Tag: 200-300

On June 24, 2020, Yang, Yonghong; Fryer, Claudia; Sharkey, Jack; Thomas, Aidan; Wais, Ulrike; Jackson, Alexander W.; Wilm, Bettina; Murray, Patricia; Zhang, Haifei published an article.Quality Control of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate) The title of the article was Perylene Diimide Nanoprobes for In Vivo Tracking of Mesenchymal Stromal Cells Using Photoacoustic Imaging. And the article contained the following:

Noninvasive bioimaging techniques are critical for assessing the biodistribution of cellular therapies longitudinally. Among them, photoacoustic imaging (PAI) can generate high-resolution images with a tissue penetration depth of ~4 cm. However, it is essential and still highly challenging to develop stable and efficient near-IR (NIR) probes with low toxicity for PAI. The authors report here the preparation and use of perylene diimide derivative (PDI) with NIR absorbance (around 700 nm) as nanoprobes for tracking mesenchymal stromal cells (MSCs) in mice. Employing an inhouse synthesized star hyperbranched polymer as a stabilizer is the key to the formation of stable PDI nanoparticles with low toxicity and high uptake by the MSCs. The PDI nanoparticles remain within the MSCs as demonstrated by in vitro and in vivo assessments. The PDI-labeled MSCs injected s.c. on the flanks of the mice are clearly visualized with PAI up to 11 days postadministration. Furthermore, bioluminescence imaging of PDI-labeled luciferase-expressing MSCs confirms that the administered cells remain viable for the duration of the experiment These PDI nanoprobes thus have good potential for tracking administered cells in vivo using PAI. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Quality Control of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)

The Article related to perylene diimide nanoprobe mesenchyme stromal cell photoacoustic imaging, in vivo tracking, organic nanoparticles, perylene diimide, photoacoustic imaging, star hyperbranched polymer and other aspects.Quality Control of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chen, Tzu-Yin; Liu, Chia-Hao; Chen, Tsung-Hsien; Chen, Mei-Ru; Liu, Shan-Wen; Lin, Pinpin; Lin, Kurt Ming-Chao published an article in 2021, the title of the article was Conditioned Media of Adipose-Derived Stem Cells Suppresses Sidestream Cigarette Smoke Extract Induced Cell Death and Epithelial-Mesenchymal Transition in Lung Epithelial Cells.Recommanded Product: 2358-84-1 And the article contains the following content:

The role of the epithelial-mesenchymal transition (EMT) in lung epithelial cells is increasingly being recognized as a key stage in the development of COPD, fibrosis, and lung cancers, which are all highly associated with cigarette smoking and with exposure to second-hand smoke. Using the exposure of human lung cancer epithelial A549 cells and non-cancerous Beas-2B cells to sidestream cigarette smoke extract (CSE) as a model, we studied the protective effects of adipose-derived stem cell-conditioned medium (ADSC-CM) against CSE-induced cell death and EMT. CSE dose-dependently induced cell death, decreased epithelial markers, and increased the expression of mesenchymal markers. Upstream regulator anal. of differentially expressed genes after CSE exposure revealed similar pathways as those observed in typical EMT induced by TGF-β1. CSE-induced cell death was clearly attenuated by ADSC-CM but not by other control media, such as a pass-through fraction of ADSC-CM or A549-CM. ADSC-CM effectively inhibited CSE-induced EMT and was able to reverse the gradual loss of epithelial marker expression associated with TGF-β1 treatment. CSE or TGF-β1 enhanced the speed of A549 migration by 2- to 3-fold, and ADSC-CM was effective in blocking the cell migration induced by either agent. Future work will build on the results of this in vitro study by defining the mol. mechanisms through which ADSC-CM protects lung epithelial cells from EMT induced by toxicants in second-hand smoke. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Recommanded Product: 2358-84-1

The Article related to lung epithelial cell death adipose stem cigarette smoke, copd, tgf-β1, adipose-derived stem cell, cigarette smoke extract, conditioned medium, epithelial–mesenchymal transition (emt) and other aspects.Recommanded Product: 2358-84-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On July 31, 2020, Arribas, Raquel L.; Bordas, Anna; Domenech Omella, Judit; Cedillo, Jose Luis; Janssens, Veerle; Montiel, Carmen; de los Rios, Cristobal published an article.Formula: C12H16O7 The title of the article was An okadaic acid fragment analogue prevents nicotine-induced resistance to cisplatin by recovering PP2A activity in non-small cell lung cancer cells. And the article contained the following:

We herein report the design, synthesis, and functional impact of an okadaic acid (OA) small analog, ITH12680, which restores the activity of phosphoprotein phosphatase 2A (PP2A), whose deficient activity has been implicated in nicotine-mediated tumor progression and chemoresistance in non-small cell lung cancer (NSCLC). For its design, we paid attention to the structure of the PP2A-OA complex, where the C16-C38 OA fragment confers PP2A affinity and selectivity, but it is not involved in the inhibitory effect. Confirming this hypothesis, PP2A activity was not inhibited by ITH12680. By contrast, the compound partially restored OA-exerted PP2A inhibition in vitro. Moreover, flow cytometry and immunoblotting experiments revealed that ITH12680 reversed nicotine-induced cisplatin resistance in NSCLC cells, as it prevented nicotine-induced reduction of Bax expression and inhibited nicotine-mediated activation of cell survival and proliferation kinases, Akt and ERK1/2. Our findings suggest that the rescue of nicotine-inhibited PP2A activity could diminish the resistance to cisplatin treatment observed in NSCLC patients who continue smoking. The experimental process involved the reaction of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate(cas: 2873-29-2).Formula: C12H16O7

The Article related to drug design nsclc pp2a chemoresistance cisplatin okadaic acid, chemoresistance, cisplatin, computer-aided drug design, non-small cell lung cancer, okadaic acid, phosphoprotein phosphatase 2a and other aspects.Formula: C12H16O7

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On February 14, 2009, Gellerman, Gary; Hazan, Eran; Kovaliov, Marina; Albeck, Amnon; Shatzmiler, Shimon published an article.Related Products of 53838-27-0 The title of the article was Synthesis of orthogonally protected optically pure ketopiperazine, diketopiperazine, ketodiazepane, and 3-aminopyrrolidone building blocks for peptidomimetic combinatorial chemistry. And the article contained the following:

A simple and convenient synthesis of orthogonally protected multi-tethered, optically pure 2-ketopiperazine, diketopiperazine, 2-ketodiazepane and 3-aminopyrrolidone scaffolds for Fmoc combinatorial chem. has been developed. It utilizes accessible chiral amino acid precursors, sequentially applying reductive alkylation, dipeptide coupling and regioselective ring formation as key steps. These scaffolds are expansion of our “pool of privileged building blocks” and can introduce valuable drug-like properties in three independent directions to any medicinally relevant piperazine-, diazepane- and pyrrolidone-based motif by “around-the-scaffold” drug optimization. The synthetic routes reported in this work are general and applicable for the preparation of a diverse library of scaffolds, controlling chirality, arm position and length as well as the nature of functional moieties at the arms for further diversification in three independent directions. In addition, these building blocks have a wide application scope in managing fast and efficient multi-cyclic optimization processes in the combinatorial chem. and drug design fields. The experimental process involved the reaction of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate(cas: 53838-27-0).Related Products of 53838-27-0

The Article related to ketopiperazine diketopiperazine ketodiazepane aminopyrrolidone protected enantiopure preparation peptidomimetic, amino acid reductive alkylation dipeptide coupling regioselective cyclization and other aspects.Related Products of 53838-27-0

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On October 2, 2020, Singh, Adesh Kumar; Kanaujiya, Vimlesh Kumar; Tiwari, Varsha; Sabiah, Shahulhameed; Kandasamy, Jeyakumar published an article.COA of Formula: C12H16O7 The title of the article was Development of Routes for the Stereoselective Preparation of β-Aryl-C-glycosides via C-1 Aryl Enones. And the article contained the following:

A wide range of enones derived from D-glucal, D-galactal, L-rhamnal, D-rhamnal, and L-arabinal underwent Heck-coupling with various arylboronic acids bearing electron-donating and -withdrawing groups in the presence of palladium acetate and 1,10-phenanthroline. These reactions provided synthetically useful C-1 aryl enones in good yields. Many sensitive functional groups as well as protecting groups present in arylboronic acids and enones, resp., remained intact under optimized conditions. The stereoselective hydrogenation of C-1 aryl enones with Pd-C/H2 provides the β-isomer of 2-deoxy-aryl-C-glycosides in excellent yield. The C-1 aryl enones were also used as precursors for the synthesis of 2-hydroxy-β-aryl-C-glycosides. Regioselective C-2 halogenation and vinylation of C-1 aryl enones were achieved in excellent yields. The experimental process involved the reaction of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate(cas: 2873-29-2).COA of Formula: C12H16O7

The Article related to protecting group arylboronic acid stereoselective hydrogenation halogenation vinylation glycal, arylglycoside stereoselective arylboronic acid heck coupling phenanthroline palladium catalyst and other aspects.COA of Formula: C12H16O7

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On February 5, 2021, Ghouilem, Juba; Tran, Christine; Grimblat, Nicolas; Retailleau, Pascal; Alami, Mouad; Gandon, Vincent; Messaoudi, Samir published an article.Product Details of 2873-29-2 The title of the article was Diastereoselective Pd-Catalyzed Anomeric C(sp3)-H Activation: Synthesis of α-(Hetero)aryl C-Glycosides. And the article contained the following:

Anomeric C-H bond activation is an unsolved long-standing synthetic challenge. Herein, we report a diastereoselective Pd-catalyzed anomeric C(sp3)-H activation methodol. that allows the synthesis of elusive C-(hetero)aryl glycosides with an exclusive α-selectivity. The experimental process involved the reaction of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate(cas: 2873-29-2).Product Details of 2873-29-2

The Article related to palladium catalyst stereoselective glycosylation heteroaryl aminoglycoside preparation, aryl aminoglycoside preparation crystal structure arylation stereoselective glycosylation heteroaryl and other aspects.Product Details of 2873-29-2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On March 1, 2020, Shiozaki, Yoko; Sakurai, Shunya; Sakamoto, Ryu; Matsumoto, Akira; Maruoka, Keiji published an article.Synthetic Route of 2873-29-2 The title of the article was Iron-Catalyzed Radical Cleavage/C-C Bond Formation of Acetal-Derived Alkylsilyl Peroxides. And the article contained the following:

A novel radical-based approach for the Fe-catalyzed selective cleavage of acetal-derived alkylsilyl peroxides, followed by the formation of a C-C bond is reported. The reaction proceeds under mild reaction conditions and exhibits a broad substrate scope with respect to the acetal moiety and the C electrophile. Mechanistic studies suggest that the present reaction proceeds through a free-radical process involving C radicals generated by the homolytic cleavage of a C-C bond within the acetal moiety. A synthetic application of this method to sugar-derived alkylsilyl peroxides is also described. The experimental process involved the reaction of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate(cas: 2873-29-2).Synthetic Route of 2873-29-2

The Article related to iron catalyzed radical cleavage bond formation acetal alkylsilyl peroxide, c−c bond cleavage, c−c bond formation, alkylsilyl peroxides, iron-catalysis, radical reaction, sugar derivatives and other aspects.Synthetic Route of 2873-29-2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yao, Wang; Wang, Hao; Zeng, Jing; Wan, Qian published an article in 2021, the title of the article was Practical synthesis of 2-deoxy sugars via metal free deiodination reactions.Formula: C12H16O7 And the article contains the following content:

2-Deoxy-glycosides, in which the C-2 hydroxyl group is replaced with a hydrogen atom, are important motifs in numerous bioactive natural products and pharmaceutical mols. Herein, an improved dilauroyl peroxide-mediated radical deiodination reaction by using cyclohexane and Et acetate as co-solvent is reported. This is an environmentally benign protocol, which operates smoothly under mild conditions and allows efficient preparation of a series of 2-deoxy-glycosides in up to 98% yields. The experimental process involved the reaction of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate(cas: 2873-29-2).Formula: C12H16O7

The Article related to solvent effect iodination deiodination dilauroyl peroxide catalyst glycoside preparation, deoxyglycoside preparation reductive deiodination lauroyl peroxide catalyst glycoside preparation and other aspects.Formula: C12H16O7

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On June 30, 2022, Liang, Liyuan; Chen, Hongyan published an article.Safety of Phenyl Salicylate The title of the article was Development and characterization of biodegradable ultraviolet protective and antibacterial polylactic acid-cellulose acetate film modified by phenyl salicylate. And the article contained the following:

The polylactic acid composite films were successfully fabricated via the technique of solvent casting using cellulose acetate (20%, wt) as the reinforcing material and Ph salicylate as the UV absorbent and antibacterial agent. Polylactic acid-cellulose acetate-Ph salicylate composite films displayed complete absorption effect at the region of UV-C (280-100 nm) and UV-B (315-280 nm), and more than 95% UV absorption effect at the region of UV-A (400-315 nm). These results indicate that the UV shielding performance of the composite films could be significantly improve by addition of Ph salicylate. Moreover, the addition of 20% Ph salicylate could improve the steam resistance, mech. properties and thermal stability of the films, and the composite films had also better antibacterial activity against Escherichia coli. The composite films could reduce the decay rate of fresh lilies and extend their storage time. The degradation characteristics of the films were explored in the natural environment and the laboratory level, which provided application prospect for the development of degradable food packaging materials with anti-UV and anti-bacteria effect. The experimental process involved the reaction of Phenyl Salicylate(cas: 118-55-8).Safety of Phenyl Salicylate

The Article related to polylactic acid cellulose acetate film phenyl salicylate antiuv antibacterial, antibacterial activity, cellulose acetate, composite film, phenyl salicylate, polylactic acid, ultraviolet resistance and other aspects.Safety of Phenyl Salicylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On July 31, 2022, Sakr, Mahmoud E. M.; Kana, Maram T. H. Abou; Elwahy, Ahmed H. M.; Abdelwahed, Mohamed S.; El-Daly, Samy A.; Ebeid, El-Zeiny M. published an article.Category: esters-buliding-blocks The title of the article was Spectroscopic Behavior and Photophysical Parameters of 2-(Acetoxymethyl)-6-(1,2,4-triazinylaminodihydroquinazolinyl)tetrahydropyran Derivative in Different Solid Hosts. And the article contained the following:

Optical and photophys. properties of 6-substituted-1,2,4-Triazine fluorescent derivative dye doped in silicate based sol-gel, homopolymer of Me methacrylate (PMMA), and copolymer (MMA/diethylene glycol dimethacrylate) (DEGDMA) were investigated. The pores of different hosts and caging of the dye were found to effect on the parameters such as molar absorptivity, cross sections of singlet-singlet electronic absorption and emission spectra, excited state lifetime, quantum yield of fluorescence. The dipole moment of electronic transition, the length of attenuation and oscillator strength of electronic transition from So → S1 have been calculated The dye was pumped with different powers using 3rd harmonic Nd: YAG laser of 355 nm and pulse duration 8 ns, with repetition rate 10 Hz. Good photo stability for dye was attained. After 55,000 pumping pulses of (10 mJ/pulse), the photo-stabilities were decreased to 53%, 48%, and 45% of the initial ASE of dye in sol gel, PMMA, and Co-polymer resp. The dye in sol-gel matrix showed improvement of photo stability compared with those in organic polymeric matrixes. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Category: esters-buliding-blocks

The Article related to spectroscopic photophys triazinylaminodihydroquinazolinyl solid host, optical property, photophysical parameters, photostability, polymeric matrices, silicate based sol–gel, solid state laser dye and other aspects.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics