Tag: 200-300

On December 27, 2002, Swenson, Rolf E.; Sowin, Thomas J.; Zhang, Henry Q. published an article.COA of Formula: C12H14F3NO2 The title of the article was Synthesis of Substituted Quinolines Using the Dianion Addition of N-Boc-anilines and α-Tolylsulfonyl-α,β-unsaturated Ketones. And the article contained the following:

A short and versatile synthesis of substituted quinolines is provided. Alkylation of sodium tolylsulfinate with bromomethyl- or chloromethyl ketones generates β-keto sulfones, e.g., I. Knoevenagel condensation of the β-keto sulfones with an aldehyde provides α-tolylsulfonyl-α,β-unsaturated ketones, e.g., II. Michael addition of the dianion of N-Boc-anilines in the presence of CuCN and LiCl with the unsaturated ketone generates a 1,4-adduct, which after deprotection of the Boc group and thermal elimination of the tolyl sulfone provides the quinoline, e.g., III. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).COA of Formula: C12H14F3NO2

The Article related to sodium tolylsulfinate halomethyl ketone alkylation, keto sulfone preparation aldehyde knoevenagel condensation, unsaturated ketone tolylsulfonyl preparation aniline dianion michael addition elimination, quinoline preparation and other aspects.COA of Formula: C12H14F3NO2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On April 10, 2003, Dhar, T. G. Murali; Potin, Dominique; Maillet, Magaili Jeannine Blandine; Launay, Michele; Nicolai, Eric Antoine; Iwanowicz, Edwin J. published a patent.Application In Synthesis of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate The title of the patent was Preparation of spiro-hydantoin compounds useful as anti-inflammatory agents. And the patent contained the following:

Title compounds I [L and K independently = O or S; X = N or CR3; Ar = aryl or heteroaryl; G is attached via T or M with provision when attached to C, G = bond, O, N, S, (un)substituted alkylene, bivalent alkoxy, etc., when G is attached to N, G = bond, (un)substituted alkylene, bivalent acyl or alkoxycarbonyl, and a bivalent alkoxy, alkylthio, aminoalkyl, sulfonyl, or sulfonamidyl wherein each of said G groups have at least one carbon atom attached to ring A; T = T1 when G-Ar is attached to T, and T2 when G-Ar is attached to M; M = M1 when G-Ar is attached to M, and M2 when G-Ar is attached to T; T1 and M1 = N, CR5; T2 and M2 = O, S, -N=, SO2, etc.; R1, R2, and R3 independently = H, halo, (un)substituted-alkyl, -alkenyl, NO2, etc.; R4 = H, (un)substituted alkyl, OH, NH2, alkoxy, etc.; R5 = H, (un)substituted alkyl, halo, CN, OH, etc.; J = O, S, -N=, SO2, substituted N, etc.; ], and pharmaceutically-acceptable salts, hydrates,enantiomers, and diastereomers, and prodrugs thereof, (I) are prepared and disclosed as inhibitors of LFA-1/ICAM and as anti-inflammatory agents. Thus, II was prepared by base catalyzed cyclization of 1-bromo-4-(1,4-dibromobutyl)benzene (preparation given) with 3-(3,5-dichlorophenyl)-1-methylimidazolidine-2,4-dione. Assays indicated I have a measurable level of activity as inhibitors of LFA-1 and/or ICAM (no data). The experimental process involved the reaction of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate(cas: 53838-27-0).Application In Synthesis of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate

The Article related to hydantoin spiro preparation antiinflammatory nsaid lfa1 icam, spiro pyrrole imidazolinedione preparation, lymphocyte function associated antigen inhibitor spirohydantoin, intercellular adhesion mol inhibitor spirohydantoin and other aspects.Application In Synthesis of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On December 19, 2005, Rajapakse, Hemaka A.; Young, Mary Beth; Zhu, Hong; Charlton, Samantha; Tsou, Nancy N. published an article.Related Products of 141940-37-6 The title of the article was Asymmetric synthesis of dihydroquinazolinones via directed ortho metalation and addition to tert-butanesulfinyl imines. And the article contained the following:

An asym. route to dihydroquinazolinones via the addition of ortho metalated substrates to tert-butanesulfinyl imines is reported. The scope of the nucleophile and electrophile components and the absolute stereochem. outcome are presented. This method was applied to the asym. synthesis of (+)-3,4-dihydro-4-phenyl-3-[1-(phenylmethyl)-4-piperidinyl]-2(1H)-quinazolinone [i.e., (+)-SM-154811 hydrochloride]. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Related Products of 141940-37-6

The Article related to quinazolinone sm 15811 asym synthesis metalation addition sulfinyl imine, propanesulfinamide carbamate metalation addition asym synthesis quinazolinone sm 15811, hiv reverse transcriptase inhibitor quinazolinone sm 15811 asym synthesis and other aspects.Related Products of 141940-37-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On August 16, 2021, Hong, Dan-Yan; Liu, Yungen; Wu, Liangliang; Lo, Vanessa Kar-Yan; Toy, Patrick H.; Law, Siu-Man; Huang, Jie-Sheng; Che, Chi-Ming published an article.COA of Formula: C12H16O7 The title of the article was RuV-Acylimido Intermediate in [Ru(IV)(Por)Cl2]-Catalyzed C-N Bond Formation: Spectroscopic Characterization, Reactivity, and Catalytic Reactions. And the article contained the following:

Metal-catalyzed C-N bond formation reactions via acylnitrene transfer have recently attracted much attention, but direct detection of the proposed acylnitrenoid/acylimido M(NCOR) (R = aryl or alkyl) species in these reactions poses a formidable challenge. Herein, the authors report on Ru(NCOR) intermediates in C-N bond formation catalyzed by [Ru(IV)(Por)Cl2]/N3COR, a catalytic method applicable to aziridine/oxazoline formation from alkenes, amination of substituted indoles, α-amino ketone formation from silyl enol ethers, amination of C(sp3)-H bonds, and functionalization of natural products and carbohydrate derivatives (up to 99% yield). Exptl. studies, including HR-ESI-MS and EPR measurements, coupled with DFT calculations, lend evidence for the formulation of the Ru(NCOR) acylnitrenoids as a Ru(V)-imido species. The experimental process involved the reaction of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate(cas: 2873-29-2).COA of Formula: C12H16O7

The Article related to ruthenium catalyzed acylnitrene transfer organic substrate alkene, aryl indolylamide preparation crystal structure, mol structure aryl indolylamide, c−n bond formation, ruv-imido complex, acylnitrene transfer, porphyrinoids, ruthenium and other aspects.COA of Formula: C12H16O7

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Codden, Christina J.; Chin, Michael T. published an article in 2022, the title of the article was Common and Distinctive Intercellular Communication Patterns in Human Obstructive and Nonobstructive Hypertrophic Cardiomyopathy.Recommanded Product: Oxybis(ethane-2,1-diyl) bis(2-methylacrylate) And the article contains the following content:

Hypertrophic Cardiomyopathy (HCM) is a common inherited disorder characterized by unexplained left ventricular hypertrophy with or without left ventricular outflow tract (LVOT) obstruction. Single-nuclei RNA-sequencing (snRNA-seq) of both obstructive and nonobstructive HCM patient samples has revealed alterations in communication between various cell types, but no direct and integrated comparison between the two HCM phenotypes has been reported. We performed a bioinformatic anal. of HCM snRNA-seq datasets from obstructive and nonobstructive patient samples to identify differentially expressed genes and distinctive patterns of intercellular communication. Differential gene expression anal. revealed 37 differentially expressed genes, predominantly in cardiomyocytes but also in other cell types, relevant to aging, muscle contraction, cell motility, and the extracellular matrix. Intercellular communication was generally reduced in HCM, affecting the extracellular matrix, growth factor binding, integrin binding, PDGF binding, and SMAD binding, but with increases in adenylate cyclase binding, calcium channel inhibitor activity, and serine-threonine kinase activity in nonobstructive HCM. Increases in neuron to leukocyte and dendritic cell communication, in fibroblast to leukocyte and dendritic cell communication, and in endothelial cell communication to other cell types, largely through changes in the expression of integrin-β1 and its cognate ligands, were also noted. These findings indicate both common and distinct physiol. mechanisms affecting the pathogenesis of obstructive and nonobstructive HCM and provide opportunities for the personalized management of different HCM phenotypes. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Recommanded Product: Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)

The Article related to hypertrophic cardiomyopathy left ventricular outflow tract obstruction intercellular communication, hypertrophic cardiomyopathy, dendritic cells, integrin-β1, left ventricular outflow tract obstruction, single-nucleus rna-sequencing and other aspects.Recommanded Product: Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On April 11, 2002, Kaila, Neelu; Chen, Lihren; Thomas, Bert E. IV; Tsao, Desiree; Tam, Steve; Bedard, Patricia W.; Camphausen, Raymond T.; Alvarez, Juan C.; Ullas, Giliyar published an article.Safety of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate The title of the article was β-C-Mannosides as Selectin Inhibitors. And the article contained the following:

Potential E- and P-selectin inhibitors were synthesized to explore a hydrophobic area on the E-selectin surface and the PSGL-1 protein binding site on the P-selectin surface that was recently defined by crystallog. Three series of mannose-based compounds (libraries A, B, and C) were synthesized using solution phase parallel synthesis. Biol. evaluation of these compounds was done using two ELISA-based assays and transferred NOE (trNOE) experiments Some of the compounds showed better activity than sLex in the P-selectin assay. The experimental process involved the reaction of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate(cas: 53838-27-0).Safety of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate

The Article related to combinatorial library mannoside preparation selectin inhibitor glycoprotein, structure activity mannoside preparation selectin inhibitor glycoprotein, aminodeoxy glycoside mannoside preparation selectin inhibitor glycoprotein psgl and other aspects.Safety of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On September 28, 2006, Koppel, Gary; Miller, Marvin published a patent.SDS of cas: 53838-27-0 The title of the patent was Preparation of oxoazetidineacetic acid derivatives as human vasopressin V1a receptor antagonists for the treatment of premenstrual disorders. And the patent contained the following:

Oxoazetidineacetic acid derivatives I [R1 = H, alkyl; R2 = H, alkyl, alkoxy, alkylthio, NC, OHC, alkylcarbonyl, (un)substituted aminocarbonyl; R3 = (un)substituted amino, amido, or ureido; R4 = (un)substituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl, alkylcarbonyl, aralkyl, etc.; R5 = R7, R7CO; R6 = HO, HS, HO2C, (un)substituted ester, amide, alc., or thiol derivatives; R7 = HO2C, (un)substituted carboxylic acid ester or amide, carboxyalkyl, alkoxycarbonylalkyl, (un)substituted aminocarbonylalkyl], particularly (oxazolidinyl)(oxo)azetidineacetic acid derivatives such as II, are prepared as antagonists of human vasopressin V1a receptors for use in the treatment and prevention of premenstrual disorders. The preparation of I uses stereoselective [2+2] cycloadditions of ketenes generated from oxazolidinyl-substituted acid chlorides and amino acid-derived imines as the key steps. Data on the binding of the title compounds to human vasopressin V1a receptors is given; for example, II binds human vasopressin V1a receptors with an IC50 value of 1.84 nM. The experimental process involved the reaction of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate(cas: 53838-27-0).SDS of cas: 53838-27-0

The Article related to oxoazetidineacetic acid nonracemic preparation vasopressin v1a receptor antagonist, premenstrual disorder treatment vasopressin v1a receptor antagonist oxoazetidineacetic acid, beta lactamyl alkanoic acid preparation treatment premenstrual disorder and other aspects.SDS of cas: 53838-27-0

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On March 1, 2007, Urade, Yoshihiro; Shigeno, Kazuhiko; Tanaka, Yuki; Kuze, Jiro; Tsuchikawa, Michinori; Hosoya, Toshiyuki published a patent.Computed Properties of 29704-38-9 The title of the patent was Preparation of pyrimidine-5-carboxamide derivatives as prostaglandin D synthase inhibitors. And the patent contained the following:

The title compounds [I; R1 = (un)substituted 5- or 6-membered unsaturated heterocyclyl or Ph; R2 = unsaturated heterocyclyl containing 1-3 heteroatom(s) selected from N, O, and S atoms containing 0-2 number of R3(CH2)m group(s), Ph containing R3(CH2)m group(s) at one or both of 3- and 4-positions; m = 0-4; R3 = halo, cyano, NO2, (un)substituted and (un)saturated heterocyclyl, (un)substituted NH2, COR6, OR7, SR8; R6 = H,HO, (un)substituted C1-6 alkoxy or NH2; R7 = H, (un)substituted C1-6 alkyl, C2-6 alkenyl, (un)substituted carbonyl; R8 = H, (un)substituted C1-6 alkyl] or salts thereof are prepared These compounds exhibit high inhibitory effect on hematopoietic prostaglandin D synthase and are useful for the prevention and/or treatment of allergic diseases, inflammatory diseases, Alzheimer’s disease, or brain injury. Thus, 2-phenoxypyrimidine-5-carboxylic acid was condensed with 4-aminobenzoic acid tert-Bu ester using 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride and 1-hydroxybenzotriazole in pyridine at 60° for 16 h to give 47% 2-phenoxy-N-(4-tert-butoxycarbonylphenyl)-5-pyrimidinecarboxamide (II). II and 2-phenoxy-N-[4-[2-[[(thiophen-2-yl)carbonyl]amino]ethyl]phenyl]-5-pyrimidinecarboxamide showed IC50 of 0.260 and 0.141 μg/mL, resp., against human hematopoietic prostaglandin D. The experimental process involved the reaction of tert-Butyl 2-(4-nitrophenyl)acetate(cas: 29704-38-9).Computed Properties of 29704-38-9

The Article related to pyrimidinecarboxamide preparation hematopoietic prostaglandin d synthase inhibitor, allergy inflammation prevention treatment pyrimidinecarboxamide preparation, alzheimer disease brain injury prevention treatment pyrimidinecarboxamide preparation and other aspects.Computed Properties of 29704-38-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Adapa, Srinivas R.; Prasad, Chalasani S. N. published an article in 1989, the title of the article was A mild and convenient preparation of tert-butyl esters by carbonylation of arylhalomethyl derivatives.Recommanded Product: tert-Butyl 2-(4-nitrophenyl)acetate And the article contains the following content:

An exceptionally mild and efficient, single-pot synthetic procedure is described for the tert-butoxycarbonylation of benzyl chloride derivatives Thus, treatment of PhCH2Cl with CO, NaOAc, PPh3, Me3COH, Pd(PPh3)2Cl2 (as catalyst), and Et3NCH2PhCl (as phase-transfer catalyst) at 80° gave 60% PhCH2CO2CMe3. The experimental process involved the reaction of tert-Butyl 2-(4-nitrophenyl)acetate(cas: 29704-38-9).Recommanded Product: tert-Butyl 2-(4-nitrophenyl)acetate

The Article related to ester tertiary butyl, phenylacetate dimethylethyl, carbonylation benzyl halide derivative catalytic, esterification benzoyl halide derivative, palladium carbonylation catalyst benzyl halide, butoxycarbonylation tertiary benzyl halide derivative and other aspects.Recommanded Product: tert-Butyl 2-(4-nitrophenyl)acetate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On November 25, 2021, Fomitskaya, Polina A.; Argunov, Dmitry A.; Tsvetkov, Yury E.; Lalov, Andrey V.; Ustyuzhanina, Nadezhda E.; Nifantiev, Nikolay E. published an article.Synthetic Route of 2873-29-2 The title of the article was Further Investigation of the 2-Azido-phenylselenylation of Glycals. And the article contained the following:

Derivatives of 2-azido-2-deoxy sugars are widely applied as precursor of 2-amino-2-deoxy sugars in the synthesis of various oligosaccharides of bacterial, fungal and mammalian origin. Heterogeneous or homogeneous azidophenylselenylation (APS) of glycals, i. e., reaction of glycals with Ph2Se2, PhI(OAc)2 and NaN3 or TMSN3 as azide radical donors, is a straightforward way to Ph 2-azido-2-deoxy-1-selenoglycosides that can be directly used as glycosyl donors. However, heterogeneous APS is characterized by insufficient reproducibility and scalability. We have studied the effect of reaction conditions on the product distribution in heterogeneous APS of 3,4,6-tri-O-acetyl-D-galactal and found the conditions that enabled reliable preparation of crystalline Ph 2-azido-2-deoxy-1-seleno-α-D-galactopyranoside triacetate in yield of 58% on the 3.7 mmol scale. APS of 3,4,6-tri-O-acetyl-D-glucal under those conditions produced a ∼1 : 1 mixture of Ph 2-azido-2-deoxy-1-seleno-α-D-gluco- and mannopyranosides in total yield of 78%. Acetoxyphenylselenylation of differently protected galactals and 3,4,6-tri-O-acetyl-D-glucal under the action of Ph2Se2 and PhI(OAc)2 has been shown to be a convenient method for the synthesis of 1-O-acetyl-2-seleno-2-deoxy derivatives, valuable intermediates in chem. of 2-deoxysugars. 2-Seleno-2-deoxy sugars were characterized in detail by NMR data including 77Se chem. shifts and nJSe-H coupling constant values. The experimental process involved the reaction of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate(cas: 2873-29-2).Synthetic Route of 2873-29-2

The Article related to oligosaccharide aminodeoxy sugar azidodeoxy bacterial synthon stereoselective azidophenylselenylation glycal, crystal structure azidophenylselenylation glycal mannopyranoside azidodeoxyseleno glycoside preparation acetoxyphenylselenylation and other aspects.Synthetic Route of 2873-29-2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics