Tag: 200-300

On January 18, 1984, Entwistle, Ian David; Boehm, Peter published a patent.Application of 29704-38-9 The title of the patent was 3-(1-Tetralinyl)-4-hydroxycoumarins. And the patent contained the following:

Title compounds (n = 0, 1, 2; R = halo; R1 = biphenylyl, halo- or cyanophenyl, phenylfuryl, phenoxyphenyl, benzyloxyphenyl, phenethylphenyl, styrylphenyl), which were prepared, exhibited rodenticidal activity. 3-(4′-Trifluoromethyl-4-biphenylyl)-1-tetralol was treated with PBr3 and 4-hydroxycoumarin to give I [n = 0, R1 = 4-(4-F3CC6H4)C6H4]. The experimental process involved the reaction of tert-Butyl 2-(4-nitrophenyl)acetate(cas: 29704-38-9).Application of 29704-38-9

The Article related to hydroxyphenylcoumarin preparation rodenticide, coumarin phenyl preparation rodenticide, phenylhydroxycoumarin preparation rodenticide, Heterocyclic Compounds (One Hetero Atom): Benzopyrans (Including Coumarins, Isocoumarins, Chromones, Benzopyrones, Dibenzopyrans, and Other Arenopyrans) and other aspects.Application of 29704-38-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wu, Huaimo; Liu, Song; Wang, Youyi; Yuan, Man; Zhang, Hong; Zhou, Hua; Xiao, Lianbo; Zheng, Changwu; Xu, Hongxi published an article in 2021, the title of the article was An efficient approach for the synthesis of 1,2-dihydroxanthones enabled by one-pot Claisen condensation/cyclization reactions.Synthetic Route of 118-55-8 And the article contains the following content:

In this report, a mild, efficient and green method for the synthesis of 1,2-dihydroxanthones (DHXs) I (R = H, Me, 3-methylbut-2-en-1-yl; R1 = H, Me; R2 = Me, Ph, 2,2,2-trifluoroethyl, but-3-en-1-yl, etc.; R3 = H, Me; R4 = H, F, OMe, Cl, Br, I; R5 = H, Me, OMe, Cl, CF3, F; R4R5 = -CH:CHCH:CH-; R6 = H, Cl, Me, prop-2-en-1-yl) and II (R7 = H, OMe) has been developed in one pot through Claisen condensation and O-cyclization under waste-induced relay catalysis with min. organic solvents. The byproduct (HMDS or NH3·H2O) of the first step turned out to be the promoter for the second step, which could efficiently proceed in aqueous media without the addition of other catalysts. The reactions using trifluoroethyl salicylates 2-OH-3-R6-4-R5-5-R4-6-R3C6HC(O)OCH2CF3 could be performed under mild conditions to ensure the generation of vulnerable DHXs I and II in high yields. The substrate scope is very broad regardless of the substituent type and its position on the structure. Specifically, the versatility of DHXs I (R = R1 = R3 = R4 = R5 = R6 = H; R2 = Me) was demonstrated by their conversion to xanthones I (R = 3-methylbut-2-en-1-yl; R1 = R3 = R4 = R5 = R6 = H; R2 = Me)/II (R7 = H) and other complex structures III/IV. The experimental process involved the reaction of Phenyl Salicylate(cas: 118-55-8).Synthetic Route of 118-55-8

The Article related to dihydroxanthone preparation green chem, cyclohexenone salicylate claisen condensation heterocyclization, Heterocyclic Compounds (One Hetero Atom): Benzopyrans (Including Coumarins, Isocoumarins, Chromones, Benzopyrones, Dibenzopyrans, and Other Arenopyrans) and other aspects.Synthetic Route of 118-55-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Iyori, Yasuaki; Chatani, Naoto published an article in 2021, the title of the article was Nickel-catalyzed C-O/O-H Annulation of Salicylate Esters with Alkynes: Activation of C-O Bond in Esters.Category: esters-buliding-blocks And the article contains the following content:

The Ni-catalyzed C-O/O-H annulation of salicylate esters with alkynes, leaded to the production of chromones was reported. The key step in the reaction was the cleavage of an acyl C-O bond. The presence of a base was essential for the reaction to proceed. The experimental process involved the reaction of Phenyl Salicylate(cas: 118-55-8).Category: esters-buliding-blocks

The Article related to salicylate ester alkyne nickel catalyst regioselective cyclization, chromone preparation, Heterocyclic Compounds (One Hetero Atom): Benzopyrans (Including Coumarins, Isocoumarins, Chromones, Benzopyrones, Dibenzopyrans, and Other Arenopyrans) and other aspects.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On January 21, 2010, Uchida, Hideharu; Ogawa, Shinichi; Makabe, Muneyoshi; Maeda, Yoshitaka published a patent.Related Products of 141940-37-6 The title of the patent was Preparation of heterocyclylidene-N-(heterocyclyl)acetamide derivatives as antagonists of transient receptor potential type I receptor (TRPV1). And the patent contained the following:

The title compounds [I; k, m, n, p = 0-2; j, q = 0-1; R1 = halo, H, heterocyclyl, alkoxy, alkoxycarbonyl, NH2, OH, CO2H, alkanoyl, cyano, NO2, etc.; R2 = halo, NH2, alkyl, aromatic heterocyclyl, oxo, etc.; X1 = O, NR3, or S(O)r; X2 = CH2, O, NR3, S(O)r (wherein r = 0-2; R3 = H, alkyl, heterocyclyl, etc.); W = CH2, CO, SO2; R7 = H, alkyl, heterocyclyl, etc.; R8 = H, halo, alkyl, heterocyclyl, etc.; a dashed line in the ring containing X1 and X2 means the fusion of two rings; L1, L2 = a single bond, (un)substituted CH2 or NH, S(O)t (t = 0-2); the “”Cycle”” moiety represents a 5-6 membered aryl or heteroaryl ring; a solid line and a dashed line between L1 and L2 mean the presence of a single bond and a double bond, resp.; and a wavy line means an E-form or Z-form], or salts thereof, or solvates of the compounds or the salts, useful as antagonists of transient receptor potential type I receptor (TRPV1), were prepared Thus, (E)-(8-trifluoromethyl-3,4-dihydro-2H-benzo[b]oxepin-5-ylidene)acetic acid was stirred with oxalyl chloride and one drop of DMF in CH2Cl2 at room temperature for 2 h, concentrated under reduced pressure, redissolved in CH2Cl2, and stirred with 6-amino-2,2-dimethyl-4H-benzo[1,4]oxazin-3-one at room temperature for 2 h to give (E)-2-(8-Trifluoromethyl-3,4-dihydrobenzo[b]oxepin-5(2H)-ylidene)-N-(2,2-dimethyl-3-oxo-2,3-dihydro-4H-benzo[1,4]oxazin-6-yl)ethanamide (II). II in vitro at <100 nM inhibited the capsaicin-induced cellular influx of calcium in CHO cells genetically transformed with human TRPV1. Pharmaceutical formulations, e.g. a tablet containing II, were described. The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Related Products of 141940-37-6

The Article related to trpv1 antagonist heterocyclylideneheterocyclylacetamide preparation, heterocyclylideneheterocyclylacetamide preparation antagonist transient receptor potential type i receptor and other aspects.Related Products of 141940-37-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On November 8, 2020, Komendova, Martina; Svobodova, Petra; Urban, Jiri published an article.Product Details of 2358-84-1 The title of the article was Photografting of polymer monoliths by a crosslinking monomer. And the article contained the following:

The surface of fifteen polymethacrylate monolithic stationary phases has been modified by a post-polymerization UV-initiated grafting reaction with bifunctional poly(ethylene glycol)dimethacrylate monomers. An effect of crosslinking monomer length, its concentration in the modification mixture, and a time of the modification reaction have been selected to control the extent of modification by a design of experiments protocol. Hydrodynamic and kinetic properties of prepared columns were characterized by capillary liquid chromatog. Regression anal. of determined data revealed that there is only a minor effect of modification reaction on column permeability, as it is rather controlled by the composition of the polymerization mixture used to prepare generic monolith. The utilization of shorter crosslinking monomer increased the formation of small pores and minimized mass transfer resistance effect. Both column efficiency and mass transfer resistance also improved when a lower concentration of crosslinking monomer in the modification mixture was used. Photografting modification decreased a neg. effect of mass transfer resistance related to a crosslink d. gradient and allowed fast isocratic separations of dopamine metabolism-related compounds Developed preparation protocol might be further utilized in the preparation of monolithic stationary phases in microfluidic devices. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Product Details of 2358-84-1

The Article related to photografting polymer monoliths crosslinking monomer chromatog, design of experiments, grafting, hypercrosslinking, mass transfer resistance, polymer monolith, small molecules and other aspects.Product Details of 2358-84-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On August 7, 2020, Ai, Han-Jun; Zhang, Youcan; Zhao, Fengqian; Wu, Xiao-Feng published an article.Computed Properties of 118-55-8 The title of the article was Rhodium-Catalyzed Carbonylative Synthesis of Aryl Salicylates from Unactivated Phenols. And the article contained the following:

In the presence of RhCl3 and 1,2-bis(dicyclohexylphosphino)ethane (dcpe), phenols underwent carbonylative esterification reactions with CO mediated by TEMPO in 1.4-dioxane/toluene to yield aryl salicylates such as Ph salicylate. Under similar conditions, but using 1,3-bis(diphenylphosphino)propane as the ligand, di-Ph carbonate was obtained as the major product. The mechanism of the reaction was studied using the reactions of potential intermediates and using kinetic isotope effects. The experimental process involved the reaction of Phenyl Salicylate(cas: 118-55-8).Computed Properties of 118-55-8

The Article related to aryl hydroxybenzoate preparation, rhodium catalyst carbonylative esterification phenol, kinetic isotope effect mechanism rhodium catalyzed carbonylative esterification phenol and other aspects.Computed Properties of 118-55-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Di Gioia, M. L.; Costanzo, P.; De Nino, A.; Maiuolo, L.; Nardi, M.; Olivito, F.; Procopio, A. published an article in 2017, the title of the article was Simple and efficient Fmoc removal in ionic liquid.Recommanded Product: 53838-27-0 And the article contains the following content:

A mild method for an efficient removal of the fluorenylmethoxycarbonyl (Fmoc) group in ionic liquid was developed. The combination of a weak base such as triethylamine and [Bmim][BF4] made the entire system more efficient for the cleavage at room temperature of various amines e.g. I and amino acid alkyl esters II [R1 = NH2, HNMe; R2 = Me, i-Pr, Ph, etc.; R3 = Me, t-Bu, CH2C6H5] short reaction times. The procedure worked well even in the case of N-Fmoc amino acids bearing acid-sensitive protecting groups and of N-alkylated amino acid alkyl esters, III, e.g. The solvent-free condition provided a complementary method for Fmoc deprotection in solution phase peptide synthesis and modern organic synthesis. The experimental process involved the reaction of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate(cas: 53838-27-0).Recommanded Product: 53838-27-0

The Article related to acetyl alkyl ester green preparation, amine amino acid methyl ester preparation acetic anhydride acetylation, amino acid alkyl ester amine deprotection ionic liquid catalyst and other aspects.Recommanded Product: 53838-27-0

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On April 13, 1988, Morimoto, Akira; Noguchi, Noryoshi published a patent.Computed Properties of 53838-27-0 The title of the patent was Preparation of 2-oxoazetidin-1-yl- and 2-oxopyrrolidin-1-yl-5-oxotetrahydrofuran-2-carboxylic acid derivatives as antibacterials. And the patent contained the following:

β-Lactams and 4-butanelactams [I; R1 = NH2, N-bonded organic group; R2 = CO2H or its derivative; n = 1,2] and salts thereof, useful as antibacterials (no data), were prepared Treatment of 2-[(2S)-2-(benzyloxycarbonylamino)-4-hydroxybutyryl]amino-2-(methylthio)glutaric acid 1-4-nitrobenzyl 5-tert-Bu diester (preparation given) with CF3CO2H containing anisole under ice-cooling for 80 min followed by Hg(OAc)2 in DMF at -50 to -20° for 20 min gave 2-[(2S)-2-(benzyloxycarbonylamino)-4-hydroxybutyryl]amino-5-oxotetrahydrofuran-2-carboxylic acid 4-nitrobenzyl ester which was cyclized by treatment with Ph3P and EtO2CN:NCO2Et in THF to give 2-[(3S)-3-(benzyloxycarbonylamino)-2-oxopyrrolidin-1-yl]-5-oxotetrahydrofuran-2-carboxylic acid 4-nitrobenzyl ester. The experimental process involved the reaction of (S)-5-tert-Butyl 1-methyl 2-aminopentanedioate(cas: 53838-27-0).Computed Properties of 53838-27-0

The Article related to oxoazetidinyloxotetrahydrofurancarboxylate preparation antibacterial, oxopyrrolidinyloxotetrahydrofurancarboxylate preparation antibacterial, beta lactam preparation antibacterial and other aspects.Computed Properties of 53838-27-0

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Shiyi; Zhou, Changqing; Xu, Yongqian; Wang, Yujia; Li, Lijiao; Pelekos, George; Ziebolz, Dirk; Schmalz, Gerhard; Qin, Zeman published an article in 2021, the title of the article was Similarity and potential relation between periimplantitis and rheumatoid arthritis on transcriptomic level: results of a bioinformatics study.Application In Synthesis of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate) And the article contains the following content:

This bioinformatics study aimed to reveal potential cross-talk genes, related pathways, and transcription factors between periimplantitis and rheumatoid arthritis (RA). The datasets GSE33774 (seven periimplantitis and eight control samples) and GSE106090 (six periimplantitis and six control samples) were included from the National Center for Biotechnol. Information (NCBI) Gene Expression Omnibus (GEO). A differential expression anal. (p < 0.05 and |logFC (fold change)| ≥ 1) and a functional enrichment anal. (p < 0.05) were performed. Based on this, a protein-protein interaction (PPI) network was constructed by Cytoscape. RA-related genes were extracted from DisGeNET database, and an overlap between periimplantitis-related genes and these RA-related genes was examined to identify potential cross-talk genes. Gene expression was merged between two datasets, and feature selection was performed by Recursive Feature Elimination (RFE) algorithm. For the feature selection cross-talk genes, support vector machine (SVM) models were constructed. The expression of these feature genes was determined from GSE93272 for RA. Finally, a network including cross-talk genes, related pathways, and transcription factors was constructed. Periimplantitis datasets included 138 common differentially expressed genes (DEGs) including 101 up- and 37 downregulated DEGs. The PPI interwork of periimplantitis comprised 1,818 nodes and 2,517 edges. The RFE method selected six features, i.e., MERTK, CD14, MAPT, CCR1, C3AR1, and FCGR2B, which had the highest prediction. Out of these feature genes, CD14 and FCGR2B were most highly expressed in periimplantitis and RA. The final activated pathway-gene network contained 181 nodes and 360 edges. Nuclear factor (NF) kappa B signaling pathway and osteoclast differentiation were identified as potentially relevant pathways. This current study revealed FCGR2B and CD14 as the most relevant potential cross-talk genes between RA and periimplantitis, which suggests a similarity between RA and periimplantitis and can serve as a theor. basis for future research. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Application In Synthesis of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)

The Article related to bioinformatic transcriptomic level rheumatoid arthritis potential relation periimplantitis, cd14, fcgr2b, bioinformatics, cross-talk genes, periimplantitis, rheumatoid arthritis and other aspects.Application In Synthesis of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On December 30, 2020, Peng, Kaiyuan; Zhao, Yao; Shahab, Shima; Mirzaeifar, Reza published an article.Application of 2358-84-1 The title of the article was Ductile Shape-Memory Polymer Composite with Enhanced Shape Recovery Ability. And the article contained the following:

In recent years, shape-memory polymers (SMPs) have received extensive attention to be used as actuators in a broad range of applications such as medical and robotic devices. Their ability to recover large deformations and their capability to be stimulated remotely have made SMPs a superior choice among different smart materials in various applications. In this study, a ductile SMP composite with enhanced shape recovery ability is synthesized and characterized. This SMP composite is made by a mixture of acrylate-based crosslinkers and monomers, as well as polystyrene (PS) with UV curing. The composite can achieve almost 100% shape recovery in 2 s by hot water or hot air. This shape recovery speed is much faster than typical acrylate-based SMPs. In addition, the composite shows excellent ductility and viscoelasticity with reduced hardness. Mol. dynamics (MD) simulations are performed for understanding the curing mechanism of this composite. With the combination of the exptl. and computational works, this study paves the way in front of designing and optimizing the future SMP devices. The experimental process involved the reaction of Oxybis(ethane-2,1-diyl) bis(2-methylacrylate)(cas: 2358-84-1).Application of 2358-84-1

The Article related to photocrosslinked shape memory polymer viscoelasticity, mechanical properties, molecular dynamics (md), polystyrene (ps), shape memory polymer composite, tertbutyl acrylate (tba) and other aspects.Application of 2358-84-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics