOV-3) xenograft models. Surprisingly, a tumor-specific signal was observed for both tested fluorescent probes, even though this signal is not linked to the presence of COX-1.N-Boc-1,6-Diaminohexane(cas: 51857-17-1Name: N-Boc-1,6-Diaminohexane) was used in this study.

N-Boc-1,6-Diaminohexane(cas: 51857-17-1) is a compound useful in organic synthesis used in the preparation of mixed self-assembled monolayers (SAMs) that resist adsorption of proteins using the reaction of amines with a SAM that presents interchain carboxylic anhydride groupsName: N-Boc-1,6-Diaminohexane

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Cokca, Ceren; Hack, Franz J.; Costabel, Daniel; Herwig, Kira; Huelsmann, Juliana; Then, Patrick; Heintzmann, Rainer; Fischer, Dagmar; Peneva, Kalina published an article in 2021. The article was titled 《PEGylation of Guanidinium and Indole Bearing Poly(methacrylamide)s – Biocompatible Terpolymers for pDNA Delivery》, and you may find the article in Macromolecular Bioscience.Quality Control of N-Boc-1,6-Diaminohexane The information in the text is summarized as follows:

This study describes the first example for shielding of a high performing terpolymer that consists of N-(2-hydroxypropyl)methacrylamide (HPMA), N-(3-guanidinopropyl)methacrylamide (GPMA), and N-(2-indolethyl)methacrylamide monomers (IEMA) by block copolymerization of a polyethylene glycol derivative – poly(nona(ethylene glycol)methyl ether methacrylate) (P(MEO9MA)) via reversible addition-fragmentation chain transfer (RAFT) polymerization The mol. weight of P(MEO9MA) is varied from 3 to 40 kg mol-1 while the comonomer content of HPMA, GPMA, and IEMA is kept comparable. The influence of P(MEO9MA) block with various mol. weights is investigated over cytotoxicity, plasmid DNA (pDNA) binding, and transfection efficiency of the resulting polyplexes. Overall, the increase in mol. weight of P(MEO9MA) block demonstrates excellent biocompatibility with higher cell viability in L-929 cells and an efficient binding to pDNA at N/P ratio of 2. The significant transfection efficiency in CHO-K1 cells at N/P ratio 20 is obtained for block copolymers with mol. weight of P(MEO9MA) up to 10 kg mol-1. Moreover, a fluorescently labeled analog of P(MEO9MA), bearing perylene monoimide methacrylamide (PMIM), is introduced as a comonomer in RAFT polymerization Polyplexes consisting of labeled block copolymer with 20 kg mol-1 of P(MEO9MA) and pDNA are incubated in Hela cells and investigated through structured illumination microscopy (SIM).N-Boc-1,6-Diaminohexane(cas: 51857-17-1Quality Control of N-Boc-1,6-Diaminohexane) was used in this study.

N-Boc-1,6-Diaminohexane(cas: 51857-17-1) can be used as a linear hexyl spacer (C6-spacer) to synthesize biodegradable poly(disulfide amine)s for gene delivery, a multifunctional dendrimer for theranostics and so on.Quality Control of N-Boc-1,6-Diaminohexane

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Synthesis, characterization and antioxidant activity of chitosan Schiff base derivatives bearing (-)-gossypol》 was published in Carbohydrate Polymers in 2020. These research results belong to Beyazit, Neslihan; Cakran, Halide Sinem; Cabir, Ali; Akiscan, Yasar; Demetgul, Cahit. Synthetic Route of C12H15ClN2O2 The article mentions the following:

In this work, two new chitosan-Schiff base derivatives (HCS-GSP and LCS-GSP) were synthesized by the condensation reaction of high mol. weight chitosan (HCS) and low mol. weight chitosan (LCS) with (-)-gossypol (GSP), resp. For this purpose, racemic gossypol was isolated from cotton seeds and it was further enantiomerically purified by diastereomeric resolution technique using L-tryptophan Me ester hydrochloride. Then, chitosan polymers were derivatized with (-)-gossypol by the condensation reaction. The isolated and synthesized compounds were characterized by phys. measurements and spectroscopic methods (elemental anal. C,H,N, Uv-vis, FT-IR, 1H&13C NMR and TG/DTG/DTA). The antioxidant activity of high mol. weight chitosan (HCS), low mol. weight chitosan (LCS) and their gossypol derivatives was evaluated as radical scavengers against 1,1-diphenyl-2-picrylhydrazyl radicals (DPPH). The results showed that both of the chitosan-gossypol derivatives (HCS-GSP and LCS-GSP) had a better ability to scavenging DPPH radical (IC50, 12 μg/mL and 16 μg/mL, resp.) than its unmodified chitosan. In the part of experimental materials, we found many familiar compounds, such as H-Trp-OMe.HCl(cas: 7524-52-9Synthetic Route of C12H15ClN2O2)

H-Trp-OMe.HCl(cas:7524-52-9) is one of amino acid derivatives. Amino acid derivatives represent an important category of skin penetration promoters. These compounds possess hydrophobic chains attached to an amino acid headgroup via a biodegradable ester bond. Due to the amphiphilic nature of these derivatives, it is possible for them to enter into the SC lipid barrier and significantly disorganize skin membrane lipids.Synthetic Route of C12H15ClN2O2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2017,Duan, Sujuan; Guo, Lu; Shi, Dandan; Shang, Mengmeng; Meng, Dong; Li, Jie published 《Development of a novel folate-modified nanobubbles with improved targeting ability to tumor cells》.Ultrasonics Sonochemistry published the findings.HPLC of Formula: 51644-96-3 The information in the text is summarized as follows:

Conjugation of folate (FOL) to nanobubbles could enhance the selective targeting to tumors expressing high levels of folate receptor (FR). To further improve the selective targeting ability of FOL-modified nanobubbles, a novel FOL-targeted nanobubble ((FOL)2-NB) with increasing FOL content (accomplished by linking two FOL mols. per DSPE-PEG2000 chain) was synthesized, through the methods of mech. shaking and low-speed centrifugation based on lipid-stabilized perfluoropropane. The bubble size and distribution range were measured by dynamic light scattering (DLS). Enhanced imaging ability was evaluated using a custom-made agarose mold with a clin. US imaging system at mech. indexes of up to 0.12 at a center frequency of 9.0 MHz. Targeted ability was also carried out in human breast cancer MCF-7 cells, which over-express the FR, by fluorescence activated cell sorting (FACS) and fluorescence microscopy, resp. (FOL)2-NB with a particle size of 286.87 ± 22.96 nm were successfully prepared, and they exhibited superior contrast imaging effect. FACS and fluorescence microscopy studies showed greater cellular targeting ability in the group of (FOL)2-NB than in their control group of Non-targeted-NB (no FOL targeted nanobubbles) and FOL-NB (one FOL mol. per DSPE-PEG2000 chain). These results suggest that a new type of stronger targeted nanobubble was successfully prepared by increasing the FOL content per DSPE-PEG2000 chain. This novel (FOL)2-NBs are potentially useful for ultrasound mol. imaging and treatment of FR-pos. tumors and are worthy for further investigation. The experimental part of the paper was very detailed, including the reaction process of tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3HPLC of Formula: 51644-96-3)

Some of the reported applications of tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3) include: synthesis of of a supermacrocycle that self-assemble to form organic nanotubes., preparation of water-soluble unsymmetrical sulforhodamine fluorophores from monobrominated sulfoxanthene dye, synthesis of functionalized porphyrins as biocompatible carrier system for photodynamic therapy (PDT).HPLC of Formula: 51644-96-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2007,Chemistry – A European Journal included an article by Xie, Yu; Yu, Zhaopeng; Huang, Xiaoying; Wang, Zhiyong; Niu, Liwen; Teng, Maikun; Li, Jing. SDS of cas: 67877-95-6. The article was titled 《Rational design of MOFs constructed from modified aromatic amino acids》. The information in the text is summarized as follows:

Three Phe and Tyr derivatives, 2-amino-3-(4-aminophenyl)-propionic acid (AAP), 3E-[5-(2-amino-2-carboxyethyl)-2-methoxyphenyl]-acrylic acid (AMPA) and 3-(4-aminophenyl)-2-(carboxymethyl-amino)-propionic acid (ACP) were chosen as the ligands to construct four kinds of novel metal-organic frameworks (MOFs) (five structures). These structures are, [CdII{(R)-AAP}(Py)(H2O)]·(ClO4), (R-1); [CdII{(S)-AAP}(H2O)]·(ClO4), (S-2); [ZnII2{(R,S)-AMPA}(H2O)], (R,S-3); [ZnII2{(R)-ACP}(Py)3]·(ClO4)2, (R-4): and the inversion twin of (R-1). Rational design to adjust the depth and the width of ligands can mediate the size and the shape of the grids of these 2-dimensional layers. Addnl., among these compounds, three pure chiral coordination polymers were obtained, owing to the inducement of chirality by the modified amino acids. This property makes them potential NLO materials. After reading the article, we found that the author used H-D-Phe(4-NO2)-OMe.HCl(cas: 67877-95-6SDS of cas: 67877-95-6)

H-D-Phe(4-NO2)-OMe.HCl(cas: 67877-95-6) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils. They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market.SDS of cas: 67877-95-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Formula: C12H15BFNO4On March 7, 2014, Qiu, Di; Wang, Shuai; Tang, Shengbo; Meng, He; Jin, Liang; Mo, Fanyang; Zhang, Yan; Wang, Jianbo published an article in Journal of Organic Chemistry. The article was 《Synthesis of Trimethylstannyl Arylboronate Compounds by Sandmeyer-Type Transformations and Their Applications in Chemoselective Cross-Coupling Reactions》. The article mentions the following:

A synthetic method based on Sandmeyer-type reactions to access both tin- and boron-substituted arenes from nitroaniline derivatives is described. This transformation can be applied to the synthesis of a series of functionalized trimethylstannyl arylboronates. In addition, the chemoselective reaction of the Stille and Suzuki-Miyaura cross-coupling reactions is explored, and a series of m- and p-terphenyl derivatives have been synthesized by conducting consecutive one-pot Stille and Suzuki-Miyaura cross-coupling reactions. In the part of experimental materials, we found many familiar compounds, such as 2-(2-Fluoro-4-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 1073353-89-5Formula: C12H15BFNO4)

2-(2-Fluoro-4-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 1073353-89-5) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils. They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market.Formula: C12H15BFNO4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2022,Nussbaum, Simon; Socie, Etienne; Yao, Liang; Yum, Jun-Ho; Moser, Jacques-E.; Sivula, Kevin published an article in Chemistry of Materials. The title of the article was 《Tuning naphththalenediimide cations for incorporation into Ruddlesden-Popper-type hybrid perovskites》.Related Products of 51857-17-1 The author mentioned the following in the article:

Layered hybrid organic-inorganic perovskite (LHOIP) materials constructed with low-band-gap chromophore-based organic spacer cations are an emerging class of materials that promise unique tunability of their optoelectronic properties. However, the large size of such chromophore-based spacer cations challenges their incorporation into a layered perovskite structure and requires further insight into the layered perovskite phase formation mechanism. Herein, we report the preparation and incorporation of asym. naphthalenediimide (NDI) spacer chromophore cations with different amine-bearing alkyl linker chains into thin films of LHOIPs. Using in situ UV-vis spectroscopic kinetic studies of the quantum well formation, we show that shorter linker chain lengths require higher annealing temperatures to form the LHOIP structure. Avrami anal. of the layered perovskite formation shows a larger Avrami coefficient (n = 3.64) for short linker chain-bearing cations compared to that for longer alkyl chain-bearing cations (n = 2.43), suggesting an evolution from three-dimensional to quasi-two-dimensional crystal growth with increasing linker chain length. Addnl., transient absorption spectroscopy and broad-band fluorescent upconversion spectroscopy indicate fast photoinduced charge transfer from the inorganic layer to the electron-accepting NDI-spacer cation. In the experimental materials used by the author, we found N-Boc-1,6-Diaminohexane(cas: 51857-17-1Related Products of 51857-17-1)

N-Boc-1,6-Diaminohexane(cas: 51857-17-1) is a compound useful in organic synthesis used in the preparation of mixed self-assembled monolayers (SAMs) that resist adsorption of proteins using the reaction of amines with a SAM that presents interchain carboxylic anhydride groupsRelated Products of 51857-17-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics