Tag: 200-300

On August 23, 2021, Jiang, Yaqiqi; Li, Bao; Ma, Nana; Shu, Sai; Chen, Yujie; Yang, Shan; Huang, Zhibin; Shi, Daqing; Zhao, Yingsheng published an article.Recommanded Product: tert-Butyl (4-(trifluoromethyl)phenyl)carbamate The title of the article was Photoredox-Catalyst-Enabled para-Selective Trifluoromethylation of tert-Butyl Arylcarbamates. And the article contained the following:

In this study, a light-promoted 4,5-dichlorofluorescein (DCFS)-enabled para-selective C-H trifluoromethylation of arylcarbamates using Langlois reagent was reported. The preliminary mechanistic study revealed that the activated organic photocatalyst coordinated with the arylcarbamate led to para-selective C-H trifluoromethylation. Ten-gram scale reaction performs well highlighting the synthetic importance of this new protocol. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Recommanded Product: tert-Butyl (4-(trifluoromethyl)phenyl)carbamate

The Article related to sodium triflinate tertiary butyl arylcarbamate dichlorofluorescein catalyst photochem trifluoromethylation, tertiary butyl trifluoromethylaryl carbamate preparation regioselective, photoirradiation, site selectivity, ten gram scale, trifluoromethylation and other aspects.Recommanded Product: tert-Butyl (4-(trifluoromethyl)phenyl)carbamate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On February 1, 2022, Nielsen, Michael Martin; Holmstroem, Thomas; Pedersen, Christian Marcus published an article.Recommanded Product: (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate The title of the article was Stereoselective O-Glycosylations by Pyrylium Salt Organocatalysis. And the article contained the following:

Despite many years of invention, the field of carbohydrate chem. remains rather inaccessible to non-specialists, which limits the scientific impact and reach of the discoveries made in the field. Aiming to increase the availability of stereoselective glycosylation chem. for non-specialists, we have discovered that several com. available pyrylium salts catalyze stereoselective O-glycosylation of a wide range of phenols and alkyl alcs. This catalytic reaction utilizes trichloroacetimidates, an easily accessible and synthetically proven electrophile, takes place under air and only initiates when all three reagents are mixed, which should provide better reproducibility by non-specialists. The reaction exhibits varying degrees of stereospecificity, resulting in β-selective glycosylation from α-trichloroacetimidates, while an α-selective glycosylation proceeds from β-trichloroacetimidates. A mechanistic study revealed that the reaction likely proceeds via an SN2-like substitution on the protonated electrophile. The experimental process involved the reaction of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate(cas: 2873-29-2).Recommanded Product: (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate

The Article related to amino acid disaccharide glycoside preparation glycosylation cytotoxicity, stereoselective glycosylation catalyze organocatalysis pyrylium salt glycoside preparation chloroacetimidate, catalysis, kinetics, pyrylium, stereospecific glycosylation mechanism and other aspects.Recommanded Product: (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Dabrowska, Aleksandra M.; Barabas, Anna; Sikorski, Artur; Wera, Michal; Brzeski, Jakub; Domzalska, Marta; Chylewska, Agnieszka published an article in 2021, the title of the article was t-Butyl 3-azido- and 3-amino-2,3-dideoxy-α-D-arabino-hexopyranosides: a concise protocol of structural and chemical profiles to identify metal ion binding modes.Related Products of 2873-29-2 And the article contains the following content:

The metal cations-polysaccharides complexes play crucial roles in the process of immune cell recognitions. Here, the authors create simpler biomimetic ligands, which emulate binding of carbohydrates in living organisms. The authors present a detailed study on the interactions of Cu2+, Ni2+ and VO2+ ions with t-Bu 3-azido- and 3-amino-2,3-dideoxy-α-D-arabino-hexopyranosides. NMR, IR and UV-visible spectroscopies as well as single crystal x-ray diffraction were used for the ligand structure determinations and showed their binding affinity of ions selected. The formation of stable complexes of Cu(II), Ni(II), VO(IV) ions and saccharides with 1:1, 1:2 and 1:3 molar ratios was proved. The coordination sites proposed are N-donor (amino or azido groups), O-donor (hydroxyl group) and endo-oxygen atoms. Addnl., parameters like shape, charge d. distribution, and sites of chem. reactivity of the sugars studied were obtained by mapping electron d. isosurface with electrostatic potential (MESP). The experimental process involved the reaction of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate(cas: 2873-29-2).Related Products of 2873-29-2

The Article related to preparation transition metal tertbutylazidodideoxy arabinohexopyranoside complex, crystal mol structure tertbutylazidodideoxy alpha arabinohexopyranoside compound, stability constant transition metal tertbutylazidodideoxy arabinohexopyranoside compound and other aspects.Related Products of 2873-29-2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On May 31, 2018, Zhang, Xuekai; Lu, Gang; Sun, Meng; Mahankali, Madhu; Ma, Yanfei; Zhang, Mingming; Hua, Wangde; Hu, Yuting; Wang, Qingbing; Chen, Jinghuo; He, Gang; Qi, Xiangbing; Shen, Weijun; Liu, Peng; Chen, Gong published an article.Reference of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate The title of the article was A general strategy for synthesis of cyclophane-braced peptide macrocycles via palladium-catalyzed intramolecular sp3 C-H arylation. And the article contained the following:

New methods capable of effecting cyclization, and forming novel three-dimensional structures while maintaining favorable physicochem. properties are needed to facilitate the development of cyclic peptide-based drugs that can engage challenging biol. targets, such as protein-protein interactions. Here, we report a highly efficient and generally applicable strategy for constructing new types of peptide macrocycles using palladium-catalyzed intramol. C(sp3)-H arylation reactions. Easily accessible linear peptide precursors of simple and versatile design can be selectively cyclized at the side chains of either aromatic or modified non-aromatic amino acid units to form various cyclophane-braced peptide cycles. This strategy provides a powerful tool to address the long-standing challenge of size- and composition-dependence in peptide macrocyclization, and generates novel peptide macrocycles with uniquely buttressed backbones and distinct loop-type three-dimensional structures. Preliminary cell proliferation screening of the pilot library revealed a potent lead compound with selective cytotoxicity toward proliferative Myc-dependent cancer cell lines. The experimental process involved the reaction of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate(cas: 53838-27-0).Reference of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate

The Article related to cyclodepsipeptide cyclophane diastereoselective synthesis antitumor structure activity crystal structure, arylation palladium catalyst transition state ring strain energy dft, amino acid iodination esterification peptide coupling solid phase synthesis and other aspects.Reference of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On November 30, 2010, Baeza, Jose Luis; Bonache, M. Angeles; Garcia-Lopez, M. Teresa; Gonzalez-Muniz, Rosario; Martin-Martinez, Mercedes published an article.Related Products of 53838-27-0 The title of the article was 2-Alkyl-2-carboxyazetidines as γ-turn inducers: incorporation into neurotrophin fragments. And the article contained the following:

Conveniently substituted 2-alkyl-2-carboxyazetidine amino acids have been incorporated into NGF and NT3 tetrapeptide sequences to investigate their utility as reverse turn inducers (γ- vs. β-turns). Despite the presence of an Asp residue at i position, highly preferred in β-turns, mol. modeling and NMR studies indicated that the azetidine-containing peptides mainly stabilized γ-turn conformations. The experimental process involved the reaction of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate(cas: 53838-27-0).Related Products of 53838-27-0

The Article related to alkyl carboxyazetidine amino acid turn gamma inducer neurotrophin peptide, solid phase peptide synthesis conformer turn conformation mol modeling, peptidomimetic hydrogen bond mol structure nmr md simulation, azetidine alkyl amino acid preparation gamma turn conformation and other aspects.Related Products of 53838-27-0

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On January 5, 1992, Sugitani, Hatsuo; Fukasawa, Masato; Katou, Kouichi published an article.Electric Literature of 1985-51-9 The title of the article was Analysis of poly-functional acrylates and methacrylates by reversed-phase liquid chromatography with photodiode-array detector. And the article contained the following:

Identification and quant. determination of crosslinking agents in photosensitive materials were studied by reversed-phase liquid chromatog. using a photodiode-array detector. Thirty-two kinds of polyfunctional acrylates and methacrylates (crosslinking agents) were studied. As a result of this study, 30 kinds of the polyfunctional (meth)acrylates were successfully identified and determined by the gradient elution method using MeCN-H2O as the eluent. This method provided good reproducibilities in the elution volumes (0.20∼3.09%) and peak areas (0.34∼0.32%) in each sample. This method was applied to the anal. of crosslinking agents in com. available solid-type and liquid-type photosensitive materials and proved to be a rapid and very accurate method. The experimental process involved the reaction of 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate)(cas: 1985-51-9).Electric Literature of 1985-51-9

The Article related to reverse phase hplc crosslinking agent determination, photosensitive composition hardener determination hplc, acrylate crosslinking agent determination hplc, methacrylate crosslinking agent determination hplc, liquid chromatog acrylate crosslinking agent determination and other aspects.Electric Literature of 1985-51-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kaberova, Zhansaya; Karpushkin, Evgeny; Nevoralova, Martina; Vetrik, Miroslav; Slouf, Miroslav; Duskova-Smrckova, Miroslava published an article in 2020, the title of the article was Microscopic structure of swollen hydrogels by scanning electron and light microscopies: artifacts and reality.HPLC of Formula: 2358-84-1 And the article contains the following content:

The exact knowledge of hydrogel microstructure, mainly its pore topol., is a key issue in hydrogel engineering. For visualization of the swollen hydrogels, the cryogenic or high vacuum scanning electron microscopies (cryo-SEM or HVSEM) are frequently used while the possibility of artifact-biased images is frequently underestimated. The major cause of artifacts is the formation of ice crystals upon freezing of the hydrated gel. Some porous hydrogels can be visualized with SEM without the danger of artifacts because the growing crystals are accommodated within already existing primary pores of the gel. In some non-porous hydrogels the secondary pores will also not be formed due to rigid network structure of gels that counteracts the crystal nucleation and growth. We have tested the limits of true reproduction of the hydrogel morphol. imposed by the swelling degree and mech. strength of gels by investigating a series of methacrylate hydrogels made by crosslinking polymerization of glycerol monomethacrylate and 2-hydroxyethyl methacrylate including their interpenetrating networks. The hydrogel morphol. was studied using cryo-SEM, HVSEM, environmental SEM (ESEM), laser scanning confocal microscopy (LSCM) and classical wide-field light microscopy (LM). The cryo-SEM and HVSEM yielded artifact-free micrographs for limited range of non-porous hydrogels and for macroporous gels. A true non-porous structure was observed free of artifacts only for hydrogels exhibiting relatively low swelling and high elastic modulus above 0.5 MPa, whereas for highly swollen and/or mech. weak hydrogels the cryo-SEM/HVSEM experiments resulted in secondary porosity. In this contribution we present several cases of severe artifact formation in PHEMA and PGMA hydrogels during their visualization by cryo-SEM and HVSEM. We also put forward empirical correlation between hydrogel morphol. and mech. parameters and the occurrence and intensity of artifacts. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).HPLC of Formula: 2358-84-1

The Article related to acrylic hydrogel preparation swelling crosslinking, pgma, phema, artifacts, hydrogel, laser scanning confocal microscopy, morphology, poly(2-hydroxyethyl methacrylate), poly(glycerol monomethacrylate), variable-pressure and environmental scanning electron microscopy and other aspects.HPLC of Formula: 2358-84-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On March 16, 2020, Xie, Tao; Zheng, Chaoying; Chen, Kuanwei; He, Haibing; Gao, Shuanhu published an article.Synthetic Route of 2873-29-2 The title of the article was Asymmetric Total Synthesis of the Complex Polycyclic Xanthone FD-594. And the article contained the following:

A highly convergent approach was developed to achieve the first asym. and scalable total synthesis of FD-594, a complex polycyclic xanthone natural product from Streptomyces sp. TA-0256, in a longest linear sequence (LLS) of 20 steps. The trans-9,10-dihydrophenanthrene-9,10-diol fragment (B-C-D ring) was generated through a new strategy involving asym. dihydroxylation followed by Cu-mediated oxidative cyclization. Late-stage stereoselective glycosylation assembled the angular hexacyclic framework with a β-linked 2,6-dideoxy trisaccharide fragment. The experimental process involved the reaction of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate(cas: 2873-29-2).Synthetic Route of 2873-29-2

The Article related to polycyclic xanthone fd594 trisaccharide preparation cross coupling cyclization, crystal structure framework stereoselective glycosylation hydroxylation hydrophenanthrenediol xanthone, glycosylation, natural products, oxidative cyclization, total synthesis, xanthones and other aspects.Synthetic Route of 2873-29-2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On June 15, 2000, Hewawasam, Piyasena; Starrett, John E., Jr. published a patent.Related Products of 141940-37-6 The title of the patent was Preparation of 3-substituted-4-arylquinolin-2-one derivatives as calcium-activated potassium (BK) channel openers. And the patent contained the following:

The title compounds (I) [wherein R and R1 = independently H or Me; R2, R3, and R4 = independently H, halogen, NO2, or CF3; R5 = Br, Cl, or NO2; R6 = H or F; R7 = Me, CRR1OH, CHO, C:NOH, COMe, or (un)substituted aryl; m = 0-1; n = 0-6] were prepared by cyclization and further reaction of 1-[2-(acylamino)phenyl]-1-phenylmethanone derivatives For example, 4-(5-chloro-2-hydroxyphenyl)-3-(2-hydroxyethyl)-6-(trifluoromethyl)-2(1H)-quinoline (II) was synthesized in a 5-step sequence starting with acylation of 1-[2-amino-5-(trifluoromethyl)phenyl]-1′-(5-chloro-2-methoxyphenyl)methanone (preparation given) with 3-carbomethoxypropionyl chloride (82%). Subsequent cyclization (100%), dehydration (78%), demethylation (86%), and reduction of the acid yielded II. II activated the cloned BK channel mSlo expressed in Xenopus oocytes, increasing whole cell outward (K+) BK-mediated currents > 200% at 20 μM. In an in vivo erectile function test on diabetic F-344 rats, II (0.1-1 mg/kg) significantly augmented intracavernous pressure/BP responses elicited by submaximal stimulation of the cavernous nerve. As BK channel openers, I are useful in the treatment of disorders which are responsive to the opening of the potassium channels, such as ischemia, stroke, convulsions, epilepsy, asthma, irritable bowel syndrome, migraine, traumatic brain injury, spinal cord injury, sexual dysfunction, and urinary incontinence. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Related Products of 141940-37-6

The Article related to arylquinolinone preparation potassium channel opener, quinolinone aryl preparation erectile dysfunction treatment, stroke treatment quinolinone aryl preparation, brain injury treatment quinolinone aryl preparation, sexual dysfunction quinolinone aryl preparation and other aspects.Related Products of 141940-37-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Joumaa, Ahmad; Gayet, Florence; Garcia-Suarez, Eduardo J.; Himmelstrup, Jonas; Riisager, Anders; Poli, Rinaldo; Manoury, Eric published an article in 2020, the title of the article was Synthesis of nixantphos core-functionalized amphiphilic nanoreactors and application to rhodium-catalyzed aqueous biphasic 1-octene hydroformylation.Formula: C12H18O5 And the article contains the following content:

A latex of amphiphilic star polymer particles, functionalized in the hydrophobic core with nixantphos and containing P(MAA-co-PEOMA) linear chains in the hydrophilic shell (nixantphos-functionalized core-crosslinked micelles, or nixantphos@CCM), has been prepared in a one-pot three-step convergent synthesis using reversible addition-fragmentation chain transfer (RAFT) polymerization in water. The synthesis involves polymerization-induced self-assembly (PISA) in the second step and chain crosslinking with di(ethylene glycol) dimethacrylate (DEGDMA) in the final step. The core consists of a functionalized polystyrene, obtained by incorporation of a new nixantphos-functionalized styrene monomer (nixantphos-styrene), which is limited to 1 mol%. The nixantphos-styrene monomer was synthesized in one step by nucleophilic substitution of the chloride of 4-chloromethylstyrene by deprotonated nixantphos in DMF at 60°C, without interference of either phosphine attack or self-induced styrene polymerization The polymer particles, after loading with the [Rh(acac)(CO)2] precatalyst to yield Rh-nixantphos@CCM, function as catalytic nanoreactors under aqueous biphasic conditions for the hydroformylation of 1-octene to yield n-nonanal selectively, with no significant amounts of the branched product 2-methyl-octanal. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Formula: C12H18O5

The Article related to octene nixantphos rhodium catalyzed core functionalized amphiphilic nanoreactor hydroformylation, raft polymerization, aqueous biphasic catalysis, hydroformylation, nixantphos, polymerization-induced self-assembly, rhodium, water-confined polymeric nanoreactors and other aspects.Formula: C12H18O5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics