Tag: 200-300

On July 15, 2011, Zhu, Mingzhao; Zheng, Nan published an article.Category: esters-buliding-blocks The title of the article was Photoinduced cleavage of N-N bonds of aromatic hydrazines and hydrazides by visible light. And the article contained the following:

A photocatalytic system involving [Ru(bpyrz)3](PF6)2·2H2O, visible light, and air has been developed for cleavage of the N-N bonds of hydrazines and hydrazides. This catalytic system is generally effective for N,N-disubstituted hydrazine and hydrazide derivatives, including arylhydrazides, N-alkyl-N-arylhydrazines, and N,N-diarylhydrazines. The utility of this cleavage reaction has been demonstrated by synthesizing a variety of secondary aromatic amines. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Category: esters-buliding-blocks

The Article related to secondary aromatic amine synthesis electrophilic amination, aromatic hydrazine hydrazide photoinduced catalytic cleavage nitrogen light ruthenium, amines, cleavage, nitrogen–nitrogen bonds, ruthenium, visible light and other aspects.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Huang, Wanqiao; Zhang, Ruzhong; Zhang, Ruxue; Yu, Jianxin; Wang, Mang published an article in 2022, the title of the article was Radical hydrotrifluoromethylation of ynamides: a route toward β-CF3 enamides.Reference of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate And the article contains the following content:

Radical hydrotrifluoromethylation of ynamides RNR2CCR1 (R = Ph, 3-chlorophenyl, benzodioxol-5-yl, etc.; R1 = H, cyclopropyl, Ph, etc.; R2 = Boc, Ac, Cbz) to provide an alternative route toward (E)-β-CF3 enamides RNR2CH=C(CF3)R1 was reported. By using PhICF3Cl as the CF3 reagent and DMF as the H-donor, the reaction occurred smoothly in the presence of NaH at room temperature Further reduction of the resulting β-CF3 enamides efficiently delivered β-CF3 amines RNHCH2CH(CF3)R1. Gram-scale synthesis was conducted to demonstrate the practicability of the method. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Reference of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate

The Article related to aryl trifluoromethyl amine preparation, trifluoromethyl enamide preparation diastereoselective deprotection reduction reaction, ynamide chlorophenyl trifluoromethyliodane radical hydrotrifluoromethylation reaction and other aspects.Reference of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On November 6, 2003, Arrhenius, Thomas; Cheng, Jie-fei; Huang, Yujin; Nadzan, Alex M. published a patent.Reference of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate The title of the patent was Preparation of azolylhexafluoropropanols and related compounds as liver X receptor (LXR) modulators. And the patent contained the following:

A method for modulation of liver X receptor comprises administration of WC(X)(AY)CF2Z [W = specified (substituted) 5-6 membered (aromatic) heterocyclyl, alkynyl; X = H, CF2Z, CF3; XY forms a double bond when A = O; Y = H; Z = F, Br, Cl, iodo, CF3; A = O, S, imino]. Thus, powd. 4Å mol. sieves, N-(pyridin-4-ylmethyl)-1,3-thiazol-2-amine (preparation given), and hexafluoroacetone trihydrate were heated in PhH at 80° for 24 h to give 1,1,1,3,3,3-hexafluoro-2-[2-[(pyridin-4-ylmethyl)amino]-1,3-thiazol-5-yl]propan-2-ol. The latter was refluxed with isonicotinic anhydride in dioxane at 100° for 2 h to give N-(pyridin-4-ylmethyl)-N-[5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-1,3-thiazol-2-yl]pyridine-4-carboxamide. This at 10 μM gave 2.49-fold induction of ABCA1 gene in THP-1 cells vs. DMSO controls. The experimental process involved the reaction of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate(cas: 53838-27-0).Reference of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate

The Article related to azolylhexafluoropropanol preparation liver x receptor lxr modulator, thiazolylhexafluoropropanol preparation liver x receptor lxr modulator, isoxazolylhexafluoropropanol preparation liver x receptor lxr modulator and other aspects.Reference of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On January 29, 2019, Ohtsuki, Yuya; Sanoh, Seigo; Santoh, Masataka; Ejiri, Yoko; Ohta, Shigeru; Kotake, Yaichiro published an article.SDS of cas: 118-55-8 The title of the article was Inhibition of cytochrome P450 3A protein degradation and subsequent increase in enzymatic activity through p38 MAPK activation by acetaminophen and salicylate derivatives. And the article contained the following:

We previously reported that acetaminophen (APAP) caused accumulation of functional CYP3A protein via inhibition of CYP3A protein degradation through reduction of glycoprotein 78 (gp78), an E3 ligase of the ubiquitin proteasome system. Furthermore, N-acetyl-m-aminophenol, a regioisomer of APAP causes CYP3A protein accumulation, whereas p-acetamidobezoic acid, in which a hydroxy group of APAP was substituted for a carboxy group, did not lead to the same effects. In this study, we selected 32 compounds including a phenolic hydroxyl group such as APAP and explored the compounds that increased CYP3A enzyme activity to analyze their common mechanism. Four compounds, including salicylate, increased CYP3A enzyme activity and led to the accumulation of functional CYP3A protein similarly to APAP. APAP and salicylate activate p38 mitogen-activated protein kinase (p38 MAPK). gp78 is known to be phosphorylated by p38 MAPK; so, we investigated the relationship between p38 MAPK and CYP3A. APAP activated p38 MAPK, decreased gp78 protein expression, and subsequently induced CYP3A protein expression in a time-dependent manner. When SB203580, a p38 MAPK inhibitor, was co-administered with APAP, the inhibitory effects of APAP on CYP3A protein degradation were suppressed. In this study, we demonstrated the involvement of the p38 MAPK-gp78 pathway in suppressing CYP3A protein degradation by APAP. Salicylate derivatives may also suppress the CYP3A protein degradation The experimental process involved the reaction of Phenyl Salicylate(cas: 118-55-8).SDS of cas: 118-55-8

The Article related to cytochrome protein degradation enzymic activity mapk activation acetaminophen salicylate, acetaminophen, cytochrome p450 3a, glycoprotein 78, protein degradation, salicylate, p38 mitogen-activated protein kinase and other aspects.SDS of cas: 118-55-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On December 31, 1989, Sivergin, Yu. M.; Grachev, A. V.; Shashkova, V. T.; Usmanov, S. M. published an article.Application of 1985-51-9 The title of the article was Investigation of the compressibility of oligoester (meth)acrylates. And the article contained the following:

The compressibility of oligoester (meth)acrylates, such as CH2:C(R)CO2(CH2)nOCOC(R):CH2 (R = H, Me; n = 2, 4, 6, 10) and diethylene glycol dimethacrylate, and the compressibility isotherms of the monomers were determined with respect to polymerization The pressure necessary for crystallization of the monomers decreased with increasing length of the (CH2) chain. Compression of the liquid monomers resulted not only in reduction of the free volume, but also in reduction of the volume of the mol. The effects of loading cycles on the compressibility isotherms are discussed briefly. The begin of polymerization ethylene glycol dimethacrylate was at 0.2-0.25 GPa and was reflected in the compressibility isotherm curves. The suitability of polymerization of oligoester (meth)acrylates is discussed briefly. The experimental process involved the reaction of 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate)(cas: 1985-51-9).Application of 1985-51-9

The Article related to compressibility oligoester methacrylate polymerization, acrylate oligoester compressibility polymerization, isotherm compressibility oligoester methacrylate monomer, ethylene glycol dimethacrylate polymerization and other aspects.Application of 1985-51-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On January 1, 2018, Fagge, Ibrahim Isah; Khalid, Khalisanni; Noh, Muhammad Azri Mohd.; Yusof, Nor Saadah Muhammad; Zain, Sharifuddin Md.; Khan, Mohammad Niyaz published an article.Synthetic Route of 118-55-8 The title of the article was Study of cationic and nonionic mixed micelles with NaBr and 3,5-Cl2C6H3CO2Na by use of probe nucleophilic reaction of piperidine with ionized phenyl salicylate. And the article contained the following:

Behaviors of cationic and nonionic mixed micelles in the form of hexadecyltrimethylammonium bromide (HDABr) and hexadecyltrimethylammonium bromide-Polyethylene glycol hexadecyl ether (C16E20), in the presence of inert salts (NaBr and 3,5-dichlorosodium benzoate), by the use of reaction probe between Pp and ionized PhSH (Pp = piperidine and PhSH = Ph salicylate), has been reported in this work. The values of RXBr (RXBr denotes ion exchange constants obtained in the presence of micelles of different structural features) or KXBr (KXBr denotes ion exchange constants obtained in the presence of micelles of the same structural features) for 3,5- Cl2C6H3CO2- were almost the same at three different [HDABr]T (0.006, 0.010 and 0.015 M). The average value of RXBr or KXBr determined, in the presence of pure HDABr micelles, using semi empirical kinetic (SEK) method appeared to be almost 21/2-fold larger (RXBr or KXBr = 198) than that in the presence of mixed HDABr-C16E20 micelles (RXBr or KXBr = 78). Rheol. measurements indicated the existence of wormlike/twisted micelles and vesicle at 0.015 M pure HDABr, various [3,5- Cl2C6H3CO2Na], and 25 and 35°C whereas there were evidence of only spherical micelles in the presence of mixed HDABr-C16E20 ([HDABr]T = 0.015 M and [C16E20]T = 0.006 M) at both temperatures The experimental process involved the reaction of Phenyl Salicylate(cas: 118-55-8).Synthetic Route of 118-55-8

The Article related to sodium bromide piperidine phenyl salicylate micelle probe nucleophilic reaction, hexadecyltrimethylammonium bromide, phenyl salicylate, piperidine, polyethylene glycol hexadecyl ether, vesicle, wormlike micelles and other aspects.Synthetic Route of 118-55-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Makuuchi, Keizo; Yoshii, Fumio; Abe, Toshihiko published an article in 1975, the title of the article was Radiation effects on poly(vinylidene fluoride). V. Radiation-induced crosslinking of poly(vinylidenefluoride) in the presence of polyfunctional monomers.Reference of 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate) And the article contains the following content:

When poly(vinylidene fluoride) (I) [24937-79-9] containing 10% mono- or polyfunctional acrylate or methacrylate was compression-molded at 210° and the sheets were irradiated with electron beams, the crosslinking efficiency of the monomers (14 used) increased in the order of monofunctional monomers < linear difunctional monomers < branched difunctional monomers < trifunctional monomers. Among a group of monomers with similar functionality, monomers having greater compatibility with I had higher crosslinking efficiency, and acrylates were poorer crosslinking agents than corresponding methacrylates because of the homopolymerization during molding. The experimental process involved the reaction of 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate)(cas: 1985-51-9).Reference of 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate)

The Article related to polyvinylidene fluoride crosslinking, acrylate crosslinking polyvinylidene fluoride, methacrylate crosslinking polyvinylidene fluoride, radiochem crosslinking polyvinylidene fluoride, electron beam crosslinking and other aspects.Reference of 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On October 1, 2019, Thakur, Kratima; Khare, Naveen K. published an article.Synthetic Route of 2873-29-2 The title of the article was Synthesis of glycoconjugate mimics by ‘click chemistry’. And the article contained the following:

Stereo-defined 2-deoxy propargyl glycosides can be used for the synthesis of corresponding 1,4-disubstituted sugar derived triazoles by using only CuI and stereo-defined sugar azide derivatives The click chem. which involves copper (I) catalyzed alkyne-azide 1,3-dipolar cycloaddition, was used to prepare a library of glycoconjugates mimics. Different sugar propargyl-2-deoxy-O-α-D-glycopyranoside derivatives and β-glycopyranosyl azide derivatives were coupled using catalyst CuI to yield triazole glycoconjugates. The catalyst CuI (2.5 equivalent) in CH3CN was found to be most efficient for the synthesis of 1,4-disubstituted triazole scaffolds affording up to 94% of optimized yield and with retention of the anomeric configuration of the starting glycosides. The key feature of this methodol. is the absence of sodium L-ascorbate/ascorbic acid which is most active substrate of current research with strong potential for click reactions. In this article, the library of novel stereoselective deoxy sugar derived triazole glycoconjugates have been synthesized and structures were determined by the 1H, 13C & 2D NMR spectroscopy. The experimental process involved the reaction of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate(cas: 2873-29-2).Synthetic Route of 2873-29-2

The Article related to click alkyne azide triazole cycloaddition catalyst preparation, triazole glycoconjugate preparation stereoselective library mol structure, 1,3-dipolar cycloaddition, click reaction, cui, glycoconjugates, stereoselectivity and other aspects.Synthetic Route of 2873-29-2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On December 31, 1984, Fujisawa, Seiichiro; Kadoma, Yoshinori; Masuhara, Eiichi published an article.Related Products of 1985-51-9 The title of the article was A calorimetric study of the interaction of synthetic phospholipid liposomes with vinyl monomers, acrylates and methacrylates. And the article contained the following:

Mono-, di-, and trimethacrylates (monomers) are widely used in dentistry as restorative materials, adhesives, prosthetic devices, etc. Residual monomers released from the cured resin have been implicated in toxicol. effects. To monitor the biol. actions at the membrane level induced by monomers, the changes in the phase transition temperature (T) and enthalpy (ΔH) of dipalmitoylphosphatidylcholine  [2644-64-6] liposomes induced by 37 different monomers were studied by DSC. The monomers that caused large changes in the T and ΔH were vinyl monomers, acrylates, monomethacrylates that contain hydroxy, carbonyl, amino, and Ph groups, dimethacrylates with short-chain substituents, and aliphatic trimethacrylates. The changes in the T and ΔH values may be due not only to hydrophobic interactions, but also to interactions induced by the double bonds or the functional groups in the monomers. On the other hand, methacrylates with simple alkyl ester linkage and dimethacrylates with bisphenol A groups exhibited the smallest effects. The changes in the T and ΔH induced by highly hydrophobic methacrylates were small due to their slower interaction. These changes in transition properties of liposomes seem to be related to biol. activities. The experimental process involved the reaction of 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate)(cas: 1985-51-9).Related Products of 1985-51-9

The Article related to monomer phospholipid liposome interaction, vinyl monomer phospholipid liposome interaction, acrylate phospholipid liposome interaction, methacrylate phospholipid liposome interaction, dental monomer interaction liposome and other aspects.Related Products of 1985-51-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On July 17, 2020, Nagai, Takuya; Mimata, Nao; Terada, Yoshihiro; Sebe, Chikayoshi; Shigehisa, Hiroki published an article.Formula: C12H14F3NO2 The title of the article was Catalytic Dealkylative Synthesis of Cyclic Carbamates and Ureas via Hydrogen Atom Transfer and Radical-Polar Crossover. And the article contained the following:

Guided by the transition metal hydrogen atom transfer and radical-polar crossover concepts, a functional-group tolerant and scalable method for the synthesis of cyclic carbamates and ureas I [R1 = Ph, 4-ClC6H4, 4-MeCOC6H4CH2, etc.; R2 = H, Me; X = O, NTs, NNs; n = 1,2,3,4], which were found in the structures of bioactive compounds was developed. This method not only provided common five-membered ring but also six-to-eight-membered ring products. The reaction proceeded through the intramol. displacement of an alkylcobalt(IV) intermediate and dealkylation by 2,4,6-collidine, the activation energies of these steps were calculated by DFT. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Formula: C12H14F3NO2

The Article related to cyclic carbamate preparation, alkenyl carbamate dealkylative hydrogen transfer crossover cobalt complex catalyst, urea cyclic preparation, isourea alkenyl dealkylative hydrogen transfer crossover cobalt complex catalyst and other aspects.Formula: C12H14F3NO2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics