Tag: 200-300

On May 20, 2022, Nandi, Shantanu; Mondal, Shuvam; Jana, Ranjan published an article.Application In Synthesis of Phenyl Salicylate The title of the article was Chemo- and regioselective benzylic C(sp3)-H oxidation bridging the gap between hetero- and homogeneous copper catalysis. And the article contained the following:

An expedient synthesis of privileged seven-membered lactones, dibenzo[c,e]oxepin-5(7H)-one through a highly chemoselective benzylic C(sp3)-H activation was disclosed. Remarkably, the formation of widely explored six-membered lactone via C(sp2)-H activation was suppressed under the present conditions. The reaction proceeded smoothly on use of inexpensive metallic copper catalyst and di-tert-Bu peroxide (DTBP). Owing to the hazards of stoichiometric DTBP, further, a sustainable metallic copper/rose bengal dual catalytic system coupled with mol. oxygen replacing DTBP was developed. A 1,5-aryl migration through Smiles rearrangement was realized from the corresponding diaryl ether substrates instead of expected eight-membered lactones. The present methodol. was scalable, applied to the total synthesis of cytotoxic and neuroprotective natural product alterlactone. The catalyst was recyclable and the reaction could be performed in a copper bottle without any added catalyst. The experimental process involved the reaction of Phenyl Salicylate(cas: 118-55-8).Application In Synthesis of Phenyl Salicylate

The Article related to orthotolylbenzoic acid copper catalyst intramol benzylic oxidation cyclization, photosensitizer orthotolylbenzoic acid copper catalyst intramol benzylic oxidation cyclization, dibenzooxepinone chemoselective regioselective preparation, catalysis, chemistry, organic chemistry and other aspects.Application In Synthesis of Phenyl Salicylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Teixeira, Priscila Camillo; Ducret, Axel; Langen, Hanno; Nogoceke, Everson; Santos, Ronaldo Honorato Barros; Nunes, Joao Paulo Silva; Benvenuti, Luiz; Levy, Debora; Bydlowski, Sergio Paulo; Bocchi, Edimar Alcides; Takara, Andreia Kuramoto; Fiorelli, Alfredo Inacio; Stolf, Noedir Antonio; Pomeranzeff, Pablo; Chevillard, Christophe; Kalil, Jorge; Cunha-Neto, Edecio published an article in 2021, the title of the article was Impairment of multiple mitochondrial energy metabolism pathways in the heart of chagas disease cardiomyopathy patients.Category: esters-buliding-blocks And the article contains the following content:

Chagas disease cardiomyopathy (CCC) is an inflammatory dilated cardiomyopathy occurring in 30% of the 6 million infected with the protozoan Trypanosoma cruzi in Latin America. Survival is significantly lower in CCC than ischemic (IC) and idiopathic dilated cardiomyopathy (DCM). Previous studies disclosed a selective decrease in mitochondrial ATP synthase alpha expression and creatine kinase activity in CCC myocardium as compared to IDC and IC, as well as decreased in vivo myocardial ATP production Aiming to identify addnl. constraints in energy metabolism specific to CCC, we performed a proteomic study in myocardial tissue samples from CCC, IC and DCM obtained at transplantation, in comparison with control myocardial tissue samples from organ donors. Left ventricle free wall myocardial samples were subject to two-dimensional electrophoresis with fluorescent labeling (2D-DIGE) and protein identification by mass spectrometry. We found altered expression of proteins related to mitochondrial energy metabolism, cardiac remodeling, and oxidative stress in the 3 patient groups. Pathways anal. of proteins differentially expressed in CCC disclosed mitochondrial dysfunction, fatty acid metabolism and transmembrane potential of mitochondria. CCC patients’ myocardium displayed reduced expression of 22 mitochondrial proteins belonging to energy metabolism pathways, as compared to 17 in DCM and 3 in IC. Significantly, 6 beta-oxidation enzymes were reduced in CCC, while only 2 of them were down-regulated in DCM and 1 in IC. We also observed that the cytokine IFN-gamma, previously described with increased levels in CCC, reduces mitochondrial membrane potential in cardiomyocytes. Results suggest a major reduction of mitochondrial energy metabolism and mitochondrial dysfunction in CCC myocardium which may be in part linked to IFN-gamma. This may partially explain the worse prognosis of CCC as compared to DCM or IC. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Category: esters-buliding-blocks

The Article related to mitochondrial energy metabolism pathway chagas disease cardiomyopathy human, chronic chagas disease cardiomyopathy, energy metabolism, idiopathic dilated cardiomyopathy, interferon-gamma, ischemic cardiomyopathy, mitochondria, proteomics, two-dimensional electrophoresis with fluorescent labeling and other aspects.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On September 23, 1999, Buchanan, John; Bohacek, Regine; Vu, Chi B.; Luke, George P. published a patent.Name: (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate The title of the patent was Preparation of heterocyclyl phosphotyrosine derivatives as SH2-mediated signal transduction inhibitors. And the patent contained the following:

Heterocyclic phosphotyrosine derivatives were prepared for inhibiting intracellular signal transduction, especially intracellular signal transduction mediated by a PDGF receptor protein, EGF receptor protein, HER2/Neu receptor protein, fibroblast growth factor receptor protein, focal adhesion kinase protein, p130 protein, or p68 protein. For example, BOC-Tyr(PO3Bn2)-OH (BOC = tert-butoxycarbonyl; Bn = benzyl) and the thiazolylamine salt (I)·TFA (four step preparation given) were coupled, the phosphate deprotected, the amine acylated, and the carboxylic acid deprotected to form the title compound (II). In an assay for binding affinities to Src SH2, thirteen compounds of the invention were determined to have IC50 values of < 50μM. In an assay for binding affinities to Zap-70 SH2, fourteen compounds of the invention exhibited IC50 values of < 50μM. This invention also relates to pharmaceutical compositions containing the compounds and prophylactic and therapeutic methods involving pharmaceutical and veterinary administration of the compounds for proliferative disease, cancer, restenosis, osteoporosis, inflammation, allergies, cardiovascular disease, or immunosuppression. The experimental process involved the reaction of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate(cas: 53838-27-0).Name: (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate

The Article related to peptide heterocyclyl phosphotyrosine preparation signal transduction inhibitor, antitumor heterocyclyl phosphotyrosine preparation antiosteoporotic antiinflammatory antiallergenic immunosuppressant, tyrosine phospho heterocyclyl preparation proliferative disease cardiovascular disease treatment and other aspects.Name: (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On December 17, 2021, Ofman, Tim P.; Kuellmer, Florian; van der Marel, Gijsbert A.; Codee, Jeroen D. C.; Overkleeft, Herman S. published an article.Related Products of 2873-29-2 The title of the article was An Orthogonally Protected Cyclitol for the Construction of Nigerose- and Dextran-Mimetic Cyclophellitols. And the article contained the following:

Cyclophellitols are potent inhibitors of exo- and endoglycosidases. Efficient synthetic methodologies are needed to fully capitalize on this intriguing class of mechanism-based enzyme de-activators. We report the synthesis of an orthogonally protected cyclitol from D-glucal (19% yield over 12 steps) and its use in the synthesis of α-(1,3)-linked di- and trisaccharide dextran mimetics. These new glycomimetics may find use as Dextranase inhibitors, and the developed chemistries in widening the palette of glyco-processing enzyme-targeting glycomimetics. The experimental process involved the reaction of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate(cas: 2873-29-2).Related Products of 2873-29-2

The Article related to epoxidation aziridination trisaccharide dextran mimetic cyclitol nigerose cyclophellitol, oligosaccharide trisaccharide dextran cyclophellitol preparation endoglycosidase inhibitor aziridine, trisaccharide dextran cyclophellitol endoglycosidase glycomimetic dextranase inhibitor glucal cyclitol and other aspects.Related Products of 2873-29-2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On October 31, 2021, Reijneveld, Josephine F.; Marino, Laura; Cao, Thinh-Phat; Cheng, Tan-Yun; Dam, Dennis; Shahine, Adam; Witte, Martin D.; Filippov, Dmitri V.; Suliman, Sara; van der Marel, Gijsbert A.; Moody, D. Branch; Minnaard, Adriaan J.; Rossjohn, Jamie; Codee, Jeroen D. C.; Van Rhijn, Ildiko published an article.Reference of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate The title of the article was Rational design of a hydrolysis-resistant mycobacterial phosphoglycolipid antigen presented by CD1c to T cells. And the article contained the following:

Whereas proteolytic cleavage is crucial for peptide presentation by classical major histocompatibility complex (MHC) proteins to T cells, glycolipids presented by CD1 mols. are typically presented in an unmodified form. However, the mycobacterial lipid antigen mannosyl-β1-phosphomycoketide (MPM) may be processed through hydrolysis in antigen presenting cells, forming mannose and phosphomycoketide (PM). To further test the hypothesis that some lipid antigens are processed, and to generate antigens that lead to defined epitopes for future tuberculosis vaccines or diagnostic tests, we aimed to create hydrolysis-resistant MPM variants that retain their antigenicity. Here, we designed and tested three different, versatile synthetic strategies to chem. stabilize MPM analogs. Crystallog. studies of CD1c complexes with these three new MPM analogs showed anchoring of the lipid tail and phosphate group that is highly comparable to nature-identical MPM, with considerable conformational flexibility for the mannose head group. MPM-3, a difluoromethylene-modified version of MPM that is resistant to hydrolysis, showed altered recognition by cells, but not by CD1c proteins, supporting the cellular antigen processing hypothesis. Furthermore, the synthetic analogs elicited T cell responses that were cross-reactive with nature-identical MPM, fulfilling important requirements for future clin. use. The experimental process involved the reaction of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate(cas: 2873-29-2).Reference of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate

The Article related to glycoside hydrolysis resistant mycobacterial glycophospholipid phosphoglycolipid antigen antibacterial, ifn interferon human cd1c antigen vaccine immunization glycophospholipid preparation, cd1c, t-cell receptor (tcr), antigen presentation, glycolipid, lipid synthesis, protein crystallization and other aspects.Reference of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On August 10, 2011, Hu, Mingyu; Li, Lin; Wu, Hao; Su, Ying; Yang, Peng-Yu; Uttamchandani, Mahesh; Xu, Qing-Hua; Yao, Shao Q. published an article.Formula: C12H15NO4 The title of the article was Multicolor, one- and two-photon imaging of enzymatic activities in live cells with fluorescently quenched activity-based probes (qABPs). And the article contained the following:

Fluorescence imaging provides an indispensable way to locate and monitor biol. targets within complex and dynamic intracellular environments. Of the various imaging agents currently available, small mol.-based probes provide a powerful tool for live cell imaging, primarily due to their desirable properties, including cell permeability (as a result of their smaller sizes), chem. tractability (e.g., different mol. structures/designs can be installed), and amenability to imaging a wide variety of biol. events. With a few exceptions, most existing small mol. probes are however not suitable for in vivo bioimaging experiments in which high-resolution studies of enzyme activity and localization are necessary. Here, the authors report a new class of fluorescently quenched activity-based probes (qABPs) which are highly modular, and can sensitively image (through multiple enzyme turnovers leading to fluorescence signal amplification) different types of enzyme activities in live mammalian cells with good spatial and temporal resolution The authors also incorporated 2-photon dyes into their modular probe design, enabling for the 1st time activity-based, fluorogenic 2-photon imaging of enzyme activities. Thus, this expands the repertoire of ‘smart’, responsive probes currently available for live cell bioimaging experiments The experimental process involved the reaction of tert-Butyl 2-(4-nitrophenyl)acetate(cas: 29704-38-9).Formula: C12H15NO4

The Article related to enzyme imaging live cell fluorescently quenched activity based probe, caspase imaging live cell fluorescently quenched activity based probe, phosphatase imaging live cell fluorescently quenched activity based probe, fluorescently quenched activity based probe preparation enzyme imaging cell and other aspects.Formula: C12H15NO4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On May 21, 2020, Ahadi, Somayeh; Awan, Shahid I.; Werz, Daniel B. published an article.Safety of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate The title of the article was Total Synthesis of Tri-, Hexa- and Heptasaccharidic Substructures of the O-Polysaccharide of Providencia rustigianii O34. And the article contained the following:

A general and efficient strategy for synthesis of tri-, hexa- and heptasaccharidic substructures of the lipopolysaccharide of Providencia rustigianii O34 is described. For the heptasaccharide seven different building blocks were employed. Special features of the structures are an α-linked galactosamine and the two embedded α-fucose units, which are either branched at positions-3 and -4 or further linked at their 2-position. Convergent strategies focused on [4+3], [3+4], and [4+2+1] coupling. Whereas the [4+3] and [3+4] coupling strategies failed the [4+2+1] strategy was successful. As monosaccharidic building blocks trichloroacetimidates and phosphates were employed. Global deprotection of the fully protected structures was achieved by Birch reaction. The experimental process involved the reaction of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate(cas: 2873-29-2).Safety of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate

The Article related to synthon lipopolysaccharide providencia rustigianii oligosaccharide preparation galactosamine coupling, oligosaccharide aminoglycoside preparation providencia rustigianii polysaccharide coupling birch, providencia rustigianii, fucose, glycosylation, lipopolysaccharide (lps), oligosaccharides and other aspects.Safety of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On March 10, 2005, Kumagai, Toshihito; Kuwada, Takeshi; Shibata, Tsuyoshi; Hayashi, Masato; Fujisawa, Yuri; Sekiguchi, Yoshinori published a patent.Computed Properties of 141940-37-6 The title of the patent was Preparation of 1-[1-(benzenesulfonyl)-3-phenyl-2-oxo-1,3-dihydro-2H-indol-3-yl]-4-fluoro-L-proline derivatives as antagonists of arginine-vasopressin V1b receptor. And the patent contained the following:

1,3-Dihydro-2H-indol-2-one derivatives represented by the formula (I) (wherein R1 = halogeno, C1-4 alkyl, C1-4 alkoxy, CF3, CF3O; R2 = H, halogeno, C1-4 alkyl, C1-4 alkoxy, CF3; or R2 is present in the 6-position of the indol-2-one and is bonded to R1 to form C3-6 alkylene; R3 = halogeno, hydroxy, C1-4 alkyl, C1-4 alkoxy, CF3O; R4 = H, halogeno, C1-4 alkyl, C1-4 alkoxy; or R4 is present in the 3-position of the Ph and is bonded to R3 to form methylenedioxy; R5 = H, F; R6 = ethylamino, dimethylamino, azetidin-1-yl, C1-4 alkoxy; R7, R8 = C1-4 alkoxy) or pharmaceutically acceptable salts thereof are prepared These compounds have antagonistic activity against an arginine-vasopressin V1b receptor and are useful for the prevention or treatment of depression, anxiety, Alzheimer’s disease, Parkinson’s disease, Huntington chorea, eating disorder, hypertension, digestive tract diseases, drug dependence, epilepsy, cerebral infarction, cerebral ischemia, cerebral edema, head trauma, inflammation, immune diseases, and alopecia. Thus, 3.78 g 3,5-dichloro-3-(2-methoxyphenyl)-1,3-dihydro-2H-indol-2-one and 7.27 g (4R)-4-fluoro-N,N-dimethyl-L-prolinamide trifluoroacetate were suspended in 40 mL CHCl3, treated with 7.47 g Et3N, and stirred at room temperature for 13 h to give, after silica gel chromatog., (+)- and (-)-(4R)-1-[5-chloro-3-(2-methoxyphenyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-4-fluoro-N,N-dimethyl-L-prolinamide (II). (-)-II (2.00 g) was added to a mixture of 0.215 g NaH and 20 mL DMF under ice-cooling, stirred for 40 min, treated with a solution of 1.27 g 2,4-dimethoxybenzenesulfonyl chloride in 5 mL DMF, and stirred for 35 min under ice-cooling and then at room temperature for 1 h to give (-)-(4R)-1-[5-chloro-1-[(2,4-dimethoxyphenyl)sulfonyl]-3-(2-methoxyphenyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-4-fluoro-N,N-dimethyl-L-prolinamide (III). III inhibited the binding of [3H]Arg-vasopressin to arginine-vasopressin receptor VIb and VIa by 50% at 1-100 x 10-9 M and 10-8-10-6 M, resp. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Computed Properties of 141940-37-6

The Article related to benzenesulfonylphenyloxodihydroindolylfluoroproline preparation antagonist arginine vasopressin v1b receptor, oxodihydroindolylfluoroprolinamide preparation antagonist arginine vasopressin v1b receptor, oxodihydroindolylfluoroproline preparation antagonist arginine vasopressin v1b receptor and other aspects.Computed Properties of 141940-37-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On June 2, 2020, Zhang, Kai; Zhong, Shifa; Zhang, Huichun published an article.Application of 118-55-8 The title of the article was Predicting Aqueous Adsorption of Organic Compounds onto Biochars, Carbon Nanotubes, Granular Activated Carbons, and Resins with Machine Learning. And the article contained the following:

predictive models are useful tools for aqueous adsorption research; however, existing (e.g., multi-linear regression [MLR]) models can only predict adsorption under specific equilibrium concentrations or for certain adsorption isotherm models. few studies have discussed data processing beyond applying different modeling algorithms to improve prediction accuracy. this work used a cosine similarity approach which focused on mining available data before developing models. the approach, to mine the most relevant data concerning the prediction target to develop models, considerably improved prediction accuracy. a machine-learning modeling process based on neural networks (NN); a group-selection data-splitting strategy for grouped adsorption data for adsorbent-adsorbate pairs under different equilibrium concentrations; and poly-parameter linear free energy relationships (pp-LFER) for aqueous adsorption of 165 organic compounds on 50 biochars, 34 C nanotubes, 35 granular activated C, and 30 polymeric resins, was developed. the final NN-LFER models, successfully applied to various equilibrium concentrations regardless of adsorption isotherm model, showed less prediction deviations than published models with root mean-square errors of 0.23-0.31 vs. 0.23-0.97 log units; the predictions were also improved by adding two key descriptors (surface area and pore volume) for the adsorbents. interpreting the NN-LFER models based on Shapley values suggested not considering adsorbent equilibrium concentration and properties in existing MLR models is a possible reason for their higher prediction deviations. The experimental process involved the reaction of Phenyl Salicylate(cas: 118-55-8).Application of 118-55-8

The Article related to biochar organic compound aqueous adsorption machine learning predictive model, carbon nanotube organic compound aqueous adsorption predictive model, granular activated carbon organic compound aqueous adsorption predictive model, resin organic compound aqueous adsorption predictive model and other aspects.Application of 118-55-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Mazzeo, Giuseppe; Longhi, Giovanna; Abbate, Sergio; Palomba, Martina; Bagnoli, Luana; Marini, Francesca; Santi, Claudio; Han, Jianlin; Soloshonok, Vadim A.; Di Crescenzo, Emilio; Ruzziconi, Renzo published an article in 2017, the title of the article was Solvent-free, uncatalyzed asymmetric “ene” reactions of N-tert-butylsulfinyl-3,3,3-trifluoroacetaldimines: a general approach to enantiomerically pure α-(trifluoromethyl)tryptamines.Recommanded Product: 141940-37-6 And the article contains the following content:

A novel approach to regioselectively substituted and stereoselectively α-trifluoromethylated tryptamines, e.g., I [Y = H, Me-5, OMe-5, Cl-5, F-5, CF3-5 or CF3-6] and II, is reported based on the ene reaction of Boc-protected 3-methyleneindolines with optically pure (R)- or (S)-tert-butanesulfinyltrifluoroacetaldimine. Boc- and sulfinylamido-protected α-trifluoromethyltryptamines are obtained in 60-70% yield and 85/15 dr by just heating equimolar amounts of the two reaction partners at 80-90 °C for 2-3 h without a solvent. The absolute configuration of the amino α-carbon has been assigned based on the vibrational CD (VCD) spectral anal. The two protecting group can be chemoselectively removed allowing further regio- and stereoselective elaboration of the ene products to various biol. interesting compounds The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Recommanded Product: 141940-37-6

The Article related to butylsulfinyl trifluoroacetaldimine stereoselective ene reaction boc protected methyleneindoline, trifluoromethyltryptamine preparation absolute configuration vibrational cd dft, regioselective elaboration trifluoromethyltryptamine, stereoselective elaboration trifluoromethyltryptamine and other aspects.Recommanded Product: 141940-37-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics