Tag: 200-300

On February 29, 2008, Bellezza, Francesca; Cipiciani, Antonio; Ruzziconi, Renzo; Spizzichino, Sara published an article.Recommanded Product: 141940-37-6 The title of the article was Nucleus- and side-chain fluorinated 3-substituted indoles by a suitable combination of organometallic and radical chemistry. And the article contained the following:

Regioselectively fluoro-, trifluoromethyl- and trifluoromethoxy-substituted 3-methyleneindolines e.g., I, have been prepared using a four-step procedure involving metalation/bromination of fluorinated Boc-protected anilines, N-propargylation of the resulting o-bromoarylcarbamate and reductive radical cyclization of the product with tributyltin hydride/AIBN. 3-Methyleneindolines, as valuable, versatile intermediates, can be transformed into highly functionalized 3-substituted indoles by ene-type reactions using different enophiles. Thus, fluoro-, trifluoromethyl- and trifluoromethoxy-substituted di-Et 2-hydroxy-2-[(1H-indol-3-yl)methyl]malonates, e.g., II, Et 2-hydroxy-3-(1H-indol-3-yl)propionates, e.g. III, and Et 2-hydroxy-3-(1H-indol-3-yl)-2-trifluormethylpropionates, e.g., IV, were obtained in 77-86% yield by simply heating the corresponding tert-Bu 3-methyleneindoline-1-carboxylate with an equimolar amount of di-Et ketomalonate, Et glyoxalate and Et 3,3,3-trifluoropyruvate, resp., at 100 °C, without solvent, for 0.5-4 h. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Recommanded Product: 141940-37-6

The Article related to aniline butyllithium carbon tetrabromide lithiation bromination, ortho bromo aniline preparation base propargyl bromide alkylation, propargyl aniline preparation aibn tributyltin hydride radical cyclization, indoline preparation enophile carbonyl ene reaction, indole hydroxy propionate derivative preparation, hydroxy malonate indole derivative preparation and other aspects.Recommanded Product: 141940-37-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Tudge, Matthew; Mashima, Hiroko; Savarin, Cecile; Humphrey, Guy; Davies, Ian published an article on February 4 ,2008. The article was titled 《Facile reduction of malonate derivatives using NaBH4/Br2: an efficient route to 1,3-diols》, and you may find the article in Tetrahedron Letters.Category: esters-buliding-blocks The information in the text is summarized as follows:

Borane-dimethoxyethane generated from sodium borohydride-bromine mixtures efficiently reduces a wide range of malonate derivatives to the corresponding 1,3-diols. This new reagent system represents a milder alternative to current methods available, providing the requisite 1,3-diols in higher yields over shorter reaction times. In the experimental materials used by the author, we found Dimethyl 2-(4-nitrophenyl)malonate(cas: 4033-88-9Category: esters-buliding-blocks)

Dimethyl 2-(4-nitrophenyl)malonate(cas: 4033-88-9) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Category: esters-buliding-blocks Polyesters are important plastics, with monomers linked by ester moieties.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Selvakumar, N.; Azhagan, A. Malar; Srinivas, D.; Krishna, G. Gopi published their research in Tetrahedron Letters on December 9 ,2002. The article was titled 《A direct synthesis of 2-arylpropenoic acid esters having nitro groups in the aromatic ring: a short synthesis of (±)-coerulescine and (±)-horsfiline》.Reference of Dimethyl 2-(4-nitrophenyl)malonate The article contains the following contents:

A short synthesis of 2-arylpropenoic acid esters that possess nitro groups in their Ph ring using common and less expensive reagents is described. The usefulness of this methodol. is substantiated by the efficient total syntheses of (±)-coerulescine (I) and (±)-horsfiline from the 2-arylpropenoic acid esters obtained. In the experimental materials used by the author, we found Dimethyl 2-(4-nitrophenyl)malonate(cas: 4033-88-9Reference of Dimethyl 2-(4-nitrophenyl)malonate)

Dimethyl 2-(4-nitrophenyl)malonate(cas: 4033-88-9) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils. They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market.Reference of Dimethyl 2-(4-nitrophenyl)malonate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Foschi, Francesca; Tagliabue, Aaron; Mihali, Voichita; Pilati, Tullio; Pecnikaj, Ilir; Penso, Michele published an article in Organic Letters. The title of the article was 《Memory of Chirality Approach to the Enantiodivergent Synthesis of Chiral Benzo[d]sultams》.Synthetic Route of C10H14ClNO2 The author mentioned the following in the article:

Nonracemic polyfluorobenzo[d]sultams (polyfluorodioxobenzoisothiazolecarboxylates) such as I (R = MeO2C, Ph; R1 = Ph, MeO2C; R2 = H, EtCH2, H2C:CHCH2) were prepared using either stereoselective cyclization of nonracemic (polyfluoroarylsulfonyl)phenylglycines such as II or by phase-transfer alkylation of polyfluorobenzosultams I (R = MeO2C, Ph; R1 = Ph, t-BuO2C; R2 = H) followed by preferential crystallization of one enantiomer of the product. Starting from (polyfluoroarylsulfonyl)phenylglycines, both enantiomers of the corresponding polyfluorobenzo[d]sultams were prepared in most cases; when DBU and N,N,N’,N’-tetramethyl-N”-tert-butylguanidine (BTMG) were used as bases in 1,2-dimethoxyethane, sultams were obtained mainly with retention of the phenylglycine stereochem. (6-94% ee), while when BTMG alone in DME was used, the sultams were obtained mainly with inversion of the phenylglycine stereochem. (8-96% ee). The structures of I (R = MeO2C; R1 = Ph; R2 = EtCH2, H2C:CHCH2) and of I (R = Ph; R1 = t-BuO2C; R2 = Me) were determined by X-ray crystallog. In addition to this study using H-Phg-OEt.HCl, there are many other studies that have used H-Phg-OEt.HCl(cas: 59410-82-1Synthetic Route of C10H14ClNO2) was used in this study.

H-Phg-OEt.HCl(cas: 59410-82-1) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Synthetic Route of C10H14ClNO2 They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Product Details of 4033-88-9On May 27, 2002, Selvakumar, N.; Yadi Reddy, B.; Sunil Kumar, G.; Iqbal, Javed published an article in Tetrahedron Letters. The article was 《Dimethyl malonate as a one-carbon source: a novel method of introducing carbon substituents onto aromatic nitro compounds. [Erratum to document cited in CA136:247364]》. The article mentions the following:

The synthesis of mostly methylated aromatic nitro compound using similar didecarboxylation has been reported by: Gurjar, M.; Reddy, D. S.;; Murugaiah, A.; Murugaiah, S. Synthesis 2000, 1659. The results came from multiple reactions, including the reaction of Dimethyl 2-(4-nitrophenyl)malonate(cas: 4033-88-9Product Details of 4033-88-9)

Dimethyl 2-(4-nitrophenyl)malonate(cas: 4033-88-9) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Product Details of 4033-88-9 They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Formula: C12H15ClN2O2In 2021 ,《Tandem Alkylation/Michael Addition Reaction of Dithiocarbamic Acids with Alkyl γ-Bromocrotonates: Access to Functionalized 1,3-Thiazolidine-2-thiones》 appeared in Synthesis. The author of the article were Khalili Foumeshi, Maryam; Ziyaei Halimehjani, Azim; Alaei, Ali; Klepetarova, Blanka; Beier, Petr. The article conveys some information:

Thiazolidine-2-thiones were prepared via a novel multicomponent reaction of primary amines (amino acids), carbon disulfide, and γ-bromocrotonates. The reaction proceeded via a domino alkylation/intramol. Michael addition to provide the corresponding thiazolidine-2-thiones in high to excellent yields. By using diamines in this protocol, bis(thiazolidine-2-thiones) derivatives were synthesized. The synthetic utility of the adducts was demonstrated by hydrolysis, amidation, and oxidation reactions. The results came from multiple reactions, including the reaction of H-Trp-OMe.HCl(cas: 7524-52-9Formula: C12H15ClN2O2)

H-Trp-OMe.HCl(cas:7524-52-9) is one of amino acid derivatives. Amino acid derivatives represent an important category of skin penetration promoters. These compounds possess hydrophobic chains attached to an amino acid headgroup via a biodegradable ester bond. Due to the amphiphilic nature of these derivatives, it is possible for them to enter into the SC lipid barrier and significantly disorganize skin membrane lipids.Formula: C12H15ClN2O2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Song, Bo; Zhang, Xinyue; Wen, Xinyi; Liu, Qi; Ma, Hua; Guo, Weihua; Tan, Mingqian; Jia, Lei; Yuan, Jingli published an article in 2021. The article was titled 《Development of a tumor-targetable heteropolymetallic lanthanide-complex-based magnetoluminescent probe for dual-modal time-gated luminescence/magnetic resonance imaging of cancer cells in vitro and in vivo》, and you may find the article in New Journal of Chemistry.Product Details of 51857-17-1 The information in the text is summarized as follows:

Probes combining luminescence and magnetic resonance (MR) imaging activities have attracted tremendous attention since they can offer both mol. and anatomical information to effectively improve the accuracy of detection. In this work, a β-diketone ligand (CDHH) was modified by covalent conjugation with an MRI contrast agent (DO3A-Gd) and a tumor-targetable biomacromol. transferrin (Tf). When Eu3+ ions were added into the mixture of two functionalized β-diketone ligands, they triggered a self-assembly to form a heteropolymetallic lanthanide complex that was conjugated to Tf. The as-prepared bioconjugate, i.e., Tf-Eu-Gd, exhibited intense long-lived luminescence (ϕ = 0.20, τ = 0.34 ms), remarkably high MR relaxivities (r1 = 9.18 mM-1 s-1 and r2 = 12.03 mM-1 s-1), as well as good water solubility, stability, and biocompatibility. Time-gated luminescence (TGL) imaging of live cells using Tf-Eu-Gd as a probe demonstrated that the probe can distinguish Tf-receptor-overexpressed cancerous cells, which enables the probe to be specifically accumulated in these cells. On the basis of magnetoluminescent properties of Tf-Eu-Gd, it was further used as a bimodal probe for both TGL and MR imaging of cancerous cells in tumor-bearing nude mice. The results indicated that Tf-Eu-Gd could significantly increase the T1-weighted MRI contrast value in the tumor region, and the TGL imaging of tumor tissue sections provided clear histol. validation of the MRI signals. The research outcomes revealed the feasibility of Tf-Eu-Gd for the tracing and precise detection of cancerous cells, which suggested its potential for serving to the clin. diagnosis, therapy, and medical research of tumor diseases. The results came from multiple reactions, including the reaction of N-Boc-1,6-Diaminohexane(cas: 51857-17-1Product Details of 51857-17-1)

N-Boc-1,6-Diaminohexane(cas: 51857-17-1) can be used as a linear hexyl spacer (C6-spacer) to synthesize biodegradable poly(disulfide amine)s for gene delivery, a multifunctional dendrimer for theranostics and so on.Product Details of 51857-17-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2022,Godfrey, Robert C.; Jones, Helen E.; Green, Nicholas J.; Lawrence, Andrew L. published an article in Chemical Science. The title of the article was 《Unified total synthesis of the brevianamide alkaloids enabled by chemical investigations into their biosynthesis》.Name: H-Trp-OMe.HCl The author mentioned the following in the article:

The bicyclo[2.2.2]diazaoctane alkaloids are a vast group of natural products which have been the focus of attention from the scientific community for several decades. This interest stems from their broad range of biol. activities, their diverse biosynthetic origins, and their topol. complex structures, which combined make them enticing targets for chem. synthesis. In this article, full details of authors synthetic studies into the chem. feasibility of a proposed network of biosynthetic pathways towards the brevianamide family of bicyclo[2.2.2]diazaoctane alkaloids are disclosed. Insights into issues of reactivity and selectivity in the biosynthesis of these structures have aided the development of a unified biomimetic synthetic strategy, which has resulted in the total synthesis of all known bicyclo[2.2.2]diazaoctane brevianamides and the anticipation of an as-yet-undiscovered congener. In the experiment, the researchers used many compounds, for example, H-Trp-OMe.HCl(cas: 7524-52-9Name: H-Trp-OMe.HCl)

H-Trp-OMe.HCl(cas:7524-52-9) is one of amino acid derivatives. Amino acid derivatives represent an important category of skin penetration promoters. These compounds possess hydrophobic chains attached to an amino acid headgroup via a biodegradable ester bond. Due to the amphiphilic nature of these derivatives, it is possible for them to enter into the SC lipid barrier and significantly disorganize skin membrane lipids.Name: H-Trp-OMe.HCl

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Solid-phase synthesis of substrate-based dipeptides and heterocyclic pseudo-dipeptides as potential NO synthase inhibitors》 was written by Touati-Jallabe, Youness; Tintillier, Thibault; Mauchauffee, Elodie; Boucher, Jean-Luc; Leroy, Jeremy; Ramassamy, Booma; Hamze, Abdallah; Mezghenna, Karima; Bouzekrini, Amine; Verna, Claudia; Martinez, Jean; Lajoix, Anne-Dominique; Hernandez, Jean-Francois. Related Products of 51644-96-3 And the article was included in ChemMedChem in 2020. The article conveys some information:

More than 160 arginine analogs modified on the C-terminus via either an amide bond or a heterocyclic moiety (1,2,4-oxadiazole, 1,3,4-oxadiazole and 1,2,4-triazole) were prepared as potential inhibitors of NO synthases (NOS). A methodol. involving formation of a thiocitrulline intermediate linked through its side-chain on a solid support followed by modification of its carboxylate group was developed. Finally, the side-chain thiourea group was either let unchanged, S-alkylated (Me, Et) or guanidinylated (Me, Et) to yield resp. after TFA treatment the corresponding thiocitrulline, S-Me/Et-isothiocitrulline and N-Me/Et-arginine substrate analogs. They all were tested against three recombinant NOS isoforms. Several compounds containing a S-Et- or a S-Me-Itc moiety and mainly belonging to both the dipeptide-like and 1,2,4-oxadiazole series were shown to inhibit nNOS and iNOS with IC50 in the 1-50μM range. Spectral studies confirmed that these new compounds interacted at the heme active site. The more active compounds were found to inhibit intra-cellular iNOS expressed in RAW264.7 and INS-1 cells with similar efficiency than the reference compounds L-NIL and SEIT. The experimental part of the paper was very detailed, including the reaction process of tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3Related Products of 51644-96-3)

Some of the reported applications of tert-Butyl (5-aminopentyl)carbamate(cas: 51644-96-3) include: synthesis of of a supermacrocycle that self-assemble to form organic nanotubes., preparation of water-soluble unsymmetrical sulforhodamine fluorophores from monobrominated sulfoxanthene dye, synthesis of functionalized porphyrins as biocompatible carrier system for photodynamic therapy (PDT).Related Products of 51644-96-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《NaClO2-mediated preparation of pyridine-2-sulfonyl chlorides and synthesis of chiral sulfonamides》 was published in Journal of Sulfur Chemistry in 2020. These research results belong to Xu, Dong; Yang, Shiyi; Gao, Aijun; Yang, Zhanhui. Application In Synthesis of H-Trp-OMe.HCl The article mentions the following:

A simple method to prepare azaarenesulfonyl chlorides by NaClO2-mediated oxidative chlorination of azaarenethiols with water as the solvent has been developed. Easy purification by simple extraction and concentration gave the products in good yields. The azaarenesulfonyl chlorides readily underwent condensation with chiral amines to afford chiral sulfonamides. In the experiment, the researchers used many compounds, for example, H-Trp-OMe.HCl(cas: 7524-52-9Application In Synthesis of H-Trp-OMe.HCl)

H-Trp-OMe.HCl(cas:7524-52-9) is one of amino acid derivatives. Amino acid derivatives represent an important category of skin penetration promoters. These compounds possess hydrophobic chains attached to an amino acid headgroup via a biodegradable ester bond. Due to the amphiphilic nature of these derivatives, it is possible for them to enter into the SC lipid barrier and significantly disorganize skin membrane lipids.Application In Synthesis of H-Trp-OMe.HCl

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics