Tag: 200-300

Torregrosa-Chinillach, Alejandro; Moragues, Adrien; Perez-Furundarena, Haritz; Chinchilla, Rafael; Gomez-Bengoa, Enrique; Guillena, Gabriela published an article in 2018, the title of the article was Enantioselective michael addition of aldehydes to maleimides organocatalyzed by a chiral primary amine-salicylamide.Computed Properties of 118-55-8 And the article contains the following content:

A primary amine-salicylamide derived from chiral trans-cyclohexane-1,2-diamine was used as an organocatalyst for the enantioselective conjugate addition of aldehydes, mainly α,α-disubstituted to N-substituted maleimides. The reaction was performed in toluene as a solvent at room temperature The corresponding enantioenriched succinimides I (R1 = Me; R2 = Me, H; R1, R2 = (CH2)4, (CH2)5; R3 = C6H5, 4-MeC6H4, 4-MeOC6H4, etc.) were obtained with high yields and enantioselectivities up to 94%. Theor. calculations were used to justify the stereoinduction. The experimental process involved the reaction of Phenyl Salicylate(cas: 118-55-8).Computed Properties of 118-55-8

The Article related to succinimide enantioselective preparation primary amine salicylamide catalyst, aldehyde maleimide michael addition, michael addition, aldehydes, asymmetric synthesis, maleimides, organocatalysis and other aspects.Computed Properties of 118-55-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On April 8, 2021, Bachmann, Joel; Gleis, Elisabeth; Schmoelzer, Stefan; Fruhmann, Gabriele; Hinrichsen, Olaf published an article.Category: esters-buliding-blocks The title of the article was Photo-DSC method for liquid samples used in vat photopolymerization. And the article contained the following:

The photo differential scanning calorimetry (photo-DSC) is an appropriate method to characterize photopolymers used in additive manufacturing (AM). Important process parameters such as optimal UV exposure time and reaction heat can be attained by this method. However, achieving reliable and meaningful results from photo-DSC experiments requires careful sample preparation, i.e. the selection of a suitable sample shape, sample mass and sample holder (crucible). The sample shapes drop and spread with 1.0 mg and 2.8 mg sample masses were studied in this study. Three different times from sample preparation until the start of the measurement (0, 4 and 7 h) were tested, to study different surface effects such as oxygen-diffusion, prior UV-curing through ambient radiation and evaporation of volatile components. While the 1.0 mg spread sample shape offers the thinnest film thickness (40μm) and thus the closest comparability to high resolution print jobs, the 2.8 mg drop shape offers a more robust sample preparation with minimized surface effects. To further reduce time-dependent surface effects, this study shows how a preexisting test protocol was shortened from 42 min to 24 min without losing measuring accuracy. Furthermore, to reduce evaporation, different covers were placed on different crucibles, which were tested over time in the device’s automated sample changer (ASC) that enables automated and consecutive measurements. The combination of a cold pressed 85μL crucible covered with a 300μL Al2O3 crucible, which is removed shortly before the actual measurement, provides the best sample preparation for the ASC since mass loss remains below 1% for up to 10 h. Finally, two two-part resin systems, namely a methacrylate-urethane and an acrylate-epoxy based resin that are used in Digital Light Synthesis (DLS) are characterized part by part and in mixed state. Together with the study of different temperatures and atmospheres, it was possible to identify not only the part with the photoinitiator and the type of system (radical or cationic), but also a difference between methacrylates and acrylates with the aid of the photo-DSC method. The experimental process involved the reaction of 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate)(cas: 1985-51-9).Category: esters-buliding-blocks

The Article related to photo dsc liquid vat photopolymerization, continous liquid interface production (clip), digital light synthesis (dls), photo dsc, photo-dsc method, sample preparation, vat photopolymerization and other aspects.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On May 17, 2019, Yalamanchili, Subbarao; Lloyd, Dina; Bennett, Clay S. published an article.Related Products of 2873-29-2 The title of the article was Synthesis of the Hexasaccharide Fragment of Landomycin A Using a Mild, Reagent-Controlled Approach. And the article contained the following:

The synthesis of the hexasaccharide fragment of landomycin A is reported. Using p-toluenesulfonyl chloride mediated dehydrative glycosylation, we constructed the deoxy-sugar linkages in a stereoselective fashion without the need for temporary prosthetic groups to control selectivity. Through this approach, the hexasaccharide was obtained in 28 steps and 8.9% overall yield, which is an order of magnitude higher than that of previously reported approaches. The experimental process involved the reaction of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate(cas: 2873-29-2).Related Products of 2873-29-2

The Article related to catalyst stereoselective dehydrative glycosylation toluenesulfonyl chloride, landomycin hexasaccharide synthesis synthon stereoselective glycosylation toluenesulfonyl chloride oligosaccharide and other aspects.Related Products of 2873-29-2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kondratov, Ivan S.; Dolovanyuk, Violetta G.; Tolmachova, Nataliya A.; Gerus, Igor I.; Bergander, Klaus; Froehlich, Roland; Haufe, Guenter published an article in 2012, the title of the article was Reactions of β-alkoxyvinyl polyfluoroalkyl ketones with ethyl isocyanoacetate and its use for the synthesis of new polyfluoroalkyl pyrroles and pyrrolidines.COA of Formula: C8H8F3NO2 And the article contains the following content:

The hitherto unreported reactions of β-alkoxyvinyl polyfluoroalkyl ketones with Et isocyanoacetate and equimolar amounts of potassium-tert-butoxide proceeded mainly in the β-position of the α,β-unsaturated ketones in cases of α-nonsubstituted I (R1 = CF3, CHF2, CF2Cl, C2F5, C3F7; R2 = H) and α-Me substituted ketones I (R1 = CHF2, CF2Cl, C2F5, C3F7; R2 = Me). Other α- or β-substituted ketones gave mainly products of initial attack at the carbonyl carbon. Depending on the solvent, the major products of β-attack do exist in different tautomeric forms. Generally the open-chain enol tautomers II (R2 = H only) predominate in the polar DMSO-d6, while the cyclic γ-hemiaminals III are the major tautomers in the less polar CDCl3. Acid treatment of the latter compounds III led to the hitherto unknown Et 5-polyfluoroalkyl-pyrrole-2-carboxylates by elimination of formic acid. Catalytic hydrogenation was used for the synthesis of earlier unknown 5-trifluoromethyl proline. The experimental process involved the reaction of Ethyl 5-(trifluoromethyl)-1H-pyrrole-2-carboxylate(cas: 1414887-27-6).COA of Formula: C8H8F3NO2

The Article related to alkoxyvinyl polyfluoroalkyl ketone ethyl isocyanoacetate regioselective substitution, open chain enol cyclic hemiaminal tautomer preparation elimination, pyrrole pyrrolidine polyfluoroalkyl preparation and other aspects.COA of Formula: C8H8F3NO2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On March 7, 2022, Wu, Jun; Kopp, Adelina; Ackermann, Lutz published an article.Computed Properties of 2873-29-2 The title of the article was Synthesis of C-Oligosaccharides through Versatile C(sp3)-H Glycosylation of Glycosides. And the article contained the following:

C-oligosaccharides are pharmacol. relevant because they are more hydrolysis-resistant than O-oligosaccharides. Despite indisputable advances, C-oligosaccharides continue to be underdeveloped, likely due to a lack of efficient and selective strategies for the assembly of the inter-glycosidic C-C linkages. In contrast, we, herein, report a versatile and robust strategy for the synthesis of structurally complex C-oligosaccharides via catalyzed C(sp3)-H activations. Thus, a wealth of complex inter-glycosidic (2→1)- and (1→1)-C-oligosaccharides becomes readily available by palladium-catalyzed C(sp3)-H glycoside glycosylation. The isolation of key palladium cycle intermediates and experiments with isotopically-labeled compounds identified a trans-stereoselectivity for the C(sp3)-H glycosylation. The glycoside C(sp3)-H activation manifold was likewise exploited for the diversification of furanoses, pyranoses and disaccharides. The experimental process involved the reaction of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate(cas: 2873-29-2).Computed Properties of 2873-29-2

The Article related to glycosylation glycoside disaccharide synthesis oligosaccharide palladium catalyzed stereoselective glycosylation, 2-deoxyglycosides, c(sp3)−h activation, c-disaccharide synthesis, palladium catalysis and other aspects.Computed Properties of 2873-29-2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Rashed, Nurnobi Md.; Siddiki, S. M. A. Hakim; Touchy, Abeda Sultana; Jamil, A. R. Md.; Poly, Sharmin Sultana; Toyao, Takashi; Maeno, Zen; Shimizu, Ken-ichi published an article in 2019, the title of the article was Direct Phenolysis Reactions of Unactivated Amides into Phenolic Esters Promoted by a Heterogeneous CeO2 Catalyst.Recommanded Product: Phenyl Salicylate And the article contains the following content:

The direct catalytic esterification of amides that leads to the construction of C-O bonds through the cleavage of amide C-N bonds is a highly attractive strategy in organic synthesis. While aliphatic and aromatic alcs. can be readily used for the alcoholysis of activated and unactivated amides, the introduction of phenols is more challenging due to their lower nucleophilicity in the phenolysis of unactivated amides. Herein, phenols can be used for the phenolysis of unactivated amides into the corresponding phenolic esters using a simple heterogenous catalytic system based on CeO2 under additive-free reaction conditions was demonstrated. The method tolerates a broad variety of functional groups (>50 examples) in the substrates. Results of kinetic studies afforded mechanistic insights into the principles governing this reaction, suggesting that the cooperative effects of the acid-base functions of catalysts would be of paramount importance for the efficient progression of the C-N bond breaking process, and consequently, CeO2 showed the best catalytic performance among the catalysts explored. The experimental process involved the reaction of Phenyl Salicylate(cas: 118-55-8).Recommanded Product: Phenyl Salicylate

The Article related to phenolic ester preparation solvent free, amide aliphatic aromatic alc direct phenolysis ceo2 catalyst, acid-base cooperation, heterogeneous catalysts, phenolic esters, phenolysis, unactivated amides and other aspects.Recommanded Product: Phenyl Salicylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On March 15, 2020, Li, Ke; Jin, Yan; Jung, Dasom; Park, Keunbae; Kim, Hireem; Lee, Jeongmi published an article.Recommanded Product: 118-55-8 The title of the article was In situ formation of thymol-based hydrophobic deep eutectic solvents: Application to antibiotics analysis in surface water based on liquid-liquid microextraction followed by liquid chromatography. And the article contained the following:

A simple and ecofriendly sample preparation method was developed for quantifying fluoroquinolone (FQ) antibiotics in surface water. Seventeen combinations of monoterpenes (menthol, thymol, and camphor), fatty acids (heptanoic, octanoic, nonanoic, and decanoic acids), and a benzoate ester (salol) were utilized for the in situ formation of hydrophobic deep eutectic solvents (hDESs) for liquid-liquid microextraction (LLME). The hDES comprising thymol and heptanoic acid (HA) exhibited the highest extraction efficiency for ofloxacin, norfloxacin, ciprofloxacin, and enrofloxacin. Optimization via the one-variable-at-a-time strategy revealed that a 2:1 ratio of thymol to HA yielded the highest efficiency for antibiotic extraction at pH 4-7. Further, response surface methodol.-based optimization suggested that the optimal extraction conditions involved the use of appropriate amounts of thymol and HA to generate 100μL of hDES in 10 mL of aqueous sample with incubation at 52°C for 5 min, followed by automated shaking for 1 min. The collected hDES phase was diluted and subjected to liquid chromatog.-UV detection anal. The established method based on in situ formation of hDES coupled with shaker-assisted LLME (in situ hDES-SA-LLME) was validated. The method was specific and showed good linearity in the 15-3000 ng mL-1 concentration range (r2 ≥ 0.9997), with a limit of detection of 3.0 ng mL-1, limit of quantification of 9.0 ng mL-1, accuracy of 84.1-113.65%, and intra-day and inter-day precision of ≤7.78% RSD and ≤7.91% RSD, resp. The method was successfully applied to three different types of real surface water samples. Without toxic volatile organic solvents, the developed method allows for safe and rapid, yet reliable, anal. of FQ antibiotics. The experimental process involved the reaction of Phenyl Salicylate(cas: 118-55-8).Recommanded Product: 118-55-8

The Article related to fluoroquinolone antibiotic liquid microextraction water deep eutectic solvent, antibiotics, hydrophobic deep eutectic solvents, in situ formation, liquid-liquid microextraction, surface water sample and other aspects.Recommanded Product: 118-55-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On September 30, 2013, Shehata, Mohamed; Durner, Juergen; Eldenez, Ayce; Van Landuyt, Kirsten; Styllou, Panorea; Rothmund, Lena; Hickel, Reinhard; Scherthan, Harry; Geurtsen, Werner; Kaina, Bernd; Carell, Thomas; Reichl, Franz X. published an article.Safety of 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate) The title of the article was Cytotoxicity and induction of DNA double-strand breaks by components leached from dental composites in primary human gingival fibroblasts. And the article contained the following:

The public interest steadily increases in the biol. adverse effects caused by components released from resin-based dental restorations. In this study, the cytotoxicity and the genotoxicity were investigated of following released components from dental resin restorations in human gingival fibroblasts (HGF): tetraethyleneglycol dimethacrylate (TEEGDMA), neopentylglycol dimethacrylate (Neopen), diphenyliodoniumchloride (DPIC), triphenyl-stibane (TPSB) and triphenylphosphane (TPP). XTT based cell viability assay was used for cytotoxicity screening of substances. γ-H2AX assay was used for genotoxicity screening. In the γ-H2AX assay, HGFs were exposed to the substances for 6 h. Induced foci represent double DNA strand breaks (DSBs), which can induce ATM-dependent phosphorylation of the histone H2AX. Cell death effects (apoptosis and necrosis), induced by the substances were visually tested by the same investigator using the fluorescent microscope. All tested substances induced a dose-dependent loss of viability in HGFs. Following toxicity ranking among the substances at EC50-concentration were found in the XTT assay (mM, mean ± SEM; n = 5): DPIC > Neopen > TPSB > TPP > TEEGDMA. DSB-foci per HGF-cell were obtained, when HGFs were exposed to the EC50-concentration of each substance in the following order (mean ± SEM; n = 3): DPIC > Neopen > TPSB > TPP > TEEGDMA. Multi-foci cells (cells that contain more than 40 foci each) in 80 HGF-cells at EC50-concentration of each substance were found as follow (mean ± SEM; n = 3): DPIC > Neopen > TPP > TPSB > TEEGDMA. Cell apoptosis contained in each substance at EC50-concentration in the following order (mean ± SEM; n = 3): DPIC > Neopen > TPSB > TPP >TEEGDMA. Cell necrosis contained in each substance at EC50-concentration in the following order (mean ± SEM; n = 3): DPIC > Neopen > TPSB > TPP > TEEGDMA. Leached components from dental resin restorations can induce DNA DSBs and cell death effects in HGFs. The experimental process involved the reaction of 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate)(cas: 1985-51-9).Safety of 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate)

The Article related to cytotoxicity genotoxicity gingival fibroblast dental composite resin restorative material, teegdma neopen dpic tpsb tpp dna double strand break, composite, dpic, hgf, neopen, teegma, tpp, tpsb, γ-h2ax assay and other aspects.Safety of 2,2-Dimethylpropane-1,3-diyl bis(2-methylacrylate)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On April 30, 2022, Li, Zhi-Bin; Shi, Li-Ying; Han, Yu-Shuai; Chen, Jing; Zhang, Shan-Qiang; Chen, Jia-Xi; Liu, Jun; Tu, Hui-Hui; Lu, Qi-Qi; Yu, Yi; Jiang, Ting-Ting; Li, Ji-Cheng published an article.COA of Formula: C12H18O5 The title of the article was Pyridoxal phosphate, pyridoxamine phosphate, and folic acid based on ceRNA regulatory network as potential biomarkers for the diagnosis of pulmonary tuberculosis. And the article contained the following:

Pulmonary tuberculosis (TB) is a serious disease burden worldwide, and its effective early diagnosis is still facing challenges. Knowledge, acquired from multi-omics integration anal. about the association between different types of differentially expressed mols. in the plasma of TB patients and the disease traits, is anticipated to improve the accuracy of TB diagnosis through the ′′integrative pattern′′. In this study, the lncRNA-miRNA-mRNA interaction network was constructed based on the competing endogenous RNA (ceRNA) hypothesis by integrating our previous data sets of lncRNA, mRNA, miRNA, and metabolites. Moreover, the key regulatory axis was established by co-expression anal. and verified at the level of metabolites. A ceRNA regulatory network consisting of 23 lncRNAs, 10 miRNAs, and 113 mRNAs was constructed. The anal. results suggested that lncRNA (OSBPL10-AS1), miRNA (has-miR-485-5p), and mRNA (SLC23A2) might be involved in the regulation of vitamin metabolism in patients with TB. Metabolite anal. showed that compared with the normal control group, TB patients had abnormal vitamin metabolism, and the expression levels of pyridoxal phosphate, pyridoxamine phosphate, and folic acid were significantly different between the two groups (p < 0.05). Integrated multi-omics anal. showed that vitamin metabolism disorder may be one of the pathol. characteristic of TB. OSBPL10-AS1, hsa-miR-485-5p, SLC23A2, pyridoxal phosphate, pyridoxamine phosphate, and folic acid may collectively constitute the ′′integrative pattern′′ of multiple biomarkers, which may provide an accurate diagnosis of TB. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).COA of Formula: C12H18O5

The Article related to pyridoxamine pyridoxal phosphate folic acid pulmonary tuberculosis diagnosis, cerna regulatory network biomarker potential, biomarkers, metabolomics, pulmonary tuberculosis, transcriptomics, vitamins, cerna and other aspects.COA of Formula: C12H18O5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On September 27, 2004, Bentz, Emilie; Moloney, Mark G.; Westaway, Susan M. published an article.Reference of tert-Butyl 2-(4-nitrophenyl)acetate The title of the article was Palladium-catalysed α-arylation of esters and amides under microwave conditions. And the article contained the following:

A rapid and convenient approach for the α-arylation of esters and amides using Reformatsky reagents under a microwave accelerated reaction protocol was established. The experimental process involved the reaction of tert-Butyl 2-(4-nitrophenyl)acetate(cas: 29704-38-9).Reference of tert-Butyl 2-(4-nitrophenyl)acetate

The Article related to ester arylation reformatsky reagent palladium catalyst microwave irradiation, amide arylation reformatsky reagent palladium catalyst microwave irradiation, aryl ester preparation, aromatic amide preparation and other aspects.Reference of tert-Butyl 2-(4-nitrophenyl)acetate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics